Knots in the Family Tree
Jun 26, 2018

Knots in the Family Tree

Lisa Cannon-Albright, PhD (Genetic Epidemiology) and Will Dere, MD (Endocrinology) are pioneering research on genetic anomalies and helping unlock secrets of major diseases based on extensive genealogical data found In Utah. ... Read More

Feb 01, 2016

Genome-Wide Association Study for Rotator Cuff Tears Identifies Two Significant Single-Nucleotide Polymorphisms

The precise etiology of rotator cuff disease is unknown, but prior evidence suggests a role for genetic factors. Limited data exist identifying specific genes associated with rotator cuff tearing. The purpose of this study was to identify specific genes or genetic variants associated with rotator cuff tearing by a genome-wide association study with an independent set of rotator cuff tear cases.... Read More

Oct 05, 2015

University of Utah Joins CDC in Effort to Stop Spread of Ebola, MRSA and Other Infectious Diseases in Health Care Settings

In its effort to develop and implement strategies to stop the spread of infectious diseases, including Ebola, in health care settings, the Centers for Disease Control and Prevention (CDC) has chosen the University of Utah and five other institutions nationwide to partner with the agency to spur innovations that help control the transmission of such organisms.... Read More

Apr 30, 2015

U honors faculty with Distinguished

The University of Utah has announced the winners of the fifth annual Distinguished Innovation and Impact Award. The award recognizes faculty who create products and initiatives with potential to change the world and improve lives.... Read More

Mar 31, 2015

Risk of Associated Conditions in Relatives of Subjects with Interstitial Cystitis.

Urological chronic pelvic pain syndrome (UCPPS) includes interstitial cystitis/painful bladder syndrome (IC/PBS), a chronic, bladder pain condition of unknown etiology. IC/PBS can co-occur with a number of associated conditions such as irritable bowel syndrome and fibromyalgia. The purpose of this study is to estimate the heritability of approximately 20 associated conditions in first-, and if appropriate second-, and third-degree relatives of IC/PBS cases to identify shared genetic contributions for the disease combinations.... Read More

Feb 01, 2015

Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States

Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this variant in AD cases and cognitively normal controls to determine whether this variant will significantly contribute to risk assessment in individuals in the United States.... Read More

Dec 01, 2014

Co-Prevalence of Other Tumors in Patients Harboring Pituitary Tumors

The cause of most pituitary tumors remains unknown, although a genetic contribution is recognized for some. The prevalence of pituitary tumors in the general population is high. Analyzing the Utah Population Database (UPDB), the authors investigated the co-prevalence of other independent primary tumors in patients with known pituitary tumors, both benign and malignant, and in the relatives of these patients.... Read More

Oct 23, 2014

Pituitary Tumors Signal Risks

People who develop tumors in their pituitary gland have a significantly higher risk for other, unrelated types of cancer—and so do their relatives, a new study using records from the Utah Population Database (UPDB) has found.... Read More

Oct 01, 2014

Glioma Transcriptional Subtyping Complements Traditional Approaches.

Gliomas traditionally have been sub-classified based on histopathological observations. However, this approach is subject to inter-observer variability, and histopathological features may not reflect the biological mechanisms that drive tumor growth. High-throughput transcriptional profiling has shown promise in objectively and reproducibly identifying glioma subtypes. Most prior studies have typically used only modest sample sizes and have sometimes overlooked important data-processing steps to ensure sample quality and to evaluate the robustness of quantitative findings. The purpose of our study was to define robust glioma subtypes by applying rigorous preprocessing and validation steps to 1,952 microarray samples aggregated from 16 prior studies. This data set is the most comprehensive collection of glioma microarray samples compiled to date.... Read More

Feb 21, 2014

Using Family History to Estimate Health Risks

Geneticist Dr. Lisa Cannon-Albright explains how knowing your genealogy can give you a head start in understanding your risk for developing disease. She also describes her work building a genealogy database incorporating Veterans Administration records, and how it may help identify soldiers more likely to suffer from post-traumatic stress disorder, substance abuse, and other complex disorders.... Read More

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