Internal Medicine Department
Hematology Division

Transplants & Medications

ACETAMINOPHEN
  Generic Name: Acetaminophen 
  Possible Uses: Relief of headaches and mild or moderate pain, or to decrease fevers. 
  Side Effects: May mask a fever from an infection, or cause liver damage if dosage exceeds three grams per day. 
  Drug Interactions:
  Special Notes:  
   
ACYCLOVIR

  Generic Name: Acyclovir
  Possible Uses: Prevent and treat viral infections like herpes infections. 
  Side Effects: Diarrhea, dizziness, rash, fatigue, change in kidney function, vein irritation, confusion, change in liver function. 
  Drug Interactions:  
  Special Notes:  
   
ADRIAMYCIN

  Generic Name: Doxorubicin 
  Possible Uses: A chemotherapy drug. 
  Side Effects: Decreased blood counts, temporary hair loss, mouth sores, loss of appetite, flu-like symptoms, heart damage, breathing difficulties, swelling in legs and feet, rash, itching, nausea, vomiting, diarrhea. May cause temporary orange or red color in urine and secretions (tears, mucous). 
  Drug Interactions:  
  Special Notes:  
   
ALLOPURINOL

  Generic Name: Allopurinol 
  Possible Uses: Decreases uric acid that is released when chemotherapy drugs kill tumor cells, protects against kidney damage. Also decreases gout. 
  Side Effects: Fever, chills, drowsiness, nausea vomiting, increased liver function tests, and rash. Rarely, causes a severe rash that progresses to severe burn-like condition called Stevens-Johnson syndrome. May decrease blood cell counts. 
  Drug Interactions:  
  Special Notes:  
   
AMOXICILLIN

  Generic Name: Amoxicillin 
  Possible Uses: Prevent or treat bacterial infections. 
  Side Effects: Diarrhea, rash, nausea, and vomiting. If patient is allergic, may cause rash, swelling, breathing difficulties. May also cause a superinfection such as vaginal fungal infection. 
  Drug Interactions: May decrease the effectiveness of oral contraceptives and increase the effects of anticoagulants such as warfarin or Coumadin¨. 
  Special Notes:  
   
AMPHOTERICIN B
  Generic Name: Amphotericin B 
  Possible Uses: Prevent or treat fungal infections. 
  Side Effects: Fever, chills, muscle shaking, nausea, vomiting, decreased electrolytes (especially potassium and magnesium), decreased blood pressure, shortness of breath, decreased kidney function, diarrhea, rash, and anemia. 
  Drug Interactions:  
  Special Notes:  
   
ANTITHYMOCYTE GLOBULIN

  Generic Name: Antithymocyte Globulin, ATG
  Possible Uses: Used in allogeneic transplants to treat or prevent graft-versus-host disease (GVHD). 
  Side Effects: Fever, chills, decreased or increased blood pressure, chest pain, fast heart beat, nausea, shortness of breath, diarrhea, irritation at injection site, decline in kidney function, swelling of mouth and throat. 
  Drug Interactions:  
  Special Notes:  
   
ATIVAN
  Generic Name: Lorazepam
  Possible Uses: Decrease anxiety, control nausea and vomiting. 
  Side Effects: Agitation, irritability, difficulty concentrating, memory loss, drowsiness, dizziness, blurred vision, breathing difficulties, muscle weakness, slurred speech. 
  Drug Interactions:  
  Special Notes:  
   
BACTRIM DS
  Generic Name: Trimethoprim/sulfamethoxazole 
  Possible Uses: Prevent or treat bacterial infections. 
  Side Effects: Rash, nausea, vomiting, diarrhea, stomach upset, decreased blood counts, change in kidney or liver function. If patient is allergic, may cause breathing difficulties, swelling of face, throat or lips. 
  Drug Interactions:  
  Special Notes:  
   
BCNU
  Generic Name: Carmustine 
  Possible Uses: Chemotherapy drug. 
  Side Effects: Nausea, vomiting, temporary hair loss, mouth sores, redness in eyes, vision problems, breathing difficulties, yellowing of skin or eyes, reversible kidney disorder, decreased coordination. 
  Drug Interactions:  
  Special Notes:  
   
BENADRYL
  Generic Name: Diphenhydramine 
  Possible Uses: Decrease allergic reaction from some medications, decrease itching, dry up mucous, decrease sinus drainage, counteract nausea/vomiting caused by chemotherapy. 
  Side Effects: Rash, sweating, chills, dry mouth, nose and throat, low blood pressure, head ache, heart palpitation, sedation, drowsiness, dizziness, decreased coordination. 
  Drug Interactions:  
  Special Notes:  
   
BUSULFAN
  Generic Name: Busulfan
  Possible Uses: Chemotherapy drug. 
  Side Effects: Decreased blood counts, nausea, diarrhea, vomiting, temporary hair loss, increase in liver function tests, infertility, cessation of menstruation, dark spots on skin, itching, cataracts, seizures, lung damage. 
  Drug Interactions:  
  Special Notes:  
   
CARAFATE
  Generic Name: Sucralfate 
  Possible Uses: Prevent or treat stomach ulcers, stomatitis or ulcers in the mouth or throat caused by chemotherapy and radiation. 
  Side Effects: Constipation, stomach gas, indigestion, dry mouth, nausea, vomiting. 
  Drug Interactions:  
  Special Notes:  
   
COMPAZINE
  Generic Name: Prochlorperazine 
  Possible Uses: Control nausea and vomiting. 
  Side Effects: Drowsiness, dizziness, blurred vision, muscle spasms, jittery feeling, rash, difficulty urinating, dry mouth, nausea, constipation, rapid heartbeat. Rarely, breathing difficulties or seizures. 
  Drug Interactions:  
  Special Notes:  
   
CYCLOPHOSPHAMIDE
  Generic Name: Cyclophosphamide 
  Possible Uses: Chemotherapy drug. 
  Side Effects: Nausea, vomiting, temporary hair loss, mouth sores, infertility, darkened skin or fingernails, swollen feet or ankles, tiredness, breathing problems, bladder irritation, bloody urine, irregular or fast heartbeat, lung disorder (usually reversible). 
  Drug Interactions:  
  Special Notes:  
   
CYCLOSPORINE
  Generic Name: Cyclosporine A 
  Possible Uses: In allogeneic transplantation, used to prevent or treat graft-versus-host disease (GVHD). 
  Side Effects: High blood pressure, decreased kidney function, muscle tremor, enlargement of the gums, seizure, acne, leg cramps, abdominal discomfort, diarrhea, nausea, vomiting, liver toxicity, kidney toxicity, hair growth, increased triglycerides. 
  Drug Interactions: There are many drug interactions with cyclosporine, please check the package insert for specific information. 
  Special Notes: Kidney function should be monitored during therapy. 
   
DECADRON
  Generic Name: Dexamethasone 
  Possible Uses: Decrease inflammation, allergic reactions, nausea, vomiting. In allogeneic transplantation, used to prevent or treat graft-versus-host disease. 
  Side Effects: Fluid retention, weight gain, increased blood sugars, increased blood pressure, restlessness, anxiety, trouble sleeping, increased appetite, indigestion, mood changes, acne, thinning of the skin, muscle cramps, dark stools, increased risk of fungal infection. 
  Drug Interactions:  
  Special Notes:  
   
DEMEROL
  Generic Name: Meperidine 
  Possible Uses: Relieve moderate to severe pain, relieve or prevent chills caused by platelet transfusions or amphotericin B. 
  Side Effects: Dizziness, drowsiness, itching, constipation, nausea, vomiting, diarrhea, nervousness, irritability, confusion, hallucinations, tremors, seizures, difficulty urinating, slow, fast or irregular heartbeat, rash, breathing difficulties. 
  Drug Interactions:  
  Special Notes: As a pain reliever it is not useful for long lasting pain. Do not use if you have kidney problems. 
   
DILAUDID
  Generic Name: Hydromorphone 
  Possible Uses: Relieve severe pain. 
  Side Effects: Shortness of breath, rash, itching, slow, fast or irregular heartbeat, difficulty urinating, constipation, nausea, vomiting, loss of appetite, drowsiness, confusion, dizziness, headache, blurred vision, sweating, cold or clammy skin. 
  Drug Interactions:  
  Special Notes:  
   
DMSO
  Generic Name: Dimethylsulfoxide 
  Possible Uses: Used during preservation of stem cells or bone marrow. 
  Side Effects: Bad taste in mouth, bad smell, decreased blood pressure when stem cells are re-infused. Rarely, allergic reaction that causes chest or throat tightness and shortness of breath. 
  Drug Interactions:  
  Special Notes:  
   
ERYTHROPOIETIN
  Generic Name: Epoietin Alpha 
  Possible Uses: Increase red blood cell counts and hemoglobin after transplant. 
  Side Effects: Pain at injection site, rash, chills, muscle or joint pain, headache, upset stomach, nausea, diarrhea, elevated blood pressure. Rarely, breathing difficulties, chest pain. 
  Drug Interactions:  
  Special Notes:  
   
ETOPOSIDE
  Generic Name: Etoposide, VP-16
  Possible Uses: Chemotherapy drug. 
  Side Effects: Nausea, vomiting, diarrhea, mouth sores, temporary hair loss, low blood pressure, loss of appetite, dizziness, lightheadedness, yellowing of skin or eyes, breathing difficulties, reversible liver disorder, tightening of lungs, irregular heartbeat, confusion, seizures. 
  Drug Interactions:  
  Special Notes:  
   
FAMCICLOVIR
  Generic Name: Famciclovir 
  Possible Uses: Treat viral infections. 
  Side Effects: Nausea, vomiting, diarrhea, headache, tiredness, rash, increase in liver enzymes, itching. If patient is allergic, may cause breathing difficulties, tightness in chest, swelling in face. 
  Drug Interactions:  
  Special Notes:  
   
FLUCONAZOLE
  Generic Name: Fluconazole
  Possible Uses: Prevent or treat fungal infections. 
  Side Effects: Nausea, vomiting, diarrhea, rash, itching, headache, stomach upset/pain, loss of appetite, dark colored urine, pale colored bowel movements, fatigue, yellow skin or eyes, change in liver function. 
  Drug Interactions:  
  Special Notes:  
   
GANCYCLOVIR
  Generic Name: Ganciclovir 
  Possible Uses: Prevent or treat viral infections, particularly cytomegalovirus. 
  Side Effects: Nausea, vomiting diarrhea, loss of appetite, drowsiness, headache, numbness or tingling in hands or feet, dizziness, nervousness, confusion, strange dreams, fatigue, weakness, rash, flu-like feeling. 
  Drug Interactions:  
  Special Notes:  
   
G-CSF
  Generic Name: Filgrastim, Neupogen
  Possible Uses: Increase the number of stem cells available for harvest in the bloodstream, speed recovery of white blood cell counts after transplant. 
  Side Effects: Bone pain, nausea, loss of appetite, fever, chills, sore throat, rash, itching, swelling in face, lips or throat, breathing difficulties, fast or irregular heartbeat, pain at injection site, enlarged spleen. 
  Drug Interactions:  
  Special Notes:  
   
GM-CSF
  Generic Name: Sargramostim 
  Possible Uses: Speed recovery of white blood cell count after transplant. Also used to move stem cells from bone marrow into the bloodstream prior to a stem cell harvest. 
  Side Effects: Reaction at injection site, chills, fever, bone pain, muscle ache, rash, itching, swelling, fatigue, headache, flushing, nausea, vomiting, diarrhea. Rarely, breathing difficulties, fast or slow or irregular heartbeat. 
  Drug Interactions:  
  Special Notes:  
   
HYDROCORTISONE
  Generic Name: Hydrocortisone 
  Possible Uses: Decrease inflammation, decrease or stop allergic reactions, decrease nausea and vomiting. In allogeneic transplants, may be used to treat or prevent graft-versus-host disease. 
  Side Effects: Fluid retention, weight gain, increased blood sugars, increased blood pressure, restlessness, anxiety, trouble sleeping, increased appetite, indigestion, mood changes, acne, thinning of the skin, muscle cramps, dark stools, increased risk of fungal infection. 
  Drug Interactions:  
  Special Notes:  
   
IMMUNE GLOBULIN
  Generic Name: Immune Globulin, IVIG
  Possible Uses: Prevent or treat infection while immune system is weak. 
  Side Effects: Fever, chills, allergic reaction, rash, flushing, tightness in chest, dizziness, nausea, vomiting, increased blood pressure, headache, fatigue, pain in back, hip or joints, kidney damage. 
  Drug Interactions:  
  Special Notes:  
   
LASIX
  Generic Name: Furosemide 
  Possible Uses: Increase urine production and decrease water in body. 
  Side Effects: Decreased potassium, decreased blood pressure, dizziness, rash, itching, decreased sodium, chloride and magnesium. Persons allergic to sulfa drugs may have an allergic reaction. 
  Drug Interactions:  
  Special Notes:  
   
LEVOFLOXACIN
  Generic Name: Levofloxicin 
  Possible Uses: Prevent or treat bacterial infection. 
  Side Effects: Stomach upset, nausea, vomiting, diarrhea, sensitivity to sunlight, headache, dizziness, change in kidney or liver function (generally temporary). Rarely, may cause seizures. If patient is allergic, may cause breathing difficulties, rash, swelling of face, throat or lips.
  Drug Interactions:  
  Special Notes:  
   
MELPHALAN
  Generic Name: Melphalan 
  Possible Uses: Chemotherapy drug used. 
  Side Effects: Nausea, vomiting, diarrhea, mouth sores, temporary hair loss, lung disorder (often reversible), skin inflammation, liver disorder (often reversible). 
  Drug Interactions:  
  Special Notes:  
   
METHOTREXATE
  Generic Name: Methotrexate 
  Possible Uses: A chemotherapy drug. 
  Side Effects: Nausea, vomiting, diarrhea, temporary hair loss, mouth sores, headache, fever, chills, sore throat, loss of appetite, breathing difficulties, rash, itching, yellow eyes or skin, dark urine, decreased urine output. 
  Drug Interactions:  
  Special Notes:  
   
MORPHINE
  Generic Name: Morphine
  Possible Uses: Relieve moderate to severe pain. 
  Side Effects: Constipation, nausea, itching, vomiting, dizziness, weakness, dry mouth, headache, blurred vision, sleepiness, rapid or slow heartbeat, breathing difficulties, swollen face, rash, hallucinations, change in behavior, confusion, tender stomach. 
  Drug Interactions:  
  Special Notes:  
   
MYCOPHENOLATE
  Generic Name: Mycophenolate Mofetil, CellCept
  Possible Uses: In allogeneic transplantation, used to prevent or treat graft-versus-host disease (GVHD). 
  Side Effects: Diarrhea, leukopenia (reduced number of white blood cells), sepsis, nausea and vomiting. There is also a higher frequency of certain infections.
  Drug Interactions:  
  Special Notes:  
   
PENICILLIN
  Generic Name: Penicillin 
  Possible Uses: Prevent or treat bacterial infections. 
  Side Effects: Skin rash, stomach upset, diarrhea, bleeding problems. If patient is allergic, may cause swollen face, throat or lips, breathing difficulties. May also cause a superinfection such as vaginal fungal infection. 
  Drug Interactions:  
  Special Notes:  
   
PENTAMIDINE
  Generic Name: Pentamidine 
  Possible Uses: Prevent or treat protozoal infections. 
  Side Effects: Decreased blood pressure, slow fast or irregular heartbeat, excessive hunger or thirst, nervousness, sweating, confusion, rash, itching, breathing difficulties, metallic taste, nausea, vomiting, decreased blood counts, decrease in blood sugar, change in kidney or liver function. 
  Drug Interactions:  
  Special Notes:  
   
PREDNISONE
  Generic Name: Prednisone 
  Possible Uses: Decrease swelling, decrease allergic reactions, control nausea or vomiting. May be used as part of chemotherapy regimen. In allogeneic transplants, used to prevent or treat graft rejection. 
  Side Effects: Fluid retention, weight gain, increase in blood sugars, increase in white cell count, restlessness, anxiety, mood changes, sweating, redness in face, thinning skin, acne, increased hair growth, irregular menstrual periods, black bowel movements, muscle weakness or cramps. 
  Drug Interactions:  
  Special Notes:  
   
TACROLIMUS
  Generic Name: Tacrolimus, FK506
  Possible Uses: In allogeneic transplantation, used to prevent or treat graft-versus-host disease (GVHD). 
  Side Effects: Decreased kidney function, tremor, diarrhea, nausea, vomiting, abdominal discomfort, glucose intolerance (with high doses). 
  Drug Interactions:  
  Special Notes:  
   
VANCOMYCIN
  Generic Name: Vancomycin 
  Possible Uses: Prevent or treat bacterial infections. 
  Side Effects: Rash, vein irritation, decrease in kidney function, stomach upset, nausea, diarrhea, dizziness, ringing in the ears, hearing difficulties. If patient is allergic, may cause swollen face, throat or lips, breathing difficulties. If infused too quickly, may cause a flushing and reddening of the skin. This is known as 'red man's syndrome' and is not an allergic reaction. 
  Drug Interactions:  
  Special Notes:  
   
ZANTAC
  Generic Name: Ranitidine 
  Possible Uses: Reduce acid in the stomach, treat or prevent ulcers and reflux. 
  Side Effects: Headache, dizziness, diarrhea, constipation, rash. 
  Drug Interactions:  
  Special Notes: