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Our Publications

Journal Articles:

 

  1. Shiu Y, He Y, Tey J, Knysheva M, Anderson B, Kauser K. Natural Vascular Scaffolding Treatment Promotes Outward Remodeling during Arteriovenous Fistula Development in Rats. Frontiers in Bioengineering and Biotechnology, section Tissue Engineering and Regenerative Medicine. Forthcoming;
  2. He Y, Northrup H, Roy-Chaudhury P, Cheung AK, Berceli SA, Shiu YT. Analyses of hemodialysis arteriovenous fistula geometric configuration and its associations with maturation and reintervention. J Vasc Surg. 2020 Oct 20;doi: 10.1016/j.jvs.2020.09.033. [Epub ahead of print] PubMed PMID: 33091518; NIHMSID:NIHMS1639278.
  3. Falzon I, Northrup H, Guo L, Totenhagen J, Lee T, Shiu YT. The geometry of arteriovenous fistulas using endothelial nitric oxide synthase mouse models. Kidney3602020 Sep 24;1(9):925-935doi: 10.34067/kid.0001832020. PubMed PMID: 33117991; PubMed Central PMCID: PMC7591147.
  4. Yang CY, Li MC, Lan CW, Lee WJ, Lee CJ, Wu CH, Tang JM, Niu YY, Lin YP, Shiu YT, Cheung AK, Lee YW, Lee OK, Chien S, Tarng DC. The Anastomotic Angle of Hemodialysis Arteriovenous Fistula Is Associated With Flow Disturbance at the Venous Stenosis Location on Angiography. Front Bioeng Biotechnol2020;8:846doi: 10.3389/fbioe.2020.00846. eCollection 2020. PubMed PMID: 32793578; PubMed Central PMCID: PMC7390971.
  5. Cho JM, Shiu YT, Symons JD, Lee T. Vasoreactivity of the Murine External Jugular Vein and Carotid Artery. J Vasc Res2020;57(5):291-301doi: 10.1159/000508129. Epub 2020 Jun 15. PubMed PMID: 32541137; PubMed Central PMCID: PMC7486270.
  6. Shiu YT, Rotmans JI, Geelhoed WJ, Pike DB, Lee T. Arteriovenous conduits for hemodialysis: how to better modulate the pathophysiological vascular response to optimize vascular access durability. Am J Physiol Renal Physiol2019 May 1;316(5):F794-F806doi: 10.1152/ajprenal.00440.2018. Epub 2019 Feb 20. Review. PubMed PMID: 30785348; PubMed Central PMCID: PMC6580244.
  7. Kubiak RW, Zelnick LR, Hoofnagle AN, Alpers CE, Terry CM, Shiu YT, Cheung AK, de Boer IH, Robinson-Cohen C, Allon M, Dember LM, Feldman HI, Himmelfarb J, Huber TS, Roy-Chaudhury P, Vazquez MA, Kusek JW, Beck GJ, Imrey PB, Kestenbaum B. Mineral Metabolism Disturbances and Arteriovenous Fistula Maturation. Eur J Vasc Endovasc Surg2019 May;57(5):719-728doi: 10.1016/j.ejvs.2019.01.022. Epub 2019 Apr 15. PubMed PMID: 31000459; PubMed Central PMCID: PMC7259372.
  8. Pike D, Shiu YT, Cho YF, Le H, Somarathna M, Isayeva T, Guo L, Symons JD, Kevil CG, Totenhagen J, Lee T. The effect of endothelial nitric oxide synthase on the hemodynamics and wall mechanics in murine arteriovenous fistulas. Sci Rep2019 Mar 12;9(1):4299doi: 10.1038/s41598-019-40683-7. PubMed PMID: 30862797; PubMed Central PMCID: PMC6414641.
  9. Park SK, La Salle DT, Cerbie J, Cho JM, Bledsoe A, Nelson A, Morgan DE, Richardson RS, Shiu YT, Boudina S, Trinity JD, Symons JD. Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans. Am J Physiol Heart Circ Physiol2019 Jan 1;316(1):H106-H112doi: 10.1152/ajpheart.00561.2018. Epub 2018 Nov 9. PubMed PMID: 30412436; PubMed Central PMCID: PMC6734082.
  10. Allon M, Litovsky SH, Tey JCS, Sundberg CA, Zhang Y, Chen Z, Fang Y, Cheung AK, Shiu YT. Abnormalities of vascular histology and collagen fiber configuration in patients with advanced chronic kidney disease. J Vasc Access2019 Jan;20(1):31-40doi: 10.1177/1129729818773305. Epub 2018 May 9. PubMed PMID: 29742957; PubMed Central PMCID: PMC6212345.
  11. He Y, Shiu YT, Pike DB, Roy-Chaudhury P, Cheung AK, Berceli SA. Comparison of hemodialysis arteriovenous fistula blood flow rates measured by Doppler ultrasound and phase-contrast magnetic resonance imaging. J Vasc Surg2018 Dec;68(6):1848-1857.e2doi: 10.1016/j.jvs.2018.02.043. Epub 2018 May 18. PubMed PMID: 29779960; PubMed Central PMCID: PMC6240398.
  12. Robbin ML, Greene T, Allon M, Dember LM, Imrey PB, Cheung AK, Himmelfarb J, Huber TS, Kaufman JS, Radeva MK, Roy-Chaudhury P, Shiu YT, Vazquez MA, Umphrey HR, Alexander L, Abts C, Beck GJ, Kusek JW, Feldman HI. Prediction of Arteriovenous Fistula Clinical Maturation from Postoperative Ultrasound Measurements: Findings from the Hemodialysis Fistula Maturation Study. J Am Soc Nephrol2018 Nov;29(11):2735-2744doi: 10.1681/ASN.2017111225. Epub 2018 Oct 11. PubMed PMID: 30309898; PubMed Central PMCID: PMC6218859.
  13. Allon M, Litovsky SH, Zhang Y, Le H, Cheung AK, Shiu YT. Association of Preexisting Arterial Intimal Hyperplasia with Arteriovenous Fistula Outcomes. Clin J Am Soc Nephrol2018 Sep 7;13(9):1358-1363doi: 10.2215/CJN.13431217. Epub 2018 Aug 23. PubMed PMID: 30139803; PubMed Central PMCID: PMC6140554.
  14. Wang K, Zelnick LR, Hoofnagle AN, Vaisar T, Henderson CM, Imrey PB, Robinson-Cohen C, de Boer IH, Shiu YT, Himmelfarb J, Beck GJ, Kestenbaum B. Alteration of HDL Protein Composition with Hemodialysis Initiation. Clin J Am Soc Nephrol2018 Aug 7;13(8):1225-1233doi: 10.2215/CJN.11321017. Epub 2018 Jul 25. PubMed PMID: 30045914; PubMed Central PMCID: PMC6086713.
  15. Kwon SH, Li L, Terry CM, Shiu YT, Moos PJ, Milash BA, Cheung AK, Blumenthal DK. Differential gene expression patterns in vein regions susceptible versus resistant to neointimal hyperplasia. Physiol Genomics2018 Aug 1;50(8):615-627doi: 10.1152/physiolgenomics.00082.2017. Epub 2018 May 11. PubMed PMID: 29750603; PubMed Central PMCID: PMC6139633.
  16. Shiu YT, Jaimes EA. Transcription Factor ETS-1 and Reactive Oxygen Species: Role in Vascular and Renal Injury. Antioxidants (Basel)2018 Jul 3;7(7)doi: 10.3390/antiox7070084. Review. PubMed PMID: 29970819; PubMed Central PMCID: PMC6071050.
  17. Martinez L, Duque JC, Tabbara M, Paez A, Selman G, Hernandez DR, Sundberg CA, Tey JCS, Shiu YT, Cheung AK, Allon M, Velazquez OC, Salman LH, Vazquez-Padron RI. Fibrotic Venous Remodeling and Nonmaturation of Arteriovenous Fistulas. J Am Soc Nephrol2018 Mar;29(3):1030-1040doi: 10.1681/ASN.2017050559. Epub 2018 Jan 2. PubMed PMID: 29295872; PubMed Central PMCID: PMC5827597.
  18. Shang F, Wang SC, Hsu CY, Miao Y, Martin M, Yin Y, Wu CC, Wang YT, Wu G, Chien S, Huang HD, Tarng DC, Shiu YT, Cheung AK, Huang PH, Chen Z, Shyy JY. MicroRNA-92a Mediates Endothelial Dysfunction in CKD. J Am Soc Nephrol2017 Nov;28(11):3251-3261doi: 10.1681/ASN.2016111215. Epub 2017 Jul 10. PubMed PMID: 28696247; PubMed Central PMCID: PMC5661278.
  19. Cheung AK, Imrey PB, Alpers CE, Robbin ML, Radeva M, Larive B, Shiu YT, Allon M, Dember LM, Greene T, Himmelfarb J, Roy-Chaudhury P, Terry CM, Vazquez MA, Kusek JW, Feldman HI. Intimal Hyperplasia, Stenosis, and Arteriovenous Fistula Maturation Failure in the Hemodialysis Fistula Maturation Study. J Am Soc Nephrol2017 Oct;28(10):3005-3013doi: 10.1681/ASN.2016121355. Epub 2017 Jul 14. PubMed PMID: 28710091; PubMed Central PMCID: PMC5619966.
  20. Alpers CE, Imrey PB, Hudkins KL, Wietecha TA, Radeva M, Allon M, Cheung AK, Dember LM, Roy-Chaudhury P, Shiu YT, Terry CM, Farber A, Beck GJ, Feldman HI, Kusek JW, Himmelfarb J. Histopathology of Veins Obtained at Hemodialysis Arteriovenous Fistula Creation Surgery. J Am Soc Nephrol2017 Oct;28(10):3076-3088doi: 10.1681/ASN.2016050598. Epub 2017 Jul 19. PubMed PMID: 28724774; PubMed Central PMCID: PMC5619951.
  21. van Ballegooijen AJ, Zelnick L, Hoofnagle AN, Hamburg NM, Robinson-Cohen C, Roy-Chaudhury P, Cheung AK, Shiu YT, de Boer IH, Himmelfarb J, Beck G, Imrey PB, Kusek JW, Kestenbaum B. Association of Vitamin D Metabolites With Arterial Function in the Hemodialysis Fistula Maturation Study. Am J Kidney Dis2017 Jun;69(6):805-814doi: 10.1053/j.ajkd.2017.01.049. Epub 2017 Mar 27. PubMed PMID: 28359657; PubMed Central PMCID: PMC5441944.
  22. Pike D, Shiu YT, Somarathna M, Guo L, Isayeva T, Totenhagen J, Lee T. High resolution hemodynamic profiling of murine arteriovenous fistula using magnetic resonance imaging and computational fluid dynamics. Theor Biol Med Model2017 Mar 20;14(1):5doi: 10.1186/s12976-017-0053-x. PubMed PMID: 28320412; PubMed Central PMCID: PMC5360029.
  23. Allon M, Greene T, Dember LM, Vita JA, Cheung AK, Hamburg NM, Imrey PB, Kaufman JS, Robbin ML, Shiu YT, Terry CM, Umphrey HR, Feldman HI. Association between Preoperative Vascular Function and Postoperative Arteriovenous Fistula Development. J Am Soc Nephrol2016 Dec;27(12):3788-3795doi: 10.1681/ASN.2015020141. Epub 2016 May 9. PubMed PMID: 27160404; PubMed Central PMCID: PMC5118472.
  24. Machin DR, Leary ME, He Y, Shiu YT, Tanaka H, Donato AJ. Ultrasound Assessment of Flow-Mediated Dilation of the Brachial and Superficial Femoral Arteries in Rats. J Vis Exp2016 Nov 3;(117)doi: 10.3791/54762. PubMed PMID: 27842366; PubMed Central PMCID: PMC5226081.
  25. Shiu YT, Litovsky SH, Cheung AK, Pike DB, Tey JC, Zhang Y, Young CJ, Robbin M, Hoyt K, Allon M. Preoperative Vascular Medial Fibrosis and Arteriovenous Fistula Development. Clin J Am Soc Nephrol2016 Sep 7;11(9):1615-23doi: 10.2215/CJN.00500116. Epub 2016 Aug 30. PubMed PMID: 27577243; PubMed Central PMCID: PMC5012471.
  26. Robbin ML, Greene T, Cheung AK, Allon M, Berceli SA, Kaufman JS, Allen M, Imrey PB, Radeva MK, Shiu YT, Umphrey HR, Young CJ. Arteriovenous Fistula Development in the First 6 Weeks after Creation. Radiology2016 May;279(2):620-9doi: 10.1148/radiol.2015150385. Epub 2015 Dec 22. PubMed PMID: 26694050; PubMed Central PMCID: PMC4851120.
  27. Kwon SH, Li L, He Y, Tey CS, Li H, Zhuplatov I, Kim SJ, Terry CM, Blumenthal DK, Shiu YT, Cheung AK. Prevention of Venous Neointimal Hyperplasia by a Multitarget Receptor Tyrosine Kinase Inhibitor. J Vasc Res2015;52(4):244-256doi: 10.1159/000442977. Epub 2016 Jan 21. PubMed PMID: 26788996; PubMed Central PMCID: PMC4761319.
  28. Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY. Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation. Circulation2015 Jan 20;131(3):289-99doi: 10.1161/CIRCULATIONAHA.114.010403. Epub 2014 Dec 8. PubMed PMID: 25486933; PubMed Central PMCID: PMC4356181.
  29. Wilkins JR, Pike DB, Gibson CC, Li L, Shiu YT. The interplay of cyclic stretch and vascular endothelial growth factor in regulating the initial steps for angiogenesis. Biotechnol Prog2015 Jan-Feb;31(1):248-57doi: 10.1002/btpr.2017. Epub 2014 Nov 13. PubMed PMID: 25376776; PubMed Central PMCID: PMC4340782.
  30. Gomez AD, Zou H, Shiu YT, Hsu EW. Characterization of regional deformation and material properties of the intact explanted vein by microCT and computational analysis. Cardiovasc Eng Technol2014 Dec;5(4):359-370doi: 10.1007/s13239-014-0190-x. PubMed PMID: 25541587; PubMed Central PMCID: PMC4273576.
  31. Wilkins JR, Pike DB, Gibson CC, Kubota A, Shiu YT. Differential effects of cyclic stretch on bFGF- and VEGF-induced sprouting angiogenesis. Biotechnol Prog2014 Jul-Aug;30(4):879-88doi: 10.1002/btpr.1883. Epub 2014 Feb 22. PubMed PMID: 24574264.
  32. Chapin LM, Edgar LT, Blankman E, Beckerle MC, Shiu YT. Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers. Cell Mol Bioeng2014 Mar 1;7(1):73-85doi: 10.1007/s12195-013-0318-3. PubMed PMID: 25110525; PubMed Central PMCID: PMC4125130.
  33. McNichols C, Wilkins J, Kubota A, Shiu YT, Aouadi SM, Kohli P. Investigating surface topology and cyclic-RGD peptide functionalization on vascular endothelialization. J Biomed Mater Res A2014 Feb;102(2):532-9doi: 10.1002/jbm.a.34700. Epub 2013 Sep 16. PubMed PMID: 23505215; PubMed Central PMCID: PMC3767770.
  34. Fitts MK, Pike DB, Anderson K, Shiu YT. Hemodynamic Shear Stress and Endothelial Dysfunction in Hemodialysis Access. Open Urol Nephrol J2014;7(Suppl 1 M5):33-44doi: 10.2174/1874303X01407010033. PubMed PMID: 25309636; PubMed Central PMCID: PMC4189833.
  35. He Y, Terry CM, Nguyen C, Berceli SA, Shiu YT, Cheung AK. Serial analysis of lumen geometry and hemodynamics in human arteriovenous fistula for hemodialysis using magnetic resonance imaging and computational fluid dynamics. J Biomech2013 Jan 4;46(1):165-9doi: 10.1016/j.jbiomech.2012.09.005. Epub 2012 Nov 1. PubMed PMID: 23122945; PubMed Central PMCID: PMC4120947.
  36. Ives SJ, Andtbacka RH, Kwon SH, Shiu YT, Ruan T, Noyes RD, Zhang QJ, Symons JD, Richardson RS. Heat and α1-adrenergic responsiveness in human skeletal muscle feed arteries: the role of nitric oxide. J Appl Physiol (1985)2012 Dec 1;113(11):1690-8doi: 10.1152/japplphysiol.00955.2012. Epub 2012 Oct 4. PubMed PMID: 23042905; PubMed Central PMCID: PMC3544510.
  37. Chapin LM, Blankman E, Smith MA, Shiu YT, Beckerle MC. Lateral communication between stress fiber sarcomeres facilitates a local remodeling response. Biophys J2012 Nov 21;103(10):2082-92doi: 10.1016/j.bpj.2012.09.038. Epub 2012 Nov 20. PubMed PMID: 23200042; PubMed Central PMCID: PMC3512046.
  38. Brinton MR, Tagge CA, Stewart RJ, Cheung AK, Shiu YT, Christensen DA. Thermal sensitivity of endothelial cells on synthetic vascular graft material. Int J Hyperthermia2012;28(2):163-74doi: 10.3109/02656736.2011.638963. PubMed PMID: 22335230.
  39. Brinton MR, Stewart RJ, Cheung AK, Christensen DA, Shiu YT. Modelling ultrasound-induced mild hyperthermia of hyperplasia in vascular grafts. Theor Biol Med Model2011 Nov 3;8:42doi: 10.1186/1742-4682-8-42. PubMed PMID: 22054016; PubMed Central PMCID: PMC3217891.
  40. Wilson BD, Gibson CC, Sorensen LK, Guilhermier MY, Clinger M, Kelley LL, Shiu YT, Li DY. Novel approach for endothelializing vascular devices: understanding and exploiting elastin-endothelial interactions. Ann Biomed Eng2011 Jan;39(1):337-46doi: 10.1007/s10439-010-0142-z. Epub 2010 Aug 25. PubMed PMID: 20737290; PubMed Central PMCID: PMC3625378.
  41. Singhal AK, Symons JD, Boudina S, Jaishy B, Shiu YT. Role of Endothelial Cells in Myocardial Ischemia-Reperfusion Injury. Vasc Dis Prev2010;7:1-14doi: 10.2174/1874120701007010001. PubMed PMID: 25558187; PubMed Central PMCID: PMC4280830.
  42. Li L, Terry CM, Shiu YT, Cheung AK. Neointimal hyperplasia associated with synthetic hemodialysis grafts. Kidney Int2008 Nov;74(10):1247-61doi: 10.1038/ki.2008.318. Epub 2008 Jul 30. Review. PubMed PMID: 18668026; PubMed Central PMCID: PMC2577126.
  43. Joung IS, Iwamoto MN, Shiu YT, Quam CT. Cyclic strain modulates tubulogenesis of endothelial cells in a 3D tissue culture model. Microvasc Res2006 Jan;71(1):1-11doi: 10.1016/j.mvr.2005.10.005. Epub 2005 Dec 20. PubMed PMID: 16368114.
  44. Chien S, Li S, Shiu YT, Li YS. Molecular basis of mechanical modulation of endothelial cell migration. Front Biosci2005 May 1;10:1985-2000doi: 10.2741/1673. Review. PubMed PMID: 15769679.
  45. Miao H, Hu YL, Shiu YT, Yuan S, Zhao Y, Kaunas R, Wang Y, Jin G, Usami S, Chien S. Effects of flow patterns on the localization and expression of VE-cadherin at vascular endothelial cell junctions: in vivo and in vitro investigations. J Vasc Res2005 Jan-Feb;42(1):77-89doi: 10.1159/000083094. Epub 2005 Jan 3. PubMed PMID: 15637443.
  46. Shiu YT, Weiss JA, Hoying JB, Iwamoto MN, Joung IS, Quam CT. The role of mechanical stresses in angiogenesis. Crit Rev Biomed Eng2005;33(5):431-510doi: 10.1615/critrevbiomedeng.v33.i5.10. Review. PubMed PMID: 16000089.
  47. Shiu YT, Li S, Marganski WA, Usami S, Schwartz MA, Wang YL, Dembo M, Chien S. Rho mediates the shear-enhancement of endothelial cell migration and traction force generation. Biophys J2004 Apr;86(4):2558-65doi: 10.1016/S0006-3495(04)74311-8. PubMed PMID: 15041692; PubMed Central PMCID: PMC1304103.
  48. Shiu YT, McIntire LV. In vitro studies of erythrocyte-vascular endothelium interactions. Ann Biomed Eng2003 Dec;31(11):1299-313doi: 10.1114/1.1630320. Review. PubMed PMID: 14758921.
  49. Shiu YT, Li S, Yuan S, Wang Y, Nguyen P, Chien S. Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner. Biochem Biophys Res Commun2003 Apr 4;303(2):548-55doi: 10.1016/s0006-291x(03)00388-7. PubMed PMID: 12659853.
  50. Shiu YT, McIntire LV, Udden MM. Sickle erythrocytes increase prostacyclin and endothelin-1 production by cultured human endothelial cells under flow conditions. Eur J Haematol2002 Mar;68(3):163-9doi: 10.1034/j.1600-0609.2002.01494.x. PubMed PMID: 12068797.
  51. Li S, Bhatia S, Hu YL, Shiu YT, Li YS, Usami S, Chien S. Effects of morphological patterning on endothelial cell migration. Biorheology2001;38(2-3):101-8PubMed PMID: 11381168.
  52. Shiu YT, Udden MM, McIntire LV. Perfusion with sickle erythrocytes up-regulates ICAM-1 and VCAM-1 gene expression in cultured human endothelial cells. Blood2000 May 15;95(10):3232-41PubMed PMID: 10807794.
  53. Inhibition of Lysyl Oxidase with β-aminopropionitrile Improves Venous Adaptation after Arteriovenous Fistula Creation. Kidney360. NIHMSID: NIHMS1657294.

Please visit https://www.ncbi.nlm.nih.gov/myncbi/yan-ting.shiu.1/bibliography/public/  for our bibliography

Book Chapters:

  1. Shiu YT. Chapter 33: Mechanical forces on cells. In Bronzino JD (Ed.), Tissue Engineering and Artificial Organs/The Biomedical Engineering Handbook (3rd edition). Boca Raton, FL, USA: CRC Press, 2006.
  2. Shiu YT. Chapter 4: Mechanical forces on cells. In Fisher JP, Mikos AG, Bronzino JD (Eds.), Tissue engineering (1st edition). Boca Raton, FL, USA: CRC Press, 2007.

Yan-Ting Shiu, PhD

Research Associate Professor,

Nephrology & Hypertension

y.shiu@hsc.utah.edu

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