Publications

A sample of major publications from the SCTM and its affiliated members:

Williams BL, Seager NA, Gardiner JD, Pappas C, Cronin MC, di San Filippo CA, Anstadt RA, Liu J, Toso M, Nichols L, Parnell TJ, Eve JR, Bartel PL, Zouache MA, Richards BT, and Hageman GS. Chromosome 10q26-Driven Age-related Macular Degeneration is Associated with Reduced Levels of HTRA1 in Human Retinal Pigment Epithelium. Proceedings of the National Academy of Sciences of the United States of America. 

Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, Hageman JL, Stockman HA, Borchardt JD, Gehrs KM, Smith RJ, Silvestri G, Russell SR, Klaver CC, Barbazetto I, Chang S, Yannuzzi LA, Barile GR, Merriam JC, Smith RT, Olsh AK, Bergeron J, Zernant J, Merriam JE, Gold B, Dean M, Allikmets R. (2005). A Common Haplotype in the Complement Regulatory Gene Factor H (HF1/CFH) Predisposes Individuals to Age-Related Macular Degeneration. Proceedings of the National Academy of Sciences of the United States of America. 102(20), 7227-32.

Zouache MA, Bennion A, Hageman JL, Pappas C, Richards BT, Hageman GS. Macular Retinal Thickness Differs Markedly in Age-Related Macular Degeneration Driven by Risk Polymorphisms on Chromosomes 1 and 10. Scientific Reports. 2020 Dec 3;10(1):21093. doi: 10.1038/s41598-020-78059-x.

Keenan TD, Toso M, Pappas C, Nichols L, Bishop PN, Hageman GS. Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH-to-F13B. Investigative Ophthalmology & Visual Science. 2015 Jul;56(8):4870-9. doi: 10.1167/iovs.15-17009. PMID: 26218915

Gold B, Merriam JE, Zernant J, Hancox LS, Taiber AJ, Gehrs K, Cramer K, Neel J, Bergeron J, Barile GR, Smith RT, Hageman GS, Dean M, Allikmets R. (2006). Variation in Factor B (BF) and Complement Component 2 (C2) Genes is Associated With Age-Related Macular Degeneration. Nature Genetics. 38(4), 458-62.

Hageman GS, Luthert PJ, Victor Chong NH, Johnson LV, Anderson DH, Mullins RF. (2001). An Integrated Hypothesis that Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration. Progress in Retinal and Eye Research. 20(6), 705-32.

Anderson DH, Radeke MJ, Gallo NB, Chapin EA, Johnson PT, Curletti CR, Hancox LS, Hu J, Ebright JN, Malek G, Hauser MA, Rickman CB, Bok D, Hageman GS, Johnson LV. (2010). The Pivotal Role of the Complement System in Aging and Age-Related Macular Degeneration: Hypothesis Re-Visited. Progress in Retinal and Eye Research. 29(2), 95-112.

Hannan JP, Laskowski J, Thurman JM, Hageman GS, Holers VM. Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. PLOS ONE. 2016 Nov 4;11(11):e0166200. doi: 10.1371/journal.pone.0166200. PMID: 27814381; PMCID: PMC5096715.

Perlee LT, Bansal AT, Gehrs K, Heier JS, Csaky K, Allikmets R, Oeth P, Paladino T, Farkas DH, Rawlings PL, Hageman GS. Inclusion of Genotype With Fundus Phenotype Improves Accuracy of Predicting Choroidal Neovascularization and Geographic Atrophy. Ophthalmology. 2013 Sep;120(9):1880-92. doi: 10.1016/j.ophtha.2013.02.007. Epub 2013 Mar 21. PMID: 23523162; PMCID: PMC3695024.

Barlow PN, Hageman GS, Lea SM. Complement Factor H: Using Atomic Resolution Structure to Illuminate Disease Mechanisms. Advances in Experimental Medicine and Biology. 2008;632:117-42. PMID: 19025119; PMCID: PMC4863441.

Kelly U, Rickman CB, Postel EA, Hauser MA, Hageman GS, Arshavsky VY, Skiba NP. (2009). Rapid and Sensitive Method for Detection of Y402, H402, I62, and V62 Variants of Complement Factor H in Human Plasma Samples Using Mass Spectrometry. Investigative Ophthalmology & Visual Science. 50(4), 1540-5.

Research Faculty

Visit these listings for a full list of publications authored by SCTM faculty: