Yang Lab Publications

Ophthalmology

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Selected Publications from the Yang Lab

  1. Yang J, Liu X, Yue G, Adamian M, Bulgakov O, Li T. (2002). Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. J Cell Biol, 159, 431-440.
  2. Yang J, Pawlyk B, Wen X, Adamian M, Soloviev M, Michaud N, Zhao Y, Sandberg, MA, Makino CL, Li T. (2007). Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals. Hum Mol Genet, 16, 1017-1029.
  3. Yang J, Liu X, Zhao Y, Adamian M, Pawlyk B, Sun X, McMillan DR, Liberman MC and Li T. (2010). Ablation of Whirlin Long Isoform Disrupts the USH2 Protein Complex and Causes Vision and Hearing Loss. PLoS Genet, 6(5), e10000955.
  4. Zou J, Luo L, Shen Z, Choido V, Ambati BK, Hauswirth WW, Yang J. (2011). Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors. Invest Ophthalmol Vis Sci, 52, 2343-2351.
  5. Wang L, Zou J, Shen Z, Song E, Yang J. (2012). Whirlin interacts with espin and modulates its actin-regulatory function: an insight into the mechanism of Usher syndrome type II. Hum Mol Genet, 21, 692-710.
  6. Zou J, Zheng T, Ren C, Askew C, Liu X, Pan B, Holt JR, Wang Y, Yang J. (2014). Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice. Hum Mol Genet, 23, 2374-2390.
  7. Chen Q, Zou J, Shen Z, Zhang W, Yang J. (2014). Whirlin and PDZ domain containing 7 (PDZD7) proteins are both required to form the quaternary protein complex associated with Usher syndrome type 2. J Biol Chem, 289, 36070-36088.
  8. Mathur P, Yang J. (2015). Usher syndrome: hearing loss, retinal degeneration and associated abnormalities. BBA-Molecular Basis of Disease, 1852, 406-420.
  9. Mathur PD, Zou J, Zheng T, Almishaal A, Wang Y, Chen Q, Wang L, Vashist D, Brown S, Park A, Yang J.(2015). Distinct expression and function of whirlin isoforms in the inner ear and retina: an insight into pathogenesis of USH2D and DFNB31. Hum Mol Genet, 24, 6213-6228.
  10. Zou J, Mathur PD, Zheng T, Wang Y, Almishaal A, Park AH, Yang J. (2015). Individual USH2 proteins make distinct contributions to the ankle link complex during development of the mouse cochlear stereociliary bundle. Hum Mol Genet, 24, 24, 6944-6957.
  11. Mathur PD, Vijayakumar S, Vashist D, Jones SM, Jones TA, Yang J. (2015). A study of whirlin isoforms in the mouse vestibular system suggests potential vestibular dysfunction in DFNB31-deficient patients.Hum Mol Genet, 24, 7017-7030.