Hans Haecker Lab
WELCOME TO THE HAECKER LAB!
The major focus of our lab is on innate immunity and inflammation, with projects ranging from molecular mechanisms of signal transduction to translational aspects of drug development. We explore how innate immune cells recognize and respond to pathogens, how genetic mutations in innate immunity contribute to inflammatory and auto-immune diseases, and how obtained information can be used to develop novel therapeutic strategies.
- Toll-like receptor (TLR) signaling
TLRs represent a key family of pathogen recognition receptors that alert the immune system upon pathogen encounter via inflammation. We use proteomic approaches (quantitative mass spectrometry) to identify novel components of TLR signaling pathways, whose function we explore in vitro and in vivo.
- Inflammatory Diseases (Lupus, Psoriasis).
We established novel mouse models based on human genetic information for the inflammatory diseases systemic lupus erythematosus and psoriasis. We use these models to explore the pathogenic mechanisms involved in order to identify direly needed novel therapeutic targets.
- Generation of conditionally immortalized hematopoietic progenitors.
We are using regulated Hox-genes to target and immortalize distinct hematopoietic progenitor cells, which can be used to explore cell differentiation and immune effector functions in vitro and in vivo.
- Drug Development.
We are using a novel phenotypic screening platform that we established recently to identify small molecule compounds for treatment of inflammatory diseases.