My research interests are divided in two main areas:
- Transplantation Immunology
- Characterization of MHC Peptide Epitopes
In relation to transplantation immunology, we perform translational research for development of diagnostic tools that can be used for predicting adverse outcomes and monitoring of post-transplant events in the setting of solid organ and hematopoietic cell transplantation. We are also interested in developing better methods for validation of new assays in clinical laboratory practice.
For characterization of MCH epitopes, our laboratory has standardized mass-spectrometric techniques for the sequencing of peptides eluted from MHC class I and class II molecules. Using this approach we are interested in determining MHC peptide epitopes involved in autoimmune and allergic diseases, and T-cell responses to infectious agents. We are also interested in the characterization of MHC peptide motifs in cell and mouse models lacking elements involve in processing and loading of peptides to classical and non-classical MHC molecules.