Members of our Division are engaged in a wide range of research projects. Some highlights are below. For more detail, please also see our publications.
Antibiotic Stewardship and Prescribing Patterns
Our stewardship investigators, Dr. Adam Hersh, Dr. Emily Thorell, Dr. Andrew Pavia, and infectious diseases pharmacist Jared Olson are participating in a cluster-randomized trial of antimicrobial stewardship interventions in 15 small hospitals associated with Intermountain Healthcare. We conduct multi-center evaluations of antibiotic stewardship’s impact on economic and clinical outcomes in pediatric care. We use national databases to understand antibiotic prescribing patterns in pediatric care and to evaluate the impact of interventions designed to improve the quality and safety of prescribing in pediatric care.
Dr. Krow Ampofo conducts a number of clinical trials in collaboration with colleagues in the Clinical Trials Office and Clinical Pharmacology Group, including studies of intravenous zanamivir, brincidofovir, valganciclovir and ceftaroline.
Epidemiology of Invasive Bacterial Infections
We use longitudinal collections of invasive bacterial isolates and the comprehensive electronic data warehouse of our partners at Intermountain Healthcare to perform a variety of studies of invasive infections with Streptococcus pneumoniae, Haemophilus influenzae and Streptococcus pyogenes.
A guide for providers and patients for GI pathogens detected by multiplex PCR.
Influenza and Respiratory Viral Infections
We study the epidemiology of respiratory viral infections, the role and impact of using viral diagnostics, and interactions between respiratory viruses and bacterial infections.
Dr. Carrie Byington studies the epidemiology, etiology, and management of infants with fever who are younger than 90 days old.
Dr. Anne Blaschke's lab focuses on development of improved diagnostic tests for bacterial and viral infections in a variety of settings and specimens including blood, pleural fluid, CSF, and joint fluid.
Dr. Carrie Byington is leading a collaboration to perform whole genome sequencing on an extensive collection of Streptococcus pneumoniae strains associated with colonization and with specific invasive syndromes. Dr. Anne Blaschke's lab is developing a simple multiplex PCR platform for serotyping of Streptococcus pneumoniae.
Dr. Krow Ampofo is the principal investigator of the CDC EPIC study (Etiology of Pneumonia in the Community). This is the largest and most detailed study of community acquired pneumonia to date.
Division members are involved in many sub studies of EPIC. They include use of next generation sequencing to detect additional and novel pathogens, comparative efficacy of strategies to manage complicated pneumonia, multiplex PCR to diagnose the etiology of empyema, and predictors of bacterial infection including bacterial colonization density and procalcitonin.