Acoustic Radiation Force Imaging
Magnetic resonance acoustic radiation force imaging (MR-ARFI) is a technique that measures the tissue displacement caused by the force exerted by the focused ultrasound beam. This displacement map, generally acquired with MR signals in a plane perpendicular to the ultrasound beam, provides information about the position and quality of the focused ultrasound beam that is complementary to MR thermometry information. While MR-ARFI is currently not used clinically on a widespread basis, it can be used to localize the ultrasound with much less energy than when using MR temperature imaging. Our group has developed three-dimensional MR-ARFI pulse sequences that perform volumetric MR-ARFI imaging with either a single point or multiple points, allowing the user to create displacement maps over a larger region. We are currently using MR-ARFI in our breast MRgFUS treatment protocol.
Odéen H, de Bever JT, Hofstetter LW, Parker DL (2019). Multiple-point magnetic resonance acoustic radiation force imaging. Magn Reson Med. 81(2):1104-1117.
de Bever, J. T., Odeen, H., Todd, N., Farrer, A. I., & Parker, D. L. (2016). Evaluation of a three-dimensional MR acoustic radiation force imaging pulse sequence using a novel unbalanced bipolar motion encoding gradient. Magn Reson Med, 76(3), 803-813. doi:10.1002/mrm.25971
de Bever, J. T., Odeen, H., Hofstetter, L. W., & Parker, D. L. (2018). Simultaneous MR thermometry and acoustic radiation force imaging using interleaved acquisition. Magn Reson Med, 79(3), 1515-1524. doi:10.1002/mrm.2682
Payne, A., de Bever, J., Farrer, A., Coats, B., Parker, D. L., & Christensen, D. A. (2015). A simulation technique for 3D MR-guided acoustic radiation force imaging. Medical physics, 42(2), 674. doi:10.1118/1.490504
Members of the Focused Ultrasound Laboratory have intellectual property in this area of research. Any conflict of interest concerns can be addressed by the investigators or the department chair.