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Focused ultrasound can be utilized to elicit mechanical bioeffects in tissue. Our laboratory has developed volumetric MR-Acoustic Radiation Force Imaging (MR-ARFI) for use in MRgFUS therapy. MR-ARFI is used to interrogate tissue displacement and is used to quickly and painlessly determine focused ultrasound position. This technique provides quantitative measurements for the monitoring and assessment of MRgFUS therapies.