Mary C. Beckerle, Ph.D.

Research Interests

  • Cell Adhesion
  • Ewing's Sarcoma
  • Cancer Biology
  • Actin Cytoskeleton Dynamics
  • Cell Motility
  • Metastasis

Labs

Lab Website

Languages

  • English
  • French

Academic Information

  • Departments: Biology - Distinguished Professor, Oncological Sciences - Adjunct Professor
  • Cancer Center Programs: Cell Response & Regulation

Academic Office Information

  • (801) 581-4485
  • Huntsman Cancer Institute
    2000 Circle of Hope, Room: 5360
    Salt Lake City, UT 84112

Academic Bio

Mary C. Beckerle, PhD

Ralph E. and Willia T. Main Presidential Professor

Chief Executive Officer and Director, Huntsman Cancer Institute

Associate Vice President of Cancer Affairs, University of Utah

Distinguished Professor of Biology

Mary Beckerle, PhD, has served as CEO and Director of Huntsman Cancer Institute since 2006, and she was appointed in 2009 to an additional key health sciences leadership role as Associate Vice President for Cancer Affairs at the University of Utah. Beckerle joined the faculty of the University of Utah in 1986, and is a distinguished professor of biology and oncological sciences, holding the Ralph E. and Willia T. Main Presidential Professorship. She earned her PhD in molecular, cellular, and developmental biology from the University of Colorado at Boulder, where she was the recipient of a Danforth Fellowship, and completed post-doctoral research at the University of North Carolina at Chapel Hill.

Beckerle’s research has defined a novel molecular pathway that regulates cell motility, and her lab is currently focused on understanding the impact of this pathway on tumor progression, particularly in Ewing’s sarcoma. Her scientific work has been continuously funded by the National Institutes of Health (NIH) and the American Cancer Society for over 20 years. She guided graduate education at the University of Utah as the director of the Interdepartmental Graduate Program in Molecular Biology for two years. In addition, Beckerle developed the Multidisciplinary Cancer Research Training Program at Huntsman Cancer Institute at the University of Utah and served for several years as the principal investigator of the National Cancer Institute grant that supported this cancer-focused training initiative. Beckerle is the principal investigator of Huntsman Cancer Institute’s NCI Cancer Center Support Grant (CCSG). She is a member of the NCI Scientific Review Group Subcommittee A (Parent Committee) for Cancer Centers.

An active participant in national and international scientific affairs, Beckerle served as president of the American Society for Cell Biology (ASCB) in 2006, and was appointed in 2010 to the American Association of Cancer Research Science Policy and Legislative Affairs Committee. She has served on numerous strategic planning and peer review committees for the NIH. She has served on the NIH Advisory Committee to the Director, as Chair of the American Cancer Society Council for Extramural Grants, and on the Coalition for Life Sciences Board of Directors. She currently serves on the Medical Advisory Board of the Howard Hughes Medical Institute, the Scientific Advisory Boards of the National Center for Biological Sciences in India, the Mechanobiology Institute in Singapore, and several National Cancer Institute (NCI)-designated cancer centers. In 2013, she was elected to the Board of Directors of the American Association for Cancer Research.

In 2000, Beckerle was appointed as a Guggenheim Fellow and a Rothschild-Yvette Mayent Award Scholar at the Curie Institute in Paris. She received the Utah Governor’s Medal for Science and Technology in 2001, the Sword of Hope Award from the American Cancer Society in 2004, and the Rosenblatt Prize for Excellence (the University of Utah’s highest honor) in 2007. Beckerle was elected as a Fellow of the American Academy of Arts and Sciences in 2008. Beckerle serves as a member of the Board of Directors of Huntsman Corporation and Johnson & Johnson.

Education History

Type School Degree
Other Training Drexel University
Executive Leadership in Academic Medicine (ELAM) Program
Fellow
Professional Other The Aspen Institute
Postdoctoral Fellowship University of North Carolina
Anatomy and Cell Biology
Postdoctoral Fellow
Doctoral Training University of Colorado
Molecular, Cellular and Developmental Biology
Ph.D.
Undergraduate Wells College
Biology and Psychology
B.A.

Global Impact

Career

Institution Description Country
Institute Curie Visiting Scholar United Kingdom

Selected Publications

Journal Article

  1. EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma.Fadul J, Bell R, Hoffman LM, Beckerle MC, Engel ME, Lessnick SL (2015). EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma. Genes Cancer, 6(3-4), 129-43.
  2. Chapin LM, Edgar LT, Blankman E, Beckerle MC, Shiu YT (2014). Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers. Cell Mol Bioeng, 7, 73-85.
  3. LIM proteins in actin cytoskeleton mechanoresponse.Smith MA, Hoffman LM, Beckerle MC (2014). LIM proteins in actin cytoskeleton mechanoresponse. Trends Cell Biol, 24(10), 575-83.
  4. Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.Sankar S, Theisen ER, Bearss J, Mulvihill T, Hoffman LM, Sorna V, Beckerle MC, Sharma S, Lessnick SL (2014). Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth. Clin Cancer Res, 20(17), 4584-97.
  5. Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma.Chaturvedi A, Hoffman LM, Jensen CC, Lin YC, Grossmann AH, Randall RL, Lessnick SL, Welm AL, Beckerle MC (2014). Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. Mol Biol Cell, 25(18), 2695-709.
  6. Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers.Chapin LM, Edgar LT, Blankman E, Beckerle MC, Shiu YT (2014). Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers. Cell Mol Bioeng, 7(1), 73-85.
  7. Teaching corporate in college.Valantine HA, Beckerle MC, Reed KL, Towner D, Zahniser NR (2014). Teaching corporate in college. Sci Transl Med, 6(251), 251fs33.
  8. A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton.Stachowiak MR, Smith MA, Blankman E, Chapin LM, Balcioglu HEAUID- ORCID httporcidorg0000-0002-0225-0180, Wang S, Beckerle MC, OShaughnessy B (2014). A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton. Proc Natl Acad Sci U S A, 111(49), 17528-33.
  9. ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma.Wiles ET, Bell R, Thomas D, Beckerle M, Lessnick SL (2013). ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma. Genes Cancer, 4(11-12), 486-500.
  10. Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants.Pronovost SM, Beckerle MC, Kadrmas JL (2013). Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants. PLoS Genet, 9(3), e1003406.
  11. LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain.Smith MA, Blankman E, Deakin NO, Hoffman LM, Jensen CC, Turner CE, Beckerle MC (2013). LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. PLoS One, 8(8), e69378.
  12. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta.Bianchi-Smiraglia A, Kunnev D, Limoge M, Lee A, Beckerle MC, Bakin AV (2013). Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. Cell Cycle, 12(21), 3377-89.
  13. A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma.Sankar S, Tanner JM, Bell R, Chaturvedi A, Randall RL, Beckerle MC, Lessnick SL (2013). A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma. Mol Cell Biol, 33(22), 4448-60.
  14. The clone wars - revenge of the metastatic rogue state: the sarcoma paradigm.Spraker HL, Price SL, Chaturvedi A, Schiffman JD, Jones KB, Lessnick SL, Beckerle M, Randall RL (2012). The clone wars - revenge of the metastatic rogue state: the sarcoma paradigm. Front Oncol, 2, 2.
  15. The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma.Chaturvedi A, Hoffman LM, Welm AL, Lessnick SL, Beckerle MC (2012). The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma. Genes Cancer, 3(2), 102-16.
  16. Lateral communication between stress fiber sarcomeres facilitates a local remodeling response.Chapin LM, Blankman E, Smith MA, Shiu YT, Beckerle MC (2012). Lateral communication between stress fiber sarcomeres facilitates a local remodeling response. Biophys J, 103(10), 2082-92.
  17. Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators.Hoffman LM, Jensen CC, Chaturvedi A, Yoshigi M, Beckerle MC (2012). Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators. Mol Biol Cell, 23(10), 1846-59.
  18. A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted.Elias MC, Pronovost SM, Cahill KJ, Beckerle MC, Kadrmas JL (2012). A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted. J Cell Sci, 125(Pt 13), 3185-94.
  19. Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation.Clark KA, Lesage-Horton H, Zhao C, Beckerle MC, Swank DM (2011). Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation. Am J Physiol Cell Physiol, 301(2), C373-82.
  20. Medical faculty development: a modern-day odyssey.Beckerle MC, Reed KL, Scott RP, Shafer MA, Towner D, Valantine HA, Zahniser NR (2011). Medical faculty development: a modern-day odyssey. Sci Transl Med, 3(104), 104cm31.
  21. Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse.Lilly B, Clark KA, Yoshigi M, Pronovost S, Wu ML, Periasamy M, Chi M, Paul RJ, Yet SF, Beckerle MC (2010). Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse. Arterioscler Thromb Vasc Biol, 30(4), 694-701.
  22. Prognostic significance of PINCH signalling in human pancreatic ductal adenocarcinoma.Scaife CL, Shea J, Emerson L, Boucher K, Firpo MA, Beckerle MC, Mulvihill SJ (2010). Prognostic significance of PINCH signalling in human pancreatic ductal adenocarcinoma. HPB (Oxford), 12(5), 352-8.
  23. The cytoskeletal regulator zyxin is required for viability in Drosophila melanogaster.Renfranz PJ, Blankman E, Beckerle MC (2010). The cytoskeletal regulator zyxin is required for viability in Drosophila melanogaster. Anat Rec (Hoboken), 293(9), 1455-69.
  24. A zyxin-mediated mechanism for actin stress fiber maintenance and repair.Smith MA, Blankman E, Gardel ML, Luettjohann L, Waterman CM, Beckerle MC (2010). A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Dev Cell, 19(3), 365-76.
  25. The LIM Protein Zyxin Binds CARP-1 and Promotes Apoptosis.Hervy M, Hoffman LM, Jensen CC, Smith M, Beckerle MC (2010). The LIM Protein Zyxin Binds CARP-1 and Promotes Apoptosis. Genes Cancer, 1(5), 506-515.
  26. How cell biologists can contribute to improving cancer outcomes.Beckerle MC (2010). How cell biologists can contribute to improving cancer outcomes. Mol Biol Cell, 21(22), 3788-9.
  27. TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness.Chastre E, Abdessamad M, Kruglov A, Bruyneel E, Bracke M, Di Gioia Y, Beckerle MC, van Roy F, Kotelevets L (2009). TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness. FASEB J, 23(3), 916-28.
  28. The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans.Han HF, Beckerle MC (2009). The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans. Mol Biol Cell, 20(9), 2361-70.
  29. The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function.Mery A, Taghli-Lamallem O, Clark KA, Beckerle MC, Wu X, Ocorr K, Bodmer R (2008). The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function. J Exp Biol, 211(Pt 1), 15-23.
  30. alpha-Actinin links LPP, but not zyxin, to cadherin-based junctions.Hansen MD, Beckerle MC (2008). alpha-Actinin links LPP, but not zyxin, to cadherin-based junctions. Biochem Biophys Res Commun, 371(1), 144-8.
  31. The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation.Pomies P, Pashmforoush M, Vegezzi C, Chien KR, Auffray C, Beckerle MC (2007). The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. Mol Biol Cell, 18(5), 1723-33.
  32. The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity.Clark KA, Bland JM, Beckerle MC (2007). The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity. J Cell Sci, 120(Pt 12), 2066-77.
  33. Characterization of RACK1 function in Drosophila development.Kadrmas JL, Smith MA, Pronovost SM, Beckerle MC (2007). Characterization of RACK1 function in Drosophila development. Dev Dyn, 236(8), 2207-15.
  34. Supervillin modulation of focal adhesions involving TRIP6/ZRP-1.Takizawa N, Smith TC, Nebl T, Crowley JL, Palmieri SJ, Lifshitz LM, Ehrhardt AG, Hoffman LM, Beckerle MC, Luna EJ (2006). Supervillin modulation of focal adhesions involving TRIP6/ZRP-1. J Cell Biol, 174(3), 447-58.
  35. From the membrane to the nucleus and back again: bifunctional focal adhesion proteins.Hervy M, Hoffman L, Beckerle MC (2006). From the membrane to the nucleus and back again: bifunctional focal adhesion proteins. Curr Opin Cell Biol, 18(5), 524-32.
  36. Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling.Hoffman LM, Jensen CC, Kloeker S, Wang CL, Yoshigi M, Beckerle MC (2006). Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling. J Cell Biol, 172(5), 771-82.
  37. Opposing roles of zyxin/LPP ACTA repeats and the LIM domain region in cell-cell adhesion.Hansen MD, Beckerle MC (2006). Opposing roles of zyxin/LPP ACTA repeats and the LIM domain region in cell-cell adhesion. J Biol Chem, 281(23), 16178-88.
  38. Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp-1.McKeown CR, Han HF, Beckerle MC (2006). Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp-1. Dev Dyn, 235(2), 530-8.
  39. Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt.Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M, Sussman MA (2005). Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. J Clin Invest, 115(10), 2716-30.
  40. The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans.Norman KR, Fazzio RT, Mellem JE, Espelt MV, Strange K, Beckerle MC, Maricq AV (2005). The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans. Cell, 123(1), 119-32.
  41. Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement.Yoshigi M, Hoffman LM, Jensen CC, Yost HJ, Beckerle MC (2005). Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement. J Cell Biol, 171(2), 209-15.
  42. The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1.Kadrmas JL, Smith MA, Clark KA, Pronovost SM, Muster N, Yates JR 3rd, Beckerle MC (2004). The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1. J Cell Biol, 167(6), 1019-24.
  43. The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion.Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle MC (2004). The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem, 279(8), 6824-33.
  44. Targeted disruption of the murine zyxin gene.Hoffman LM, Nix DA, Benson B, Boot-Hanford R, Gustafsson E, Jamora C, Menzies AS, Goh KL, Jensen CC, Gertler FB, Fuchs E, Fassler R, Beckerle MC (2003). Targeted disruption of the murine zyxin gene. Mol Cell Biol, 23(1), 70-9.
  45. Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors.Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ (2003). Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Dev Cell, 4(1), 107-18.
  46. ALP and MLP distribution during myofibrillogenesis in cultured cardiomyocytes.Henderson JR, Pomies P, Auffray C, Beckerle MC (2003). ALP and MLP distribution during myofibrillogenesis in cultured cardiomyocytes. Cell Motil Cytoskeleton, 54(3), 254-65.
  47. Molecular and phylogenetic characterization of Zyx102, a Drosophila orthologue of the zyxin family that interacts with Drosophila Enabled.Renfranz PJ, Siegrist SE, Stronach BE, Macalma T, Beckerle MC (2003). Molecular and phylogenetic characterization of Zyx102, a Drosophila orthologue of the zyxin family that interacts with Drosophila Enabled. Gene, 305(1), 13-26.
  48. Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes.Clark KA, McGrail M, Beckerle MC (2003). Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes. Development, 130(12), 2611-21.
  49. LPP, a LIM protein highly expressed in smooth muscle.Gorenne I, Nakamoto RK, Phelps CP, Beckerle MC, Somlyo AV, Somlyo AP (2003). LPP, a LIM protein highly expressed in smooth muscle. Am J Physiol Cell Physiol, 285(3), C674-85.
  50. Expression of the gene encoding the LIM protein CRP2: a developmental profile.Henderson JR, Brown D, Richardson JA, Olson EN, Beckerle MC (2002). Expression of the gene encoding the LIM protein CRP2: a developmental profile. J Histochem Cytochem, 50(1), 107-11.
  51. Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers.Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC (2002). Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. J Biol Chem, 277(11), 9580-9.
  52. Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy.Pashmforoush M, Pomies P, Peterson KL, Kubalak S, Ross J Jr, Hefti A, Aebi U, Beckerle MC, Chien KR (2001). Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nat Med, 7(5), 591-7.
  53. Targeting of zyxin to sites of actin membrane interaction and to the nucleus.Nix DA, Fradelizi J, Bockholt S, Menichi B, Louvard D, Friederich E, Beckerle MC (2001). Targeting of zyxin to sites of actin membrane interaction and to the nucleus. J Biol Chem, 276(37), 34759-67.
  54. Identification of a CArG box-dependent enhancer within the cysteine-rich protein 1 gene that directs expression in arterial but not venous or visceral smooth muscle cells.Lilly B, Olson EN, Beckerle MC (2001). Identification of a CArG box-dependent enhancer within the cysteine-rich protein 1 gene that directs expression in arterial but not venous or visceral smooth muscle cells. Dev Biol, 240(2), 531-47.
  55. Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm.Neufeld KL, Nix DA, Bogerd H, Kang Y, Beckerle MC, Cullen BR, White RL (2000). Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc Natl Acad Sci U S A, 97(22), 12085-90.
  56. Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins.Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (2000). Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. J Biol Chem, 275(29), 22503-11.
  57. Fine mapping of the alpha-actinin binding site within cysteine-rich protein.Harper BD, Beckerle MC, Pomies P (2000). Fine mapping of the alpha-actinin binding site within cysteine-rich protein. Biochem J, 350 Pt 1, 269-74.
  58. LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor.Zhao MK, Wang Y, Murphy K, Yi J, Beckerle MC, Gilmore TD (1999). LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor. Gene Expr, 8(4), 207-17.
  59. Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesis.Stronach BE, Renfranz PJ, Lilly B, Beckerle MC (1999). Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesis. Mol Biol Cell, 10(7), 2329-42.
  60. The LIM protein, CRP1, is a smooth muscle marker.Henderson JR, Macalma T, Brown D, Richardson JA, Olson EN, Beckerle MC (1999). The LIM protein, CRP1, is a smooth muscle marker. Dev Dyn, 214(3), 229-38.
  61. A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans.Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G (1999). A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol, 144(1), 45-57.
  62. Solution structure of the chicken cysteine-rich protein, CRP1, a double-LIM protein implicated in muscle differentiation.Yao X, Perez-Alvarado GC, Louis HA, Pomies P, Hatt C, Summers MF, Beckerle MC (1999). Solution structure of the chicken cysteine-rich protein, CRP1, a double-LIM protein implicated in muscle differentiation. Biochemistry, 38(18), 5701-13.
  63. Purification and characterization of an alpha-actinin-binding PDZ-LIM protein that is up-regulated during muscle differentiation.Pomies P, Macalma T, Beckerle MC (1999). Purification and characterization of an alpha-actinin-binding PDZ-LIM protein that is up-regulated during muscle differentiation. J Biol Chem, 274(41), 29242-50.
  64. Molecular dissection of zyxin function reveals its involvement in cell motility.Drees BE, Andrews KM, Beckerle MC (1999). Molecular dissection of zyxin function reveals its involvement in cell motility. J Cell Biol, 147(7), 1549-60.
  65. LIM domains of cysteine-rich protein 1 (CRP1) are essential for its zyxin-binding function.Schmeichel KL, Beckerle MC (1998). LIM domains of cysteine-rich protein 1 (CRP1) are essential for its zyxin-binding function. Biochem J, 331 ( Pt 3), 885-92.
  66. The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis.Yi J, Beckerle MC (1998). The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis. Genomics, 49(2), 314-6.
  67. Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains.Ahern-Djamali SM, Comer AR, Bachmann C, Kastenmeier AS, Reddy SK, Beckerle MC, Walter U, Hoffmann FM (1998). Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains. Mol Biol Cell, 9(8), 2157-71.
  68. Purification and assay of zyxin.Schmeichel KL, Stronach BE, Beckerle MC (1998). Purification and assay of zyxin. Methods Enzymol, 298, 62-76.
  69. Molecular dissection of a LIM domain.Schmeichel KL, Beckerle MC (1997). Molecular dissection of a LIM domain. Mol Biol Cell, 8(2), 219-30.
  70. Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus.Nix DA, Beckerle MC (1997). Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. J Cell Biol, 138(5), 1139-47.
  71. Structural and functional similarities between the human cytoskeletal protein zyxin and the ActA protein of Listeria monocytogenes.Golsteyn RM, Beckerle MC, Koay T, Friederich E (1997). Structural and functional similarities between the human cytoskeletal protein zyxin and the ActA protein of Listeria monocytogenes. J Cell Sci, 110 ( Pt 16), 1893-906.
  72. CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin.Pomies P, Louis HA, Beckerle MC (1997). CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin. J Cell Biol, 139(1), 157-68.
  73. Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression.Louis HA, Pino JD, Schmeichel KL, Pomies P, Beckerle MC (1997). Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression. J Biol Chem, 272(43), 27484-91.
  74. Structure of the cysteine-rich intestinal protein, CRIP.Perez-Alvarado GC, Kosa JL, Louis HA, Beckerle MC, Winge DR, Summers MF (1996). Structure of the cysteine-rich intestinal protein, CRIP. J Mol Biol, 257(1), 153-74.
  75. SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin.Hobert O, Schilling JW, Beckerle MC, Ullrich A, Jallal B (1996). SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. Oncogene, 12(7), 1577-81.
  76. Two muscle-specific LIM proteins in Drosophila.Stronach BE, Siegrist SE, Beckerle MC (1996). Two muscle-specific LIM proteins in Drosophila. J Cell Biol, 134(5), 1179-95.
  77. Molecular characterization of human zyxin.Macalma T, Otte J, Hensler ME, Bockholt SM, Louis HA, Kalff-Suske M, Grzeschik KH, von der Ahe D, Beckerle MC (1996). Molecular characterization of human zyxin. J Biol Chem, 271(49), 31470-8.
  78. The cysteine-rich protein family of highly related LIM domain proteins.Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (1995). The cysteine-rich protein family of highly related LIM domain proteins. J Biol Chem, 270(48), 28946-54.
  79. Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP.Perez-Alvarado GC, Miles C, Michelsen JW, Louis HA, Winge DR, Beckerle MC, Summers MF (1994). Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP. Nat Struct Biol, 1(6), 388-98.
  80. Common metal ion coordination in LIM domain proteins.Kosa JL, Michelsen JW, Louis HA, Olsen JI, Davis DR, Beckerle MC, Winge DR (1994). Common metal ion coordination in LIM domain proteins. Biochemistry, 33(2), 468-77.
  81. Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton.Crawford AW, Pino JD, Beckerle MC (1994). Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton. J Cell Biol, 124(1-2), 117-27.
  82. The LIM domain is a modular protein-binding interface.Schmeichel KL, Beckerle MC (1994). The LIM domain is a modular protein-binding interface. Cell, 79(2), 211-9.
  83. Mutational analysis of the metal sites in an LIM domain.Michelsen JW, Sewell AK, Louis HA, Olsen JI, Davis DR, Winge DR, Beckerle MC (1994). Mutational analysis of the metal sites in an LIM domain. J Biol Chem, 269(15), 11108-13.
  84. The LIM motif defines a specific zinc-binding protein domain.Michelsen JW, Schmeichel KL, Beckerle MC, Winge DR (1993). The LIM motif defines a specific zinc-binding protein domain. Proc Natl Acad Sci U S A, 90(10), 4404-8.
  85. Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets.Bertagnolli ME, Beckerle MC (1993). Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets. J Cell Biol, 121(6), 1329-42.
  86. Talin distribution and phosphorylation in thrombin-activated platelets.Bertagnolli ME, Locke SJ, Hensler ME, Bray PF, Beckerle MC (1993). Talin distribution and phosphorylation in thrombin-activated platelets. J Cell Sci, 106 ( Pt 4), 1189-99.
  87. An interaction between zyxin and alpha-actinin.Crawford AW, Michelsen JW, Beckerle MC (1992). An interaction between zyxin and alpha-actinin. J Cell Biol, 116(6), 1381-93.
  88. Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton.Sadler I, Crawford AW, Michelsen JW, Beckerle MC (1992). Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton. J Cell Biol, 119(6), 1573-87.
  89. Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions.Crawford AW, Beckerle MC (1991). Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. J Biol Chem, 266(9), 5847-53.
  90. The adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to a tumor-promoting phorbol ester.Beckerle MC (1990). The adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to a tumor-promoting phorbol ester. Cell Regul, 1(2), 227-36.
  91. Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets.Beckerle MC, Miller DE, Bertagnolli ME, Locke SJ (1989). Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets. J Cell Biol, 109(6 Pt 2), 3333-46.
  92. Identification and subcellular location of talin in various cell types and tissues by means of [125I]vinculin overlay, immunoblotting and immunocytochemistry.Drenckhahn D, Beckerle M, Burridge K, Otto J (1988). Identification and subcellular location of talin in various cell types and tissues by means of [125I]vinculin overlay, immunoblotting and immunocytochemistry. Eur J Cell Biol, 46(3), 513-22.
  93. Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion.Beckerle MC, Burridge K, DeMartino GN, Croall DE (1987). Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion. Cell, 51(4), 569-77.
  94. Demonstration of a relationship between talin and P235, a major substrate of the calcium-dependent protease in platelets.Beckerle MC, OHalloran T, Burridge K (1986). Demonstration of a relationship between talin and P235, a major substrate of the calcium-dependent protease in platelets. J Cell Biochem, 30(3), 259-70.
  95. Talin is a post-synaptic component of the rat neuromuscular junction.Sealock R, Paschal B, Beckerle M, Burridge K (1986). Talin is a post-synaptic component of the rat neuromuscular junction. Exp Cell Res, 163(1), 143-50.
  96. Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage.Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K (1986). Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature, 320(6062), 531-3.
  97. Identification of a new protein localized at sites of cell-substrate adhesion.Beckerle MC (1986). Identification of a new protein localized at sites of cell-substrate adhesion. J Cell Biol, 103(5), 1679-87.
  98. Identification of talin as a major cytoplasmic protein implicated in platelet activation.OHalloran T, Beckerle MC, Burridge K (1985). Identification of talin as a major cytoplasmic protein implicated in platelet activation. Nature, 317(6036), 449-51.
  99. Microinjected fluorescent polystyrene beads exhibit saltatory motion in tissue culture cells.Beckerle MC (1984). Microinjected fluorescent polystyrene beads exhibit saltatory motion in tissue culture cells. J Cell Biol, 98(6), 2126-32.
  100. Analysis of the role of microtubules and actin in erythrophore intracellular motility.Beckerle MC, Porter KR (1983). Analysis of the role of microtubules and actin in erythrophore intracellular motility. J Cell Biol, 96(2), 354-62.
  101. Porter KR, Beckerle MC, McNiven MA (1983). The Cytoplasmic Matrix. Mol Cell Biol, 2, 259-302.
  102. Inhibitors of dynein activity block intracellular transport in erythrophores.Beckerle MC, Porter KR (1982). Inhibitors of dynein activity block intracellular transport in erythrophores. Nature, 295(5851), 701-3.

Review

  1. The LIM domain: from the cytoskeleton to the nucleus.Kadrmas JL, Beckerle MC (2004). The LIM domain: from the cytoskeleton to the nucleus. [Review]. Nat Rev Mol Cell Biol, 5(11), 920-31.