Mary C. Beckerle, PhD

Research Interests

  • Cell Adhesion
  • Ewing's Sarcoma
  • Cancer Biology
  • Actin Cytoskeleton Dynamics
  • Metastasis
  • Cell Motility

Labs

Lab Website

Languages

  • English
  • French

Academic Information

  • Departments: Biology - Distinguished Professor, Oncological Sciences - Adjunct Professor
  • Cancer Center Programs: Cell Response & Regulation

Academic Office Information

  • 801-581-4485
  • Huntsman Cancer Institute
    2000 Circle of Hope, Room: 5360
    Salt Lake City, UT 84112

Academic Bio

Mary C. Beckerle, PhD

Jon M. Huntsman Presidential Endowed Chair

Chief Executive Officer and Director, Huntsman Cancer Institute

Associate Vice President of Cancer Affairs, University of Utah

Distinguished Professor of Biology

Mary Beckerle, PhD, has served as CEO and Director of Huntsman Cancer Institute since 2006, and she was appointed in 2009 to an additional key health sciences leadership role as Associate Vice President for Cancer Affairs at the University of Utah. Beckerle joined the faculty of the University of Utah in 1986, and is a distinguished professor of biology and oncological sciences, holding the Jon M. Huntsman Presidential Endowed Chair. She earned her PhD in molecular, cellular, and developmental biology from the University of Colorado at Boulder, where she was the recipient of a Danforth Fellowship, and completed post-doctoral research at the University of North Carolina at Chapel Hill.

Beckerle’s research has defined a novel molecular pathway that regulates cell motility, and her lab is currently focused on understanding the impact of this pathway on tumor progression, particularly in Ewing’s sarcoma. Her scientific work has been continuously funded by the National Institutes of Health (NIH) and the over 20 years. She guided graduate education at the University of Utah as the director of the Interdepartmental Graduate Program in Molecular Biology for two years. In addition, Beckerle developed the Multidisciplinary Cancer Research Training Program at Huntsman Cancer Institute at the University of Utah and served for several years as the principal investigator of the National Cancer Institute grant that supported this cancer-focused training initiative. Beckerle is the principal investigator of Huntsman Cancer Institute’s NCI Cancer Center Support Grant (CCSG). She is a member of the NCI Scientific Review Group Subcommittee A (Parent Committee) for Cancer Centers.

An active participant in national and international scientific affairs, Beckerle served as president of the American Society for Cell Biology (ASCB) in 2006, and was appointed in 2010 to the American Association of Cancer Research Science Policy and Legislative Affairs Committee. She has served on numerous strategic planning and peer review committees for the NIH. She has served on the NIH Advisory Committee to the Director, as Chair of the American Cancer Society Council for Extramural Grants, and on the Coalition for Life Sciences Board of Directors. She currently serves on the Medical Advisory Board of the Howard Hughes Medical Institute, the Scientific Advisory Boards of the National Center for Biological Sciences in India, the Mechanobiology Institute in Singapore, and several National Cancer Institute (NCI)-designated cancer centers. In 2013, she was elected to the Board of Directors of the American Association for Cancer Research. She was selected by Vice President Biden to serve as a member of the National Blue Ribbon Panel on the Cancer Moonshot Initiative in 2016.

In 2000, Beckerle was appointed as a Guggenheim Fellow and a Rothschild-Yvette Mayent Award Scholar at the Curie Institute in Paris. She received the Utah Governor’s Medal for Science and Technology in 2001, the Sword of Hope Award from the American Cancer Society in 2004, and the Rosenblatt Prize for Excellence (the University of Utah’s highest honor) in 2007. Beckerle was elected as a Fellow of the American Academy of Arts and Sciences in 2008. Beckerle serves as a member of the Board of Directors of Huntsman Corporation and Johnson & Johnson.

Education History

Type School Degree
Other Training Drexel University
Executive Leadership in Academic Medicine (ELAM) Program
Fellow
Professional Other The Aspen Institute
Postdoctoral Fellowship University of North Carolina
Anatomy and Cell Biology
Postdoctoral Fellow
Doctoral Training University of Colorado
Molecular, Cellular and Developmental Biology
Ph.D.
Undergraduate Wells College
Biology and Psychology
B.A.

Global Impact

Career

Institution Description Country
Institute Curie Visiting Scholar United Kingdom

Selected Publications

Journal Article

  1. Fadul J, Bell R, Hoffman LM, Beckerle MC, Engel ME, Lessnick SL (2015). EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma. Genes Cancer, 6(3-4), 129-43.
  2. Chapin LM, Edgar LT, Blankman E, Beckerle MC, Shiu YT (2014). Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers. Cell Mol Bioeng, 7, 73-85.
  3. Smith MA, Hoffman LM, Beckerle MC (2014). LIM proteins in actin cytoskeleton mechanoresponse. Trends Cell Biol, 24(10), 575-83.
  4. Sankar S, Theisen ER, Bearss J, Mulvihill T, Hoffman LM, Sorna V, Beckerle MC, Sharma S, Lessnick SL (2014). Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth. Clin Cancer Res, 20(17), 4584-97.
  5. Chaturvedi A, Hoffman LM, Jensen CC, Lin YC, Grossmann AH, Randall RL, Lessnick SL, Welm AL, Beckerle MC (2014). Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. Mol Biol Cell, 25(18), 2695-709.
  6. Chapin LM, Edgar LT, Blankman E, Beckerle MC, Shiu YT (2014). Mathematical modeling of the dynamic mechanical behavior of neighboring sarcomeres in actin stress fibers. Cell Mol Bioeng, 7(1), 73-85.
  7. Valantine HA, Beckerle MC, Reed KL, Towner D, Zahniser NR (2014). Teaching corporate in college. Sci Transl Med, 6(251), 251fs33.
  8. Stachowiak MR, Smith MA, Blankman E, Chapin LM, Balcioglu HE, Wang S, Beckerle MC, OShaughnessy B (2014). A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton. Proc Natl Acad Sci U S A, 111(49), 17528-33.
  9. Wiles ET, Bell R, Thomas D, Beckerle M, Lessnick SL (2013). ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma. Genes Cancer, 4(11-12), 486-500.
  10. Pronovost SM, Beckerle MC, Kadrmas JL (2013). Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants. PLoS Genet, 9(3), e1003406.
  11. Smith MA, Blankman E, Deakin NO, Hoffman LM, Jensen CC, Turner CE, Beckerle MC (2013). LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. PLoS One, 8(8), e69378.
  12. Bianchi-Smiraglia A, Kunnev D, Limoge M, Lee A, Beckerle MC, Bakin AV (2013). Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. Cell Cycle, 12(21), 3377-89.
  13. Sankar S, Tanner JM, Bell R, Chaturvedi A, Randall RL, Beckerle MC, Lessnick SL (2013). A novel role for keratin 17 in coordinating oncogenic transformation and cellular adhesion in Ewing sarcoma. Mol Cell Biol, 33(22), 4448-60.
  14. Spraker HL, Price SL, Chaturvedi A, Schiffman JD, Jones KB, Lessnick SL, Beckerle M, Randall RL (2012). The clone wars - revenge of the metastatic rogue state: the sarcoma paradigm. Front Oncol, 2, 2.
  15. Chaturvedi A, Hoffman LM, Welm AL, Lessnick SL, Beckerle MC (2012). The EWS/FLI Oncogene Drives Changes in Cellular Morphology, Adhesion, and Migration in Ewing Sarcoma. Genes Cancer, 3(2), 102-16.
  16. Chapin LM, Blankman E, Smith MA, Shiu YT, Beckerle MC (2012). Lateral communication between stress fiber sarcomeres facilitates a local remodeling response. Biophys J, 103(10), 2082-92.
  17. Hoffman LM, Jensen CC, Chaturvedi A, Yoshigi M, Beckerle MC (2012). Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators. Mol Biol Cell, 23(10), 1846-59.
  18. Elias MC, Pronovost SM, Cahill KJ, Beckerle MC, Kadrmas JL (2012). A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted. J Cell Sci, 125(Pt 13), 3185-94.
  19. Clark KA, Lesage-Horton H, Zhao C, Beckerle MC, Swank DM (2011). Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation. Am J Physiol Cell Physiol, 301(2), C373-82.
  20. Beckerle MC, Reed KL, Scott RP, Shafer MA, Towner D, Valantine HA, Zahniser NR (2011). Medical faculty development: a modern-day odyssey. Sci Transl Med, 3(104), 104cm31.
  21. Lilly B, Clark KA, Yoshigi M, Pronovost S, Wu ML, Periasamy M, Chi M, Paul RJ, Yet SF, Beckerle MC (2010). Loss of the serum response factor cofactor, cysteine-rich protein 1, attenuates neointima formation in the mouse. Arterioscler Thromb Vasc Biol, 30(4), 694-701.
  22. Scaife CL, Shea J, Emerson L, Boucher K, Firpo MA, Beckerle MC, Mulvihill SJ (2010). Prognostic significance of PINCH signalling in human pancreatic ductal adenocarcinoma. HPB (Oxford), 12(5), 352-8.
  23. Renfranz PJ, Blankman E, Beckerle MC (2010). The cytoskeletal regulator zyxin is required for viability in Drosophila melanogaster. Anat Rec (Hoboken), 293(9), 1455-69.
  24. Smith MA, Blankman E, Gardel ML, Luettjohann L, Waterman CM, Beckerle MC (2010). A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Dev Cell, 19(3), 365-76.
  25. Hervy M, Hoffman LM, Jensen CC, Smith M, Beckerle MC (2010). The LIM Protein Zyxin Binds CARP-1 and Promotes Apoptosis. Genes Cancer, 1(5), 506-515.
  26. Beckerle MC (2010). How cell biologists can contribute to improving cancer outcomes. Mol Biol Cell, 21(22), 3788-9.
  27. Chastre E, Abdessamad M, Kruglov A, Bruyneel E, Bracke M, Di Gioia Y, Beckerle MC, van Roy F, Kotelevets L (2009). TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness. FASEB J, 23(3), 916-28.
  28. Han HF, Beckerle MC (2009). The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans. Mol Biol Cell, 20(9), 2361-70.
  29. Mery A, Taghli-Lamallem O, Clark KA, Beckerle MC, Wu X, Ocorr K, Bodmer R (2008). The Drosophila muscle LIM protein, Mlp84B, is essential for cardiac function. J Exp Biol, 211(Pt 1), 15-23.
  30. Hansen MD, Beckerle MC (2008). alpha-Actinin links LPP, but not zyxin, to cadherin-based junctions. Biochem Biophys Res Commun, 371(1), 144-8.
  31. Pomies P, Pashmforoush M, Vegezzi C, Chien KR, Auffray C, Beckerle MC (2007). The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation. Mol Biol Cell, 18(5), 1723-33.
  32. Clark KA, Bland JM, Beckerle MC (2007). The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity. J Cell Sci, 120(Pt 12), 2066-77.
  33. Kadrmas JL, Smith MA, Pronovost SM, Beckerle MC (2007). Characterization of RACK1 function in Drosophila development. Dev Dyn, 236(8), 2207-15.
  34. Takizawa N, Smith TC, Nebl T, Crowley JL, Palmieri SJ, Lifshitz LM, Ehrhardt AG, Hoffman LM, Beckerle MC, Luna EJ (2006). Supervillin modulation of focal adhesions involving TRIP6/ZRP-1. J Cell Biol, 174(3), 447-58.
  35. Hervy M, Hoffman L, Beckerle MC (2006). From the membrane to the nucleus and back again: bifunctional focal adhesion proteins. Curr Opin Cell Biol, 18(5), 524-32.
  36. Hoffman LM, Jensen CC, Kloeker S, Wang CL, Yoshigi M, Beckerle MC (2006). Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling. J Cell Biol, 172(5), 771-82.
  37. Hansen MD, Beckerle MC (2006). Opposing roles of zyxin/LPP ACTA repeats and the LIM domain region in cell-cell adhesion. J Biol Chem, 281(23), 16178-88.
  38. McKeown CR, Han HF, Beckerle MC (2006). Molecular characterization of the Caenorhabditis elegans ALP/Enigma gene alp-1. Dev Dyn, 235(2), 530-8.
  39. Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M, Sussman MA (2005). Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt. J Clin Invest, 115(10), 2716-30.
  40. Norman KR, Fazzio RT, Mellem JE, Espelt MV, Strange K, Beckerle MC, Maricq AV (2005). The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans. Cell, 123(1), 119-32.
  41. Yoshigi M, Hoffman LM, Jensen CC, Yost HJ, Beckerle MC (2005). Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement. J Cell Biol, 171(2), 209-15.
  42. Kadrmas JL, Smith MA, Clark KA, Pronovost SM, Muster N, Yates JR 3rd, Beckerle MC (2004). The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1. J Cell Biol, 167(6), 1019-24.
  43. Kloeker S, Major MB, Calderwood DA, Ginsberg MH, Jones DA, Beckerle MC (2004). The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem, 279(8), 6824-33.
  44. Hoffman LM, Nix DA, Benson B, Boot-Hanford R, Gustafsson E, Jamora C, Menzies AS, Goh KL, Jensen CC, Gertler FB, Fuchs E, Fassler R, Beckerle MC (2003). Targeted disruption of the murine zyxin gene. Mol Cell Biol, 23(1), 70-9.
  45. Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ (2003). Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors. Dev Cell, 4(1), 107-18.
  46. Henderson JR, Pomies P, Auffray C, Beckerle MC (2003). ALP and MLP distribution during myofibrillogenesis in cultured cardiomyocytes. Cell Motil Cytoskeleton, 54(3), 254-65.
  47. Renfranz PJ, Siegrist SE, Stronach BE, Macalma T, Beckerle MC (2003). Molecular and phylogenetic characterization of Zyx102, a Drosophila orthologue of the zyxin family that interacts with Drosophila Enabled. Gene, 305(1), 13-26.
  48. Clark KA, McGrail M, Beckerle MC (2003). Analysis of PINCH function in Drosophila demonstrates its requirement in integrin-dependent cellular processes. Development, 130(12), 2611-21.
  49. Gorenne I, Nakamoto RK, Phelps CP, Beckerle MC, Somlyo AV, Somlyo AP (2003). LPP, a LIM protein highly expressed in smooth muscle. Am J Physiol Cell Physiol, 285(3), C674-85.
  50. Henderson JR, Brown D, Richardson JA, Olson EN, Beckerle MC (2002). Expression of the gene encoding the LIM protein CRP2: a developmental profile. J Histochem Cytochem, 50(1), 107-11.
  51. Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC (2002). Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. J Biol Chem, 277(11), 9580-9.
  52. Pashmforoush M, Pomies P, Peterson KL, Kubalak S, Ross J Jr, Hefti A, Aebi U, Beckerle MC, Chien KR (2001). Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nat Med, 7(5), 591-7.
  53. Nix DA, Fradelizi J, Bockholt S, Menichi B, Louvard D, Friederich E, Beckerle MC (2001). Targeting of zyxin to sites of actin membrane interaction and to the nucleus. J Biol Chem, 276(37), 34759-67.
  54. Lilly B, Olson EN, Beckerle MC (2001). Identification of a CArG box-dependent enhancer within the cysteine-rich protein 1 gene that directs expression in arterial but not venous or visceral smooth muscle cells. Dev Biol, 240(2), 531-47.
  55. Neufeld KL, Nix DA, Bogerd H, Kang Y, Beckerle MC, Cullen BR, White RL (2000). Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc Natl Acad Sci U S A, 97(22), 12085-90.
  56. Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle MC, Golsteyn RM (2000). Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. J Biol Chem, 275(29), 22503-11.
  57. Harper BD, Beckerle MC, Pomies P (2000). Fine mapping of the alpha-actinin binding site within cysteine-rich protein. Biochem J, 350 Pt 1, 269-74.
  58. Zhao MK, Wang Y, Murphy K, Yi J, Beckerle MC, Gilmore TD (1999). LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor. Gene Expr, 8(4), 207-17.
  59. Stronach BE, Renfranz PJ, Lilly B, Beckerle MC (1999). Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesis. Mol Biol Cell, 10(7), 2329-42.
  60. Henderson JR, Macalma T, Brown D, Richardson JA, Olson EN, Beckerle MC (1999). The LIM protein, CRP1, is a smooth muscle marker. Dev Dyn, 214(3), 229-38.
  61. Hobert O, Moerman DG, Clark KA, Beckerle MC, Ruvkun G (1999). A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol, 144(1), 45-57.
  62. Yao X, Perez-Alvarado GC, Louis HA, Pomies P, Hatt C, Summers MF, Beckerle MC (1999). Solution structure of the chicken cysteine-rich protein, CRP1, a double-LIM protein implicated in muscle differentiation. Biochemistry, 38(18), 5701-13.
  63. Pomies P, Macalma T, Beckerle MC (1999). Purification and characterization of an alpha-actinin-binding PDZ-LIM protein that is up-regulated during muscle differentiation. J Biol Chem, 274(41), 29242-50.
  64. Drees BE, Andrews KM, Beckerle MC (1999). Molecular dissection of zyxin function reveals its involvement in cell motility. J Cell Biol, 147(7), 1549-60.
  65. Schmeichel KL, Beckerle MC (1998). LIM domains of cysteine-rich protein 1 (CRP1) are essential for its zyxin-binding function. Biochem J, 331 ( Pt 3), 885-92.
  66. Yi J, Beckerle MC (1998). The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis. Genomics, 49(2), 314-6.
  67. Ahern-Djamali SM, Comer AR, Bachmann C, Kastenmeier AS, Reddy SK, Beckerle MC, Walter U, Hoffmann FM (1998). Mutations in Drosophila enabled and rescue by human vasodilator-stimulated phosphoprotein (VASP) indicate important functional roles for Ena/VASP homology domain 1 (EVH1) and EVH2 domains. Mol Biol Cell, 9(8), 2157-71.
  68. Schmeichel KL, Stronach BE, Beckerle MC (1998). Purification and assay of zyxin. Methods Enzymol, 298, 62-76.
  69. Schmeichel KL, Beckerle MC (1997). Molecular dissection of a LIM domain. Mol Biol Cell, 8(2), 219-30.
  70. Nix DA, Beckerle MC (1997). Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. J Cell Biol, 138(5), 1139-47.
  71. Golsteyn RM, Beckerle MC, Koay T, Friederich E (1997). Structural and functional similarities between the human cytoskeletal protein zyxin and the ActA protein of Listeria monocytogenes. J Cell Sci, 110 ( Pt 16), 1893-906.
  72. Pomies P, Louis HA, Beckerle MC (1997). CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin. J Cell Biol, 139(1), 157-68.
  73. Louis HA, Pino JD, Schmeichel KL, Pomies P, Beckerle MC (1997). Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression. J Biol Chem, 272(43), 27484-91.
  74. Perez-Alvarado GC, Kosa JL, Louis HA, Beckerle MC, Winge DR, Summers MF (1996). Structure of the cysteine-rich intestinal protein, CRIP. J Mol Biol, 257(1), 153-74.
  75. Hobert O, Schilling JW, Beckerle MC, Ullrich A, Jallal B (1996). SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. Oncogene, 12(7), 1577-81.
  76. Stronach BE, Siegrist SE, Beckerle MC (1996). Two muscle-specific LIM proteins in Drosophila. J Cell Biol, 134(5), 1179-95.
  77. Macalma T, Otte J, Hensler ME, Bockholt SM, Louis HA, Kalff-Suske M, Grzeschik KH, von der Ahe D, Beckerle MC (1996). Molecular characterization of human zyxin. J Biol Chem, 271(49), 31470-8.
  78. Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (1995). The cysteine-rich protein family of highly related LIM domain proteins. J Biol Chem, 270(48), 28946-54.
  79. Perez-Alvarado GC, Miles C, Michelsen JW, Louis HA, Winge DR, Beckerle MC, Summers MF (1994). Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP. Nat Struct Biol, 1(6), 388-98.
  80. Kosa JL, Michelsen JW, Louis HA, Olsen JI, Davis DR, Beckerle MC, Winge DR (1994). Common metal ion coordination in LIM domain proteins. Biochemistry, 33(2), 468-77.
  81. Crawford AW, Pino JD, Beckerle MC (1994). Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton. J Cell Biol, 124(1-2), 117-27.
  82. Schmeichel KL, Beckerle MC (1994). The LIM domain is a modular protein-binding interface. Cell, 79(2), 211-9.
  83. Michelsen JW, Sewell AK, Louis HA, Olsen JI, Davis DR, Winge DR, Beckerle MC (1994). Mutational analysis of the metal sites in an LIM domain. J Biol Chem, 269(15), 11108-13.
  84. Michelsen JW, Schmeichel KL, Beckerle MC, Winge DR (1993). The LIM motif defines a specific zinc-binding protein domain. Proc Natl Acad Sci U S A, 90(10), 4404-8.
  85. Bertagnolli ME, Beckerle MC (1993). Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets. J Cell Biol, 121(6), 1329-42.
  86. Bertagnolli ME, Locke SJ, Hensler ME, Bray PF, Beckerle MC (1993). Talin distribution and phosphorylation in thrombin-activated platelets. J Cell Sci, 106 ( Pt 4), 1189-99.
  87. Crawford AW, Michelsen JW, Beckerle MC (1992). An interaction between zyxin and alpha-actinin. J Cell Biol, 116(6), 1381-93.
  88. Sadler I, Crawford AW, Michelsen JW, Beckerle MC (1992). Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton. J Cell Biol, 119(6), 1573-87.
  89. Crawford AW, Beckerle MC (1991). Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. J Biol Chem, 266(9), 5847-53.
  90. Beckerle MC (1990). The adhesion plaque protein, talin, is phosphorylated in vivo in chicken embryo fibroblasts exposed to a tumor-promoting phorbol ester. Cell Regul, 1(2), 227-36.
  91. Beckerle MC, Miller DE, Bertagnolli ME, Locke SJ (1989). Activation-dependent redistribution of the adhesion plaque protein, talin, in intact human platelets. J Cell Biol, 109(6 Pt 2), 3333-46.
  92. Drenckhahn D, Beckerle M, Burridge K, Otto J (1988). Identification and subcellular location of talin in various cell types and tissues by means of [125I]vinculin overlay, immunoblotting and immunocytochemistry. Eur J Cell Biol, 46(3), 513-22.
  93. Beckerle MC, Burridge K, DeMartino GN, Croall DE (1987). Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion. Cell, 51(4), 569-77.
  94. Beckerle MC, OHalloran T, Burridge K (1986). Demonstration of a relationship between talin and P235, a major substrate of the calcium-dependent protease in platelets. J Cell Biochem, 30(3), 259-70.
  95. Sealock R, Paschal B, Beckerle M, Burridge K (1986). Talin is a post-synaptic component of the rat neuromuscular junction. Exp Cell Res, 163(1), 143-50.
  96. Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K (1986). Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage. Nature, 320(6062), 531-3.
  97. Beckerle MC (1986). Identification of a new protein localized at sites of cell-substrate adhesion. J Cell Biol, 103(5), 1679-87.
  98. OHalloran T, Beckerle MC, Burridge K (1985). Identification of talin as a major cytoplasmic protein implicated in platelet activation. Nature, 317(6036), 449-51.
  99. Beckerle MC (1984). Microinjected fluorescent polystyrene beads exhibit saltatory motion in tissue culture cells. J Cell Biol, 98(6), 2126-32.
  100. Beckerle MC, Porter KR (1983). Analysis of the role of microtubules and actin in erythrophore intracellular motility. J Cell Biol, 96(2), 354-62.
  101. Porter KR, Beckerle MC, McNiven MA (1983). The Cytoplasmic Matrix. Mol Cell Biol, 2, 259-302.
  102. Beckerle MC, Porter KR (1982). Inhibitors of dynein activity block intracellular transport in erythrophores. Nature, 295(5851), 701-3.

Review

  1. Kadrmas JL, Beckerle MC (2004). The LIM domain: from the cytoskeleton to the nucleus. [Review]. Nat Rev Mol Cell Biol, 5(11), 920-31.

Book Chapter

  1. Crawford AW, Beckerle MC (1990). Cell-substratum adhesion: Mechanism and Regulation. In George M. Malacinski (Ed.), Cytoplasmic Organization Systems. Primers in Developmental Biology, Vol. IV. New York: McGraw-Hill.