Cynthia Burrows, Ph.D.

Research Interests

  • Origins of Life
  • DNA Sequencing Technology
  • DNA Damage

Languages

  • English

Academic Information

  • Departments: Chemistry - Distinguished Professor
  • Cancer Center Programs: Nuclear Control of Cell Growth & Differentiation

Academic Office Information

  • (801) 585-7290
  • Henry Eyring Chemistry Building
    Chemistry
    315 S 1400 E
    Salt Lake City, UT 84112

Academic Bio

Cynthia Burrows, PhD, is a distinguished professor in the Department of Chemistry at the University of Utah and a member of the Nuclear Control of Cell Growth and Differentiation Program at Huntsman Cancer Institute.Burrows studies chemical processes that result in the formation of mutations. Mutations in DNA result in cancer, so by understanding how mutations develop, researchers hope to find ways to prevent them.Burrows was awarded the Arthur C. Cope Scholar Award from the American Chemical Society. She received a bachelor's degree from the University of Colorado, Boulder, and a PhD from Cornell University, New York.

Education History

Type School Degree
Postdoctoral Training Université Louis Pasteur
Advisor: Jean-Marie Lehn
Postdoctoral Training
Doctoral Training Cornell University
Chemistry
Ph.D.
Undergraduate University of Colorado
Chemistry
B.A.

Global Impact

Education History

Type School Degree Country
Postdoctoral Training Université Louis Pasteur
Advisor: Jean-Marie Lehn
Postdoctoral Training France

Selected Publications

Journal Article

  1. G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA.Fleming AM, Burrows CJ (2013). G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA. Chem Res Toxicol, 26(4), 593-607.
  2. Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context.Zhou J, Liu M, Fleming AM, Burrows CJ, Wallace SS (2013). Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context. J Biol Chem, 288(38), 27263-72.
  3. Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair.McKibbin PL, Fleming AM, Towheed MA, Van Houten B, Burrows CJ, David SS (2013). Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair. J Am Chem Soc, 135(37), 13851-61.
  4. Electrical Current Signatures of DNA Base Modifications in Single Molecules Immobilized in the alpha-Hemolysin Ion Channel.Wolna AH, Fleming AM, An N, He L, White HS, Burrows CJ (2013). Electrical Current Signatures of DNA Base Modifications in Single Molecules Immobilized in the alpha-Hemolysin Ion Channel. Isr J Chem, 53(6-7), 417-430.
  5. Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin.Fleming AM, Orendt AM, He Y, Zhu J, Dukor RK, Burrows CJ (2013). Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin. J Am Chem Soc, 135(48), 18191-204.
  6. Crown ether-electrolyte interactions permit nanopore detection of individual DNA abasic sites in single molecules.An N, Fleming AM, White HS, Burrows CJ (2012). Crown ether-electrolyte interactions permit nanopore detection of individual DNA abasic sites in single molecules. Proc Natl Acad Sci U S A, 109(29), 11504-9.
  7. Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairing.Fleming AM, Muller JG, Dlouhy AC, Burrows CJ (2012). Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairing. J Am Chem Soc, 134(36), 15091-102.
  8. Whence flavins? Redox-active ribonucleotides link metabolism and genome repair to the RNA world.Nguyen KV, Burrows CJ (2012). Whence flavins? Redox-active ribonucleotides link metabolism and genome repair to the RNA world. Acc Chem Res, 45(12), 2151-9.
  9. Sequence-specific single-molecule analysis of 8-oxo-7,8-dihydroguanine lesions in DNA based on unzipping kinetics of complementary probes in ion channel recordings.Schibel AE, Fleming AM, Jin Q, An N, Liu J, Blakemore CP, White HS, Burrows CJ (2011). Sequence-specific single-molecule analysis of 8-oxo-7,8-dihydroguanine lesions in DNA based on unzipping kinetics of complementary probes in ion channel recordings. J Am Chem Soc, 133(37), 14778-84.
  10. Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts.Zhao X, Krishnamurthy N, Burrows CJ, David SS (2010). Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts. Biochemistry, 49(8), 1658-66.
  11. Nanopore detection of 8-oxo-7,8-dihydro-2'-deoxyguanosine in immobilized single-stranded DNA via adduct formation to the DNA damage site.Schibel AE, An N, Jin Q, Fleming AM, Burrows CJ, White HS (2010). Nanopore detection of 8-oxo-7,8-dihydro-2'-deoxyguanosine in immobilized single-stranded DNA via adduct formation to the DNA damage site. J Am Chem Soc, 132(51), 17992-5.
  12. Electronic structure of DNA--unique properties of 8-oxoguanosine.Markus TZ, Daube SS, Naaman R, Fleming AM, Muller JG, Burrows CJ (2009). Electronic structure of DNA--unique properties of 8-oxoguanosine. J Am Chem Soc, 131(1), 89-95.
  13. Surviving an Oxygen Atmosphere: DNA Damage and Repair.Burrows CJ (2009). Surviving an Oxygen Atmosphere: DNA Damage and Repair. ACS Symp Ser Am Chem Soc, 2009, 147-156.