You Han Bae, PhD
- Protein drug stabilization and controlled release
- Polymeric systems for rechargeable cell delivery
- Self-assembled super intelligent nanoparticulates for sensitive and resistant tumor targeting
- Departments: Pharmaceutics and Pharmaceutical Chemistry - Professor
- Cancer Center Programs: Experimental Therapeutics
Academic Office Information
421 Wakara Way, Room: Suite 315
Salt Lake City, UT 84108
You Han Bae, PhD, is a Professor in the Department of Pharmaceutics & Pharmaceutical Chemistry and an Adjunct Professor in the Department of Bioengineering at the University of Utah. He is an investigator of the Huntsman Cancer Institute and a member of the Experimental Therapeutics Program.Dr. Bae’s research interests include selective targeting of drugs to acidic extracellular environments, which often surround cancer cells. His lab also studies self-assembled super pH-sensitive nanoparticles as a potential drug delivery system for treating cancers which are multidrug resistant. He is also interested in developing delivery systems for protein biologics, as well as improved gene delivery systems.Bae received a PhD from and completed postdoctoral training at the University of Utah.
|Postdoctoral Fellowship||University of Utah
|Doctoral Training||University of Utah
|Undergraduate||Seoul National University
|Undergraduate||Seoul National University
|Korea Institute of Science and Technology||Researcher (Polymer Chemistry Lab)||Korea|
|Kwangju Institute of Science and Technology||Associate Professor||Korea|
|Kwangju Institute of Science and Technology, Department of Materials Science and Engineering||Professor||Korea|
|Kwangju Institute of Science and Technology, Department of Materials Science and Engineering||Adjunct Professor||Korea|
|University of Paris-13||Visiting Professor||United Kingdom|
- Kim KS, Park W, Hu J, Bae YH, Na K (2014). A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle. Biomaterials, 35(1), 337-43.
- Yim H, Park SJ, Bae YH, Na K (2013). Biodegradable cationic nanoparticles loaded with an anticancer drug for deep penetration of heterogeneous tumours. Biomaterials, 34(31), 7674-82.
- Hu J, Miura S, Na K, Bae YH (2013). pH-responsive and charge shielded cationic micelle of poly(l-histidine)-block-short branched PEI for acidic cancer treatment. J Control Release, 172(1), 69-76.
- Lee YJ, Kang HC, Hu J, Nichols JW, Jeon YS, Bae YH (2012). pH-Sensitive polymeric micelle-based pH probe for detecting and imaging acidic biological environments. Biomacromolecules, 13(9), 2945-51.
- Nichols JW, Bae YH (2012). Odyssey of a cancer nanoparticle: from injection site to site of action. Nano Today, 7(6), 606-618.
- Bae YH, Park K (2011). Targeted drug delivery to tumors: myths, reality and possibility. J Control Release, 153(3), 198-205.
- Bae YH (2011). Apoptosis-targeted drug delivery. J Control Release, 154(3), 213.
- Mishra D, Kang HC, Bae YH (2011). Reconstitutable charged polymeric (PLGA)(2)-b-PEI micelles for gene therapeutics delivery. Biomaterials, 32(15), 3845-54.
- Gao ZG, Tian L, Hu J, Park IS, Bae YH (2011). Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles. J Control Release, 152(1), 84-9.
- Kang HC, Samsonova O, Bae YH (2010). Trafficking microenvironmental pHs of polycationic gene vectors in drug-sensitive and multidrug-resistant MCF7 breast cancer cells. Biomaterials, 31(11), 3071-8.
- Park KM, Kang HC, Cho JK, Chung IJ, Cho SH, Bae YH, Na K (2009). All-trans-retinoic acid (ATRA)-grafted polymeric gene carriers for nuclear translocation and cell growth control. Biomaterials, 30(13), 2642-52.
- Kim D, Gao ZG, Lee ES, Bae YH (2009). In vivo evaluation of doxorubicin-loaded polymeric micelles targeting folate receptors and early endosomal pH in drug-resistant ovarian cancer. Mol Pharm, 6(5), 1353-62.
- Sethuraman VA, Lee MC, Bae YH (2008). A biodegradable pH-sensitive micelle system for targeting acidic solid tumors. Pharm Res, 25(3), 657-66.
- Oh KT, Lee ES, Kim D, Bae YH (2008). L-histidine-based pH-sensitive anticancer drug carrier micelle: reconstitution and brief evaluation of its systemic toxicity. Int J Pharm, 358(1-2), 177-83.
- Kim D, Lee ES, Park K, Kwon IC, Bae YH (2008). Doxorubicin loaded pH-sensitive micelle: antitumoral efficacy against ovarian A2780/DOXR tumor. Pharm Res, 25(9), 2074-82.
- Lee ES, Gao Z, Kim D, Park K, Kwon IC, Bae YH (2008). Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance. J Control Release, 129(3), 228-36.
- Kim D, Lee ES, Oh KT, Gao ZG, Bae YH (2008). Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double-targeting folate receptor and early endosomal pH. Biomaterials, 4(11), 2043-50.
- Na K, Lee ES, Bae YH (2007). Self-organized nanogels responding to tumor extracellular pH: pH-dependent drug release and in vitro cytotoxicity against MCF-7 cells. Bioconjug Chem, 18(5), 1568-74.
- Mohajer G, Lee ES, Bae YH (2007). Enhanced intercellular retention activity of novel pH-sensitive polymeric micelles in wild and multidrug resistant MCF-7 cells. Pharm Res, 24(9), 1618-27.
- Qiu LY, Bae YH (2007). Self-assembled polyethylenimine-graft-poly(epsilon-caprolactone) micelles as potential dual carriers of genes and anticancer drugs. Biomaterials, 28(28), 4132-42.