You Han Bae, PhD

Research Interests

  • Self-assembled super intelligent nanoparticulates for sensitive and resistant tumor targeting
  • Polymeric systems for rechargeable cell delivery
  • Protein drug stabilization and controlled release

Languages

  • English

Academic Information

  • Departments: Pharmaceutics and Pharmaceutical Chemistry - Professor
  • Cancer Center Programs: Experimental Therapeutics

Academic Office Information

  • 421 Wakara Way, Room: Suite 315
    Salt Lake City, UT 84108

Academic Bio

You Han Bae, PhD, is a Professor in the Department of Pharmaceutics & Pharmaceutical Chemistry and an Adjunct Professor in the Department of Bioengineering at the University of Utah. He is an investigator of the Huntsman Cancer Institute and a member of the Experimental Therapeutics Program.Dr. Bae’s research interests include selective targeting of drugs to acidic extracellular environments, which often surround cancer cells. His lab also studies self-assembled super pH-sensitive nanoparticles as a potential drug delivery system for treating cancers which are multidrug resistant. He is also interested in developing delivery systems for protein biologics, as well as improved gene delivery systems.Bae received a PhD from and completed postdoctoral training at the University of Utah.

Education History

Type School Degree
Postdoctoral Fellowship University of Utah
Pharmaceutics
Postdoctoral Fellow
Doctoral Training University of Utah
Pharmaceutics
Ph.D.
Undergraduate Seoul National University
Chemical Engineering
B.S.

Global Impact

Education History

Type School Degree Country
Undergraduate Seoul National University
Chemical Engineering
B.S. Korea

Career

Institution Description Country
Korea Institute of Science and Technology Researcher (Polymer Chemistry Lab) Korea
Kwangju Institute of Science and Technology Associate Professor Korea
Kwangju Institute of Science and Technology, Department of Materials Science and Engineering Professor Korea
Kwangju Institute of Science and Technology, Department of Materials Science and Engineering Adjunct Professor Korea
University of Paris-13 Visiting Professor United Kingdom

Selected Publications

Journal Article

  1. A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle.Kim KS, Park W, Hu J, Bae YH, Na K (2014). A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle. Biomaterials, 35(1), 337-43.
  2. Biodegradable cationic nanoparticles loaded with an anticancer drug for deep penetration of heterogeneous tumours.Yim H, Park SJ, Bae YH, Na K (2013). Biodegradable cationic nanoparticles loaded with an anticancer drug for deep penetration of heterogeneous tumours. Biomaterials, 34(31), 7674-82.
  3. pH-responsive and charge shielded cationic micelle of poly(l-histidine)-block-short branched PEI for acidic cancer treatment.Hu J, Miura S, Na K, Bae YH (2013). pH-responsive and charge shielded cationic micelle of poly(l-histidine)-block-short branched PEI for acidic cancer treatment. J Control Release, 172(1), 69-76.
  4. pH-Sensitive polymeric micelle-based pH probe for detecting and imaging acidic biological environments.Lee YJ, Kang HC, Hu J, Nichols JW, Jeon YS, Bae YH (2012). pH-Sensitive polymeric micelle-based pH probe for detecting and imaging acidic biological environments. Biomacromolecules, 13(9), 2945-51.
  5. Odyssey of a cancer nanoparticle: from injection site to site of action.Nichols JW, Bae YH (2012). Odyssey of a cancer nanoparticle: from injection site to site of action. Nano Today, 7(6), 606-618.
  6. Targeted drug delivery to tumors: myths, reality and possibility.Bae YH, Park K (2011). Targeted drug delivery to tumors: myths, reality and possibility. J Control Release, 153(3), 198-205.
  7. Apoptosis-targeted drug delivery.Bae YH (2011). Apoptosis-targeted drug delivery. J Control Release, 154(3), 213.
  8. Reconstitutable charged polymeric (PLGA)(2)-b-PEI micelles for gene therapeutics delivery.Mishra D, Kang HC, Bae YH (2011). Reconstitutable charged polymeric (PLGA)(2)-b-PEI micelles for gene therapeutics delivery. Biomaterials, 32(15), 3845-54.
  9. Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles.Gao ZG, Tian L, Hu J, Park IS, Bae YH (2011). Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles. J Control Release, 152(1), 84-9.
  10. Trafficking microenvironmental pHs of polycationic gene vectors in drug-sensitive and multidrug-resistant MCF7 breast cancer cells.Kang HC, Samsonova O, Bae YH (2010). Trafficking microenvironmental pHs of polycationic gene vectors in drug-sensitive and multidrug-resistant MCF7 breast cancer cells. Biomaterials, 31(11), 3071-8.
  11. All-trans-retinoic acid (ATRA)-grafted polymeric gene carriers for nuclear translocation and cell growth control.Park KM, Kang HC, Cho JK, Chung IJ, Cho SH, Bae YH, Na K (2009). All-trans-retinoic acid (ATRA)-grafted polymeric gene carriers for nuclear translocation and cell growth control. Biomaterials, 30(13), 2642-52.
  12. In vivo evaluation of doxorubicin-loaded polymeric micelles targeting folate receptors and early endosomal pH in drug-resistant ovarian cancer.Kim D, Gao ZG, Lee ES, Bae YH (2009). In vivo evaluation of doxorubicin-loaded polymeric micelles targeting folate receptors and early endosomal pH in drug-resistant ovarian cancer. Mol Pharm, 6(5), 1353-62.
  13. A biodegradable pH-sensitive micelle system for targeting acidic solid tumors.Sethuraman VA, Lee MC, Bae YH (2008). A biodegradable pH-sensitive micelle system for targeting acidic solid tumors. Pharm Res, 25(3), 657-66.
  14. L-histidine-based pH-sensitive anticancer drug carrier micelle: reconstitution and brief evaluation of its systemic toxicity.Oh KT, Lee ES, Kim D, Bae YH (2008). L-histidine-based pH-sensitive anticancer drug carrier micelle: reconstitution and brief evaluation of its systemic toxicity. Int J Pharm, 358(1-2), 177-83.
  15. Doxorubicin loaded pH-sensitive micelle: antitumoral efficacy against ovarian A2780/DOXR tumor.Kim D, Lee ES, Park K, Kwon IC, Bae YH (2008). Doxorubicin loaded pH-sensitive micelle: antitumoral efficacy against ovarian A2780/DOXR tumor. Pharm Res, 25(9), 2074-82.
  16. Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance.Lee ES, Gao Z, Kim D, Park K, Kwon IC, Bae YH (2008). Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance. J Control Release, 129(3), 228-36.
  17. Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double-targeting folate receptor and early endosomal pH.Kim D, Lee ES, Oh KT, Gao ZG, Bae YH (2008). Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double-targeting folate receptor and early endosomal pH. Biomaterials, 4(11), 2043-50.
  18. Self-organized nanogels responding to tumor extracellular pH: pH-dependent drug release and in vitro cytotoxicity against MCF-7 cells.Na K, Lee ES, Bae YH (2007). Self-organized nanogels responding to tumor extracellular pH: pH-dependent drug release and in vitro cytotoxicity against MCF-7 cells. Bioconjug Chem, 18(5), 1568-74.
  19. Enhanced intercellular retention activity of novel pH-sensitive polymeric micelles in wild and multidrug resistant MCF-7 cells.Mohajer G, Lee ES, Bae YH (2007). Enhanced intercellular retention activity of novel pH-sensitive polymeric micelles in wild and multidrug resistant MCF-7 cells. Pharm Res, 24(9), 1618-27.
  20. Self-assembled polyethylenimine-graft-poly(epsilon-caprolactone) micelles as potential dual carriers of genes and anticancer drugs.Qiu LY, Bae YH (2007). Self-assembled polyethylenimine-graft-poly(epsilon-caprolactone) micelles as potential dual carriers of genes and anticancer drugs. Biomaterials, 28(28), 4132-42.