Jared P. Rutter, Ph.D.

Research Interests

  • Cell Communication
  • Metabolism
  • Cell Signaling
  • Metabolism Regulation

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Biochemistry - Professor
  • Cancer Center Programs: Nuclear Control of Cell Growth & Differentiation

Academic Office Information

  • (801) 581-3340
  • Emma Eccles Jones Research Building
    Biochemistry
    15 North Medical Drive East, Room: 5200K
    Salt Lake City, UT 84112

Academic Bio

Jared Rutter, PhD, is a professor in the Department of Biochemistry at the University of Utah and a member of the Nuclear Control of Cell Growth and Differentiation Program at Huntsman Cancer Institute.

Rutter studies how cells sense and detect energy needs for growth. Understanding the energy-sensing pathways in cells is important in cancer research because these pathways are often overactive in cancer and a good target for new chemotherapy treatments.

Rutter received a bachelor's degree from Brigham Young University, Utah, and a PhD from the University of Texas Southwestern Medical Center at Dallas.

Education History

Type School Degree
Postdoctoral Fellowship University of Texas Southwestern Medical Center
Postdoctoral Fellow
Doctoral Training University of Texas Southwestern Medical Center, Steven L. McKnight, advisor
Cell and Molecular Biology
Ph.D.
Undergraduate Brigham Young University
Molecular Biology; emphasis in Chemistry
B.S.

Selected Publications

Journal Article

  1. Pressing mitochondrial genetics forward.Chen YC, Rutter J (2014). Pressing mitochondrial genetics forward. Cell Rep, 7(3), 599-600.
  2. Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins.Chen YC, Umanah GK, Dephoure N, Andrabi SA, Gygi SP, Dawson TM, Dawson VL, Rutter J (2014). Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins. EMBO J, 33(14), 1548-64.
  3. SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration.Van Vranken JG, Bricker DK, Dephoure N, Gygi SP, Cox JE, Thummel CS, Rutter J (2014). SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell Metab, 20(2), 241-52.
  4. The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase.Na U, Yu W, Cox J, Bricker DK, Brockmann K, Rutter J, Thummel CS, Winge DR (2014). The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase. Cell Metab, 20(2), 253-66.
  5. PAS kinase drives lipogenesis through SREBP-1 maturation.Wu X, Romero D, Swiatek WI, Dorweiler I, Kikani CK, Sabic H, Zweifel BS, McKearn J, Blitzer JT, Nickols GA, Rutter J (2014). PAS kinase drives lipogenesis through SREBP-1 maturation. Cell Rep, 8(1), 242-55.
  6. X Wu, D Romero, WI Swaitek, I Dorweiler, CK Kikani, H Savic, BS Zweifel, J McKearn, JT Blitzer, GA Nickols, J Rutter (2014). PAS Kinase drives lipogenesis through SREPB-1 maturation. Cell Rep, 8(242).
  7. Intramolecular interactions control Vms1 translocation to damaged mitochondria.Heo JM, Nielson JR, Dephoure N, Gygi SP, Rutter J (2013). Intramolecular interactions control Vms1 translocation to damaged mitochondria. Mol Biol Cell, 24(9), 1263-73.
  8. Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3beta in pancreatic beta-cells.Semache M, Zarrouki B, Fontes G, Fogarty S, Kikani C, Chawki MB, Rutter J, Poitout V (2013). Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3beta in pancreatic beta-cells. J Biol Chem, 288(34), 24825-33.
  9. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J (2012). A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science, 337(6090), 96-100.
  10. Revealing the allosterome: systematic identification of metabolite-protein interactions.Orsak T, Smith TL, Eckert D, Lindsley JE, Borges CR, Rutter J (2012). Revealing the allosterome: systematic identification of metabolite-protein interactions. Biochemistry, 51(1), 225-32.
  11. PAS kinase promotes cell survival and growth through activation of Rho1.Cardon CM, Beck T, Hall MN, Rutter J (2012). PAS kinase promotes cell survival and growth through activation of Rho1. Sci Signal, 5(209), ra9.
  12. Identification of a protein mediating respiratory supercomplex stability.Chen YC, Taylor EB, Dephoure N, Heo JM, Tonhato A, Papandreou I, Nath N, Denko NC, Gygi SP, Rutter J (2012). Identification of a protein mediating respiratory supercomplex stability. Cell Metab, 15(3), 348-60.

Review

  1. Hallmarks of a new era in mitochondrial biochemistry.Pagliarini DJ, Rutter J (2013). Hallmarks of a new era in mitochondrial biochemistry. [Review]. Genes Dev, 27(24), 2615-27.
  2. PAS kinase: integrating nutrient sensing with nutrient partitioning.Cardon CM, Rutter J (2012). PAS kinase: integrating nutrient sensing with nutrient partitioning. [Review]. Semin Cell Dev Biol, 23(6), 626-30.
  3. Proliferation and metabolism: it's as easy as APC.Tantin D, Rutter J (2012). Proliferation and metabolism: it's as easy as APC. [Review]. Cell Metab, 15(4), 413-4.

Patent

  1. Rutter J (2012). Compositions and Methods for Modulating Mitochondrial Pyruvate Carrier Activity (Provisional Patent).