Duong P. Huynh, PhD


  • English

Academic Information

  • Departments: Neurology - Research Associate Professor

Education History

Type School Degree
Postdoctoral Fellowship Cedars-Sinai Medical Center
Neurogenetics Laboratory
Postdoctoral Fellow
Doctoral Training University of California
Biochemistry/Molecular Biology, Neurobiology
Undergraduate California State University

Selected Publications

Journal Article

  1. Gallego-Iradi C, Bickford JS, Khare S, Hall A, Nick JA, Salmasinia D, Wawrowsky K, Bannykh S, Huynh DP, Rincon-Limas DE, Pulst SM, Nick HS, Fernandez-Funez P, Waters MF (08/28/2014). KCNC3(R420H), a K(+) channel mutation causative in spinocerebellar ataxia 13 displays aberrant intracellular trafficking. Neurobiol Dis, 71, 71:270-9.
  2. Dansithong W, Paul S, Scoles DR, Pulst SM, Huynh DP (09/01/2015). Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening. PLoS ONE, 10(8), e0136930.
  3. Huynh DP, Maalouf M, Silva AJ, Schweizer FE, Pulst SM (2009). Dissociated fear and spatial learning in mice with deficiency of ataxin-2. PLoS ONE, 4(7), e6235.
  4. Liu J, Tang TS, Tu H, Nelson O, Herndon E, Huynh DP, Pulst SM, Bezprozvanny I (2009). Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. J Neurosci, 29(29), 9148-62.
  5. Huynh DP, Nguyen DT, Pulst-Korenberg JB, Brice A, Pulst SM (2007). Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death. Exp Neurol, 203(2), 531-41.
  6. Ng H, Pulst SM, Huynh DP (2007). Ataxin-2 mediated cell death is dependent on domains downstream of the polyQ repeat. Exp Neurol, 208(2), 207-15.
  7. Kiehl TR, Nechiporuk A, Figueroa KP, Keating MT, Huynh DP, Pulst SM (2006). Generation and characterization of Sca2 (ataxin-2) knockout mice. Biochem Biophys Res Commun, 339(1), 17-24.
  8. Pulst SM, Santos N, Wang D, Yang H, Huynh D, Velazquez L, Figueroa PK (2005). Spinocerebellar Ataxia type 2: PolyQ Repeat Variation in the CACNA1A Channel Modifies Age of Onset. Brain, 128(Pt 10), 2297-2303.
  9. Glass AS, Huynh DP, Franck T, Woitalla D, Muller T, Pulst SM, Berg D, Kruger R, Riess O (2004). Screening for mutations in synaptotagmin XI in Parkinson's disease. J Neural Transm Suppl, (68), 21-8.
  10. Huynh DP, Yang HT, Vakharia H, Nguyen D, Pulst SM (2003). Expansion of the polyQ repeat in ataxin-2 alters its Golgi localization, disrupts the Golgi complex and causes cell death. Hum Mol Genet, 12(13), 1485-96.
  11. Huynh DP, Scoles DR, Nguyen D, Pulst SM (2003). The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. Hum Mol Genet, 12(20), 2587-97.
  12. Costa RM, Yang T, Huynh DP, Pulst SM, Viskochil DH, Silva AJ, Brannan CI (2001). Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1. Nat Genet, 27(4), 399-405.
  13. Konakova M, Huynh DP, Yong W, Pulst SM (2001). Cellular distribution of torsin A and torsin B in normal human brain. Arch Neurol, 58(6), 921-7.
  14. Kiehl TR, Shibata H, Vo T, Huynh DP, Pulst SM (2001). Identification and expression of a mouse ortholog of A2BP1. Mamm Genome, 12(8), 595-601.
  15. Huynh DP, Dy M, Nguyen D, Kiehl TR, Pulst SM (2001). Differential expression and tissue distribution of parkin isoforms during mouse development. Brain Res Dev Brain Res, 130(2), 173-81.
  16. Shibata H, Huynh DP, Pulst SM (2000). A novel protein with RNA-binding motifs interacts with ataxin-2. Hum Mol Genet, 9(9), 1303-13.
  17. Scoles DR, Huynh DP, Chen MS, Burke SP, Gutmann DH, Pulst SM (2000). The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate. Hum Mol Genet, 9(11), 1567-74.
  18. Huynh DP, Figueroa K, Hoang N, Pulst SM (2000). Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human. Nat Genet, 26(1), 44-50.
  19. Huynh DP, Scoles DR, Ho TH, Del Bigio MR, Pulst SM (2000). Parkin is associated with actin filaments in neuronal and nonneural cells. Ann Neurol, 48(5), 737-44.
  20. Huynh DP, Del Bigio MR, Ho DH, Pulst SM (1999). Expression of ataxin-2 in brains from normal individuals and patients with Alzheimer's disease and spinocerebellar ataxia 2. Ann Neurol, 45(2), 232-41.
  21. Scoles DR, Huynh DP, Morcos PA, Coulsell ER, Robinson NG, Tamanoi F, Pulst SM (1998). Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin. Nat Genet, 18(4), 354-9.
  22. Nechiporuk T, Huynh DP, Figueroa K, Sahba S, Nechiporuk A, Pulst SM (1998). The mouse SCA2 gene: cDNA sequence, alternative splicing and protein expression. Hum Mol Genet, 7(8), 1301-9.
  23. Huynh DP, Mautner V, Baser ME, Stavrou D, Pulst SM (1997). Immunohistochemical detection of schwannomin and neurofibromin in vestibular schwannomas, ependymomas and meningiomas. J Neuropathol Exp Neurol, 56(4), 382-90.
  24. Huynh DP, Vinters HV, Ho DH, Ho VV, Pulst SM (1997). Neuronal expression and intracellular localization of presenilins in normal and Alzheimer disease brains. J Neuropathol Exp Neurol, 56(9), 1009-17.
  25. Huynh DP, Pulst SM (1996). Neurofibromatosis 2 antisense oligodeoxynucleotides induce reversible inhibition of schwannomin synthesis and cell adhesion in STS26T and T98G cells. Oncogene, 13(1), 73-84.
  26. Huynh DP, Tran TM, Nechiporuk T, Pulst SM (1996). Expression of neurofibromatosis 2 transcript and gene product during mouse fetal development. Cell Growth Differ, 7(11), 1551-61.
  27. Huynh DP, Ho VV, Pulst SM (1996). Characterization and expression of presenilin 1 in mouse brain. Neuroreport, 7(15-17), 2423-8.
  28. Huynh DP, Nechiporuk T, Pulst SM (1994). Differential expression and tissue distribution of type I and type II neurofibromins during mouse fetal development. Dev Biol, 161(2), 538-51.
  29. Sainz J, Huynh DP, Figueroa K, Ragge NK, Baser ME, Pulst SM (1994). Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas. Hum Mol Genet, 3(6), 885-91.
  30. Huynh DP, Nechiporuk T, Pulst SM (1994). Alternative transcripts in the mouse neurofibromatosis type 2 (NF2) gene are conserved and code for schwannomins with distinct C-terminal domains. Hum Mol Genet, 3(7), 1075-9.
  31. Huynh DP, Lin CT, Pulst SM (1992). Expression of neurofibromin, the neurofibromatosis 1 gene product: studies in human neuroblastoma cells and rat brain. Neurosci Lett, 143(1-2), 233-6.