Gwenael Layec, PhD

Research Interests

  • Cardiovascular Physiology
  • Human Physiology
  • Musculoskeletal Physiology
  • Mitochondria
  • Metabolism
  • Musculoskeletal Rehabilitation
  • Geriatrics
  • Pulmonary Disease, Chronic Obstructive

Languages

  • English
  • French

Academic Information

  • Departments: Internal Medicine - Research Assistant Professor, Nutrition and Integrative Physiology - Adjunct Assistant Professor
  • Divisions: Geriatrics

Academic Office Information

  • VA Medical Center
    Department of Internal Medicine
    GRECC 182, 500 Foothill Drive, Room: 1D23A
    Salt Lake City, UT

Research Statement

My current research aims to better understand the role of oxidative stress in mediating vascular and energetic abnormalities in the context of aging and age–related diseases (e.g. Chronic Obstructive Pulmonary Disease and Peripheral Arterial Disease), and investigate pharmacologic or exercise-based therapeutic strategies that can mitigate its deleterious consequences. To achieve this goal, I use an integrative approach from the cellular level to the whole organism in humans. In the collaborative environment provided by the UVRL, I have access to state-of-the-art techniques, which encompasses: high-resolution ultrasound Doppler, drug infusion techniques, magnetic resonance spectroscopy (31P and 1H) and imaging of the skeletal muscle, direct motor nerve stimulation, Clark-type respirometers, electron paramagnetic resonance spectroscopy, and a host of molecular and cellular biology techniques.

Academic Bio

After completing my doctorate at the University of Mediteranee (Centre de Résonance Magnétique Biologique et Médicale, UMR CNRS 6612) in the area of human muscle bioenergetics using magnetic resonance spectroscopy and imaging techniques, I joined the UVRL in 2010 for my post-doctoral training. During my post-doctoral fellowship, my research activities have focused on studying the muscle and vascular (dys)function accompanying healthy aging and disease (predominantly Chronic Obstructive Pulmonary Disease). My other primary responsibility was to help the laboratory establish the Magnetic Resonance techniques that now allow us to non-invasively investigate the biological mechanisms underlying the changes in physiological function with aging and disease. In 2015, I have been appointed Assistant Professor at the Department of Internal Medicine, Division of Geriatrics. My current research aims to better understand the role of oxidative stress in mediating vascular and energetic abnormalities in the context of aging and age–related diseases (e.g. Chronic Obstructive Pulmonary Disease and Peripheral Arterial Disease), and investigate pharmacologic or exercise-based therapeutic strategies that can mitigate its deleterious consequences.

Education History

Type School Degree
Postdoctoral Fellowship University of Utah
Postdoctoral Fellow
Doctoral Training University of the Mediterranean
Human Movement Science, Physiology
Ph.D.
Graduate Training Montpellier University I
Human Movement Science, Applied Physiology
M.S.
Undergraduate Montpellier University I
Human Movement Science, Applied Physiology
B.S.

Global Impact

Education History

Type School Degree Country
Doctoral Training University of the Mediterranean
Human Movement Science, Physiology
Ph.D. France
Graduate Training Montpellier University I
Human Movement Science, Applied Physiology
M.S. France
Undergraduate Montpellier University I
Human Movement Science, Applied Physiology
B.S. France

Career

Institution Description Country
University of the Mediterranean Attaché temporaire d'enseignement et de recherche (Lecturer) France
Center for Magnetic Resonance in Biology and Medicine, UMR CNRS 6612 PhD Student France

Selected Publications

Journal Article

  1. Venturelli M, Layec G, Trinity J, Hart CR, Broxterman RM, Richardson RS (2017). Single passive leg movement-induced hyperemia: a simple vascular function assessment without a chronotropic response. J Appl Physiol (1985), 122(1), 28-37.
  2. Broxterman RM, Layec G, Hureau TJ, Amann M, Richardson RS (2017). Skeletal muscle bioenergetics during all-out exercise: mechanistic insight into the oxygen uptake slow component and neuromuscular fatigue. J Appl Physiol (1985), 122(5), 1208-1217.
  3. Layec G, Hart CR, Trinity JD, Kwon OS, Rossman MJ, Broxterman RM, Le Fur Y, Jeong EK, Richardson RS (2017). Oxygen delivery and the restoration of the muscle energetic balance following exercise: Implications for delayed muscle recovery in patients with COPD. Am J Physiol Endocrinol Metab, ajpendo.00462.2016.
  4. Park SY, Ives SJ, Gifford JR, Andtbacka RH, Hyngstrom JR, Reese V, Layec G, Bharath LP, Symons JD, Richardson RS (2016). Impact of age on the vasodilatory function of human skeletal muscle feed arteries. Am J Physiol Heart Circ Physiol, 310(2), H217-25.
  5. Gifford JR, Garten RS, Nelson AD, Trinity JD, Layec G, Witman MA, Weavil JC, Mangum T, Hart C, Etheredge C, Jessop J, Bledsoe A, Morgan DE, Wray DW, Rossman MJ, Richardson RS (2016). Symmorphosis and skeletal muscle VO2 max : in vivo and in vitro measures reveal differing constraints in the exercise-trained and untrained human. J Physiol, 594(6), 1741-51.
  6. Layec G, Bringard A, Le Fur Y, Micallef JP, Vilmen C, Perrey S, Cozzone PJ, Bendahan D (2016). Mitochondrial Coupling and Contractile Efficiency in Humans with High and Low V O2peaks. Med Sci Sports Exerc, 48(5), 811-21.
  7. Trinity JD, Wray DW, Witman MA, Layec G, Barrett-OKeefe Z, Ives SJ, Conklin JD, Reese V, Zhao J, Richardson RS (2016). Ascorbic acid improves brachial artery vasodilation during progressive handgrip exercise in the elderly through a nitric oxide-mediated mechanism. Am J Physiol Heart Circ Physiol, 310(6), H765-74.
  8. Layec G, Gifford JR, Trinity JD, Hart CR, Garten RS, Park SY, Le Fur Y, Jeong EK, Richardson RS (2016). Accuracy and precision of quantitative 31P-MRS measurements of human skeletal muscle mitochondrial function. Am J Physiol Endocrinol Metab, 311(2), E358-66.
  9. Layec G, Trinity JD, Hart CR, Le Fur Y, Sorensen JR, Jeong EK, Richardson RS (2016). Evidence of a metabolic reserve in the skeletal muscle of elderly people. Aging (Albany NY), 9(1), 52-67.
  10. Groot HJ, Rossman MJ, Trinity JD, Layec G, Ives SJ, Richardson RS (2015). Passive leg movement-induced vasodilation in women: the impact of age. Am J Physiol Heart Circ Physiol, 309(5), H995-H1002.
  11. Gifford JR, Trinity JD, Layec G, Garten RS, Park SY, Rossman MJ, Larsen S, Dela F, Richardson RS (2015). Quadriceps exercise intolerance in patients with chronic obstructive pulmonary disease: the potential role of altered skeletal muscle mitochondrial respiration. J Appl Physiol (1985), 119(8), 882-8.
  12. Layec G, Hart CR, Trinity JD, Le Fur Y, Jeong EK, Richardson RS (2015). Skeletal muscle work efficiency with age: the role of non-contractile processes. Clin Sci (Lond), 128(3), 213-23.
  13. Hart CR, Layec G, Trinity JD, Liu X, Kim SE, Groot HJ, Le Fur Y, Sorensen JR, Jeong EK, Richardson RS (2015). Evidence of Preserved Oxidative Capacity and Oxygen Delivery in the Plantar Flexor Muscles With Age. J Gerontol A Biol Sci Med Sci, 70(9), 1067-76.
  14. Trinity JD, Groot HJ, Layec G, Rossman MJ, Ives SJ, Morgan DE, Gmelch BS, Bledsoe A, Richardson RS (2015). Passive leg movement and nitric oxide-mediated vascular function: the impact of age. Am J Physiol Heart Circ Physiol, 308(6), H672-9.
  15. Layec G, Bringard A, Le Fur Y, Micallef JP, Vilmen C, Perrey S, Cozzone PJ, Bendahan D (2015). Opposite effects of hyperoxia on mitochondrial and contractile efficiency in human quadriceps muscles. Am J Physiol Regul Integr Comp Physiol, 308(8), R724-33.
  16. Richardson RS, Wary C, Wray DW, Hoff J, Rossiter HB, Layec G, Carlier PG (2015). MRS Evidence of Adequate O2 Supply in Human Skeletal Muscle at the Onset of Exercise. Med Sci Sports Exerc, 47(11), 2299-2307.
  17. Layec G, Trinity JD, Hart CR, Kim SE, Groot HJ, Le Fur Y, Sorensen JR, Jeong EK, Richardson RS (2015). The impact of age on exercise-induced ATP supply during supra-maximal plantar flexion in humans, DOI: 10.1152/ajpregu.00522.2014. Am J Physiol Regul Integr Comp Physiol, ajpregu.00522.2014.
  18. Groot HJ, Trinity JD, Layec G, Rossman MJ, Ives SJ, Morgan DE, Bledsoe A, Richardson RS (2015). The role of nitric oxide in passive leg movement-induced vasodilatation with age: insight from alterations in femoral perfusion pressure. J Physiol, 593(17), 3917-28.
  19. Venturelli M, Amann M, Layec G, McDaniel J, Trinity JD, Fjeldstad AS, Ives SJ, Yonnet G, Richardson RS (2014). Passive leg movement-induced hyperaemia with a spinal cord lesion: evidence of preserved vascular function. Acta Physiol (Oxf), 210(2), 429-39.
  20. Layec G, Trinity JD, Hart CR, Kim SE, Groot HJ, Le Fur Y, Sorensen JR, Jeong EK, Richardson RS (2014). In vivo evidence of an age-related increase in ATP cost of contraction in the plantar flexor muscles. Clin Sci (Lond), 126(8), 581-92.
  21. Layec G, Venturelli M, Jeong EK, Richardson RS (2014). The validity of anthropometric leg muscle volume estimation across a wide spectrum: from able-bodied adults to individuals with a spinal cord injury. J Appl Physiol (1985), 116(9), 1142-7.
  22. Trinity JD, Groot HJ, Layec G, Rossman MJ, Ives SJ, Richardson RS (2014). Impact of age and body position on the contribution of nitric oxide to femoral artery shear rate: implications for atherosclerosis. Hypertension, 63(5), 1019-25.
  23. Trinity JD, Layec G, Lee JF (2014). Heterogeneity of blood flow: impact of age on muscle specific tissue perfusion during exercise. J Physiol, 592(Pt 8), 1729-30.
  24. Donato AJ, Henson GD, Hart CR, Layec G, Trinity JD, Bramwell RC, Enz RA, Morgan RG, Reihl KD, Hazra S, Walker AE, Richardson RS, Lesniewski LA (2014). The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction. J Physiol, 592(Pt 18), 4083-96.
  25. Layec G, Haseler LJ, Richardson RS (2013). Reduced muscle oxidative capacity is independent of O2 availability in elderly people. Age (Dordr), 35(4), 1183-92.
  26. Groot HJ, Trinity JD, Layec G, Rossman MJ, Ives SJ, Richardson RS (2013). Perfusion pressure and movement-induced hyperemia: evidence of limited vascular function and vasodilatory reserve with age. Am J Physiol Heart Circ Physiol, 304(4), H610-9.
  27. Layec G, Haseler LJ, Hoff J, Hart CR, Liu X, Le Fur Y, Jeong EK, Richardson RS (2013). Short-term training alters the control of mitochondrial respiration rate before maximal oxidative ATP synthesis. Acta Physiol (Oxf), 208(4), 376-86.
  28. Layec G, Trinity JD, Hart CR, Hopker J, Passfield L, Coen PM, Conley KE, Hunter GR, Fisher G, Ferguson RA, Sasaki K, Malatesta D, Maffiuletti NA, Borrani F, Minetti AE, Rice CL, Dalton BH, McNeil CJ, Power GA, Manini TM (2013). Comments on point: counterpoint: skeletal muscle mechanical efficiency does/does not increase with age. J Appl Physiol (1985), 114(8), 1114-8.
  29. Layec G, Malucelli E, Le Fur Y, Manners D, Yashiro K, Testa C, Cozzone PJ, Iotti S, Bendahan D (2013). Effects of exercise-induced intracellular acidosis on the phosphocreatine recovery kinetics: a 31P MRS study in three muscle groups in humans. NMR Biomed, 26(11), 1403-11.
  30. Amann M, Venturelli M, Ives SJ, McDaniel J, Layec G, Rossman MJ, Richardson RS (2013). Peripheral fatigue limits endurance exercise via a sensory feedback-mediated reduction in spinal motoneuronal output. J Appl Physiol (1985), 115(3), 355-64.
  31. Layec G, Haseler LJ, Trinity JD, Hart CR, Liu X, Le Fur Y, Jeong EK, Richardson RS (2013). Mitochondrial function and increased convective O2 transport: implications for the assessment of mitochondrial respiration in vivo. J Appl Physiol (1985), 115(6), 803-11.
  32. Trinity JD, Wray DW, Witman MA, Layec G, Barrett-OKeefe Z, Ives SJ, Conklin JD, Reese V, Richardson RS (2013). Contribution of nitric oxide to brachial artery vasodilation during progressive handgrip exercise in the elderly. Am J Physiol Regul Integr Comp Physiol, 305(8), R893-9.
  33. Layec G, Richardson RS (2012). Training to improve performance: one leg at a time. Acta Physiol (Oxf), 205(1), 186-8.
  34. Layec G, Haseler LJ, Richardson RS (2012). The effect of higher ATP cost of contraction on the metabolic response to graded exercise in patients with chronic obstructive pulmonary disease. J Appl Physiol (1985), 112(6), 1041-8.
  35. Trinity JD, Groot HJ, Layec G, Rossman MJ, Ives SJ, Runnels S, Gmelch B, Bledsoe A, Richardson RS (2012). Nitric oxide and passive limb movement: a new approach to assess vascular function. J Physiol, 590(Pt 6), 1413-25.
  36. Bringard A, Layec G, Micallef JP, Bendahan D, Perrey S (2012). Gas exchange measurements within a magnetic environment: validation of a new system. Respir Physiol Neurobiol, 182(1), 37-46.
  37. Layec G, Bringard A, Yashiro K, Le Fur Y, Vilmen C, Micallef JP, Perrey S, Cozzone PJ, Bendahan D (2012). The slow components of phosphocreatine and pulmonary oxygen uptake can be dissociated during heavy exercise according to training status. Exp Physiol, 97(8), 955-69.
  38. Layec G, Bringard A, Le Fur Y, Vilmen C, Micallef JP, Perrey S, Cozzone PJ, Bendahan D (2011). Comparative determination of energy production rates and mitochondrial function using different 31P MRS quantitative methods in sedentary and trained subjects. NMR Biomed, 24(4), 425-38.
  39. Layec G, Haseler LJ, Hoff J, Richardson RS (2011). Evidence that a higher ATP cost of muscular contraction contributes to the lower mechanical efficiency associated with COPD: preliminary findings. Am J Physiol Regul Integr Comp Physiol, 300(5), R1142-7.