Adam Frost, M.D., Ph.D.

Research Interests

  • Electron Cryo-Microscopy
  • Cell Division
  • Cytokinesis
  • Structural Biology
  • Membrane Biology

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Biochemistry - Adjunct Assistant Professor
  • Cancer Center Programs: Cell Response & Regulation

Academic Office Information

  • (801) 581-8899
  • Emma Eccles Jones Medical Research Building
    Biochemistry
    15 N Medical Dr E, Room: 3240B
    Salt Lake City, UT

Academic Bio

Adam Frost, MD, PhD, is an Assistant Professor in the Department of Biochemistry, and a member of the Cell Response and Regulation Program at the Huntsman Cancer Institute.

Frost studies the molecular and structural biology of membrane trafficking, with a special focus on the mechanisms that determine membrane shape and topology. His work with membrane-binding proteins has led him to focus recently on the mechanisms that govern the cell division cycle. Structural work in the Frost lab has led to direct, molecular scale views of the cell division machinery as it engages and reshapes cellular membranes. This approach has direct relevance to understanding many diseases, especially cancer. Several components of the cell division machinery have been implicated genetically in tumor formation, but until now there has been no direct method for studying their mechanisms of action.

Education History

Type School Degree
Postdoctoral Fellowship University of California, San Francisco
Cellular and Molecular Pharmacology
Postdoctoral Fellow
Professional Medical Yale University School of Medicine
M.D.
Doctoral Training Yale University
Cell and Structural Biology
Ph.D.
Undergraduate Brigham Young University
Honors Biochemistry
B.S.

Selected Publications

Journal Article

  1. Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A (2015). Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Science, 347(6217), 75-8.
  2. Structural and functional studies of membrane remodeling machines.Kalia R, Talledge N, Frost A (2015). Structural and functional studies of membrane remodeling machines. Methods Cell Biol, 128, 165-200.
  3. Structure and membrane remodeling activity of ESCRT-III helical polymers.McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A (2015). Structure and membrane remodeling activity of ESCRT-III helical polymers. Science, 350(6267), 1548-51.
  4. Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM (2013). Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc Natl Acad Sci U S A, 110(15), E1342-51.
  5. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress.Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS (2012). A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell, 151(5), 1042-54.
  6. Endosis and exosis: new names for fusion and budding.Busath DD, Woodbury DJ, Frost A (2012). Endosis and exosis: new names for fusion and budding. J Membr Biol, 245(11), 759-60.
  7. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions.Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS (2012). Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell, 149(6), 1339-52.
  8. Structural basis of membrane bending by the N-BAR protein endophilin.Mim C, Cui H, Gawronski-Salerno JA, Frost A, Lyman E, Voth GA, Unger VM (2012). Structural basis of membrane bending by the N-BAR protein endophilin. Cell, 149(1), 137-45.
  9. Membrane trafficking: decoding vesicle identity with contrasting chemistries.Frost A (2011). Membrane trafficking: decoding vesicle identity with contrasting chemistries. Curr Biol, 21(19), R811-3.

Abstract

  1. Visualizing BAR-Dependent Membrane Remodeling.Mim C, Gawronski-Salerno J, Unger VM, Frost A (2012). Visualizing BAR-Dependent Membrane Remodeling [Abstract]. Microsc Microanal, 18 Suppl 2, 44-5.

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