Tracey J. Lamb, PhD

Research Interests

  • Malaria Immunopathogenesis

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Pathology - Associate Professor
  • Divisions: Microbiology and Immunology

Academic Office Information

  • 801-213-2097
  • Emma Eccles Jones Medical Research Building
    Pathology Department
    15 N Medical Dr E, Room: 1420A
    Salt Lake City, UT

Email: tracey.lamb@path.utah.edu

Education History

Type School Degree
Research Fellow National Institute for Medical Research
Malaria Immunology, MRC Career Development Fellow
Research Fellow
Doctoral Training University of Edinburgh
Parasite Immunology
Ph.D.
Undergraduate University of Glasgow
Parasitology (1st Class honors)
B.Sc. (Hons)
Other Training Marine Biology Laboratory Biology of Parasitism Summer Course

Global Impact

Education History

Type School Degree Country
Research Fellow National Institute for Medical Research
Malaria Immunology, MRC Career Development Fellow
Research Fellow United Kingdom
Doctoral Training University of Edinburgh
Parasite Immunology
Ph.D. United Kingdom
Undergraduate University of Glasgow
Parasitology (1st Class honors)
B.Sc. (Hons) United Kingdom

Career

Institution Description Country
University of Reading Lecturer, Immunology of Infectious Diseases United Kingdom
NIMR Postdoctoral Fellow United Kingdom
Center du Pasteur Cameroun Adjunct Scientist Cameroon

Selected Publications

Journal Article

  1. Lin J, Sondekamp J, Cunningham D, Deroost K, Tshitenge T, McLaughlin S, Lamb T, Spencer-Dean B, Hosking C, Ramesar J, Janse C, Graham C, OGarra A, Langhorne J (2017). Signatures of malaria-associated pathology revealed by high-resolution whole blood transcriptomicsin a rodent model of malaria. Sci Rep, 7, 41722.
  2. Joyner C, Moreno A, Meyer EV, Cabrera-Mora M, MaHPIC Consortium, Kissinger JC, Barnwell JW, Galinski MR (2016). Plasmodium cynomolgi infections in rhesus macaques display clinical and parasitological features pertinent to modelling vivax malaria pathology and relapse infections. Malaria Journal, 15(1), 451.
  3. Hudson LE, Stewart TP, Fasken MB, Corbett AH, Lamb TJ (2016). Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice. J Vis Exp, (108), e53453.
  4. Hudson LE, McDermott CD, Stewart TP, Hudson WH, Rios D, Fasken MB, Corbett AH, Lamb TJ (2016). Characterization of the Probiotic Yeast Saccharomyces boulardii in the Healthy Mucosal Immune System. PLoS One, 11(4), e0153351.
  5. Mimche PN, Brady LM, Bray CF, Lee CM, Thapa M, King TP, Quicke K, McDermott CD, Mimche SM, Grakoui A, Morgan ET, Lamb TJ (2015). The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice. Hepatology, 62(3), 900-14.
  6. Matar CG, Anthony NR, OFlaherty BM, Jacobs NT, Priyamvada L, Engwerda CR, Speck SH, Lamb TJ (2015). Gammaherpesvirus Co-infection with Malaria Suppresses Anti-parasitic Humoral Immunity. PLoS Pathog, 11(5), e1004858.
  7. Mimche PN, Brady LM, Keeton S, Fenne DS, King TP, Quicke KM, Hudson LE, Lamb TJ (2015). Expression of the Receptor Tyrosine Kinase EphB2 on Dendritic Cells Is Modulated by Toll-Like Receptor Ligation but Is Not Required for T Cell Activation. PLoS One, 10(9), e0138835.
  8. Hudson LE, Fasken MB, McDermott CD, McBride SM, Kuiper EG, Guiliano DB, Corbett AH, Lamb TJ (2014). Functional heterologous protein expression by genetically engineered probiotic yeast Saccharomyces boulardii. PLoS One, 9(11), e112660.
  9. Abanyie FA, McCracken C, Kirwan P, Molloy SF, Asaolu SO, Holland CV, Gutman J, Lamb TJ (2013). Ascaris co-infection does not alter malaria-induced anaemia in a cohort of Nigerian preschool children. Malar J, 12, 1.
  10. Freitas do Rosario AP, Lamb T, Spence P, Stephens R, Lang A, Roers A, Muller W, OGarra A, Langhorne J (2012). IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J Immunol, 188(3), 1178-90.
  11. Fairlie-Clarke KJ, Lamb TJ, Langhorne J, Graham AL, Allen JE (2010). Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivity. BMC Immunol, 11, 6.
  12. Saunders A, Lamb T, Pascall J, Hutchings A, Dion C, Carter C, Hepburn L, Langhorne J, Butcher GW (2009). Expression of GIMAP1, a GTPase of the immunity-associated protein family, is not up-regulated in malaria. Malaria Journal, 8, 53.
  13. Cadman ET, Abdallah AY, Voisine C, Sponaas AM, Corran P, Lamb T, Brown D, Ndungu F, Langhorne J (2008). Alterations of splenic architecture in malaria are induced independently of Toll-like receptors 2, 4, and 9 or MyD88 and may affect antibody affinity. Infect Immun, 76(9), 3924-31.
  14. Lamb TJ, Harris A, Le Goff L, Read AF, Allen JE (2008). Litomosoides sigmodontis: vaccine-induced immune responses against Wolbachia surface protein can enhance the survival of filarial nematodes during primary infection. Exp Parasitol, 118(2), 285-9.
  15. Lamb TJ, Langhorne J (2008). The severity of malarial anaemia in Plasmodium chabaudi infections of BALB/c mice is determined independently of the number of circulating parasites. Malar J, 7, 68.
  16. Lamb TJ, Voisine C, Koernig S, Egan CA, Harnett W, Langhorne J (2007). The pathology of Plasmodium chabaudi infection is not ameliorated by the secreted filarial nematode immunomodulatory molecule, ES-62. Parasite Immunol, 29(5), 271-6.
  17. Graham AL, Lamb TJ, Read AF, Allen JE (2005). Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency. J Infect Dis, 191(3), 410-21.
  18. Graham AL, Taylor MD, Le Goff L, Lamb TJ, Magennis M, Allen JE (2005). Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis. Microbes Infect, 7(4), 612-8.
  19. Lamb TJ, Graham AL, Le Goff L, Allen JE (2005). Co-infected C57BL/6 mice mount appropriately polarized and compartmentalized cytokine responses to Litomosoides sigmodontis and Leishmania major but disease progression is altered. Parasite Immunol, 27(9), 317-24.
  20. Lamb TJ, Le Goff L, Kurniawan A, Guiliano DB, Fenn K, Blaxter ML, Read AF, Allen JE (2004). Most of the response elicited against Wolbachia surface protein in filarial nematode infection is due to the infective larval stage. J Infect Dis, 189(1), 120-7.
  21. Le Goff L, Lamb TJ, Graham AL, Harcus Y, Allen JE (2002). IL-4 is required to prevent filarial nematode development in resistant but not susceptible strains of mice. Int J Parasitol, 32(10), 1277-84.
  22. Djikeng A, Ferreira L, DAngelo M, Dolezal P, Lamb T, Murta S, Triggs V, Ulbert S, Villarino A, Renzi S, Ullu E, Tschudi C (2001). Characterization of a candidate Trypanosoma brucei U1 small nuclear RNA gene. Mol Biochem Parasitol, 113(1), 109-15.

Review

  1. Hudson LE, Anderson SE, Corbett AH, Lamb TJ (2017). Gleaning Insights from Fecal Microbiota Transplantation and Probiotic Studies for the Rational Design of Combination Microbial Therapies. [Review]. Clinical Microbiology Reviews, 30(1), 191-231.
  2. King T, Lamb T (2015). Interferon-gamma: The Jekyll and Hyde of Malaria. [Review]. PLoS Pathog, 11(10), e1005118.
  3. Matar CG, Jacobs NT, Speck SH, Lamb TJ, Moormann AM (2015). Does EBV alter the pathogenesis of malaria? [Review]. Parasite Immunology, 37(9), 433-45.
  4. Stephens R, Culleton RL, Lamb TJ (2012). The contribution of Plasmodium chabaudi to our understanding of malaria. [Review]. Trends in Parasitology, 28(2), 73-82.
  5. Lamb TJ, Schenk MP, Todryk SM (2010). How do malaria parasites activate dendritic cells? [Review]. Future Microbiology, 5(8), 1167-71.
  6. Fenton A, Lamb T, Graham AL (2008). Optimality analysis of Th1/Th2 immune responses during microparasite-macroparasite co-infection, with epidemiological feedbacks. [Review]. Parasitology, 135(7), 841-53.
  7. Lamb TJ, Graham AL, Petrie A (2008). T testing the immune system. [Review]. Immunity, 28(3), 288-92.
  8. Lamb TJ, Brown DE, Potocnik AJ, Langhorne J (2006). Insights into the immunopathogenesis of malaria using mouse models. [Review]. Expert Rev Mol Med, 8(6), 1-22.