Lamb Lab
WELCOME TO THE LAMB HOST-PATHOGEN INTERACTIONS LAB!
We work on host-pathogen interactions in both humans and using mouse model systems. We are particularly interested in the host immune environment and how this shapes the pathogenesis of infection. As evident in SARS-CovID19, the pathogenesis of infection ranges from asymptomatic to lethal. This is also the case in many infections. The pathogenesis of infection often contains an immune component and much of our work investigates the immune mechanisms that lead to disease during infection.
Current mouse models of infection running in the lab include parasitic infection (Plasmodium parasites that cause malaria), viral infection (MHV-68 infections that mimic gammaherpesvirus infections such as EBV; LCMV, influenza; respiratory syncytial virus) and bacterial infections (Streptococcus pneumonia).
We have a field site based at the Centre Pasteur Cameroon where we work on both malaria and helminth infections in collaboration with Dr Lawrence Ayong.
Co-infection of gammaherpes viruses such as Epstein Barr Virus can worsen the symptoms of malaria
Identification of the SML-4 and SML-5 antigens secreted from muscle stage larvae of T. spiralis
EphA2 is a molecule that drives breakdown of the blood brain barrier in cerebral malaria
Malaria-associated liver fibrosis is driven by EphB2
Platelets contribute to organ damage in malaria
Development of the probiotic yeast Saccharomyces boulardii as a tool for oral delivery of immunomodulators
Make a contribution to science by supporting our work!
You can make a tax-deductible charitable donation to support research into malaria through our direct link to the University of Utah gifting page.
Help us make new discoveries to cure malaria