Adam Frost

Adam Frost, MD, PhD

Languages spoken: English

Academic Information

Departments Adjunct - Biochemistry

Academic Office Information

frost@biochem.utah.edu

Lab

Research Interests

  • Electron Cryo-Microscopy
  • Structural Biology
  • Membrane Biology
  • Cell Division
  • Cytokinesis

Adam Frost, MD, PhD, is an Assistant Professor in the Department of Biochemistry, and a member of the Cell Response and Regulation Program at the Huntsman Cancer Institute.

Frost studies the molecular and structural biology of membrane trafficking, with a special focus on the mechanisms that determine membrane shape and topology. His work with membrane-binding proteins has led him to focus recently on the mechanisms that govern the cell division cycle. Structural work in the Frost lab has led to direct, molecular scale views of the cell division machinery as it engages and reshapes cellular membranes. This approach has direct relevance to understanding many diseases, especially cancer. Several components of the cell division machinery have been implicated genetically in tumor formation, but until now there has been no direct method for studying their mechanisms of action.

Education History

Postdoctoral Fellowship University of California, San Francisco
 Postdoctoral Fellow
Yale University School of Medicine
 MD
Doctoral Training Yale University
 PhD
Brigham Young University
 BS

Selected Publications

Journal Article

  1. McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A (2015). Structure and membrane remodeling activity of ESCRT-III helical polymers. Science, 350(6267), 1548-51. (Read full article)
  2. Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A (2015). Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Science, 347(6217), 75-8. (Read full article)
  3. Kalia R, Talledge N, Frost A (2015). Structural and functional studies of membrane remodeling machines. Methods Cell Biol, 128, 165-200. (Read full article)
  4. Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM (2013). Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc Natl Acad Sci U S A, 110(15), E1342-51. (Read full article)
  5. Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS (2012). A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell, 151(5), 1042-54. (Read full article)
  6. Busath DD, Woodbury DJ, Frost A (2012). Endosis and exosis: new names for fusion and budding. J Membr Biol, 245(11), 759-60. (Read full article)
  7. Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS (2012). Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell, 149(6), 1339-52. (Read full article)
  8. Mim C, Cui H, Gawronski-Salerno JA, Frost A, Lyman E, Voth GA, Unger VM (2012). Structural basis of membrane bending by the N-BAR protein endophilin. Cell, 149(1), 137-45. (Read full article)
  9. Frost A (2011). Membrane trafficking: decoding vesicle identity with contrasting chemistries. Curr Biol, 21(19), R811-3. (Read full article)

Abstract

  1. Mim C, Gawronski-Salerno J, Unger VM, Frost A (2012). Visualizing BAR-Dependent Membrane Remodeling. [Abstract]. Microsc Microanal, 18 Suppl 2, 44-5. (Read full article)