Aja Aravamudhan

Aja Aravamudhan, PhD, NRCC-CC

Languages spoken: English

Academic Information

Departments Primary - Pathology

Board Certification

  • American Board of Clinical Chemistry

Education History

Undergraduate Anna University
 BS
Doctoral Training UConn Health, University of Connecticut School of Medicine
 PhD
Postdoctoral Training Yale University
 Postdoctoral Associate
Postdoctoral Fellowship Mayo Clinic
 Postdoctoral Research Fellow
Fellowship University of Minnesota
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Kumbar SG, Toti US, Deng M, James R, Laurencin CT, Aravamudhan A, Harmon M, Ramos DM (2011). Novel mechanically competent polysaccharide scaffolds for bone tissue engineering. Biomed Mater, 6(6), 065005.
  2. Aravamudhan A, Ramos DM, Nip J, Subramanian A, James R, Harmon MD, Yu X, Kumbar SG (2013). Osteoinductive small molecules: growth factor alternatives for bone tissue engineering. Curr Pharm Des, 19(19), 3420-8.
  3. Aravamudhan A, Ramos DM, Nip J, Harmon MD, James R, Deng M, Laurencin CT, Yu X, Kumbar SG (2013). Cellulose and collagen derived micro-nano structured scaffolds for bone tissue engineering. J Biomed Nanotechnol, 9(4), 719-31.
  4. Aravamudhan A, Ramos DM, Nip J, Kalajzic I, Kumbar SG (2018). Micro-Nanostructures of Cellulose-Collagen for Critical Sized Bone Defect Healing. Macromol Biosci, 18(2).
  5. Manoukian OS, Aravamudhan A, Lee P, Arul MR, Yu X, Rudraiah S, Kumbar SG (2018). Spiral Layer-by-Layer Micro-Nanostructured Scaffolds for Bone Tissue Engineering. ACS Biomater Sci Eng, 4(6), 2181-2192.
  6. Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin D (2019). CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis. JCI insight, 5(12),
  7. Haak AJ, Kostallari E, Sicard D, Ligresti G, Choi KM, Caporarello N, Jones DL, Tan Q, Meridew J, Diaz Espinosa AM, Aravamudhan A, Maiers JL, Britt RD Jr, Roden AC, Pabelick CM, Prakash YS, Nouraie SM, Li X, Zhang Y, Kass DJ, Lagares D, Tager AM, Varelas X, Shah VH, Tschumperlin D (2019). Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis. Science translational medicine, 11(516),
  8. Liu W, Meridew JA, Aravamudhan A, Ligresti G, Tschumperlin DJ, Tan (2019). Targeted regulation of fibroblast state by CRISPR-mediated CEBPA expression. Respiratory research, 20(1), 281.
  9. Aravamudhan A, Haak AJ, Choi KM, Meridew JA, Caporarello N, Jones DL, Tan Q, Ligresti G, Tschumperlin D (2020). TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation. American journal of physiology. Lung cellular and molecular physiology, 318(5), L852-L863.
  10. Caporarello N, Meridew JA, Aravamudhan A, Jones DL, Austin SA, Pham TX, Haak AJ, Moo Choi K, Tan Q, Haresi A, Huang SK, Katusic ZS, Tschumperlin DJ, Ligresti (2020). Vascular dysfunction in aged mice contributes to persistent lung fibrosis. Aging cell, 19(8), e13196.
  11. Choi KM, Haak AJ, Diaz Espinosa AM, Cummins KA, Link PA, Aravamudhan A, Wood DK, Tschumperlin D (2021). GPCR-mediated YAP/TAZ inactivation in fibroblasts via EPAC1/2, RAP2C, and MAP4K7. Journal of cellular physiology, 236(11), 7759-7774.
  12. Dieffenbach PB, Aravamudhan A, Fredenburgh LE, Tschumperlin D (2022). The Mechanobiology of Vascular Remodeling in the Aging Lung. Physiology (Bethesda, Md.), 37(1), 28-38.
  13. Gao AY, Diaz Espinosa AM, Gianì F, Pham TX, Carver CM, Aravamudhan A, Bartman CM, Ligresti G, Caporarello N, Schafer MJ, Haak A (2022). Pim-1 kinase is a positive feedback regulator of the senescent lung fibroblast inflammatory secretome. American journal of physiology. Lung cellular and molecular physiology, 323(6), L685-L697.
  14. Aravamudhan A, Dieffenbach PB, Choi KM, Link PA, Meridew JA, Haak AJ, Fredenburgh LE, Tschumperlin D (2024). Non-canonical IKB kinases regulate YAP/TAZ and pathological vascular remodeling behaviors in pulmonary artery smooth muscle cells. Physiological reports, 12(7), e15999.
  15. Aravamudhan A, Scalf C, Greenwood MP, Muluhngwi (2025). The Effect of Clinical Decision Support Intervention on Monitoring for Donor Specific Antibodies. jfaf030. The journal of applied laboratory medicine,