Alex Shcheglovitov

Alex Shcheglovitov, PhD

Languages spoken: English, Ukrainian, Russian

Academic Information

Departments Primary - Neurobiology , Adjunct - Psychiatry

Divisions: Adult Psychiatry

Lab

Education History

Undergraduate National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute"
 BS
Graduate Training National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute"
 MS
Doctoral Training Bogomoletz Institute of Physiology
 PhD
Postdoctoral Training Department of Pharmacology, University of Virginia
 Postdoctoral Training
Postdoctoral Training Stanford University
 Postdoctoral Training

Selected Publications

Journal Article

  1. Shcheglovitov A, Zhelay T, Vitko Y, Osipenko V, Perez-Reyes E, Kostyuk P, Shuba Y (2005). "Contrasting the effects of nifedipine on subtypes of endogenous and recombinant T-type Ca2+ channels.". Biochem Pharmacol, 69(5), 841-54.
  2. Shcheglovitov A, Kostyuk P, Shuba Y (2007). "Selectivity signatures of three isoforms of recombinant T-type Ca2+ channels.". Biochim Biophys Acta, 1768(6), 1406-19.
  3. *Shcheglovitov A, *Vitko I, Bidaud I, Baumgart JP, Navarro-Gonzalez MF, Grayson TH, Lory P, Hill CE, Perez-Reyes E (* equally contributed authors) (2008). "Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels.". FEBS Lett, 582(27), 3765-70.
  4. *Shcheglovitov A, Vitko I, Lazarenko RM, Orestes P, Todorovic SM, *Perez-Reyes E (* corresponding authors) (2012). "Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels.". J Gen Physiol, 139(3), 219-34.
  5. *Eckle VS, *Shcheglovitov A, *Vitko I, Dey D, Yap CC, Winckler B, Perez-Reyes E (* equally contributed authors) (2014). "Mechanisms by which a CACNA1H mutation in epilepsy patients increases seizure susceptibility.". J Physiol, 592(Pt 4), 795-809.
  6. *Yoo AS, *Sun AX, *Li L, *Shcheglovitov A, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GR (* equally contributed authors) (2011). "MicroRNA-mediated conversion of human fibroblasts to neurons.". Nature, 476(7359), 228-31.
  7. Shcheglovitov A, Shcheglovitova O, Yazawa M, Portmann T, Shu R, Sebastiano V, Krawisz A, Froehlich W, Bernstein JA, Hallmayer JF, Dolmetsch RE (2013). "SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.". Nature, 503(7475), 267-71.
  8. Park CY, Shcheglovitov A, Dolmetsch R (2010). "The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels.". Science, 330(6000), 101-5.
  9. Pasca SP, Portmann T, Voineagu I, Yazawa M, Shcheglovitov A, Pasca AM, Cord B, Palmer TD, Chikahisa S, Nishino S, Bernstein JA, Hallmayer J, Geschwind DH, Dolmetsch RE (2011). "Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome.". Nat Med, 17(12), 1657-62.
  10. Krey JF, Pasca SP, Shcheglovitov A, Yazawa M, Schwemberger R, Rasmusson R, Dolmetsch RE (2013). "Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons.". Nat Neurosci, 16(2), 201-9.
  11. *Vitko I, *Shcheglovitov A, Baumgart JP, Arias-Olguin II, Murbartian J, Arias JM, Perez-Reyes E (2008). "Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity.". PLoS One, 3(10), e3560.
  12. Nguyen HN, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P, Kee K, Schule B, Dolmetsch RE, Langston W, Palmer TD, Pera RR (2011). "LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.". Cell Stem Cell, 8(3), 267-80.

Editorial

  1. Shcheglovitov A, Rao M, Yoo (2019). Special issue on stem cell and tissue engineering in development, disease, and repair. Developmental dynamics, 248(1), 7-9.