Andrew S. Weyrich

Andrew S. Weyrich, PhD

Languages spoken: English

Academic Information

Departments Adjunct - Internal Medicine

Divisions: Public Health

Dr. Andrew S. Weyrich’s research examines how blood clots in health and disease. His group made the seminal discovery in 2005 that anucleate human platelets splice precursor messenger RNA into products that regulate inflammation. This paradigm shifting observation revolutionized the field of hematology, and has led to thousands of studies that use mRNA profiling to understand how platelets regulate thrombosis and inflammation - which is now referred to as "thromboinflammation". Dr. Weyrich has delivered more than 100 national and international talks and keynote addresses, and he has received numerous investigator research awards from the Arteriosclerosis, Thrombosis and Vascular Biology (ATVB), the International Society of Thrombosis and Haemostasis (ISTH), and the prestigious William Dameshek prize from the American Society of Hematology (ASH). The University of Utah has also recognized him with an H.A. and Edna Benning Presidential Endowed Chair and he recently received the John R. Hoidal Senior Investigator Award. Dr. Weyrich has published more than 150 peer-reviewed articles and has been funded by the National Institute of Health (NIH) for over 25 years, including during his tenure as the Vice President for Research (VPR). Dr. Weyrich is also a member of the esteemed NIH National Heart, Lung, and Blood (NHLBI) advisory council.

U Research Leadership

In addition to Dr. Weyrich’s prolific research work, he also serves as the University of Utah’s Vice President for Research and President of the University’s Research Foundation and Innovation District since July 2016. Previous to these appointments, he was the Associate Dean of Research at the Health Sciences. As a leader of the U’s research community, Dr. Weyrich has implemented strategic initiatives and programs that continues to drive diverse and inclusive research excellence at the U and also contributes more than $500 million annually to the Utah economy. During his service, the U’s research portfolio has been on an upward trajectory with an average annual increase of 27% in extramural awards that totaled over $3.5 billion dollars. The U received national research recognitions including membership in the Association of American Universities and the Association of Public and Land-grant Universities (APLU) Innovation and Economic Prosperity designation. He has also launched numerous research programs, including critical topics in: Women in Violence; COVID-19; Opioid Crisis; and Equity, Diversity, and Inclusion in Research. Since assuming responsibility in 2019, Dr. Weyrich spearheaded important safety initiatives in research laboratories and work spaces to strengthen campus-wide safety that included restructuring of Environmental Health and Safety (EHS) and the development of stronger working relationships between EHS and research-intensive units. He also worked with UU Health Operations and the Research Cores to stand-up surveillance testing for the entire UU community. Dr. Weyrich’s support for future generations in research is built upon his passion for mentorship and student engagement. Dr. Weyrich has taught and mentored undergraduate, graduate, and medical students since his career began, and he currently directs training grant programs that support research for medical students and postdoctoral fellows. He also works closely with Undergraduate Research Programs at the U to help provide impactful resources to enhance the U student research experience and career mobility.

Education History

Undergraduate Baldwin-Wallace College, Ohio
 BS
Graduate Training Wake Forest University
 MA
Doctoral Training Bowman Gray School of Medicine
 PhD
Postdoctoral Fellowship Thomas Jefferson University, Jefferson Medical College
 Postdoctoral Fellow
Postdoctoral Fellowship University of Utah, Nora Eccles Harrison CVRTI
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Chen K, Coonrod EM, Kumanovics A, Franks ZF, Durtschi JD, Margraf RL, Wu W, Heikal NM, Augustine NH, Ridge PG, Hill HR, Jorde LB, Weyrich AS, Zimmerman GA, Gundlapalli AV, Bohnsack JF, Voelkerding K (2013). Germline mutations in NFKB2 implicate the noncanonical NF-kappaB pathway in the pathogenesis of common variable immunodeficiency. American journal of human genetics, 93(5), 812-24.
  2. Major HD, Campbell RA, Silver RM, Branch DW, Weyrich A (2014). Synthesis of sFlt-1 by platelet-monocyte aggregates contributes to the pathogenesis of preeclampsia. American journal of obstetrics and gynecology, 210(6), 547.e1-7.
  3. Weyrich AS, Solis GA, Li KS, Tulenko TN, Santamore W (1992). Platelet amplification of vasospasm. The American journal of physiology, 263(2 Pt 2), H349-58.
  4. Buerke M, Weyrich AS, Lefer A (1994). Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil-released mediators. The American journal of physiology, 266(1 Pt 2), H128-36.
  5. Franks ZG, Campbell RA, Weyrich AS, Rondina M (2010). Platelet-leukocyte interactions link inflammatory and thromboembolic events in ischemic stroke. Annals of the New York Academy of Sciences, 1207, 11-17.
  6. Weyrich AS, Zimmerman G (2013). Platelets in lung biology. Annual review of physiology, 75, 569-91.
  7. Buerke M, Guckenbiehl M, Schwertz H, Buerke U, Hilker M, Platsch H, Richert J, Bomm S, Zimmerman GA, Lindemann S, Mueller-Werdan U, Werdan K, Darius H, Weyrich A (2007). Intramural delivery of Sirolimus prevents vascular remodeling following balloon injury. Biochimica et biophysica acta, 1774(1), 5-15.
  8. Yost CC, Cody MJ, Harris ES, Thornton NL, McInturff AM, Martinez ML, Chandler NB, Rodesch CK, Albertine KH, Petti CA, Weyrich AS, Zimmerman G (2009). Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood, 113(25), 6419-27.
  9. Foulks JM, Marathe GK, Michetti N, Stafforini DM, Zimmerman GA, McIntyre TM, Weyrich A (2009). PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids. Blood, 113(26), 6699-706.
  10. Weyrich AS, Zimmerman G (2009). Comparative genomics: fishing nets hemostatic catch. Blood, 113(19), 4479-80.
  11. Schwertz H, Zimmerman GA, Weyrich A (2009). Fibrinogen selects selectins. Blood, 114(2), 234.
  12. Rowley JW, Weyrich AS, Campbell R (2009). TGFBIp: more than meets the eye?. Blood, 114(25), 5113-4.
  13. Schwertz H, Koster S, Kahr WH, Michetti N, Kraemer BF, Weitz DA, Blaylock RC, Kraiss LW, Greinacher A, Zimmerman GA, Weyrich A (2010). Anucleate platelets generate progeny. Blood, 115(18), 3801-9.
  14. Pawlinski R, Wang JG, Owens AP 3rd, Williams J, Antoniak S, Tencati M, Luther T, Rowley JW, Low EN, Weyrich AS, Mackman (2010). Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood, 116(5), 806-14.
  15. Rowley JW, Oler AJ, Tolley ND, Hunter BN, Low EN, Nix DA, Yost CC, Zimmerman GA, Weyrich A (2011). Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood, 118(14), e101-11.
  16. Cecchetti L, Tolley ND, Michetti N, Bury L, Weyrich AS, Gresele (2011). Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events. Blood, 118(7), 1903-11.
  17. Kraemer BF, Campbell RA, Schwertz H, Franks ZG, Vieira de Abreu A, Grundler K, Kile BT, Dhakal BK, Rondina MT, Kahr WH, Mulvey MA, Blaylock RC, Zimmerman GA, Weyrich A (2012). Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets. Blood, 120(25), 5014-20.
  18. Rowley JW, Weyrich A (2013). Coordinate expression of transcripts and proteins in platelets. Blood, 121(26), 5255-6.
  19. Kahr WH, Lo RW, Li L, Pluthero FG, Christensen H, Ni R, Vaezzadeh N, Hawkins CE, Weyrich AS, Di Paola J, Landolt-Marticorena C, Gross P (2013). Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice. Blood, 122(19), 3349-58.
  20. Hottz ED, Lopes JF, Freitas C, Valls-de-Souza R, Oliveira MF, Bozza MT, Da Poian AT, Weyrich AS, Zimmerman GA, Bozza FA, Bozza P (2013). Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation. Blood, 122(20), 3405-14.
  21. Schubert S, Weyrich AS, Rowley J (2014). A tour through the transcriptional landscape of platelets. Blood, 124(4), 493-502.
  22. Rondina MT, Weyrich A (2015). Dengue virus pirates human platelets. Blood, 126(3), 286-7.
  23. Rowley JW, Chappaz S, Corduan A, Chong MM, Campbell R, Khoury A, Manne BK, Wurtzel JG, Michael JV, Goldfinger LE, Mumaw MM, Nieman MT, Kile BT, Provost P, Weyrich A (2016). Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets. Blood, 127(14), 1743-51.
  24. Rondina MT, Weyrich A (2016). Arf6 arbitrates fibrinogen endocytosis. Blood, 127(11), 1383-4.
  25. Kapur R, Kim M, Aslam R, McVey MJ, Tabuchi A, Luo A, Liu J, Li Y, Shanmugabhavananthan S, Speck ER, Zufferey A, Yousef G, Zhang H, Rondina MT, Weyrich AS, Porcelijn L, Kuebler WM, Slutsky AS, Semple J (2017). T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10. Blood, 129(18), 2557-2569.
  26. Rowley JW, Weyrich A (2017). Ribosomes in platelets protect the messenger. Blood, 129(17), 2343-2345.
  27. Michael JV, Wurtzel JGT, Mao GF, Rao AK, Kolpakov MA, Sabri A, Hoffman NE, Rajan S, Tomar D, Madesh M, Nieman MT, Yu J, Edelstein LC, Rowley JW, Weyrich AS, Goldfinger L (2017). Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth. Blood, 130(5), 567-580.
  28. Weyrich AS, Denis MM, Schwertz H, Tolley ND, Foulks J, Spencer E, Kraiss LW, Albertine KH, McIntyre TM, Zimmerman G (2007). mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets. Blood, 109, 1975-1983.
  29. Schwertz H, Koster S, Kahr, WH, Michetti N, Kraemer BF, Weitz DA, Blaylock RC, Kraiss LW, Greinacher A, Zimmerman GA, Weyrich A (2010). Anucleate platelets generate progeny. Blood, 115, 3801-3809.
  30. Foulks JM, Marathe GK, Michetti N, Stafforini DM, Zimmerman GA, McIntyre TM, Weyrich A (2009). PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids. Blood, 113, 6699-706.
  31. Yost CC, Cody MJ, Harris ES, Thornton NL, McInturff AM, Martinez ML, Chandler NB, Rodesch CK, Albertine KH, Petti CA, Weyrich AS, Zimmerman G (2009). Impaired neutrophil extracellular trap (NET) formation: A novel innate immune deficiency of human neonates. Blood, 113, 6419-27.
  32. Rowley JW, Oler A, Tolley ND, Hunter B, Low EN, Nix DA, Yost CC, Zimmerman GA, Weyrich A (2011). Genome wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood, 118(14), e101-11.
  33. Pawlinski R, Wang JG, Owens AP 3rd, Williams J, Antoniak S, Tencati M, Luther T, Rowley JW, Low EN, Weyrich AS, Mackman (2010). Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood, 116(5), 806-814.
  34. Cecchetti L, Tolley ND, Michetti N, Bury L, Weyrich AS, Gresele (2011). Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events. Blood, 118(7), 1903-11.
  35. Madden JL, Drakos SG, Stehlik J, McKellar SH, Rondina MT, Weyrich AS, Selzman C (2014). Baseline red blood cell osmotic fragility does not predict the degree of post-LVAD hemolysis. ASAIO journal (American Society for Artificial Internal Organs, 60(5), 524-8.
  36. Solis GA, Kutcher MA, Weyrich AS, Santamore W (1991). Albumin prevents platelet deposition following angioplasty. Journal of interventional cardiology, 3, 265-271.
  37. Kahr WH, Hinckley J, Li L, Schwertz H, Christensen H, Rowley JW, Pluthero FG, Urban D, Fabbro S, Nixon B, Gadzinski R, Storck M, Wang K, Ryu GY, Jobe SM, Schutte BC, Moseley J, Loughran NB, Parkinson J, Weyrich AS, Di Paola (2011). Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome. Nature genetics, 43(8), 738-40.
  38. Kahr WHA, Hinckley J, Li L, Schwertz H, Christensen H, Rowley JW, Pluthero FG, Urban D, Fabbro S, Nixon B, Gadzinski R, Storck M, Wang K, Ryu G-Y, Jobe SM, Schutte BC, Moseley J, Loughran NB, Parkinson J, Weyrich AS, Di Paola (2011). Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome. Nature genetics, 43(8), 738-40.
  39. Schwertz H, Rowley JW, Tolley ND, Campbell RA, Weyrich A (2012). Assessing protein synthesis by platelets. Methods in molecular biology (Clifton, N.J.), 788, 141-53.
  40. Santamore WP, Weyrich AS, Iskandrian A (1991). Coronary artery spasm revisited. Coronary artery disease, 2, 259-266.
  41. Carey C, Siegfried MR, Ma XL, Weyrich AS, Lefer A (1992). Antishock and endothelial protective actions of a NO donor in mesenteric ischemia and reperfusion. Circulatory shock, 38(3), 209-16.
  42. Lefer AM, Weyrich AS, Buerke (1994). Role of selectins, a new family of adhesion molecules, in ischaemia-reperfusion injury. Cardiovascular research, 28(3), 289-94.
  43. Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, Lindemann S, Yost CC, Rubner FJ, Albertine KH, Swoboda KJ, Fratto CM, Tolley E, Kraiss LW, McIntyre TM, Zimmerman GA, Weyrich A (2005). Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell, 122(3), 379-91.
  44. Rondina MT, Brewster B, Grissom CK, Zimmerman GA, Kastendieck DH, Harris ES, Weyrich A (2012). In vivo platelet activation in critically ill patients with primary 2009 influenza A(H1N1). Chest, 141(6), 1490-5.
  45. Weyrich AS, Ma XL, Buerke M, Murohara T, Armstead VE, Lefer AM, Nicolas JM, Thomas AP, Lefer DJ, Vinten-Johansen (1994). Physiological concentrations of nitric oxide do not elicit an acute negative inotropic effect in unstimulated cardiac muscle. Circulation research, 75(4), 692-700.
  46. Ma XL, Weyrich AS, Lefer DJ, Lefer A (1993). Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium. Circulation research, 72(2), 403-12.
  47. Galt SW, Lindemann S, Medd D, Allen LL, Kraiss LW, Harris ES, Prescott SM, McIntyre TM, Weyrich AS, Zimmerman G (2001). Differential regulation of matrix metalloproteinase-9 by monocytes adherent to collagen and platelets. Circulation research, 89(6), 509-16.
  48. Galt SW, Lindemann S, Allen L, Medd DJ, Falk JM, McIntyre TM, Prescott SM, Kraiss LW, Zimmerman GA, Weyrich A (2002). Outside-in signals delivered by matrix metalloproteinase-1 regulate platelet function. Circulation research, 90(10), 1093-9.
  49. Weyrich AS, Ma XL, Lefer A (1992). The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat. Circulation, 86(1), 279-88.
  50. Ma XL, Weyrich AS, Lefer DJ, Buerke M, Albertine KH, Kishimoto TK, Lefer A (1993). Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium. Circulation, 88(2), 649-58.
  51. Weyrich AS, Denis MM, Kuhlmann-Eyre JR, Spencer ED, Dixon DA, Marathe GK, McIntyre TM, Zimmerman GA, Prescott S (2005). Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates. Circulation, 111(5), 633-42.
  52. Chen K, Rondina MT, Weyrich A (2013). A sticky story for signal transducer and activator of transcription 3 in platelets. Circulation, 127(4), 421-3.
  53. Berry MJ, Weyrich AS, Robergs RA, Krause KM, Ingalls C (1989). Ratings of perceived exertion in individuals with varying fitness levels during walking and running. European journal of applied physiology and occupational physiology, 58(5), 494-9.
  54. Foulks JM, Weyrich AS, Zimmerman GA, McIntyre T (2008). A yeast PAF acetylhydrolase ortholog suppresses oxidative death. Free radical biology & medicine, 45(4), 434-42.
  55. Foulks JM, Weyrich AS, Zimmerman GA, McIntyre T (2008). A yeast PAF acetylhydrolase ortholog suppresses oxidative death. Free radical biology & medicine, 45(4), 434-442.
  56. Berry MJ, Robergs RA, Weyrich AS, Puntenney P (1988). Ventilatory responses of trained and untrained subjects during running and walking. International journal of sports medicine, 9(5), 325-9.
  57. Hidari KI, Weyrich AS, Zimmerman GA, McEver R (1997). Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils. The Journal of biological chemistry, 272(45), 28750-6.
  58. Lindemann S, Tolley ND, Eyre JR, Kraiss LW, Mahoney TM, Weyrich A (2001). Integrins regulate the intracellular distribution of eukaryotic initiation factor 4E in platelets. A checkpoint for translational control. The Journal of biological chemistry, 276(36), 33947-51.
  59. Feldhaus MJ, Weyrich AS, Zimmerman GA, McIntyre T (2002). Ceramide generation in situ alters leukocyte cytoskeletal organization and beta 2-integrin function and causes complete degranulation. The Journal of biological chemistry, 277(6), 4285-93.
  60. Watanabe J, Marathe GK, Neilsen PO, Weyrich AS, Harrison KA, Murphy RC, Zimmerman GA, McIntyre T (2003). Endotoxins stimulate neutrophil adhesion followed by synthesis and release of platelet-activating factor in microparticles. The Journal of biological chemistry, 278(35), 33161-8.
  61. Jiang H, Weyrich AS, Zimmerman GA, McIntyre T (2004). Endothelial cell confluence regulates cyclooxygenase-2 and prostaglandin E2 production that modulate motility. The Journal of biological chemistry, 279(53), 55905-13.
  62. Pabla R, Weyrich AS, Dixon DA, Bray PF, McIntyre TM, Prescott SM, Zimmerman G (1999). Integrin-dependent control of translation: engagement of integrin alphaIIbbeta3 regulates synthesis of proteins in activated human platelets. The Journal of cell biology, 144(1), 175-84.
  63. Lindemann S, Tolley ND, Dixon DA, McIntyre TM, Prescott SM, Zimmerman GA, Weyrich A (2001). Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. The Journal of cell biology, 154(3), 485-90.
  64. Schwertz H, Weyrich A (2010). Platelet precursors display bipolar behavior. The Journal of cell biology, 191(4), 699-700.
  65. Thon JN, Peters CG, Machlus KR, Aslam R, Rowley J, Macleod H, Devine MT, Fuchs TA, Weyrich AS, Semple JW, Flaumenhaft R, Italiano JE J (2012). T granules in human platelets function in TLR9 organization and signaling. The Journal of cell biology, 198(4), 561-74.
  66. Schmid DI, Schwertz H, Jiang H, Campbell RA, Weyrich AS, McIntyre TM, Zimmerman GA, Kraiss L (2013). Translational control of JunB, an AP-1 transcription factor, in activated human endothelial cells. Journal of cellular biochemistry, 114(7), 1519-28.
  67. Weyrich AS, McIntyre TM, McEver RP, Prescott SM, Zimmerman G (1995). Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion. Signal integration and NF-kappa B translocation. The Journal of clinical investigation, 95(5), 2297-303.
  68. Weyrich AS, Ma XY, Lefer DJ, Albertine KH, Lefer A (1993). In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury. The Journal of clinical investigation, 91(6), 2620-9.
  69. Buerke M, Weyrich AS, Zheng Z, Gaeta FC, Forrest MJ, Lefer A (1994). Sialyl Lewisx-containing oligosaccharide attenuates myocardial reperfusion injury in cats. The Journal of clinical investigation, 93(3), 1140-8.
  70. Weyrich AS, Elstad MR, McEver RP, McIntyre TM, Moore KL, Morrissey JH, Prescott SM, Zimmerman G (1996). Activated platelets signal chemokine synthesis by human monocytes. The Journal of clinical investigation, 97(6), 1525-34.
  71. Lehr HA, Weyrich AS, Saetzler RK, Jurek A, Arfors KE, Zimmerman GA, Prescott SM, McIntyre T (1997). Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking. The Journal of clinical investigation, 99(10), 2358-64.
  72. Modur V, Feldhaus MJ, Weyrich AS, Jicha DL, Prescott SM, Zimmerman GA, McIntyre T (1997). Oncostatin M is a proinflammatory mediator. In vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules. The Journal of clinical investigation, 100(1), 158-68.
  73. Dixon DA, Tolley ND, Bemis-Standoli K, Martinez ML, Weyrich AS, Morrow JD, Prescott SM, Zimmerman G (2006). Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. The Journal of clinical investigation, 116(10), 2727-38.
  74. Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE Jr, Christensen H, Kahr WH, Li DY, Weyrich A (2014). Proteasome function is required for platelet production. The Journal of clinical investigation, 124(9), 3757-66.
  75. Yost CC, Denis MM, Lindemann S, Rubner FJ, Marathe GK, Buerke M, McIntyre TM, Weyrich AS, Zimmerman G (2004). Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events. The Journal of experimental medicine, 200(5), 671-80.
  76. Schwertz H, Tolley ND, Foulks JM, Denis MM, Risenmay BW, Buerke M, Tilley RE, Rondina MT, Harris EM, Kraiss LW, Mackman N, Zimmerman GA, Weyrich A (2006). Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. The Journal of experimental medicine, 203(11), 2433-40.
  77. Kessel JM, Hayflick J, Weyrich AS, Hoffman PA, Gallatin M, McIntyre TM, Prescott SM, Zimmerman G (1998). Coengagement of ICAM-3 and Fc receptors induces chemokine secretion and spreading by myeloid leukocytes. Journal of immunology (Baltimore, Md., 160(11), 5579-87.
  78. Miyazaki Y, Bunting M, Stafforini DM, Harris ES, McIntyre TM, Prescott SM, Frutuoso VS, Amendoeira FC, de Oliveira Nascimento D, Vieira-de-Abreu A, Weyrich AS, Castro-Faria-Neto HC, Zimmerman G (2008). Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections. Journal of immunology (Baltimore, Md., 180(1), 590-600.
  79. Hottz ED, Medeiros-de-Moraes IM, Vieira-de-Abreu A, de Assis EF, Vals-de-Souza R, Castro-Faria-Neto HC, Weyrich AS, Zimmerman GA, Bozza FA, Bozza P (2014). Platelet activation and apoptosis modulate monocyte inflammatory responses in dengue. Journal of immunology (Baltimore, Md., 193(4), 1864-72.
  80. Campbell RA, Franks Z, Bhatnagar A, Rowley JW, Manne BK, Supiano MA, Schwertz H, Weyrich AS, Rondina M (2018). Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging. Journal of immunology (Baltimore, Md., 200(1), 295-304.
  81. Miyazaki Y, Bunting M, Stafforini DM, Harris ES, McIntyre TM, Prescott SM, Frutuoso VS, Amendoeira FC, de Oliveira Nascimento D, Vieira-de-Abreu A, Weyrich AS, Castro-Faria-Neto HC, Zimmerman G (2008). Integrin ¿Dß2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections. Journal of immunology (Baltimore, Md., 180(1), 590-600.
  82. Weyrich AS, Buerke M, Albertine KH, Lefer A (1995). Time course of coronary vascular endothelial adhesion molecule expression during reperfusion of the ischemic feline myocardium. Journal of leukocyte biology, 57(1), 45-55.
  83. Albertine KH, Weyrich AS, Ma XL, Lefer DJ, Becker LC, Lefer A (1994). Quantification of neutrophil migration following myocardial ischemia and reperfusion in cats and dogs. Journal of leukocyte biology, 55(5), 557-66.
  84. Chen J, Yang L, Foulks JM, Weyrich AS, Marathe GK, McIntyre T (2007). Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. Journal of lipid research, 48(11), 2365-76.
  85. Chen J, Yang L, Foulks JM, Weyrich AS, Marathe GK, McIntyre T (2007). Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. Journal of lipid research, 48(11), 2365-2376.
  86. Denis HL, Lamontagne-Proulx J, St-Amour I, Mason SL, Rowley JW, Cloutier N, Tremblay ME, Vincent AT, Gould PV, Chouinard S, Weyrich AS, Rondina MT, Barker RA, Boilard E, Cicchetti (2019). Platelet abnormalities in Huntington's disease. Journal of neurology, neurosurgery, and psychiatry, 90(3), 272-283.
  87. Ma XL, Weyrich AS, Krantz S, Lefer A (1992). Mechanisms of the cardioprotective actions of WEB-2170, bepafant, a platelet activating factor antagonist, in myocardial ischemia and reperfusion. The Journal of pharmacology and experimental therapeutics, 260(3), 1229-36.
  88. Buerke M, Weyrich AS, Murohara T, Queen C, Klingbeil CK, Co MS, Lefer A (1994). Humanized monoclonal antibody DREG-200 directed against I-selectin protects in feline myocardial reperfusion injury. The Journal of pharmacology and experimental therapeutics, 271(1), 134-42.
  89. Zimmerman ES, Sherman MP, Blackett JL, Neidleman JA, Kreis C, Mundt P, Williams SA, Warmerdam M, Kahn J, Hecht FM, Grant RM, de Noronha CM, Weyrich AS, Greene WC, Planelles (2006). HIV-1 Vpr induces DNA replication stress in vitro and in vivo. Journal of virology, 80, 10407-10418.
  90. Kraiss LW, Alto NM, Dixon DA, McIntyre TM, Weyrich AS, Zimmerman G (2003). Fluid flow regulates E-selectin protein levels in human endothelial cells by inhibiting translation. Journal of vascular surgery, 37(1), 161-8.
  91. Brant-Zawadski PB, Schmid DI, Jiang H, Weyrich AS, Zimmerman GA, Kraiss L (2007). Translational control in endothelial cells. Journal of vascular surgery, 45 Suppl A, A8-14.
  92. Weyrich AS, Rejeski WJ, Brubaker PH, Parks J (1992). The effects of testosterone on lipids and eicosanoids in cynomolgus monkeys. Medicine and science in sports and exercise, 24(3), 333-8.
  93. Berry MJ, Stoneman JV, Weyrich AS, Burney (1991). Dissociation of the ventilatory and lactate thresholds following caffeine ingestion. Medicine and science in sports and exercise, 23(4), 463-9.
  94. Weyrich AS, Messier SP, Ruhmann BS, Berry M (1989). Effects of bat composition, grip firmness, and impact location on postimpact ball velocity. Medicine and science in sports and exercise, 21(2), 199-205.
  95. Weyrich AS, Herb RA, Berry M (1987). The influence of diet and exercise on lipoproteins. North Carolina medical journal, 23, 10-13.
  96. Lefer AM, Ma XL, Weyrich AS, Scalia (1993). Mechanism of the cardioprotective effect of transforming growth factor beta 1 in feline myocardial ischemia and reperfusion. Proceedings of the National Academy of Sciences of the United States of America, 90(3), 1018-22.
  97. Weyrich AS, Dixon DA, Pabla R, Elstad MR, McIntyre TM, Prescott SM, Zimmerman G (1998). Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proceedings of the National Academy of Sciences of the United States of America, 95(10), 5556-61.
  98. Mahoney TS, Weyrich AS, Dixon DA, McIntyre T, Prescott SM, Zimmerman G (2001). Cell adhesion regulates gene expression at translational checkpoints in human myeloid leukocytes. Proceedings of the National Academy of Sciences of the United States of America, 98(18), 10284-9.
  99. Lindemann, SW, Yost CC, Denis MM, McIntyre TY, Weyrich AS, Zimmerman G (2004). Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs. Proceedings of the National Academy of Sciences of the United States of America, 101, 7076-7081.
  100. Zimmerman GA, Weyrich A (2010). Immunology. Arsonists in rheumatoid arthritis. Science (New York, N.Y.), 327(5965), 528-9.
  101. Kraemer BF, Weyrich A (2013). Polyubiquinated protein depots in platelets and megakaryocytes from patients with ANKRD26-RT. Thrombosis and haemostasis, 109(2), 180.
  102. Franks Z, Campbell RA, Vieira de Abreu A, Holloway JT, Marvin JE, Kraemer BF, Zimmerman GA, Weyrich AS, Rondina M (2013). Methicillin-resistant Staphylococcus aureus-induced thrombo-inflammatory response is reduced with timely antibiotic administration. Thrombosis and haemostasis, 109(4), 684-95.
  103. Kraemer BF, Weyrich AS, Lindemann (2013). Protein degradation systems in platelets. Thrombosis and haemostasis, 110(5), 920-4.
  104. Smith TL, Weyrich A (2011). Platelets as central mediators of systemic inflammatory responses. Thrombosis research, 127(5), 391-4.
  105. Rondina MT, Grissom CK, Men S, Harris ES, Schwertz H, Zimmerman GA, Weyrich A (2012). Whole blood flow cytometry measurements of in vivo platelet activation in critically-Ill patients are influenced by variability in blood sampling techniques. Thrombosis research, 129(6), 729-35.
  106. Rondina MT, Carlisle M, Fraughton T, Brown SM, Miller RR 3rd, Harris ES, Weyrich AS, Zimmerman GA, Supiano MA, Grissom C (2015). Platelet-monocyte aggregate formation and mortality risk in older patients with severe sepsis and septic shock. The journals of gerontology. Series A, Biological sciences and medical sciences, 70(2), 225-31.
  107. Jiang H, Schwertz H, Schmid DI, Jones BB, Kriesel J, Martinez ML, Weyrich AS, Zimmerman GA, Kraiss L (2012). Different mechanisms preserve translation of programmed cell death 8 and JunB in virus-infected endothelial cells. Arteriosclerosis, thrombosis, and vascular biology, 32(4), 997-1004.
  108. Fidler TP, Middleton EA, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel E (2017). Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arteriosclerosis, thrombosis, and vascular biology, 37(9), 1628-1639.
  109. Campbell RA, Vieira-de-Abreu A, Rowley JW, Franks ZG, Manne BK, Rondina MT, Kraiss LW, Majersik JJ, Zimmerman GA, Weyrich A (2017). Clots Are Potent Triggers of Inflammatory Cell Gene Expression: Indications for Timely Fibrinolysis. Arteriosclerosis, thrombosis, and vascular biology, 37(10), 1819-1827.
  110. Schwertz H, Rowley JW, Schumann GG, Thorack U, Campbell RA, Manne BK, Zimmerman GA, Weyrich AS, Rondina M (2018). Endogenous LINE-1 (Long Interspersed Nuclear Element-1) Reverse Transcriptase Activity in Platelets Controls Translational Events Through RNA-DNA Hybrids. Arteriosclerosis, thrombosis, and vascular biology, 38(4), 801-815.
  111. Holly SP, Chang JW, Li W, Niessen S, Phillips RM, Piatt R, Black JL, Smith MC, Boulaftali Y, Weyrich AS, Bergmeier W, Cravatt BF, Parise L (2013). Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation. Chemistry & biology, 20(9), 1125-34.
  112. Rowley JW, Schwertz H, Weyrich A (2012). Platelet mRNA: the meaning behind the message. Current opinion in hematology, 19(5), 385-91.
  113. Harris ES, Weyrich AS, Zimmerman G (2013). Lessons from rare maladies: leukocyte adhesion deficiency syndromes. Current opinion in hematology, 20(1), 16-25.
  114. Kraiss LW, Weyrich AS, Alto NM, Dixon DA, Ennis TM, Modur V, McIntyre TM, Prescott SM, Zimmerman G (2000). Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells. American journal of physiology. Heart and circulatory physiology, 278(5), H1537-44.
  115. Rondina MT, Schwertz H, Harris ES, Kraemer BF, Campbell RA, Mackman N, Grissom CK, Weyrich AS, Zimmerman G (2011). The septic milieu triggers expression of spliced tissue factor mRNA in human platelets. Journal of thrombosis and haemostasis, 9(4), 748-58.
  116. Hottz ED, Oliveira MF, Nunes PC, Nogueira RM, Valls-de-Souza R, Da Poian AT, Weyrich AS, Zimmerman GA, Bozza PT, Bozza F (2013). Dengue induces platelet activation, mitochondrial dysfunction and cell death through mechanisms that involve DC-SIGN and caspases. Journal of thrombosis and haemostasis, 11(5), 951-62.
  117. Rondina MT, Freitag M, Pluthero FG, Kahr WH, Rowley JW, Kraiss LW, Franks Z, Zimmerman GA, Weyrich AS, Schwertz (2016). Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets. Journal of thrombosis and haemostasis, 14(5), 1082-94.
  118. Nance D, Campbell RA, Rowley JW, Downie JM, Jorde LB, Kahr WH, Mereby SA, Tolley ND, Zimmerman GA, Weyrich AS, Rondina M (2016). Combined variants in factor VIII and prostaglandin synthase-1 amplify hemorrhage severity across three generations of descendants. Journal of thrombosis and haemostasis, 14(11), 2230-2240.
  119. Schwertz H, Rowley JW, Zimmerman GA, Weyrich AS, Rondina M (2017). Retinoic acid receptor-alpha regulates synthetic events in human platelets. Journal of thrombosis and haemostasis, 15(12), 2408-2418.
  120. Manne BK, Munzer P, Badolia R, Walker-Allgaier B, Campbell RA, Middleton E, Weyrich AS, Kunapuli SP, Borst O, Rondina M (2018). PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway. Journal of thrombosis and haemostasis, 16(6), 1211-1225.
  121. Basak I, Bhatlekar S, Manne BK, Stoller M, Hugo S, Kong X, Ma L, Rondina MT, Weyrich AS, Edelstein LC, Bray P (2019). miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway. Journal of thrombosis and haemostasis, 17(3), 511-524.
  122. Rondina MT, Schwertz H, Harris ES, Kraemer BF, Campbell RA, Mackman N, Grissom CK, Weyrich AS, Zimmerman G (2011). The septic milieu triggers expression of spliced tissue factor mRNA in human platelets. Journal of thrombosis and haemostasis, 9, 748-758.
  123. Jones CF, Campbell RA, Franks Z, Gibson CC, Thiagarajan G, Vieira-de-Abreu A, Sukavaneshvar S, Mohammad SF, Li DY, Ghandehari H, Weyrich AS, Brooks BD, Grainger D (2012). Cationic PAMAM dendrimers disrupt key platelet functions. Molecular pharmaceutics, 9(6), 1599-611.
  124. Bosque A, Famiglietti M, Weyrich AS, Goulston C, Planelles (2011). Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cells. PLoS pathogens, 7(10), e1002288.
  125. Kraemer BF, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WH, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich A (2011). Novel anti-bacterial activities of beta-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS pathogens, 7(11), e1002355.
  126. Kraemer BF, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WHA, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich A (2011). Novel anti-bacterial activities of ß-defensin 1 in human platelets: Suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS pathogens, 7(11), e1002355.
  127. Rondina MT, Weyrich A (2012). Targeting phosphodiesterases in anti-platelet therapy. Handbook of experimental pharmacology, (210), 225-38.
  128. Vieira-de-Abreu A, Campbell RA, Weyrich AS, Zimmerman G (2012). Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum. Seminars in immunopathology, 34(1), 5-30.
  129. Jones CF, Campbell RA, Brooks AE, Assemi S, Tadjiki S, Thiagarajan G, Mulcock C, Weyrich AS, Brooks BD, Ghandehari H, Grainger D (2012). Cationic PAMAM dendrimers aggressively initiate blood clot formation. ACS nano, 6(11), 9900-10.
  130. Schubert S, Schwertz H, Weyrich AS, Franks ZG, Lindemann S, Otto M, Behr H, Loppnow H, Schlitt A, Russ M, Presek P, Werdan K, Buerke (2011). Staphylococcus aureus alpha-toxin triggers the synthesis of B-cell lymphoma 3 by human platelets. Toxins, 3(2), 120-33.
  131. Schubert S, Schwertz H, Weyrich AS, Franks ZG, Lindemann S, Otto M, Behr H, Loppnow H, Schlitt A, Russ M, Presek P, Werdan K, Buerke (2011). Staphylococcus aureus ¿-toxin triggers the synthesis of B-cell lymphoma 3 by human platelets. Toxins, 3, 120-133.
  132. Mesquita EC, Hottz ED, Amancio RT, Carneiro AB, Palhinha L, Coelho LE, Grinsztejn B, Zimmerman GA, Rondina MT, Weyrich AS, Bozza PT, Bozza F (2018). Persistent platelet activation and apoptosis in virologically suppressed HIV-infected individuals. Scientific reports, 8(1), 14999.
  133. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel E (2017). Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell reports, 20(4), 881-894.
  134. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel E (2017). Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell reports, 21(6), 1705.
  135. Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE Jr, Weyrich AS, Bear JE, Bergmeier (2017). Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice. Blood advances, 1(18), 1398-1408.
  136. Berry MJ, Puntenney PJ, Weyrich AS, Robergs R (1990). Stride frequency as a determinant of the ventilatory threshold. 19, 129-142.

Review

  1. Campbell RA, Tolley ND, Schwertz H, Weyrich A (2011). Platelet protein synthesis and translational control. Current proteomics, 8, 200-207.

Book Chapter

  1. Smith MC, Schwertz H, Zimmerman GA, Weyrich A (2013). The Platelet Proteome. Platelets, 103-116.
  2. Vieira-de-Abreu A, Rondina MT, Weyrich AS, Zimmerman G (2013). Platelets in Disease: Inflammation. Platelets, 733-766.
  3. Zimmerman GA, Elstad MR, Lorant DE, McIntyre TM, Prescott SM, Topham MK, Weyrich AS, Whatley R (1997). Platelet-activating factor (PAF): Signaling and adhesion in cell-cell interactions. 416, 297-304.
  4. Zimmerman GA,Dixon DA,McIntyre TM,Prescott SM,Weyrich A (2003). Molecular Mechanisms of Juxtacrine Cell Signaling in Microvascular Responses and Inflammation. 203-217.
  5. Lindemann SW,McIntyre TM,Prescott SM,Zimmerman GA,Weyrich A (2005). Expanding the functional repertoire of platelets in thrombosis and inflammation: signal-dependent protein synthesis. 149-174.
  6. Weyrich AS,Zimmerman G (2002). Selectins. 5, 2876-2880.
  7. Lefer AM, Ma XL, Weyrich AS, Lefer D (1993). Endothelial dysfunction and neutrophil adherence as critical events in the development of reperfusion injury. 41, 127-135.
  8. Schwertz H, Rowley JW, Tolley ND, Campbell RA, Weyrich A (2012). Assessing Protein Synthesis by Platelets. 3, 141-153.
  9. Harris ES, Rondina MT, Schwertz H, Weyrich AS, Zimmerman G (2010). Pathogenesis of sepsis and sepsis-induced acute lung injury. 369-419.
  10. Schwertz H, Weyrich AS, Zimmerman G (2007). Interacoes entre plaquetas, leucocitos e endotelia na resposta inflamatoria sistemica e na sepse. (Cellular interactions of platelets, leukocytes and endothelum in systemic inflammatory responses and sepsis). 107-120.

Editorial

  1. Weyrich AS, Kraiss LK, Zimmerman G (2008). Trading places: mRNA transfer between cells. Blood, 110(7), 2219.
  2. Weyrich AS, Schwertz H, Mackman (2007). Platelet tissue factor comes of age. Blood, 109(12), 5069-5070.
  3. Bozza FA, Weyrich A (2008). Mitochondria push platelets past their prime. Blood, 111(5), 2496-2497.
  4. Weyrich AS, Prescott SM, Zimmerman G (2002). Platelets, endothelial cells, inflammatory chemokines, and restenosis: complex signaling in the vascular play book. Circulation, 106(12), 1433-5.