Andrey A. Shabalin

Andrey A. Shabalin, PhD

Languages spoken: Russian, English

Academic Information

Departments Primary - Psychiatry

Divisions: Adult Psychiatry

Academic Office Information

andrey.shabalin@utah.edu

Education History

Fellowship Virginia Commonwealth University
 Postdoctoral Research Associate
University of North Carolina at Chapel Hill
 Postdoctoral Research Associate
Doctoral Training University of North Carolina at Chapel Hill
 PhD
New Economic School
 MA
Graduate Training M.V.Lomonosov Moscow State University
 MS

Selected Publications

Journal Article

  1. Xia K, Shabalin AA, Yin Z, Chung W, Sullivan PF, Wright FA, Styner M, Gilmore JH, Santelli RC, Zou F (2022). TwinEQTL: Ultra Fast and Powerful Association Analysis for eQTL and GWAS in Twin Studies. Genetics, 221.
  2. Merrill CB, Montgomery AB, Pabon MA, Shabalin AA, Rodan AR, Rothenfluh A (2022). Harnessing changes in open chromatin determined by ATAC-seq to generate insulin-responsive reporter constructs. BMC Genomics, 23(1), 399.
  3. Love T, Shabalin AA, Kember RL, Docherty AR, Zhou H, Koppelmans V, Gelernter J, Baker AK, Hartwell E, Dubroff J, Zubieta JK, Kranzler HR (2022). Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function. Neuropsychopharmacology, 47(10), 1784-1790.
  4. Coon H, Shabalin A, Bakian AV, DiBlasi E, Monson ET, Kirby A, Chen D, Fraser A, Yu Z, Staley M, Callor WB, Christensen ED, Crowell SE, Gray D, Crockett DK, Li QS, Keeshin B, Docherty AR (2022). Extended familial risk of suicide death is associated with younger age at death and elevated polygenic risk of suicide. Am J Med Genet B Neuropsychiatr Genet, 189(3-4), 60-73.
  5. Ip HF, van der Laan CM, Krapohl EML, Brikell I, Snchez-Mora C, Nolte IM, St Pourcain B, Bolhuis K, Palviainen T, Zafarmand H, Colodro-Conde L, Gordon S, Zayats T, Aliev F, Jiang C, Wang CA, Saunders G, Karhunen V, Hammerschlag AR, Adkins DE, Border R, Peterson RE, Prinz JA, Thiering E, Seppl I, Vilor-Tejedor N, Ahluwalia TS, Day FR, Hottenga JJ, Allegrini AG, Rimfeld K, Chen Q, Lu Y, Martin J, Soler Artigas M, Rovira P, Bosch R, Espaol G, Ramos Quiroga JA, Neumann A, Ensink J, Grasby K, Morosoli JJ, Tong X, Marrington S, Middeldorp C, Scott JG, Vinkhuyzen A, Shabalin AA, Corley R, Evans LM, Sugden K, Alemany S, Sass L, Vinding R, Ruth K, Tyrrell J, Davies GE, Ehli EA, Hagenbeek FA, De Zeeuw E, Van Beijsterveldt TCEM, Larsson H, Snieder H, Verhulst FC, Amin N, Whipp AM, Korhonen T, Vuoksimaa E, Rose RJ, Uitterlinden AG, Heath AC, Madden P, Haavik J, Harris JR, Helgeland, Johansson S, Knudsen GPS, Njolstad PR, Lu Q, Rodriguez A, Henders AK, Mamun A, Najman JM, Brown S, Hopfer C, Krauter K, Reynolds C, Smolen A, Stallings M, Wadsworth S, Wall TL, Silberg JL, Miller A, Keltikangas-Jrvinen L, Hakulinen C, Pulkki-Rback L, Havdahl A, Magnus P, Raitakari OT, Perry JRB, Llop S, Lopez-Espinosa MJ, Bnnelykke K, Bisgaard H, Sunyer J, Lehtimki T, Arseneault L, Standl M, Heinrich J, Boden J, Pearson J, Horwood LJ, Kennedy M, Poulton R, Eaves LJ, Maes HH, Hewitt J, Copeland WE, Costello EJ, Williams GM, Wray N, Jrvelin MR, McGue M, Iacono W, Caspi A, Moffitt TE, Whitehouse A, Pennell CE, Klump KL, Burt SA, Dick DM, Reichborn-Kjennerud T, Martin NG, Medland SE, Vrijkotte T, Kaprio J, Tiemeier H, Davey Smith G, Hartman CA, Oldehinkel AJ, Casas M, Ribass M, Lichtenstein P, Lundstrm S, Plomin R, Bartels M, Nivard MG, Boomsma DI (2021). Genetic association study of childhood aggression across raters, instruments, and age. Transl Psychiatry, 11(1), 413.
  6. Monson ET, Shabalin AA, Docherty AR, DiBlasi E, Bakian AV, Li QS, Gray D, Keeshin B, Crowell SE, Mullins N, Willour VL, Coon H (2021). Assessment of suicide attempt and death in bipolar affective disorder: a combined clinical and genetic approach. Transl Psychiatry, 11(1), 379.
  7. DiBlasi E, Shabalin AA, Monson ET, Keeshin BR, Bakian AV, Kirby AV, Ferris E, Chen D, William N, Gaj E, Klein M, Jerominski L, Callor WB, Christensen E, Smith KR, Fraser A, Yu Z, Gray D, PsychChip Investigators of the Psychiatric Genomics Consortium, Camp NJ, Stahl EA, Li QS, Docherty AR, Coon H (2021). Rare protein-coding variants implicate genes involved in risk of suicide death. Am J Med Genet B Neuropsychiatr Genet, 186(8), 508-520.
  8. Guintivano J, Shabalin AA, Chan RF, Rubinow DR, Sullivan PF, Meltzer-Brody S, Aberg KA, van den Oord EJCG (2020). Test-statistic inflation in methylome-wide association studies. Epigenetics, 15(11), 1163-1166.
  9. Waszczuk MA, Docherty AR, Shabalin AA, Miao J, Yang X, Kuan PF, Bromet E, Kotov R, Luft BJ (2020). Polygenic prediction of PTSD trajectories in 9/11 responders. Psychol Med, 1-9.
  10. Docherty AR, Shabalin AA, DiBlasi E, Monson E, Mullins N, Adkins DE, Bacanu SA, Bakian AV, Crowell S, Chen D, Darlington TM, Callor WB, Christensen ED, Gray D, Keeshin B, Klein M, Anderson JS, Jerominski L, Hayward C, Porteous DJ, McIntosh A, Li Q, Coon H (2021). Genome-Wide Association Study of Suicide Death and Polygenic Prediction of Clinical Antecedents. Am J Psychiatry, 177(10), 917-927.
  11. Docherty AR, Shabalin AA, Adkins DE, Mann F, Krueger RF, Bacanu SA, Campbell A, Hayward C, Porteous DJ, McIntosh AM, Kendler KS (2020). Molecular Genetic Risk for Psychosis Is Associated With Psychosis Risk Symptoms in a Population-Based UK Cohort: Findings From Generation Scotland. Schizophr Bull.
  12. Chan RF, Turecki G, Shabalin AA, Guintivano J, Zhao M, Xie LY, van Grootheest G, Kaminsky ZA, Dean B, Penninx BWJH, Aberg KA, van den Oord EJCG (2019). Cell Type-Specific Methylome-wide Association Studies Implicate Neurotrophin and Innate Immune Signaling in Major Depressive Disorder. Biol Psychiatry, 87(5), 431-442.
  13. Clark SL, Hattab MW, Chan RF, Shabalin AA, Han LKM, Zhao M, Smit JH, Jansen R, Milaneschi Y, Xie LY, van Grootheest G, Penninx BWJH, Aberg KA, van den Oord EJCG (2019). A methylation study of long-term depression risk. Mol Psychiatry.
  14. Anderson JS, Shade J, DiBlasi E, Shabalin AA, Docherty AR (2018). Polygenic risk scoring and prediction of mental health outcomes. Curr Opin Psychol, 27, 77-81.
  15. Clark SL, Costin BN, Chan RF, Johnson AW, Xie L, Jurmain JL, Kumar G, Shabalin AA, Pandey AK, Aberg KA, Miles MF, van den Oord E (2018). A Whole Methylome Study of Ethanol Exposure in Brain and Blood: An Exploration of the Utility of Peripheral Blood as Proxy Tissue for Brain in Alcohol Methylation Studies. Alcohol Clin Exp Res, 42(12), 2360-2368.
  16. Coon H, Darlington TM, DiBlasi E, Callor WB, Ferris E, Fraser A, Yu Z, William N, Das SC, Crowell SE, Chen D, Anderson JS, Klein M, Jerominski L, Cannon D, Shabalin A, Docherty A, Williams M, Smith KR, Keeshin B, Bakian AV, Christensen E, Li QS, Camp NJ, Gray D (2018). Genome-wide significant regions in 43 Utah high-risk families implicate multiple genes involved in risk for completed suicide. Mol Psychiatry, 25(11), 3077-3090.
  17. Docherty AR, Fonseca-Pedrero E, Debban M, Chan RCK, Linscott RJ, Jonas KG, Cicero DC, Green MJ, Simms LJ, Mason O, Watson D, Ettinger U, Waszczuk M, Rapp A, Grant P, Kotov R, DeYoung CG, Ruggero CJ, Eaton NR, Krueger RF, Patrick C, Hopwood C, ONeill FA, Zald DH, Conway CC, Adkins DE, Waldman ID, van Os J, Sullivan PF, Anderson JS, Shabalin AA, Sponheim SR, Taylor SF, Grazioplene RG, Bacanu SA, Bigdeli TB, Haenschel C, Malaspina D, Gooding DC, Nicodemus K, Schultze-Lutter F, Barrantes-Vidal N, Mohr C, Carpenter WT, Cohen AS (2018). Enhancing Psychosis-Spectrum Nosology Through an International Data Sharing Initiative. Schizophr Bull, 44(suppl_2), S460-S467.
  18. Aberg KA, Dean B, Shabalin AA, Chan RF, Han LKM, Zhao M, van Grootheest G, Xie LY, Milaneschi Y, Clark SL, Turecki G, Penninx BWJH, van den Oord EJCG (2018). Methylome-wide association findings for major depressive disorder overlap in blood and brain and replicate in independent brain samples. Mol Psychiatry.
  19. Xia H, Jahr FM, Kim NK, Xie L, Shabalin AA, Bryois J, Sweet DH, Kronfol MM, Palasuberniam P, McRae M, Riley BP, Sullivan PF, van den Oord EJ, McClay JL (2018). Building a schizophrenia genetic network: transcription factor 4 regulates genes involved in neuronal development and schizophrenia risk. Hum Mol Genet, 27(18), 3246-3256.
  20. Aberg KA, Shabalin AA, Chan RF, Zhao M, Kumar G, van Grootheest G, Clark SL, Xie LY, Milaneschi Y, Penninx BWJH, van den Oord EJCG (2018). Convergence of evidence from a methylome-wide CpG-SNP association study and GWAS of major depressive disorder. Transl Psychiatry, 8(1), 162.
  21. Han LKM, Aghajani M, Clark SL, Chan RF, Hattab MW, Shabalin AA, Zhao M, Kumar G, Xie LY, Jansen R, Milaneschi Y, Dean B, Aberg KA, van den Oord EJCG, Penninx BWJH (2018). Epigenetic Aging in Major Depressive Disorder. Am J Psychiatry, 175(8), 774-782.
  22. Li G, Shabalin AA, Rusyn I, Wright FA, Nobel AB (2016). An empirical Bayes approach for multiple tissue eQTL analysis. Biostatistics, 19(3), 391-406.
  23. Shabalin AA, Hattab MW, Clark SL, Chan RF, Kumar G, Aberg KA, van den Oord EJCG (2017). RaMWAS: fast methylome-wide association study pipeline for enrichment platforms. Bioinformatics, 34(13), 2283-2285.
  24. Palowitch J, Shabalin A, Zhou YH, Nobel AB, Wright FA (2017). Estimation of cis-eQTL effect sizes using a log of linear model. Biometrics, 74(2), 616-625.
  25. Aberg KA, Chan RF, Xie L, Shabalin AA, van den Oord EJCG (2017). Methyl-CpG-Binding Domain Sequencing: MBD-seq. Methods Mol Biol, 1708, 171-189.
  26. Aberg KA, Chan RF, Shabalin AA, Zhao M, Turecki G, Staunstrup NH, Starnawska A, Mors O, Xie LY, van den Oord EJ (2017). A MBD-seq protocol for large-scale methylome-wide studies with (very) low amounts of DNA. Epigenetics, 12(9), 743-750.

Other

  1. Jami ES, Hammerschlag AR, Ip HF, Allegrini AG, Benyamin B, Border R, Diemer EW, Jiang C, Karhunen V, Lu Y, Lu Q, Mallard TT, Mishra PP, Nolte IM, Palviainen T, Peterson RE, Sallis HM, Shabalin AA, Tate AE, Thiering E, Vilor-Tejedor N, Wang C, Zhou A, Adkins DE, Alemany S, Ask H, Chen Q, Corley RP, Ehli EA, Evans LM, Havdahl A, Hagenbeek FA, Hakulinen C, Henders AK, Hottenga JJ, Korhonen T, Mamun A, Marrington S, Neumann A, Rimfeld K, Rivadeneira F, Silberg JL, van Beijsterveldt CE, Vuoksimaa E, Whipp AM, Tong X, Andreassen OA, Boomsma DI, Brown SA, Burt SA, Copeland W, Dick DM, Harden KP, Harris KM, Hartman CA, Heinrich J, Hewitt JK, Hopfer C, Hypponen E, Jarvelin MR, Kaprio J, Keltikangas-Jrvinen L, Klump KL, Krauter K, Kuja-Halkola R, Larsson H, Lehtimki T, Lichtenstein P, Lundstrm S, Maes HH, Magnus P, Munaf MR, Najman JM, Njlstad PR, Oldehinkel AJ, Pennell CE, Plomin R, Reichborn-Kjennerud T, Reynolds C, Rose RJ, Smolen A, Snieder H, Stallings M, Standl M, Sunyer J, Tiemeier H, Wadsworth SJ, Wall TL, Whitehouse AJO, Williams GM, Ystrm E, Nivard MG, Bartels M, Middeldorp CM (2022). Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms. J Am Acad Child Adolesc Psychiatry (61(7), pp. 934-945). United States.
  2. Docherty AR, Bakian AV, DiBlasi E, Shabalin AA, Chen D, Keeshin B, Monson E, Christensen ED, Li Q, Gray D, Coon H (2022). Suicide and Psychosis: Results From a Population-Based Cohort of Suicide Death (N = 4380). Schizophr Bull (48(2), pp. 457-462). United States.
  3. Alkelai A, Greenbaum L, Docherty AR, Shabalin AA, Povysil G, Malakar A, Hughes D, Delaney SL, Peabody EP, McNamara J, Gelfman S, Baugh EH, Zoghbi AW, Harms MB, Hwang HS, Grossman-Jonish A, Aggarwal V, Heinzen EL, Jobanputra V, Pulver AE, Lerer B, Goldstein DB (2021). The benefit of diagnostic whole genome sequencing in schizophrenia and other psychotic disorders. Mol Psychiatry (27(3), pp. 1435-1447). England.
  4. Mullins N, Kang J, Campos AI, Coleman JRI, Edwards AC, Galfalvy H, Levey DF, Lori A, Shabalin A, Starnawska A, Su MH, Watson HJ, Adams M, Awasthi S, Gandal M, Hafferty JD, Hishimoto A, Kim M, Okazaki S, Otsuka I, Ripke S, Ware EB, Bergen AW, Berrettini WH, Bohus M, Brandt H, Chang X, Chen WJ, Chen HC, Crawford S, Crow S, DiBlasi E, Duriez P, Fernndez-Aranda F, Fichter MM, Gallinger S, Glatt SJ, Gorwood P, Guo Y, Hakonarson H, Halmi KA, Hwu HG, Jain S, Jamain S, Jimnez-Murcia S, Johnson C, Kaplan AS, Kaye WH, Keel PK, Kennedy JL, Klump KL, Li D, Liao SC, Lieb K, Lilenfeld L, Liu CM, Magistretti PJ, Marshall CR, Mitchell JE, Monson ET, Myers RM, Pinto D, Powers A, Ramoz N, Roepke S, Rozanov V, Scherer SW, Schmahl C, Sokolowski M, Strober M, Thornton LM, Treasure J, Tsuang MT, Witt SH, Woodside DB, Yilmaz Z, Zillich L, Adolfsson R, Agartz I, Air TM, Alda M, Alfredsson L, Andreassen OA, Anjorin A, Appadurai V, Soler Artigas M, Van der Auwera S, Azevedo MH, Bass N, Bau CHD, Baune BT, Bellivier F, Berger K, Biernacka JM, Bigdeli TB, Binder EB, Boehnke M, Boks MP, Bosch R, Braff DL, Bryant R, Budde M, Byrne EM, Cahn W, Casas M, Castelao E, Cervilla JA, Chaumette B, Cichon S, Corvin A, Craddock N, Craig D, Degenhardt F, Djurovic S, Edenberg HJ, Fanous AH, Foo JC, Forstner AJ, Frye M, Fullerton JM, Gatt JM, Gejman PV, Giegling I, Grabe HJ, Green MJ, Grevet EH, Grigoroiu-Serbanescu M, Gutierrez B, Guzman-Parra J, Hamilton SP, Hamshere ML, Hartmann A, Hauser J, Heilmann-Heimbach S, Hoffmann P, Ising M, Jones I, Jones LA, Jonsson L, Kahn RS, Kelsoe JR, Kendler KS, Kloiber S, Koenen KC, Kogevinas M, Konte B, Krebs MO, Landn M, Lawrence J, Leboyer M, Lee PH, Levinson DF, Liao C, Lissowska J, Lucae S, Mayoral F, McElroy SL, McGrath P, McGuffin P, McQuillin A, Medland SE, Mehta D, Melle I, Milaneschi Y, Mitchell PB, Molina E, Morken G, Mortensen PB, Mller-Myhsok B, Nievergelt C, Nimgaonkar V, Nthen MM, ODonovan MC, Ophoff RA, Owen MJ, Pato C, Pato MT, Penninx BWJH, Pimm J, Pistis G, Potash JB, Power RA, Preisig M, Quested D, Ramos-Quiroga JA, Reif A, Ribass M, Richarte V, Rietschel M, Rivera M, Roberts A, Roberts G, Rouleau GA, Rovaris DL, Rujescu D, Snchez-Mora C, Sanders AR, Schofield PR, Schulze TG, Scott LJ, Serretti A, Shi J, Shyn SI, Sirignano L, Sklar P, Smeland OB, Smoller JW, Sonuga-Barke EJS, Spalletta G, Strauss JS, witkowska B, Trzaskowski M, Turecki G, Vilar-Rib L, Vincent JB, Vlzke H, Walters JTR, Shannon Weickert C, Weickert TW, Weissman MM, Williams LM, Wray NR, Zai CC, Ashley-Koch AE, Beckham JC, Hauser ER, Hauser MA, Kimbrel NA, Lindquist JH, McMahon B, Oslin DW, Qin X, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, German Borderline Genomics Consortium, MVP Suicide Exemplar Workgroup, VA Million Veteran Program, Agerbo E, Brglum AD, Breen G, Erlangsen A, Esko T, Gelernter J, Hougaard DM, Kessler RC, Kranzler HR, Li QS, Martin NG, McIntosh AM, Mors O, Nordentoft M, Olsen CM, Porteous D, Ursano RJ, Wasserman D, Werge T, Whiteman DC, Bulik CM, Coon H, Demontis D, Docherty AR, Kuo PH, Lewis CM, Mann JJ, Rentera ME, Smith DJ, Stahl EA, Stein MB, Streit F, Willour V, Ruderfer DM (2021). Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors. Biol Psychiatry (91(3), pp. 313-327). United States.
  5. Colbert SMC, Hatoum AS, Shabalin A, Li QS, Coon H, Nelson EC, Agrawal A, Docherty AR, Johnson EC (2021). Exploring the genetic overlap of suicide-related behaviors and substance use disorders. Am J Med Genet B Neuropsychiatr Genet (186(8), pp. 445-455). United States.