Anna E. Beaudin

Anna E. Beaudin, PhD

Languages spoken: English

Academic Information

Departments Primary - Internal Medicine , Adjunct - Human Genetics , Adjunct - Pathology

Divisions: Hematology & Hematologic Malignancies

Lab

Dr. Anna E. Beaudin is an Associate Professor and Associate Chief of Basic Research in the Division of Hematology and Hematologic Malignancies, Department of Internal Medicine at the University of Utah School of Medicine. She holds adjunct appointments in the Department of Human Genetics and the Division of Microbiology and Immunology in the Department of Pathology and is a member of the Molecular Medicine Program and the Cell Response and Regulation Program at the Huntsman Cancer Institute.

The overarching goal of Dr. Beaudin's research is to define the contribution of fetal hematopoiesis, or blood production, to immune development, immune function, and disease susceptibility across the lifespan. Hematopoietic stem cells (HSCs) are responsible for sustaining production of all blood and immune cells across the lifespan. Dr. Beaudin's research focuses on fetal HSCs and the process of fetal hematopoiesis, in which transient HSCs produce a series of distinct blood and immune cells that function to meet the discrete immunological needs of the fetus across development. Fetal-derived immune cells are fundamentally distinct from immune cells produced in adulthood -- they defy conventional phenotypic and functional definitions, and seed developing organs where they persist across the lifespan of the animal to support tissue homeostasis. The Beaudin lab utilizes single-cell analysis, fate-mapping, and in vivo analysis in mouse models to investigate how these specialized cells are made during fetal hematopoiesis in order to gain insight into the role of these cells in tissue development, regeneration, and disease pathogenesis across the lifespan. We also investigate how perturbation of fetal hematopoiesis by extrinsic stimuli during development (infection, nutrition) shapes susceptibility to immune dysfunction by disrupting immune system establishment and reshaping the trajectory of adult hematopoiesis.

Dr. Beaudin's training is highly interdisciplinary, spanning nutritional sciences, biochemistry, and developmental and stem cell biology, thereby allowing her to make unique contributions to research at the intersection of development, hematopoiesis, and immunology. Originally from Los Angeles, California, Dr. Beaudin completed a B.A. in Psychology and Ph.D. in Nutritional sciences at Cornell University in Ithaca, New York. She continued her postdoctoral work at UC Santa Cruz, where she used a fate-mapping approach to discover a novel, transient hematopoietic progenitor that serves as a cell of origin for fetal-restricted innate-like lymphocytes (Beaudin et al, Cell Stem Cell, 2016; Beaudin & Forsberg, Blood, 2016). Since opening her lab in 2016, Dr. Beaudin's work has been funded by several NIH-funded awards, the Hellman Foundation, and she is a recipient of the Pew Biomedical Scholars Award. Dr. Beaudin is an active member of the International Society of Experimental Hematology, the American Society of Hematology, and the American Association of Immunologists. She was also elected as a council member for the Midwinter Conference of Immunologists. Dr. Beaudin is an active reviewer for journals including Science, Nature, Cell Stem Cell, Stem Cell Reports, Blood, and Nature Communications, and her work has been published in high-profile journals such as Cell Stem Cell, Cell Reports, EMBO Journal, and Development.

Education History

Doctoral Training Cornell University
 PhD
Brown University
 MS
Undergraduate Cornell University
 BA

Selected Publications

Journal Article

  1. Lopez DA, Griffin A, Aguilar LM, Deering-Rice C, Myers EJ, Warren KJ, Welner RS, Beaudin AE (2024). Prenatal inflammation remodels lung immunity and function by programming ILC2 hyperactivation. Cell Rep, 43(7), 114365. (Read full article)
  2. Poscablo DM, Worthington AK, Smith-Berdan S, Rommel MGE, Manso BA, Adili R, Mok L, Reggiardo RE, Cool T, Mogharrab R, Myers J, Dahmen S, Medina P, Beaudin AE, Boyer SW, Holinstat M, Jonsson VD, Forsberg EC (2024). An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis. Cell, 187(12), 3090-3107.e21. (Read full article)
  3. Lopez DA, Otsuka KS, Apostol AC, Posada J, Snchez-Arcila JC, Jensen KD, Beaudin AE (2023). Both maternal IFNγ exposure and acute prenatal infection with Toxoplasma gondii activate fetal hematopoietic stem cells. EMBO J, 42(14), e112693. (Read full article)
  4. Smith FL, Savage HP, Luo Z, Tipton CM, Lee FE, Apostol AC, Beaudin AE, Lopez DA, Jensen I, Keller S, Baumgarth N (2023). B-1 plasma cells require non-cognate CD4 T cell help to generate a unique repertoire of natural IgM. J Exp Med, 220(4). (Read full article)
  5. Lopez DA, Beaudin AE (2022). Isolation and Characterization of Fetal Liver Hematopoietic Stem Cells. Methods Mol Biol, 2567, 99-112. (Read full article)
  6. Lopez DA, Apostol AC, Lebish EJ, Valencia CH, Romero-Mulero MC, Pavlovich PV, Hernandez GE, Forsberg EC, Cabezas-Wallscheid N, Beaudin AE (2022). Prenatal inflammation perturbs murine fetal hematopoietic development and causes persistent changes to postnatal immunity. Cell Rep, 41(8), 111677. (Read full article)
  7. Worthington AK, Cool T, Poscablo DM, Hussaini A, Beaudin AE, Forsberg EC (2022). IL7Rα, but not Flk2, is required for hematopoietic stem cell reconstitution of tissue-resident lymphoid cells. Development, 149(8). (Read full article)
  8. Hernandez GE, Ma F, Martinez G, Firozabadi NB, Salvador J, Juang LJ, Leung J, Zhao P, Lopez DA, Ardehali R, Beaudin AE, Kastrup CJ, Pellegrini M, Flick MJ, Iruela-Arispe ML (2022). Aortic intimal resident macrophages are essential for maintenance of the non-thrombogenic intravascular state. Nat Cardiovasc Res, 1(1), 67-84. (Read full article)
  9. Beaudin AE (2021). Takes one to B1a: Dismantling the origin of mantle cell lymphoma. Journal of Experimental Medicine.
  10. Lopez DA, Beaudin AE (2021). Layered immunity of the developing thymus. Blood.
  11. Apostol AC, Lopez DA, Beaudin AE (2020). A "Switch" in time through genes aligned: Unraveling the genomic landscape of HSC development. Cell Stem Cell.
  12. Apostol AC, Jensen KDC, Beaudin AE (2020). Training the fetal immune system through maternal inflammation: A layered hygiene hypothesis. Frontiers in Immunology.
  13. Leung GA, Cool T, Valencia CH, Worthington A, Beaudin AE, Forsberg EC (2019). The lymphoid-associated interleukin-7 receptor (IL-7R) regulates tissue resident macrophage development. Development.
  14. Boyer SW, Rajendiran S, Beaudin AE, Perez-Cunningham J, Smith-Berdan S, Martin EW, Muthuswamy PK, Cheung C, Tsang H, Landon M, Forsberg EC (2019). Clonal and quantitative in vivo assessment of hematopoietic stem and progenitor cell differentiation. Stem Cell Reports.
  15. Valentine KM, Davini D, Lawrence TJ, Mullins GN, Mansala M, Al-Kuhlani M, Pinney JM, Davis JK, Beaudin AE, Sindi SS, Gravano DM, Hoyer KK (2018). CD8 Follicular T Cells Promote B Cell Antibody Class Switch in Autoimmune Disease. J Immunol.
  16. Cole CK, Byrne A, Beaudin AE, Forsberg EC, Vollmers C (2018). Tn5Prime, a Tn5 based 5’ Capture Method for Single Cell RNA-seq. Nucleic Acids Research.
  17. Apostol AC, Beaudin AE (2018). Reversing time: EZH1 deficiency hastens definitive hematopoiesis. Cell Stem Cell.
  18. Byrne A, Beaudin AE, Olsen HE, Jain M, Cole C, Palmer T, DuBois RM, Forsberg EC, Akeson M, Vollmers C (2017). Nanopore Long-Read RNAseq Reveals Widespread Transcriptional Variation Among the Surface Receptors of Individual B cells. Nature Communications.
  19. Beaudin AE, Forsberg EC (2016). To B1a or not to B1a: do hematopoietic stem cells contribute to tissue-resident immune cells? Blood.
  20. Beaudin AE, Boyer SW, Perez-Cunningham J, Hernandez GE, Derderian SC, Jujuvarapu C, Aaserude E, MacKenzie T, Forsberg EC (2016). A transient development hematopoietic stem cell gives rise to innate-like B- and T-cells. Cell Stem Cell.
  21. Hoeffel G, Chen J, Lavin Y, Low D, Almeida A, See P, Beaudin AE, Lum J, Low I, Forsberg EC, Poidinger M, Zolezzi F, Larbi A, Ng LG, Chan JKY, Greter M, Becher B, Samokhvalov IM, Merad M, Ginhoux F (2015). C-Myb+ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity.
  22. Epelman S, Lavine KJ, Beaudin AE, Sojka D, Brija T, Schwendener R, Forsberg EC, Yokoyama W, Murphy KM, Colonna M, Randolph GJ, Mann DL (2014). Novel cardiac macrophage populations during steady-state and inflammation. Immunity.
  23. Beaudin AE, Boyer SW, Forsberg EC (2013). Flk2/Flt3 promotes both myeloid and lymphoid development by expanding non-self-renewing multipotent hematopoietic progenitor cells. Experimental Hematology.

Review

  1. Tseng NA, Beaudin AE (2023). The impact of prenatal inflammation on hematopoietic development. [Review]. Curr Opin Hematol, 30(4), 130-136. (Read full article)
  2. Otsuka KS, Nielson C, Firpo MA, Park AH, Beaudin AE (2021). Early Life Inflammation and the Developing Hematopoietic and Immune Systems: The Cochlea as a Sensitive Indicator of Disruption. [Review]. Cells, 10(12). (Read full article)

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