
Education History
Postdoctoral Fellowship |
Carnegie Institution |
Postdoctoral Fellow |
---|---|---|
Fred Hutchinson Cancer Research Center |
Postdoctoral Fellow | |
Doctoral Training |
University of Washington |
PhD |
Rice University |
BA |
Selected Publications
Journal Article
- Simon L Currie, Desmond K Lau, Jedediah J Doane, Frank G Whitby, Mark Okon, Lawrence P McIntosh, and Barbara J Graves (In Press). Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4, and ETV5. (Epub ahead of print) Nucleic Acids Res.
- Perez-Borrajero C, Lin CS, Okon M, Scheu K, Graves BJ, Murphy MEP, McIntosh LP (2018). The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor. J Mol Biol, 431(3), 593-614.
- Currie SL, Warner SL, Vankayalapati H, Liu X, Sharma S, Bearss DJ, Graves BJ (2018). Development of High-Throughput Screening Assays for Inhibitors of ETS Transcription Factors. SLAS Discov, 24(1), 77-85.
- Madison BJ, Clark KA, Bhachech N, Hollenhorst PC, Graves BJ, Currie SL (2018). Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN-FOS at composite DNA sites. J Biol Chem, 293(48), 18624-18635.
- Currie SL, Doane JJ, Evans KS, Bhachech N, Madison BJ, Lau DKW, McIntosh LP, Skalicky JJ, Clark KA, Graves BJ (2017). ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain. J Mol Biol, 429(20), 2975-2995.
- Currie SL, Lau DKW, Doane JJ, Whitby FG, Okon M, McIntosh LP, Graves BJ (2016). Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5. Nucleic Acids Res, 45(5), 2223-2241.
- Desjardins G, Okon M, Graves BJ, McIntosh LP (2016). Conformational Dynamics and the Binding of Specific and Nonspecific DNA by the Autoinhibited Transcription Factor Ets-1. Biochemistry, 55(29), 4105-18.
- De S, Okon M, Graves BJ, McIntosh LP (2016). Autoinhibition of ETV6 DNA Binding Is Established by the Stability of Its Inhibitory Helix. J Mol Biol, 428(8), 1515-30.
- Desjardins G, Meeker CA, Bhachech N, Currie SL, Okon M, Graves BJ, McIntosh LP (2014). Synergy of aromatic residues and phosphoserines within the intrinsically disordered DNA-binding inhibitory elements of the Ets-1 transcription factor. Proc Natl Acad Sci U S A, 111(30), 11019-24.
- Coyne HJ 3rd, De S, Okon M, Green SM, Bhachech N, Graves BJ, McIntosh LP (2012). Autoinhibition of ETV6 (TEL) DNA binding: appended helices sterically block the ETS domain. J Mol Biol, 421(1), 67-84.
- Hollenhorst PC, Ferris MW, Hull MA, Chae H, Kim S, Graves BJ (2011). Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells. Genes Dev, 25(20), 2147-57.
- Green SM, Coyne HJ 3rd, McIntosh LP, Graves BJ (2010). DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association. J Biol Chem, 285(24), 18496-504.
- Seidel JJ, Graves BJ (2002). An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors. Genes Dev, 16(1), 127-37.
Review
- Hollenhorst PC, McIntosh LP, Graves BJ (2011). Genomic and biochemical insights into the specificity of ETS transcription factors. [Review]. Annu Rev Biochem, 80, 437-71.