Education History
| Undergraduate |
University of Calicut |
BS |
|---|---|---|
| Graduate Training |
Cochin University of Science and Technology |
MS |
| Doctoral Training |
Cochin University of Science and Technology |
PhD |
| Postdoctoral Training |
Nanyang Technological University |
Postdoctoral Training |
| Postdoctoral Training |
University of Utah |
Postdoctoral Training |
Selected Publications
Journal Article
- Zhong M, Balakrishnan B, Guo AJ, Lai (2023). AAV9-based PMM2 gene replacement augments PMM2 expression and improves glycosylation in primary fibroblasts of patients with phosphomannomutase 2 deficiency (PMM2-CDG). Molecular genetics and metabolism reports, 38, 101035.
- Balakrishnan B, Altassan R, Budhraja R, Liou W, Lupo A, Bryant S, Mankouski A, Radenkovic S, Preston GJ, Pandey A, Boudina S, Kozicz T, Morava E, Lai (2023). AAV-based gene therapy prevents and halts the progression of dilated cardiomyopathy in a mouse model of phosphoglucomutase 1 deficiency (PGM1-CDG). Translational research, 257, 1-14.
- Liu L, Tang M, Pragani R, Whitby FG, Zhang YQ, Balakrishnan B, Fang Y, Karavadhi S, Tao D, LeClair CA, Hall MD, Marugan JJ, Boxer M, Shen M, Hill CP, Lai K, Patnaik (2021). Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. Journal of medicinal chemistry, 64(18), 13551-13571.
- Balakrishnan B, An D, Nguyen V, DeAntonis C, Martini PGV, Lai (2020). Novel mRNA-Based Therapy Reduces Toxic Galactose Metabolites and Overcomes Galactose Sensitivity in a Mouse Model of Classic Galactosemia. Molecular therapy, 28(1), 304-312.
- Balakrishnan B, Verheijen J, Lupo A, Raymond K, Turgeon C, Yang Y, Carter KL, Whitehead KJ, Kozicz T, Morava E, Lai (2019). A novel phosphoglucomutase-deficient mouse model reveals aberrant glycosylation and early embryonic lethality. Journal of inherited metabolic disease, 42(5), 998-1007.
- Balakrishnan B, Siddiqi A, Mella J, Lupo A, Li E, Hollien J, Johnson J, Lai (2019). Salubrinal enhances eIF2¿ phosphorylation and improves fertility in a mouse model of Classic Galactosemia. Biochimica et biophysica acta. Molecular basis of disease, 1865(11), 165516.
- Balakrishnan B, Nicholas C, Siddiqi A, Chen W, Bales E, Feng M, Johnson J, Lai (2017). Reversal of aberrant PI3K/Akt signaling by Salubrinal in a GalT-deficient mouse model. Biochimica et biophysica acta. Molecular basis of disease, 1863(12), 3286-3293.
- Yuzyuk T, Balakrishnan B, Schwarz EL, De Biase I, Hobert J, Longo N, Mao R, Lai K, Pasquali (2018). Effect of genotype on galactose-1-phosphate in classic galactosemia patients. Molecular genetics and metabolism, 125(3), 258-265.
- Frigeni M, Balakrishnan B, Yin X, Calderon FRO, Mao R, Pasquali M, Longo (2017). Functional and molecular studies in primary carnitine deficiency. Human mutation, 38(12), 1684-1699.
- Balakrishnan B, Chen W, Tang M, Huang X, Cakici DD, Siddiqi A, Berry G, Lai (2016). Galactose-1 phosphate uridylyltransferase (GalT) gene: A novel positive regulator of the PI3K/Akt signaling pathway in mouse fibroblasts. Biochemical and biophysical research communications, 470(1), 205-212.
- Chen W, Caston R, Balakrishnan B, Siddiqi A, Parmar K, Tang M, Feng M, Lai (2017). Assessment of ataxia phenotype in a new mouse model of galactose-1 phosphate uridylyltransferase (GALT) deficiency. Journal of inherited metabolic disease, 40(1), 131-137.
- Balakrishnan B, Chellappan S, Krishna JG, Basheer SM, Elyas KK, Bahkali AH, Chandrasekaran (2011). Protease inhibitor from Moringa oleifera with potential for use as therapeutic drug and as seafood preservative. Saudi journal of biological sciences, 18(3), 273-81.
Conference Proceedings
- Zhong M, Balakrishnan B, Guo AJ, Lai (2023). AAV9-based PMM2 gene replacement augments PMM2 expression and improves glycosylation in primary fibroblasts of patients with phosphomannomutase 2 deficiency (PMM2-CDG).