Brian D. Evavold

Brian D. Evavold, PhD

Languages spoken: English

Academic Information

Departments Primary - Pathology

Academic Office Information

brian.evavold@path.utah.edu

Lab

Research Statement

My research centers on how antigen recognition by T cells determines cell phenotype, fate, and outcome of the adaptive immune response. Understanding the mechanisms driving T cell activation provides novel insight into the basis of autoimmune disease and effective response to infections.

Education History

Undergraduate St. Olaf College
 BA
Doctoral Training University of Chicago
 PhD
Postdoctoral Fellowship Washington University
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Singh NK, Alonso JA, Harris DT, Anderson SD, Ma J, Hellman LM, Rosenberg AM, Kolawole EM, Evavold BD, Kranz DM, Baker B (2020). An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes. Biochemistry, 59(43), 4163-4175.
  2. Spear TT, Evavold BD, Baker BM, Nishimura M (2019). Understanding TCR affinity, antigen specificity, and cross-reactivity to improve TCR gene-modified T cells for cancer immunotherapy. Cancer immunology, immunotherapy, 68(11), 1881-1889.
  3. Bettini M, Scavuzzo MA, Liu B, Kolawole E, Guo L, Evavold BD, Borowiak M, Bettini M (2020). A Critical Insulin TCR Contact Residue Selects High-Affinity and Pathogenic Insulin-Specific T Cells. Diabetes, 69(3), 392-400.
  4. Liu B, Hood JD, Kolawole EM, Woodruff DM, Vignali DA, Bettini M, Evavold B (2020). A Hybrid Insulin Epitope Maintains High 2D Affinity for Diabetogenic T Cells in the Periphery. Diabetes, 69(3), 381-391.
  5. Kim H, Perovanovic J, Shakya A, Shen Z, German CN, Ibarra A, Jafek JL, Lin NP, Evavold BD, Chou DH, Jensen PE, He X, Tantin (2021). Targeting transcriptional coregulator OCA-B/Pou2af1 blocks activated autoreactive T cells in the pancreas and type 1 diabetes. The Journal of experimental medicine, 218(3),
  6. DiToro D, Winstead CJ, Pham D, Witte S, Andargachew R, Singer JR, Wilson CG, Zindl CL, Luther RJ, Silberger DJ, Weaver BT, Kolawole EM, Martinez RJ, Turner H, Hatton RD, Moon JJ, Way SS, Evavold BD, Weaver C (2018). Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells. Science (New York, N.Y.), 361(6407),
  7. Wu P, Zhang T, Liu B, Fei P, Cui L, Qin R, Zhu H, Yao D, Martinez RJ, Hu W, An C, Zhang Y, Liu J, Shi J, Fan J, Yin W, Sun J, Zhou C, Zeng X, Xu C, Wang J, Evavold BD, Zhu C, Chen W, Lou (2019). Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition. Molecular cell, 73(5), 1015-1027.e7.
  8. Hong J, Ge C, Jothikumar P, Yuan Z, Liu B, Bai K, Li K, Rittase W, Shinzawa M, Zhang Y, Palin A, Love P, Yu X, Salaita K, Evavold BD, Singer A, Zhu (2018). A TCR mechanotransduction signaling loop induces negative selection in the thymus. Nature immunology, 19(12), 1379-1390.
  9. Thomas AM, Beskid NM, Blanchfield JL, Rosado AM, García AJ, Evavold BD, Babensee J (2020). Localized hydrogel delivery of dendritic cells for attenuation of multiple sclerosis in a murine model. Journal of biomedical materials research. Part A, e37118.
  10. Kolawole EM, Lamb TJ, Evavold B (2020). Relationship of 2D Affinity to T Cell Functional Outcomes. International journal of molecular sciences, 21(21),
  11. Kolawole EM, Andargachew R, Liu B, Jacobs JR, Evavold B (2018). 2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes. Frontiers in immunology, 9, 2348.
  12. Shwetank, Frost EL, Mockus TE, Ren HM, Toprak M, Lauver MD, Netherby-Winslow CS, Jin G, Cosby JM, Evavold BD, Lukacher A (2019). PD-1 Dynamically Regulates Inflammation and Development of Brain-Resident Memory CD8 T Cells During Persistent Viral Encephalitis. Frontiers in immunology, 10, 783.
  13. Krummey SM, Morris AB, Jacobs JR, McGuire DJ, Ando S, Tong KP, Zhang W, Robertson J, Guasch SA, Araki K, Larsen CP, Evavold BD, Kissick HT, Ford M (2020). CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence. Cell reports, 30(5), 1282-1291.e5.
  14. Chow IT, Gates TJ, Papadopoulos GK, Moustakas AK, Kolawole EM, Notturno RJ, McGinty JW, Torres-Chinn N, James EA, Greenbaum C, Nepom GT, Evavold BD, Kwok W (2019). Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes. Science advances, 5(8), eaaw9336.
  15. Ren HM, Kolawole EM, Ren M, Jin G, Netherby-Winslow CS, Wade Q, Shwetank, Rahman ZSM, Evavold BD, Lukacher A (2020). IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection. Science immunology, 5(51),
  16. Zhao X, Kolawole EM, Chan W, Feng Y, Yang X, Gee MH, Jude KM, Sibener LV, Fordyce PM, Germain RN, Evavold BD, Garcia K (2022). Tuning T cell receptor sensitivity through catch bond engineering. Science (New York, N.Y.), 376(6589), eabl5282.
  17. Ma VP, Hu Y, Kellner AV, Brockman JM, Velusamy A, Blanchard AT, Evavold BD, Alon R, Salaita (2022). The magnitude of LFA-1/ICAM-1 forces fine-tune TCR-triggered T cell activation. Science advances, 8(8), eabg4485.
  18. Reed JS, Nayan R, Deckers M, Evavold BD, Lamb T (2024). Influenza-induced alveolar macrophages protect against death by malaria-associated acute lung injury. bioRxiv,
  19. Eggert J, Zinzow-Kramer WM, Hu Y, Kolawole EM, Tsai YL, Weiss A, Evavold BD, Salaita K, Scharer CD, Au-Yeung B (2024). Cbl-b mitigates the responsiveness of naive CD8(+) T cells that experience extensive tonic T cell receptor signaling. Science signaling, 17(822), eadh0439.
  20. Evavold B (2023). Force in Immunology: There Is Often a Catch. Journal of immunology (Baltimore, Md., 211(3), 307.
  21. Lo WL, Kuhlmann M, Rizzuto G, Ekiz HA, Kolawole EM, Revelo MP, Andargachew R, Li Z, Tsai YL, Marson A, Evavold BD, Zehn D, Weiss (2023). A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function. Nature immunology, 24(4), 676-689.
  22. Nguyen NX, Richens AW, Sircy LM, Allard DE, Kolawole EM, Evavold BD, Bettini M, Hale J (2023). Immunogen-Specific Strengths and Limitations of the Activation-Induced Marker Assay for Assessing Murine Antigen-Specific CD4+ T Cell Responses. Journal of immunology (Baltimore, Md., 210(7), 916-925.
  23. Jing Y, Kong Y, Allard D, Liu B, Kolawole E, Sprouse M, Evavold B, Bettini M, Bettini (2023). Increased TCR signaling in regulatory T cells is disengaged from TCR affinity. bioRxiv,
  24. Beskid NM, Kolawole EM, Coronel MM, Nguyen B, Evavold B, García AJ, Babensee J (2022). IL-10-Functionalized Hydrogels Support Immunosuppressive Dendritic Cell Phenotype and Function. ACS biomaterials science & engineering, 8(10), 4341-4353.
  25. Zinzow-Kramer WM, Kolawole EM, Eggert J, Evavold BD, Scharer CD, Au-Yeung B (2022). Strong Basal/Tonic TCR Signals Are Associated with Negative Regulation of Naive CD4(+) T Cells. ImmunoHorizons, 6(9), 671-683.
  26. Faust MA, Gibbs L, Oviedo JM, Cornwall DH, Fairfax KC, Zhou Z, Lamb TJ, Evavold B (2024). B Cells Influence Encephalitogenic T Cell Frequency to Myelin Oligodendrocyte Glycoprotein (MOG)38-49 during Full-length MOG Protein-Induced Demyelinating Disease. ImmunoHorizons, 8(9), 729-739.

Review

  1. Faust MA, Rasé VJ, Lamb TJ, Evavold B (2023). What's the Catch? The Significance of Catch Bonds in T Cell Activation. Journal of immunology (Baltimore, Md., 211(3), 333-342.

Letter

  1. Guo L, Jacob S, Manne BK, Kolawole EM, Guo S, Wang X, Murray D, Tugolukova EA, Portier I, Kosaka Y, Barba C, Rondina MT, Evavold B, Morley C, Bhatlekar S, Bray P (2024). Actin-bundling protein L-plastin promotes megakaryocyte rigidity and dampens proplatelet formation. Haematologica, 109(1), 331-336.