Christopher A. Reilly

Christopher A. Reilly, PhD

Languages spoken: English

Academic Information

Departments Primary - , Adjunct - Anesthesiology , Adjunct - Pediatrics

Divisions:

Academic Office Information

Chris.Reilly@pharm.utah.edu

Research Interests

  • Capsaicin
  • TRPV1
  • P450
  • Respiratory Toxicology
  • Reactive Intermediates
  • ROS
  • Mass Spectrometry

Dr. Reilly is a Professor in the Department of Pharmacology and Toxicology at the University of Utah. His research focuses on elucidating biochemical mechanisms by which xenobiotics interact with and affect, in beneficial and adverse ways, humans. Dr. Reilly’s research program focuses on: 1) the role of transient receptor potential (TRP) ion channels in environmental lung diseases such as asthma and COPD; 2) the role of cytochrome P450 enzymes in regulating the toxicity and therapeutic efficacy of xenobiotics; and 3) drug discovery, specifically focusing on TRP modulators to manage inflammation, pain, respiratory and other diseases. His teaching is mainly focused on pharmacological and toxicological mechanisms surrounding drug-drug interactions, treatment and causation of airway diseases, and basic immunology and pathology.

Education History

Postdoctoral Fellowship University of Utah College of Pharmacy, Department of Pharmacology and Toxicology
 Postdoctoral Fellow
Utah State University
 PhD
Undergraduate University of Utah
 BS
Undergraduate Stockton State College

Selected Publications

Journal Article

  1. Memon TA, Nguyen ND, Burrell KL, Scott AF, Almestica-Roberts M, Rapp E, Deering-Rice CE, Reilly CA (2021). Wood Smoke Particles Stimulate MUC5AC Overproduction by Human Bronchial Epithelial Cells Through TRPA1 and EGFR Signaling. Toxicol Sci, 174(2), 278-290.
  2. Zhu J, Tian K, Reilly CA, Qiu X (2019). Capsaicinoid metabolism by the generalist Helicoverpa armigera and specialist H. assulta: Species and tissue differences. Pestic Biochem Physiol, 163, 164-174.
  3. Mohammadpour R, Yazdimamaghani M, Reilly CA, Ghandehari H (2018). Transient Receptor Potential Ion Channel-Dependent Toxicity of Silica Nanoparticles and Poly(amido amine) Dendrimers. J Pharmacol Exp Ther, 370(3), 751-760.
  4. Lin Z, Kakule TB, Reilly CA, Beyhan S, Schmidt EW (2019). Secondary Metabolites of Onygenales Fungi Exemplified by Aioliomyces pyridodomos. J Nat Prod, 82(6), 1616-1626.
  5. Rower JE, Anderson DJ, Sherwin CM, Reilly CA, Ballard PL, McEvoy CT, Wilkins DG (2019). Development and validation of an assay for quantifying budesonide in dried blood spots collected from extremely low gestational age neonates. J Pharm Biomed Anal, 167, 7-14.
  6. Memon T, Yarishkin O, Reilly CA, Kriaj D, Olivera BM, Teichert RW (2019). trans-Anethole of Fennel Oil is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel. Mol Pharmacol, 95(4), 433-441.
  7. Scott AF, Reilly CA (2019). Wood and Biomass Smoke: Addressing Human Health Risks and Exposures. Chem Res Toxicol, 32(2), 219-221.
  8. Kaur K, Jaramillo IC, Mohammadpour R, Sturrock A, Ghandehari H, Reilly C, Paine R 3rd, Kelly KE (2019). Effect of collection methods on combustion particle physicochemical properties and their biological response in a human macrophage-like cell line. J Environ Sci Health A Tox Hazard Subst Environ Eng, 54(12), 1170-1185.
  9. Lin Z, Phadke S, Lu Z, Beyhan S, Abdel Aziz MH, Reilly C, Schmidt EW (2018). Onydecalins, Fungal Polyketides with Anti- Histoplasma and Anti-TRP Activity. J Nat Prod, 81(12), 2605-2611.
  10. Deering-Rice CE, Nguyen N, Lu Z, Cox JE, Shapiro D, Romero EG, Mitchell VK, Burrell KL, Veranth JM, Reilly CA (2018). Activation of TRPV3 by Wood Smoke Particles and Roles in Pneumotoxicity. Chem Res Toxicol, 31(5), 291-301.
  11. Jaramillo IC, Sturrock A, Ghiassi H, Woller DJ, Deering-Rice CE, Lighty JS, Paine R, Reilly C, Kelly KE (2017). Effects of fuel components and combustion particle physicochemical properties on toxicological responses of lung cells. J Environ Sci Health A Tox Hazard Subst Environ Eng, 53(4), 295-309.
  12. Lamb JG, Romero EG, Lu Z, Marcus SK, Peterson HC, Veranth JM, Deering-Rice CE, Reilly CA (2017). Activation of Human Transient Receptor Potential Melastatin-8 (TRPM8) by Calcium-Rich Particulate Materials and Effects on Human Lung Cells. Mol Pharmacol, 92(6), 653-664.
  13. Bevans T, Deering-Rice C, Stockmann C, Rower J, Sakata D, Reilly C (2017). Inhaled Remimazolam Potentiates Inhaled Remifentanil in Rodents. Anesth Analg, 124(5), 1484-1490.
  14. Deering-Rice CE, Stockmann C, Romero EG, Lu Z, Shapiro D, Stone BL, Fassl B, Nkoy F, Uchida DA, Ward RM, Veranth JM, Reilly CA (2016). Characterization of Transient Receptor Potential Vanilloid-1 (TRPV1) Variant Activation by Coal Fly Ash Particles and Associations with Altered Transient Receptor Potential Ankyrin-1 (TRPA1) Expression and Asthma. J Biol Chem, 291(48), 24866-24879.
  15. Bevans T, Deering-Rice C, Stockmann C, Light A, Reilly C, Sakata DJ (2016). Inhaled Remifentanil in Rodents. Anesth Analg, 122(6), 1831-8.
  16. Deering-Rice CE, Shapiro D, Romero EG, Stockmann C, Bevans TS, Phan QM, Stone BL, Fassl B, Nkoy F, Uchida DA, Ward RM, Veranth JM, Reilly CA (2015). Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma. Am J Respir Cell Mol Biol, 53(6), 893-901.
  17. Linakis MW, Stockmann C, Campbell SC, Williams RV, Burch PT, Lambert LM, Sherwin CM, Reilly CA, Spigarelli MG (2015). Quantitative Assay Validation for Oxandrolone in Human Plasma Using LC-MS-MS. J Anal Toxicol, 39(7), 526-31.
  18. Rose TM, Reilly CA, Deering-Rice CE, Brewster C, Brewster C (2014). Inhibition of FAAH, TRPV1, and COX2 by NSAID-serotonin conjugates. Bioorg Med Chem Lett, 24(24), 5695-5698.
  19. Deering-Rice CE, Mitchell VK, Romero EG, Abdel Aziz MH, Ryskamp DA, Kriaj D, Gopal VR, Reilly CA (2014). Drofenine: A 2-APB Analogue with Greater Selectivity for Human TRPV3. Pharmacol Res Perspect, 2(5), e00062.
  20. Lin Z, Koch M, Abdel Aziz MH, Galindo-Murillo R, Tianero MD, Cheatham TE, Barrows LR, Reilly CA, Schmidt EW (2014). Oxazinin A, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus. Org Lett, 16(18), 4774-7.
  21. Roberts JK, Moore CD, Romero EG, Ward RM, Yost GS, Reilly CA (2013). Regulation of CYP3A genes by glucocorticoids in human lung cells. F1000Res, 2, 173.
  22. Stockmann C, Fassl B, Gaedigk R, Nkoy F, Uchida DA, Monson S, Reilly CA, Leeder JS, Yost GS, Ward RM (2013). Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control. J Pediatr, 162(6), 1222-7, 1227.e1-2.
  23. Shapiro D, Deering-Rice CE, Romero EG, Hughen RW, Light AR, Veranth JM, Reilly CA (2013). Activation of transient receptor potential ankyrin-1 (TRPA1) in lung cells by wood smoke particulate material. Chem Res Toxicol, 26(5), 750-8.
  24. Roberts JK, Moore CD, Ward RM, Yost GS, Reilly CA (2013). Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes. J Pharmacol Exp Ther, 345(2), 308-16.
  25. Fariss MW, Gilmour MI, Reilly CA, Liedtke W, Ghio AJ (2013). Emerging mechanistic targets in lung injury induced by combustion-generated particles. Toxicol Sci, 132(2), 253-67.
  26. Moore CD, Roberts JK, Orton CR, Murai T, Fidler TP, Reilly CA, Ward RM, Yost GS (2013). Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos, 41(2), 379-89.
  27. Lin Z, Torres JP, Ammon MA, Marett L, Teichert RW, Reilly CA, Kwan JC, Hughen RW, Flores M, Tianero MD, Peraud O, Cox JE, Light AR, Villaraza AJ, Haygood MG, Concepcion GP, Olivera BM, Schmidt EW (2013). A bacterial source for mollusk pyrone polyketides. Chem Biol, 20(1), 73-81.
  28. Reilly CA, Henion F, Bugni TS, Ethirajan M, Stockmann C, Pramanik KC, Srivastava SK, Yost GS (2013). Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by p450 enzymes. Chem Res Toxicol, 26(1), 55-66.
  29. Deering-Rice CE, Johansen ME, Roberts JK, Thomas KC, Romero EG, Lee J, Yost GS, Veranth JM, Reilly CA (2012). Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material. Mol Pharmacol, 81(3), 411-9.
  30. Thomas KC, Roberts JK, Deering-Rice CE, Romero EG, Dull RO, Lee J, Yost GS, Reilly CA (2012). Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury. Am J Physiol Lung Cell Mol Physiol, 302(1), L111-9.
  31. Alex AB, Saunders GW, Dalp-Charron A, Reilly CA, Wilcox KS (2011). CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors. Neurotoxicology, 32(4), 392-9.
  32. Deering-Rice CE, Romero EG, Shapiro D, Hughen RW, Light AR, Yost GS, Veranth JM, Reilly CA (2011). Electrophilic components of diesel exhaust particles (DEP) activate transient receptor potential ankyrin-1 (TRPA1): a probable mechanism of acute pulmonary toxicity for DEP. Chem Res Toxicol, 24(6), 950-9.
  33. Lin Z, Reilly CA, Antemano R, Hughen RW, Marett L, Concepcion GP, Haygood MG, Olivera BM, Light A, Schmidt EW (2011). Nobilamides A-H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteria. J Med Chem, 54(11), 3746-55.
  34. Thomas KC, Ethirajan M, Shahrokh K, Sun H, Lee J, Cheatham TE 3rd, Yost GS, Reilly CA (2011). Structure-activity relationship of capsaicin analogs and transient receptor potential vanilloid 1-mediated human lung epithelial cell toxicity. J Pharmacol Exp Ther, 337(2), 400-10.
  35. Murai T, Reilly CA, Ward RM, Yost GS (2010). The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme. Chem Res Toxicol, 23(8), 1356-64.
  36. Moore CD, Reilly CA, Yost GS (2010). CYP3A4-Mediated oxygenation versus dehydrogenation of raloxifene. Biochemistry, 49(21), 4466-75.
  37. Sabnis AS, Shadid M, Yost GS, Reilly CA (2008). Human lung epithelial cells express a functional cold-sensing TRPM8 variant. Am J Respir Cell Mol Biol, 39(4), 466-74.
  38. Kartha JS, Skordos KW, Sun H, Hall C, Easterwood LM, Reilly CA, Johnson EF, Yost GS (2008). Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase. Biochemistry, 47(37), 9756-70.
  39. Sabnis AS, Reilly CA, Veranth JM, Yost GS (2008). Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures. Am J Physiol Lung Cell Mol Physiol, 295(1), L194-200.
  40. Veranth JM, Cutler NS, Kaser EG, Reilly CA, Yost GS (2008). Effects of cell type and culture media on Interleukin-6 secretion in response to environmental particles. Toxicol In Vitro, 22(2), 498-509.
  41. Sun H, Ehlhardt WJ, Kulanthaivel P, Lanza DL, Reilly CA, Yost GS (2007). Dehydrogenation of indoline by cytochrome P450 enzymes: a novel "aromatase" process. J Pharmacol Exp Ther, 322(2), 843-51.
  42. Thomas KC, Sabnis AS, Johansen ME, Lanza DL, Moos PJ, Yost GS, Reilly CA (2007). Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. J Pharmacol Exp Ther, 321(3), 830-8.
  43. Phillips JD, Bergonia HA, Reilly CA, Franklin MR, Kushner JP (2007). A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda. Proc Natl Acad Sci U S A, 104(12), 5079-84.
  44. Johansen ME, Reilly CA, Yost GS (2006). TRPV1 antagonists elevate cell surface populations of receptor protein and exacerbate TRPV1-mediated toxicities in human lung epithelial cells. Toxicol Sci, 89(1), 278-86.
  45. Pershing LK, Reilly CA, Corlett JL, Crouch DJ (2006). Assessment of pepper spray product potency in Asian and Caucasian forearm skin using transepidermal water loss, skin temperature and reflectance colorimetry. J Appl Toxicol, 26(1), 88-97.
  46. Reilly CA, Yost GS (2006). Metabolism of capsaicinoids by P450 enzymes: a review of recent findings on reaction mechanisms, bio-activation, and detoxification processes. Drug Metab Rev, 38(4), 685-706.
  47. Reilly CA, Yost GS (2005). Structural and enzymatic parameters that determine alkyl dehydrogenation/hydroxylation of capsaicinoids by cytochrome p450 enzymes. Drug Metab Dispos, 33(4), 530-6.
  48. Reilly CA, Johansen ME, Lanza DL, Lee J, Lim JO, Yost GS (2005). Calcium-dependent and independent mechanisms of capsaicin receptor (TRPV1)-mediated cytokine production and cell death in human bronchial epithelial cells. J Biochem Mol Toxicol, 19(4), 266-75.
  49. Veranth JM, Reilly CA, Veranth MM, Moss TA, Langelier CR, Lanza DL, Yost GS (2004). Inflammatory cytokines and cell death in BEAS-2B lung cells treated with soil dust, lipopolysaccharide, and surface-modified particles. Toxicol Sci, 82(1), 88-96.
  50. Pershing LK, Reilly CA, Corlett JL, Crouch DJ (2004). Effects of vehicle on the uptake and elimination kinetics of capsaicinoids in human skin in vivo. Toxicol Appl Pharmacol, 200(1), 73-81.
  51. Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG (2004). Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes. Drug Metab Dispos, 32(9), 1032-9.
  52. Simmonds AC, Ghanayem BI, Sharma A, Reilly CA, Millen B, Yost GS, Forkert PG (2004). Bioactivation of 1,1-dichloroethylene by CYP2E1 and CYP2F2 in murine lung. J Pharmacol Exp Ther, 310(3), 855-64.
  53. Reilly CA, Crouch DJ (2004). Analysis of the nutritional supplement 1AD, its metabolites, and related endogenous hormones in biological matrices using liquid chromatography-tandem mass spectrometry. J Anal Toxicol, 28(1), 1-10.
  54. Reilly CA, Taylor JL, Lanza DL, Carr BA, Crouch DJ, Yost GS (2003). Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors. Toxicol Sci, 73(1), 170-81.
  55. Reilly CA, Ehlhardt WJ, Jackson DA, Kulanthaivel P, Mutlib AE, Espina RJ, Moody DE, Crouch DJ, Yost GS (2003). Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol, 16(3), 336-49.
  56. Reilly CA, Crouch DJ, Yost GS, Fatah AA (2002). Determination of capsaicin, nonivamide, and dihydrocapsaicin in blood and tissue by liquid chromatography-tandem mass spectrometry. J Anal Toxicol, 26(6), 313-9.
  57. Welch KD, Reilly CA, Aust SD (2002). The role of cysteine residues in the oxidation of ferritin. Free Radic Biol Med, 33(3), 399-408.
  58. Reilly CA, Crouch DJ, Andranyak DA, Yost GS (2002). Detection of Pepper Spray Residues on Fabrics Using Liquid Chromatography-Mass Spectrometry. J Forensic Sci, 47, 37-43.
  59. Reilly CA, Crouch DJ, Yost GS (2001). Quantitative analysis of capsaicinoids in fresh peppers, oleoresin capsicum and pepper spray products. J Forensic Sci, 46(3), 502-9.
  60. Reilly CA, Crouc DJ, Yost GS, Fatah AA (2001). Determination of capsaicin, dihydrocapsaicin, and nonivamide in self-defense weapons by liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry. J Chromatogr A, 912(2), 259-67.
  61. Reilly CA, Sorlie M, Aust SD (1998). Evidence for a protein-protein complex during iron loading into ferritin by ceruloplasmin. Arch Biochem Biophys, 354(1), 165-71.
  62. Reilly CA, Aust SD (1997). Stimulation of the ferroxidase activity of ceruloplasmin during iron loading into ferritin. Arch Biochem Biophys, 347(2), 242-8.
  63. Reilly CA, Aust SD (1997). Peroxidase substrates stimulate the oxidation of hydralazine to metabolites which cause single-strand breaks in DNA. Chem Res Toxicol, 10(3), 328-34.

Book Chapter

  1. Reilly, CA (In Press). Cytochrome P450-Dependent Modification of Capsaicinoids: Pharmacological Inactivation and Bioactivation Mechanisms. In Srivastava, S.K. (Eds.), Role of Capsaicin in Oxidative Stress and Cancer. New York: Springer.
  2. Reilly, CA (2010). Neurogenic Inflammation: The Role of TRP Channels in the Lung. In McQueen, C.A. (Eds.), Comprehensive Toxicology (2nd, 8-Respiratory Toxicology, pp. 129-149). Oxford, UK: Elsevier.
  3. Reilly, CA, Yost, GS (2009). Sites of Extra Hepatic Metabolism, Part I: Lung. In Weinkers, L., Pearson, P (Eds.), Handbook of Drug Metabolism (2nd, Drugs and teh Pharmaceutical Sciences, Volume 186, pp. 243-272). Informa Healthcare.
  4. Reilly CA, Veranth JM, Veronesi B, Yost GS (2006). Vanilloid Receptors in Respiratory Tissues: Identification, Function, Significance, and Potential Involvement in Human Airway Disease. In Hayes, A.W., Thomas, J.A., Gardner, D. (Eds.), Toxicology of the Lung (4th, pp. 297-350). London: CRC Press, Taylor and Francis.
  5. Reilly CA, Aust SD (2001). Measurement of lipid peroxidation. In Curr Protoc Toxicol (Chapter 2, pp. Unit2.4). United States.
  6. Reilly CA, Aust SD (1999). Biological Oxidations Catalyzed by Iron Released from Ferritin. In Rhodes, C. (Eds.), Toxicology of the Human Environment: the critical role of free radicals (pp. 155-90). London: Taylor and Francis Press.

Letter

  1. Bevans-Warren TS, Clegg DO Jr, Sakata DJ, Reilly CA (2018). Remifentanil Stability. [Letter to the editor]. Anesth Analg, 127(3), e51-e52.
  2. Stockmann C, Reilly CA, Fassl B, Gaedigk R, Nkoy F, Stone B, Roberts JK, Uchida DA, Leeder JS, Sherwin CM, Spigarelli MG, Yost GS, Ward RM (2015). Effect of CYP3A5*3 on asthma control among children treated with inhaled beclomethasone. [Letter to the editor]. J Allergy Clin Immunol, 136(2), 505-7.
  3. Stockmann C, Ross JS, Sherwin CMT, Reilly CA, McDowell B, Fassl B, Nkoy F, Maloney CG, Spigarelli MG (2014). Rate of asthma trial outcomes reporting on ClinicalTrials.gov and in the published literature. [Letter to the editor]. J Allergy Clin Immunol, 134(6), 1443-1446.

Other

  1. Reilly CA (2003). The Science of Pepper Sprays. Law and Order Magazine (51(7), pp. 124-30).
  2. Reilly, CA (2003). The Science of pepper Sprays. Law and Order Magazine (51(7), pp. 124-130).