Clement Y. Chow

Clement Y. Chow, PhD

Languages spoken: English

Academic Information

Departments Primary - Human Genetics

Education History

Undergraduate Cornell University
 BA
Doctoral Training University of Michigan
 PhD
Postdoctoral Fellowship Cornell University
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Sirot LK, LaFlamme BA, Sitnik JL, Rubinstein CD, Avila FW, Chow CY, Wolfner MF (2009). Molecular social interactions: Drosophila melanogaster seminal fluid proteins as a case study. Adv Genet, 68, 23-56.
  2. Chow CY, Landers JE, Bergren SK, Sapp PC, Grant AE, Jones JM, Everett L, Lenk GM, McKenna-Yasek DM, Weisman LS, Figlewicz D, Brown RH, Meisler MH (2009). Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS. Am J Hum Genet, 84(1), 85-8.
  3. Zhang X, Chow CY, Sahenk Z, Shy ME, Meisler MH, Li J (2008). Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration. Brain, 131(Pt 8), 1990-2001.
  4. Chow CY, Kelsey KJ, Wolfner MF, Clark AG (2016). Candidate genetic modifiers of retinitis pigmentosa identified by exploiting natural variation in Drosophila. Hum Mol Genet, 25(4), 651-9.
  5. Owings KG, Lowry JB, Bi Y, Might M, Chow CY (2018). Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches. Hum Mol Genet, 27(6), 1055-1066.
  6. Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS (2008). VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J, 27(24), 3221-34.
  7. Chow CY, Wolfner MF, Clark AG (2010). The genetic basis for male x female interactions underlying variation in reproductive phenotypes of Drosophila. Genetics, 186(4), 1355-65.
  8. Chow CY, Wolfner MF, Clark AG (2013). Large neurological component to genetic differences underlying biased sperm use in Drosophila. Genetics, 193(1), 177-85.
  9. Lavoy S, Chittoor-Vinod VG, Chow CY, Martin I (2018). Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease. Genetics, 209(4), 1345-1356.
  10. Palu RAS, Dalton HM, Chow C (2020). Decoupling of Apoptosis from Activation of the ER Stress Response by the Drosophila Metallopeptidase superdeath. Genetics, 214(4), 913-925.
  11. Im KM, Kirchhoff T, Wang X, Green T, Chow CY, Vijai J, Korn J, Gaudet MM, Fredericksen Z, Shane Pankratz V, Guiducci C, Crenshaw A, McGuffog L, Kartsonaki C, Morrison J, Healey S, Sinilnikova OM, Mai PL, Greene MH, Piedmonte M, Rubinstein WS, Hogervorst FB, Rookus MA, Collee JM, Hoogerbrugge N, van Asperen CJ, Meijers-Heijboer HE, Van Roozendaal CE, Caldes T, Perez-Segura P, Jakubowska A, Lubinski J, Huzarski T, Blecharz P, Nevanlinna H, Aittomaki K, Lazaro C, Blanco I, Barkardottir RB, Montagna M, D'Andrea E, Devilee P, Olopade OI, Neuhausen SL, Peissel B, Bonanni B, Peterlongo P, Singer CF, Rennert G, Lejbkowicz F, Andrulis IL, Glendon G, Ozcelik H, Toland AE, Caligo MA, Beattie MS, Chan S, Domchek SM, Nathanson KL, Rebbeck TR, Phelan C, Narod S, John EM, Hopper JL, Buys SS, Daly MB, Southey MC, Terry MB, Tung N, Hansen TV, Osorio A, Benitez J, Duran M, Weitzel JN, Garber J, Hamann U, Peock S, Cook M, Oliver CT, Frost D, Platte R, Evans DG, Eeles R, Izatt L, Paterson J, Brewer C, Hodgson S, Morrison PJ, Porteous M, Walker L, Rogers MT, Side LE, Godwin AK, Schmutzler RK, Wappenschmidt B, Laitman Y, Meindl A, Deissler H, Varon-Mateeva R, Preisler-Adams S, Kast K, Venat-Bouvet L, Stoppa-Lyonnet D, Chenevix-Trench G, Easton DF, Klein RJ, Daly MJ, Friedman E, Dean M, Clark AG, Altshuler DM, Antoniou AC, Couch FJ, Offit K, Gold (2011). Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers. Human genetics, 130(5), 685-99.
  12. Delbare SYN, Chow CY, Wolfner MF, Clark A (2017). Roles of Female and Male Genotype in Post-Mating Responses in Drosophila melanogaster. The Journal of heredity, 108(7), 740-753.
  13. Chow CY, Zhang Y, Dowling JJ, Jin N, Adamska M, Shiga K, Szigeti K, Shy ME, Li J, Zhang X, Lupski JR, Weisman LS, Meisler M (2007). Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature, 448(7149), 68-72.
  14. Zhang Y, Zolov SN, Chow CY, Slutsky SG, Richardson SC, Piper RC, Yang B, Nau JJ, Westrick RJ, Morrison SJ, Meisler MH, Weisman L (2007). Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proceedings of the National Academy of Sciences of the United States of America, 104(44), 17518-23.
  15. Chow CY, Wolfner MF, Clark A (2013). Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes. Proceedings of the National Academy of Sciences of the United States of America, 110(22), 9013-8.
  16. Chow C (2016). Bringing genetic background into focus. Nature reviews. Genetics, 17(2), 63-4.
  17. McKinney BC, Chow CY, Meisler MH, Murphy G (2008). Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6). Genes, brain, and behavior, 7(6), 629-38.
  18. Lenk GM, Ferguson CJ, Chow CY, Jin N, Jones JM, Grant AE, Zolov SN, Winters JJ, Giger RJ, Dowling JJ, Weisman LS, Meisler M (2011). Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J. PLoS genetics, 7(6), e1002104.
  19. Chow CY, Wang X, Riccardi D, Wolfner MF, Clark A (2015). The genetic architecture of the genome-wide transcriptional response to ER stress in the mouse. PLoS genetics, 11(2), e1004924.
  20. Palu RAS, Chow C (2018). Baldspot/ELOVL6 is a conserved modifier of disease and the ER stress response. PLoS genetics, 14(8), e1007557.
  21. Chow CY, Avila FW, Clark AG, Wolfner M (2015). Induction of excessive endoplasmic reticulum stress in the Drosophila male accessory gland results in infertility. PloS one, 10(3), e0119386.
  22. Palu RAS, Ong E, Stevens K, Chung S, Owings KG, Goodman AG, Chow C (2019). Natural Genetic Variation Screen in Drosophila Identifies Wnt Signaling, Mitochondrial Metabolism, and Redox Homeostasis Genes as Modifiers of Apoptosis. G3 (Bethesda, Md.), 9(12), 3995-4005.
  23. Ahlers LRH, Trammell CE, Carrell GF, Mackinnon S, Torrevillas BK, Chow CY, Luckhart S, Goodman A (2019). Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors. Cell reports, 29(7), 1946-1960.e5.
  24. Thorpe HJ, Owings KG, Aziz MC, Haller M, Coelho E, Chow C (2024). Drosophila models of phosphatidylinositol glycan biosynthesis class A congenital disorder of glycosylation (PIGA-CDG) mirror patient phenotypes. G3 (Bethesda, Md.), 14(3),
  25. Owings KG, Chow C (2024). A Drosophila screen identifies a role for histone methylation in ER stress preconditioning. G3 (Bethesda, Md.), 14(2),
  26. Johnstone EB, Gorsi B, Coelho E, Moore B, Farr AM, Cooper AR, Mardis ER, Rajkovic A, Chow CY, Yandell M, Welt C (2023). DIS3 Variants are Associated With Primary Ovarian Insufficiency: Importance of Transcription/Translation in Oogenesis. The Journal of clinical endocrinology and metabolism, 108(9), 2330-2335.
  27. Dalton HM, Viswanatha R, Brathwaite R Jr, Zuno JS, Berman AR, Rushforth R, Mohr SE, Perrimon N, Chow C (2022). A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. PLoS genetics, 18(9), e1010430.
  28. Russell ND, Jorde LB, Chow C (2023). Characterizing genetic variation in the regulation of the ER stress response through computational and cis-eQTL analyses. G3 (Bethesda, Md.), 13(12),
  29. Hope KA, Berman AR, Peterson RT, Chow C (2022). An in vivo drug repurposing screen and transcriptional analyses reveals the serotonin pathway and GSK3 as major therapeutic targets for NGLY1 deficiency. PLoS genetics, 18(6), e1010228.
  30. Russell ND, Chow C (2022). The dynamic effect of genetic variation on the in vivo ER stress transcriptional response in different tissues. G3 (Bethesda, Md.), 12(6),
  31. Gorsi B, Hernandez E, Moore MB, Moriwaki M, Chow CY, Coelho E, Taylor E, Lu C, Walker A, Touraine P, Nelson LM, Cooper AR, Mardis ER, Rajkovic A, Yandell M, Welt C (2022). Causal and Candidate Gene Variants in a Large Cohort of Women With Primary Ovarian Insufficiency. The Journal of clinical endocrinology and metabolism, 107(3), 685-714.
  32. Talsness DM, Owings KG, Coelho E, Mercenne G, Pleinis JM, Partha R, Hope KA, Zuberi AR, Clark NL, Lutz CM, Rodan AR, Chow C (2020). A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency. eLife, 9,
  33. Thorpe HJ, Partha R, Little J, Clark NL, Chow C (2024). Evolutionary rate covariation is pervasive between glycosylation pathways and points to potential disease modifiers. PLoS genetics, 20(9), e1011406.
  34. Thorpe HJ, Pedersen BS, Dietze M, Link N, Quinlan AR, Bonkowsky JL, Thomas A, Chow C (2025). Identification of CNTN2 as a genetic modifier of PIGA-CDG in a family with incomplete penetrance and in Drosophila. American journal of human genetics,
  35. Dalton HM, Young NJ, Berman AR, Evans HD, Peterson SJ, Patterson KA, Chow C (2024). A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential therapeutics for the rare disease DPAGT1-CDG. PLoS genetics, 20(10), e1011458.
  36. Malone Jenkins S, Palmquist RN, Moore B, Boyden SE, Nicholas TJ, Bayrak-Toydemir P, Mao R, Farrell JAR, Holt CH, Rynearson SG, Solorzano CM, Ward A, Best DH, Al-Sweel N, Bentley DL, Brunelli L, Chow CY, Close DW, Cormier MJ, Deshotel MJ, Durtschi J, Eide EJ, Floyd L, Fredrickson EK, Fulmer ML, Hernandez EJ, Kapron AL, Karren MA, Lewis RG, Miller CE, Murtaugh LC, Nicholson KE, Noble K, O'Fallon BD, O'Shea JM, Pattison DC, Pedersen BS, Petersen BJ, Peterson BD, Pizzo L, Reynolds HM, Rindler P, Torr CB, Wen T, Yost HJ, Zhao J, Yandell M, Marth GT, Quinlan AR, Carey JC, Shayota BJ, Tristani-Firouzi M, Bonkowsky J (2025). The Utah NeoSeq Project: a collaborative multidisciplinary program to facilitate genomic diagnostics in the neonatal intensive care unit. NPJ genomic medicine, 10(1), 26.

Review

  1. Chow CY, Reiter L (2017). Etiology of Human Genetic Disease on the Fly. Trends in genetics, 33(6), 391-398.