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Colin K. Grissom, MD

Languages spoken: English

Academic Information

Departments Primary - Internal Medicine

Divisions: Public Health

Board Certification

  • American Board of Internal Medicine (Sub: Critical Care Medicine)
  • American Board of Internal Medicine (Sub: Pulmonary Disease)
  • National Board of Echocardiography (Special Competence in Adult Echocardiography)
  • National Board of Echocardiography (Critical Care Echocardiography)

Colin K. Grissom, MD, is the Co-Medical Director of the Shock Trauma Intensive Care Unit and Director of Critical Care Echocardiography at Intermountain Medical Center. Dr. Grissom supervises critical care fellows, internal medicine residents, emergency medicine residents, and transitional interns in the care of critically ill medical and surgical patients. Dr. Grissom was the leader in bringing critical care ultrasound and echocardiography to the bedside in this multidisciplinary 24-bed intensive care unit. He was the recipient of a University of Utah Department of Medicine Teaching Award in 2006.

Research Statement

Colin K. Grissom, MD, is a clinical researcher with over 100 publications listed in PubMed. His primary areas of interest are clinical research on mechanical ventilation, the acute respiratory distress syndrome, sepsis, and applications of echocardiography and ultrasound to critically ill patients. He is the Principal Investigator for the Utah Center of the NIH/NHLBI Preventiona and Early Treatment of Acute Lung Injury (PETAL) clinical trials network. Other research intersts include high altitude illness, avalanche victim physiology, and hypothermia.

Education History

Undergraduate Yale University
 BA
Professional Medical Yale University School of Medicine
 MD
Residency University of Washington
 Resident
Fellowship University of Utah Hospital
 Fellow
Fellowship University of Utah School of Medicine, Department of Anesthesiology and Cardiology
 Fellow

Selected Publications

Journal Article

  1. Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz H, Kosaka Y, Manne BK, Krauel K, Tolley ND, Eustes AS, Guo L, Paine R 3rd, Harris ES, Zimmerman GA, Weyrich AS, Rondina M (2019). Sepsis alters the transcriptional and translational landscape of human and murine platelets. Blood, 134(12), 911-923.
  2. Brown SM, Beesley SJ, Stubben C, Wilson EL, Presson AP, Grissom C, Maguire C, Rondina MT, Hopkins R (2021). Postseptic Cognitive Impairment and Expression of APOE in Peripheral Blood: The Cognition After SepsiS (CASS) Observational Pilot Study. Journal of intensive care medicine, 36(3), 262-270.
  3. Carlton EF, Ice E, Barbaro RP, Kampuis L, Moss M, Angus DC, Banner-Goodspeed VM, Ginde AA, Gong MN, Grissom CK, Hou PC, Huang DT, Hough CTL, Talmor DS, Thompson BT, Yealy DM, Couper MP, Iwashyna TJ, NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Network (2021). Recall of clinical trial participation and attrition rates in survivors of acute respiratory distress syndrome. Journal of critical care, 64, 160-164.
  4. Allen L, Knighton AJ, Wolfe D, Belnap T, Brunisholz KD, Carmichael H, Allen T, Peltan I, Grissom C, Srivastava (2020). Implementing Evidence-Based Clinical Practice in the Critical Care Setting. Quality management in health care, 29(2), 123-125.
  5. Allen L, Knighton AJ, Brunisholz KD, Wolfe D, Kean J, Belnap TW, Grissom C, Srivastava (2020). Increasing Adherence to Evidence-Based Care Using Root Cause Analysis. Quality management in health care, 29(4), 282-284.
  6. Lanspa MJ, Cirulis MM, Wiley BM, Olsen TD, Wilson EL, Beesley SJ, Brown SM, Hirshberg EL, Grissom C (2021). Right Ventricular Dysfunction in Early Sepsis and Septic Shock. Chest, 159(3), 1055-1063.
  7. Beesley SJ, Sorensen J, Walkey AJ, Tonna JE, Lanspa MJ, Hirshberg E, Grissom CK, Horne BD, Burk R, Abraham TP, Paine R, Brown S (2021). Long-Term Implications of Abnormal Left Ventricular Strain During Sepsis. Critical care medicine, 49(4), e444-e453.
  8. Blagev DP, Harris D, Dunn AC, Guidry DW, Grissom CK, Lanspa M (2019). Clinical presentation, treatment, and short-term outcomes of lung injury associated with e-cigarettes or vaping: a prospective observational cohort study. Lancet (London, England), 394(10214), 2073-2083.
  9. National Heart, Lung, and Blood Institute PETAL Clinical Trials Network., Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus D (2019). Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome. The New England journal of medicine, 380(21), 1997-2008.
  10. McIntosh SE, Little CE, Seibert TD, Polukoff NE, Grissom C (2020). Avalanche airbag post-burial active deflation - The ability to create an air pocket to delay asphyxiation and prolong survival. Resuscitation, 146, 155-160.
  11. Morris AH, Stagg B, Lanspa M, Orme J, Clemmer TP, Weaver LK, Thomas F, Grissom CK, Hirshberg E, East TD, Wallace CJ, Young MP, Sittig DF, Pesenti A, Bombino M, Beck E, Sward KA, Weir C, Phansalkar SS, Bernard GR, Taylor Thompson B, Brower R, Truwit JD, Steingrub J, Duncan Hite R, Willson DF, Zimmerman JJ, Nadkarni VM, Randolph A, Curley MAQ, Newth CJL, Lacroix J, Agus MSD, Lee KH, deBoisblanc BP, Scott Evans R, Sorenson DK, Wong A, Boland MV, Grainger DW, Dere WH, Crandall AS, Facelli JC, Huff SM, Haug PJ, Pielmeier U, Rees SE, Karbing DS, Andreassen S, Fan E, Goldring RM, Berger KI, Oppenheimer BW, Wesley Ely E, Gajic O, Pickering B, Schoenfeld DA, Tocino I, Gonnering RS, Pronovost PJ, Savitz LA, Dreyfuss D, Slutsky AS, Crapo JD, Angus D, Pinsky MR, James B, Berwick (2021). Enabling a learning healthcare system with automated computer protocols that produce replicable and personalized clinician actions. Journal of the American Medical Informatics Association, 28(6), 1330-1344.
  12. Mor-Cohen R, Zucker M, Grissom C, Brown SM, Seligsohn U, Campbell RA, Blair AM, Rondina M (2019). The reduced form of coagulation factor XI is associated with illness severity and coagulopathy in critically-ill septic patients. Journal of thrombosis and thrombolysis, 47(2), 186-191.
  13. Morales-Ortíz J, Rondina MT, Brown SM, Grissom C, Washington A (2018). High Levels of Soluble Triggering Receptor Expressed on Myeloid Cells-Like Transcript (TLT)-1 Are Associated With Acute Respiratory Distress Syndrome. Clinical and applied thrombosis/hemostasis, 24(7), 1122-1127.
  14. McIntosh SE, Brant-Zawadzki G, Milliner BH, Christensen ED, Nyberg AA, Grissom CK, Olivares CR, Kim HS, Tremper (2019). Cause of Death in Utah Avalanche Fatalities, 2006-2007 through 2017-2018 Winter Seasons. Wilderness & environmental medicine, 30(2), 191-194.
  15. Luks AM, Auerbach PS, Freer L, Grissom CK, Keyes LE, McIntosh SE, Rodway GW, Schoene RB, Zafren K, Hackett P (2019). Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Acute Altitude Illness: 2019 Update. Wilderness & environmental medicine, 30(4S), S3-S18.
  16. Dow J, Giesbrecht GG, Danzl DF, Brugger H, Sagalyn EB, Walpoth B, Auerbach PS, McIntosh SE, Némethy M, McDevitt M, Schoene RB, Rodway GW, Hackett PH, Zafren K, Bennett BL, Grissom C (2019). Wilderness Medical Society Clinical Practice Guidelines for the Out-of-Hospital Evaluation and Treatment of Accidental Hypothermia: 2019 Update. Wilderness & environmental medicine, 30(4S), S47-S69.
  17. McIntosh SE, Freer L, Grissom CK, Auerbach PS, Rodway GW, Cochran A, Giesbrecht GG, McDevitt M, Imray CH, Johnson EL, Pandey P, Dow J, Hackett P (2019). Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Frostbite: 2019 Update. Wilderness & environmental medicine, 30(4S), S19-S32.
  18. Lipman GS, Gaudio FG, Eifling KP, Ellis MA, Otten EM, Grissom C (2019). Wilderness Medical Society Clinical Practice Guidelines for the Prevention and Treatment of Heat Illness: 2019 Update. Wilderness & environmental medicine, 30(4S), S33-S46.
  19. Lanspa MJ, Peltan ID, Jacobs JR, Sorensen JS, Carpenter L, Ferraro JP, Brown SM, Berry JG, Srivastava R, Grissom C (2019). Driving pressure is not associated with mortality in mechanically ventilated patients without ARDS. Critical care (London, England), 23(1), 424.
  20. Luks AM, Freer L, Grissom CK, McIntosh SE, Schoene RB, Swenson ER, Hackett P (2020). COVID-19 Lung Injury is Not High Altitude Pulmonary Edema. High altitude medicine & biology, 21(2), 192-193.
  21. Luks AM, Grissom C, Freer L, Hackett (2016). Medication Use Among Mount Everest Climbers: Practice and Attitudes. High altitude medicine & biology, 17(4), 315-322.
  22. Luks AM, Grissom C (2021). Return to High Altitude After Recovery from Coronavirus Disease 2019. High altitude medicine & biology, 22(2), 119-127.
  23. Brown SM, Peltan ID, Webb B, Kumar N, Starr N, Grissom C, Buckel WR, Srivastava R, Harris ES, Leither LM, Johnson SA, Paine R 3rd, Greene (2020). Hydroxychloroquine versus Azithromycin for Hospitalized Patients with Suspected or Confirmed COVID-19 (HAHPS). Protocol for a Pragmatic, Open-Label, Active Comparator Trial. Annals of the American Thoracic Society, 17(8), 1008-1015.
  24. Brown SM, Peltan I, Kumar N, Leither L, Webb BJ, Starr N, Grissom CK, Buckel WR, Srivastava R, Butler AM, Groat D, Haaland B, Ying J, Harris E, Johnson S, Paine R 3rd, Greene (2020). Hydroxychloroquine vs. Azithromycin for Hospitalized Patients with COVID-19 (HAHPS): Results of a Randomized, Active Comparator Trial. Annals of the American Thoracic Society,
  25. Cirulis MM, Beesley SJ, Wilson EL, Stubben C, Olsen TD, Hirshberg EL, Smith LM, Lanspa MJ, Abraham TP, Grissom CK, Rondina MT, Brown S (2019). The peripheral blood transcriptome in septic cardiomyopathy: an observational, pilot study. Intensive care medicine experimental, 7(1), 57.
  26. Beesley SJ, Egan E, Lanspa MJ, Wilson EL, Hirshberg EL, Grissom CK, Burk R, Brown S (2020). Unanticipated critical findings on echocardiography in septic patients. The ultrasound journal, 12(1), 12.
  27. Knighton AJ, Kean J, Wolfe D, Allen L, Jacobs J, Carpenter L, Winberg C, Berry JG, Peltan ID, Grissom CK, Srivastava (2020). Multi-factorial barriers and facilitators to high adherence to lung-protective ventilation using a computerized protocol: a mixed methods study. Implementation science communications, 1(1), 67.
  28. Knighton AJ, Kuttler KG, Ranade-Kharkar P, Allen L, Throne T, Jacobs JR, Carpenter L, Winberg C, Johnson K, Shrestha N, Ferraro JP, Wolfe D, Peltan ID, Srivastava R, Grissom C (2022). An alert tool to promote lung protective ventilation for possible acute respiratory distress syndrome. JAMIA open, 5(2), ooac050.
  29. Tonna JE, Peltan ID, Brown SM, Grissom CK, Presson AP, Herrick JS, Vasques F, Keenan H (2021). Positive End-Expiratory Pressure and Respiratory Rate Modify the Association of Mechanical Power and Driving Pressure With Mortality Among Patients With Acute Respiratory Distress Syndrome. Critical care explorations, 3(12), e0583.
  30. National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network, Shapiro NI, Douglas IS, Brower RG, Brown SM, Exline MC, Ginde AA, Gong MN, Grissom CK, Hayden D, Hough CL, Huang W, Iwashyna TJ, Jones AE, Khan A, Lai P, Liu KD, Miller CD, Oldmixon K, Park PK, Rice TW, Ringwood N, Semler MW, Steingrub JS, Talmor D, Thompson BT, Yealy DM, Self W (2023). Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. The New England journal of medicine, 388(6), 499-510.
  31. Morris AH, Horvat C, Stagg B, Grainger DW, Lanspa M, Orme J, Clemmer TP, Weaver LK, Thomas FO, Grissom CK, Hirshberg E, East TD, Wallace CJ, Young MP, Sittig DF, Suchyta M, Pearl JE, Pesenti A, Bombino M, Beck E, Sward KA, Weir C, Phansalkar S, Bernard GR, Thompson BT, Brower R, Truwit J, Steingrub J, Hiten RD, Willson DF, Zimmerman JJ, Nadkarni V, Randolph AG, Curley MAQ, Newth CJL, Lacroix J, Agus MSD, Lee KH, deBoisblanc BP, Moore FA, Evans RS, Sorenson DK, Wong A, Boland MV, Dere WH, Crandall A, Facelli J, Huff SM, Haug PJ, Pielmeier U, Rees SE, Karbing DS, Andreassen S, Fan E, Goldring RM, Berger KI, Oppenheimer BW, Ely EW, Pickering BW, Schoenfeld DA, Tocino I, Gonnering RS, Pronovost PJ, Savitz LA, Dreyfuss D, Slutsky AS, Crapo JD, Pinsky MR, James B, Berwick D (2022). Computer clinical decision support that automates personalized clinical care: a challenging but needed healthcare delivery strategy. Journal of the American Medical Informatics Association, 30(1), 178-194.
  32. Campbell RA, Manne BK, Banerjee M, Middleton EA, Ajanel A, Schwertz H, Denorme F, Stubben C, Montenont E, Saperstein S, Page L, Tolley ND, Lim DL, Brown SM, Grissom CK, Sborov DW, Krishnan A, Rondina M (2022). IFITM3 regulates fibrinogen endocytosis and platelet reactivity in nonviral sepsis. The Journal of clinical investigation, 132(23),
  33. Peltan ID, Knighton AJ, Barney BJ, Wolfe D, Jacobs JR, Klippel C, Allen L, Lanspa MJ, Leither LM, Brown SM, Srivastava R, Grissom C (2022). Delivery of Lung Protective Ventilation for Acute Respiratory Distress Syndrome: A Hybrid Implementation-Effectiveness Trial. Annals of the American Thoracic Society,
  34. Grissom CK, Lanspa MJ, Groat D, Jacobs JR, Carpenter L, Kuttler KG, Leither L, Peltan ID, Brown SM, Srivastava (2023). Implementation of Lung-Protective Ventilation in Patients With Acute Respiratory Failure. Critical care medicine, 51(6), 797-807.
  35. Graham JD, Grissom C (2023). From Pac-Man to UltraMan. Critical care medicine, 51(3), 415-418.
  36. Olsen GH, Gee PM, Wolfe D, Winberg C, Carpenter L, Jones C, Jacobs JR, Leither L, Peltan ID, Singer SJ, Asch SM, Grissom CK, Srivastava R, Knighton A (2023). Awakening and breathing coordination: A mixed-methods analysis of determinants of implementation. Annals of the American Thoracic Society,

Letter

  1. Lanspa MJ, Olsen TD, Wilson EL, Beesley SM, Brown SM, Hirshberg EL, Grissom CK, Cirulis MM, Wiley B (2021). Response. Chest, 159(4), 1685-1686.
  2. Hirshberg EL, Lanspa MJ, Brown SM, Dean NC, Grissom C (2019). The authors reply. Critical care medicine, 47(8), e724-e726.
  3. McIntosh SE, Little CE, Seibert TD, Polukoff NE, Grissom C (2020). Reply to: Reconsidering the air pocket around mouth and nose as a positive outcome predictor in completely buried avalanche victims. Resuscitation, 152, 210-211.
  4. Brillhart A, McIntosh S, Dow J, Grissom (2016). In response to Epidemiology of Search and Rescue in Baxter State Park: Dangers of Descent and Fatigue. Wilderness & environmental medicine, 27(2), 344-5.
  5. McIntosh SE, Hemphill M, McDevitt MC, Gurung TY, Ghale M, Knott JR, Thapa GB, Basnyat B, Dow J, Weber DC, Grissom C (2019). In Reply to Dr Bennett. Wilderness & environmental medicine, 30(3), 334-335.
  6. Lanspa MJ, Cirulis MM, Wiley BM, Olsen TD, Wilson EL, Beesley SM, Brown SM, Hirshberg EL, Grissom C (2021). Response. Chest, 160(3), e319-e320.

Other

  1. Horne BD, Bledsoe JR, Muhlestein JB, May HT, Peltan ID, Webb BJ, Carlquist JF, Bennett ST, Rea S, Bair TL, Grissom CK, Knight S, Ronnow BS, Le VT, Stenehjem E, Woller SC, Knowlton KU, Anderson J (2022). Association of the Intermountain Risk Score with major adverse health events in patients positive for COVID-19: an observational evaluation of a US cohort. BMJ open, 12(3), e053864.