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Daisuke Shimura

Daisuke Shimura, PhD

Languages spoken: English

Academic Information

Departments Primary - Surgery

Divisions: Cardiothoracic Surgery

Academic Office Information

Education History

Postdoctoral Fellowship University of Utah
Postdoctoral Fellow
Cedars-Sinai Medical Center
Postdoctoral Fellow
Graduate Training Waseda University
Waseda University
Undergraduate Waseda University

Selected Publications

Journal Article

  1. Shimura D, Hunter J, Katsumata M, Shaw RM (2022). Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein. J Vis Exp, (181).
  2. Shimura D, Nuebel E, Baum R, Valdez SE, Xiao S, Warren JS, Palatinus JA, Hong T, Rutter J, Shaw RM (2021). Protective mitochondrial fission induced by stress-responsive protein GJA1-20k. Elife, 10.
  3. Xiao S, Shimura D, Baum R, Hernandez DM, Agvanian S, Nagaoka Y, Katsumata M, Lampe PD, Kleber AG, Hong T, Shaw RM (2019). Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias. J Clin Invest, 130(9), 4858-4870.
  4. Sjoqvist S, Kasai Y, Shimura D, Ishikawa T, Ali N, Iwata T, Kanai N (2019). Oral keratinocyte-derived exosomes regulate proliferation of fibroblasts and epithelial cells. Biochem Biophys Res Commun, 514(3), 706-712.
  5. Nakai G, Shimura D, Uesugi K, Kajimura I, Jiao Q, Kusakari Y, Soga T, Goda N, Minamisawa S (2018). Pyruvate dehydrogenase activation precedes the down-regulation of fatty acid oxidation in monocrotaline-induced myocardial toxicity in mice. Heart Vessels, 34(3), 545-555.
  6. Sjqvist S, Ishikawa T, Shimura D, Kasai Y, Imafuku A, Bou-Ghannam S, Iwata T, Kanai N (2019). Exosomes derived from clinical-grade oral mucosal epithelial cell sheets promote wound healing. J Extracell Vesicles, 8(1), 1565264.
  7. Basheer WA, Fu Y, Shimura D, Xiao S, Agvanian S, Hernandez DM, Hitzeman TC, Hong T, Shaw RM (2018). Stress response protein GJA1-20k promotes mitochondrial biogenesis, metabolic quiescence, and cardioprotection against ischemia/reperfusion injury. JCI Insight, 3(20).
  8. L P, Jiao Q, Shimura D, Kusakari Y, Liu F, Minamisawa S (2018). Distinct Vascular Remodeling Pattern of Adult Rats with Carotid-Jugular Shunt. Ann Vasc Surg, 49, 168-178.
  9. Kusakari Y, Urashima T, Shimura D, Amemiya E, Miyasaka G, Yokota S, Fujimoto Y, Akaike T, Inoue T, Minamisawa S (2017). Impairment of Excitation-Contraction Coupling in Right Ventricular Hypertrophied Muscle with Fibrosis Induced by Pulmonary Artery Banding. PLoS One, 12(1), e0169564.
  10. Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I, Akaike T, Kusakari Y, Fujiwara M, Ogawa K, Goda N, Ida H, Minamisawa S (2016). Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats. PLoS One, 11(2), e0148666.
  11. Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, Jin M, Yokota T, Ishikawa Y, Nakano A, Goda N, Minamisawa S (2015). Heterozygous deletion of sarcolipin maintains normal cardiac function. Am J Physiol Heart Circ Physiol, 310(1), H92-103.
  12. Shimura D, Nakai G, Jiao Q, Osanai K, Kashikura K, Endo K, Soga T, Goda N, Minamisawa S (2013). Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart. Am J Physiol Heart Circ Physiol, 305(4), H494-505.


  1. Shimura D, Shaw RM (2022). GJA1-20k and Mitochondrial Dynamics. [Review]. Front Physiol, 13, 867358.
  2. Shimura D, Nakano A, Minamisawa S (2016). Sarcolipin in atrium-specific gene targeting. [Review]. Cardiovasc Regen Med, 3, e1297.