Derek J. Dosdall

Derek J. Dosdall, PhD

Languages spoken: Spanish, English

Academic Information

Departments Primary - Surgery , Adjunct - Internal Medicine

Divisions: Cardiovascular Medicine , Cardiothoracic Surgery

Derek J. Dosdall, PhD, is an associate professor at the University of Utah in the Depatment of Surgery, Division of Cardiothoracic Surgery. He has adjunct appointments in the Department of Bioengineering and the Deparmtment of Internal Medicine, Division of Cardiovascular Medicine. He received his PhD in Bioengineering from Arizona State University and did postdoctoral training at the University of Alabama at Birmingham.

His research interests are focused on mapping of cardiac arrhythmias. He has developed chronic animal models of atrial fibrillation to investigate the substrate and conduction changes that occur in the cardiac tissue over time. He is working to determine the role of fibrosis in conduction disturbances and the development of atrial fibrillation. He is also studying the role of the specialized conduction system in the ventricles and the onset and maintenance of dangerous cardiac arrhythmias.

Education History

Undergraduate Brigham Young University
 BS
Graduate Training Arizona State University
 MS
Doctoral Training Arizona State University
 PhD
Postdoctoral Training University of Alabama at Birmingham
 Postdoctoral Training

Selected Publications

Journal Article

  1. Khan MS, Yamashita K, Sharma V, Ranjan R, Selzman CH, Dosdall D (2020). Perioperative Biomarkers Predicting Postoperative Atrial Fibrillation Risk After Coronary Artery Bypass Grafting: A Narrative Review. Journal of cardiothoracic and vascular anesthesia, 34(7), 1933-1941. (Read full article)
  2. Angel N, Li LI, Macleod RS, Marrouche N, Ranjan R, Dosdall D (2015). Diverse Fibrosis Architecture and Premature Stimulation Facilitate Initiation of Reentrant Activity Following Chronic Atrial Fibrillation. Journal of cardiovascular electrophysiology, 26(12), 1352-60. (Read full article)
  3. Robichaux RP, Dosdall DJ, Osorio J, Garner NW, Li L, Huang J, Ideker R (2010). Periods of highly synchronous, non-reentrant endocardial activation cycles occur during long-duration ventricular fibrillation. Journal of cardiovascular electrophysiology, 21(11), 1266-73. (Read full article)
  4. Yamashita K, Kwan E, Kamali R, Ghafoori E, Steinberg BA, MacLeod RS, Dosdall DJ, Ranjan (2020). Blanking period after radiofrequency ablation for atrial fibrillation guided by ablation lesion maturation based on serial MR imaging. Journal of cardiovascular electrophysiology, 31(2), 450-456. (Read full article)
  5. Kamali R, Schroeder J, DiBella E, Steinberg B, Han F, Dosdall DJ, Macleod RS, Ranjan (2020). Reproducibility of clinical late gadolinium enhancement magnetic resonance imaging in detecting left atrial scar after atrial fibrillation ablation. Journal of cardiovascular electrophysiology, 31(11), 2824-2832. (Read full article)
  6. Reno CM, Bayles J, Huang Y, Oxspring M, Hirahara AM, Dosdall DJ, Fisher S (2019). Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias Are Mediated by the Parasympathetic Nervous System in Rats. Diabetes, 68(11), 2107-2119. (Read full article)
  7. Khan MS, Lange M, Ranjan R, Sharma V, Glotzbach JP, Selzman C, Dosdall D (2021). Premature atrial stimulation accentuates conduction abnormalities in cardiac surgery patients that develop postoperative atrial fibrillation. Journal of electrocardiology, 69, 36-43. (Read full article)
  8. Yamashita K, Silvernagel J, Kwan E, Kamali R, Ghafoori E, MacLeod R, Dosdall DJ, Ranjan (2019). Changes in atrial electrophysiological and structural substrate and their relationship to histology in a long-term chronic canine atrial fibrillation model. Pacing and clinical electrophysiology, 42(7), 930-936. (Read full article)
  9. Yamashita K, Hu N, Ranjan R, Selzman CH, Dosdall D (2019). Clinical Risk Factors for Postoperative Atrial Fibrillation among Patients after Cardiac Surgery. The Thoracic and cardiovascular surgeon, 67(2), 107-116. (Read full article)
  10. Hirahara AM, Lange M, Shah A, Khan MS, Ranjan R, Stoddard G, Dosdall D (2021). His bundle pacing shows similar ventricular electrical activation as sinus: selective and nonselective His pacing indistinguishable. American journal of physiology. Heart and circulatory physiology, 320(1), H13-H22. (Read full article)
  11. Dosdall DJ, Fast VG, Ideker R (2010). Mechanisms of defibrillation. Annual review of biomedical engineering, 12, 233-58. (Read full article)
  12. Shah AR, Khan MS, Hirahara AM, Lange M, Ranjan R, Dosdall D (2020). A real-time system for selectively sensing and pacing the His-bundle during sinus rhythm and ventricular fibrillation. Biomedical engineering online, 19(1), 19. (Read full article)
  13. Lange M, Hirahara AM, Ranjan R, Stoddard GJ, Dosdall D (2021). Atrial slow conduction develops and dynamically expands during premature stimulation in an animal model of persistent atrial fibrillation. PloS one, 16(10), e0258285. (Read full article)
  14. Huang J, Dosdall DJ, Cheng KA, Li L, Rogers JM, Ideker R (2014). The importance of Purkinje activation in long duration ventricular fibrillation. Journal of the American Heart Association, 3(1), e000495. (Read full article)
  15. Khan MS, Yamashita K, Sharma V, Ranjan R, Dosdall D (2020). RNAs and Gene Expression Predicting Postoperative Atrial Fibrillation in Cardiac Surgery Patients Undergoing Coronary Artery Bypass Grafting. Journal of clinical medicine, 9(4), (Read full article)
  16. Shah AR, Khan MS, Hirahara AM, Lange M, Ranjan R, Dosdall D (2020). In Vitro/Ex Vivo Investigation of Modified Utah Electrode Array to Selectively Sense and Pace the Sub-Surface Cardiac His Bundle. ACS biomaterials science & engineering, 6(6), 3335-3348. (Read full article)
  17. Yamashita K, Kamali R, Kwan E, MacLeod RS, Dosdall DJ, Ranjan (2020). Effective Ablation Settings That Predict Chronic Scar After Left Atrial Ablation. JACC. Clinical electrophysiology, 6(2), 143-152. (Read full article)
  18. Kamali R, Kump J, Ghafoori E, Lange M, Hu N, Bunch TJ, Dosdall DJ, Macleod RS, Ranjan (2021). Area Available for Atrial Fibrillation to Propagate Is an Important Determinant of Recurrence After Ablation. JACC. Clinical electrophysiology, 7(7), 896-908. (Read full article)
  19. Kamali R, Gillete K, Tate J, Abhyankar DA, Dosdall DJ, Plank G, Bunch TJ, Macleod RS, Ranjan (2023). Treatment Planning for Atrial Fibrillation Using Patient-Specific Models Showing the Importance of Fibrillatory-Areas. Annals of biomedical engineering, 51(2), 329-342. (Read full article)
  20. Ishidoya Y, Kwan E, Dosdall DJ, Macleod RS, Navaravong L, Steinberg BA, Jared Bunch T, Ranjan (2022). Shorter distance between the esophagus and the left atrium is associated with higher rates of esophageal thermal injury after radiofrequency ablation. Journal of cardiovascular electrophysiology, 33(7), 1460-1471. (Read full article)
  21. Ishidoya Y, Kwan E, Dosdall DJ, Macleod RS, Navaravong L, Steinberg BA, Bunch TJ, Ranjan (2022). Short-term natural course of esophageal thermal injury after ablation for atrial fibrillation. Journal of cardiovascular electrophysiology, 33(7), 1450-1459. (Read full article)
  22. Shah AR, Khan MS, Lange M, Hirahara AM, Stoddard G, Ranjan R, Dosdall D (2022). During Early VF in Rabbit Hearts, His Bundle Pacing is Less Effective Than Working Myocardial Pacing in Modulating Left Ventricular Activation Rates. Cardiovascular engineering and technology, 13(3), 452-465. (Read full article)
  23. Kamali R, Kwan E, Regouski M, Bunch TJ, Dosdall DJ, Hsu E, Macleod RS, Polejaeva I, Ranjan (2023). Contribution of atrial myofiber architecture to atrial fibrillation. PloS one, 18(1), e0279974. (Read full article)
  24. Lange M,Kwan E,Dosdall DJ,MacLeod RS,Bunch TJ,Ranjan (2022). Case report: Personalized computational model guided ablation for left atrial flutter. Frontiers in cardiovascular medicine, 9, (Read full article)
  25. Yamashita K,Ghafoori E,Silvernagel J,Ashton J,Dosdall DJ,MacLeod R,Ranjan (2019). The effective contact force to minimize edema relative to chronic lesion formation during radiofrequency ablation in ventricular wall. International heart journal, 60(6), 1407-1414. (Read full article)
  26. Khan MS, Smego D, Ishidoya Y, Hirahara AM, Offei E, Ruiz Castillo MS, Gharbia O, Li H, Palatinus JA, Krueger L, Hong T, Hoareau GL, Ranjan R, Selzman CH, Shaw RM, Dosdall D (2023). A canine model of chronic ischemic heart failure. American journal of physiology. Heart and circulatory physiology, 324(6), H751-H761. (Read full article)
  27. Hirahara AM, Khan MS, Gharbia OA, Lange M, Ishidoya Y, Smego D, Ranjan R, Stoddard GJ, Selzman CH, Dosdall D (2023). Antitachycardia pacing at the His bundle is safer than conventional right ventricular antitachycardia pacing in a canine myocardial ischemic injury model. Journal of cardiovascular electrophysiology, 34(5), 1249-1256. (Read full article)
  28. Hunt B, Kwan E, Tasdizen T, Bergquist J, Lange M, Orkild B, MacLeod RS, Dosdall DJ, Ranjan (2023). Transfer Learning for Improved Classification of Drivers in Atrial Fibrillation. Computing in cardiology, 50, (Read full article)
  29. Hirahara AM, Khan MS, Ishidoya Y, Smego D, Roman O, Ranjan R, Krueger L, Hoareau G, Selzman CH, Dosdall D (2024). Canine Model of Ischemia-Induced Ventricular Tachycardia. The Journal of surgical research, 293, 196-203. (Read full article)
  30. Khan MS, Kyriakopoulos CP, Taleb I, Dranow E, Scott M, Ranjan R, Yin M, Tseliou E, Alharethi R, Caine W, Shaw RM, Selzman CH, Drakos SG*, Dosdall DJ*, *Co-Corresponding Author (2022). Baseline QRS duration associates with cardiac recovery in patients with continuous-flow left ventricular assist device implantation. American heart journal plus, 22, 100211. (Read full article)
  31. Dong J, Kwan E, Bergquist JA, Steinberg BA, Dosdall DJ, DiBella EVR, MacLeod RS, Bunch TJ, Ranjan (2024). Ablation-induced left atrial mechanical dysfunction recovers in weeks after ablation. Journal of interventional cardiac electrophysiology, (Read full article)
  32. Paccione EN, Lange M, Orkild BA, Bergquist JA, Kwan E, Hunt B, Dosdall D, Macleod RS, Ranjan (2023). Effects of Biventricular Pacing Locations on Anti-Tachycardia Pacing Success in a Patient-Specific Model. Computing in cardiology, 2023, (Read full article)
  33. Dong J, Kwan E, Bergquist JA, Steinberg BA, Dosdall DJ, DiBella EVR, MacLeod RS, Bunch TJ, Ranjan (2024). Ablation-induced left atrial mechanical dysfunction recovers in weeks after ablation. Journal of interventional cardiac electrophysiology, (Read full article)
  34. Dong J, Kwan E, Bergquist JA, Dosdall DJ, DiBella EV, MacLeod RS, Stoddard GJ, Konstantidinis K, Steinberg BA, Bunch TJ, Ranjan (2024). Left atrial functional changes associated with repeated catheter ablations for atrial fibrillation. Journal of cardiovascular electrophysiology, (Read full article)
  35. Hunt B, Kwan E, Paccione E, Orkild B, Yazaki K, Bergquist J, Dong J, MacLeod RS, Dosdall DJ, Ranjan (2024). Are Drivers Recurring or Ephemeral? Observations from Serial Mapping of Persistent Atrial Fibrillation. Europace, (Read full article)
  36. Kwan E, Hunt B, Paccione EN, Orkild BA, Bergquist JA, Ishidoya Y, Yazaki K, Mendes JK, DiBella EVR, MacLeod RS, Dosdall DJ, Ranjan (2024). Functional and Structural Remodeling as Atrial Fibrillation Progresses in a Persistent Atrial Fibrillation Canine Model. JACC. Clinical electrophysiology, 11(4), 720-734. (Read full article)
  37. Kwan E, Ghafoori E, Good W, Regouski M, Moon B, Fish JM, Hsu E, Polejaeva IA, MacLeod RS, Dosdall DJ, Ranjan (2024). Diffuse functional and structural abnormalities in fibrosis: Potential structural basis for sustaining atrial fibrillation. Heart rhythm, (Read full article)
  38. Ishidoya Y, Kwan E, Hunt B, Lange M, Sharma T, Dosdall DJ, Macleod RS, Kholmovski EG, Bunch TJ, Ranjan (2024). Effective ablation settings that predict chronic scar after atrial ablation with HELIOSTAR¿ multi-electrode radiofrequency balloon catheter. Journal of interventional cardiac electrophysiology, (Read full article)
  39. Lange M, Kwan E, Dosdall DJ, MacLeod RS, Bunch TJ, Ranjan (2022). Case report: Personalized computational model guided ablation for left atrial flutter. Frontiers in cardiovascular medicine, 9, 893752. (Read full article)
  40. Khan MS, Smego D, Li J, Ishidoya Y, Offei E, Ruiz Castillo MS, Hirahara AM, Balmaceda P, Hunter J, Athavale A, Revelo MP, Palatinus JA, Selzman CH, Ranjan R, Hong T, Dosdall DJ*, Shaw RM*, *Co-Corresponding Author (2025). AAV9-cBIN1 gene therapy rescues chronic heart failure due to ischemic cardiomyopathy in a canine model. Communications medicine, 5(1), 93. (Read full article)
  41. Hunt B, Kwan E, Bergquist J, Brundage J, Orkild B, Dong J, Paccione E, Yazaki K, MacLeod RS, Dosdall DJ, Tasdizen T, Ranjan (2025). Contrastive pretraining improves deep learning classification of endocardial electrograms in a preclinical model. Heart rhythm O2, 6(4), 473-480. (Read full article)
  42. Shah, Ankur R and Yazaki, Kyoichiro and Seamons, Benjamin and Offei, Emmanuel and Castilo, Sofia Ruiz and Li, Hui and Khan, Muhammad S and Hitchcock, Robert and Ranjan, Ravi and Dosdall, Derek (2025). Multiple electrode leads facilitate left bundle branch area pacing: A concept evaluation study. Heart Rhythm O2, 6(7), 1005-1010.
  43. Shah AR, Yazaki K, Seamons B, Offei E, Castilo SR, Li H, Khan MS, Hitchcock R, Ranjan R, Dosdall D (2025). Multiple electrode leads facilitate left bundle branch area pacing: A concept evaluation study. Heart rhythm O2, 6(7), 1005-1010. (Read full article)
  44. Yazaki K, Kwan E, Ishidoya Y, Stoddard GJ, Dosdall DJ, Navaravong L, Groh CA, Steinberg BA, Bunch TJ, Ranjan (2025). Prospective validation of SURPOINT index for creating atrial scar using Magnetic Resonance Imaging. Europace, 27(10), (Read full article)
  45. Offei E, Ishidoya Y, Smego D, Castillo SR, Khan MS, Yazaki K, Shah A, Vaziri AY, Lange M, Hirahara AM, Li H, Stoddard GJ, Ranjan R, Dosdall D (2025). Antitachycardia Pacing is More Effective When Delivered to the Left Bundle Branch Area Compared to the Right Ventricle in a Pre-clinical Model of Ischemic Ventricular Tachycardia. bioRxiv, (Read full article)
  46. Kwan E, Hunt B, Paccione E, Orkild BA, Bergquist JA, Yazaki K, Polejaeva I, Hsu E, Dosdall D, MacLeod RS, Ranjan (2024). Structural Differences in Transgenic Animals Associated with Atrial Fibrillation. Computing in cardiology, 51, (Read full article)
  47. Offei E, Yazaki K, Ishidoya Y, Castillo MSR, Vaziri AY, Shah A, Dosdall DJ, Khan M (2025). Left Bundle Branch Area Pacing Preserves Mechanical Strain and Synchrony Compared to Right Ventricular Apical Pacing in an Acute Paired Preclinical Model. bioRxiv, (Read full article)

Book Chapter

  1. Dosdall DJ,Ideker R (2014). Mechanisms of Ventricular Tachycardia and Fibrillation. Cardiac Electrophysiology: From Cell to Bedside: Sixth Edition, 475-482. (Read full article)
  2. Dosdall DJ,Tabereaux PB,Ideker R (2012). Advances in Mapping of Ventricular Fibrillation and Defibrillation: Role of the Purkinje System. Cardiac Mapping: Fourth Edition, 459-466. (Read full article)
  3. Kay GN,Dosdall DJ,Shepard R (2011). Cardiac Electrical Stimulation. Clinical Cardiac Pacing, Defibrillation and Resynchronization Therapy, 3-39. (Read full article)
  4. Dosdall DJ,Ideker R (2009). Cardiac arrhythmias. TASER® Conducted Electrical Weapons: Physiology, Pathology, and Law, 119-131. (Read full article)
  5. Ideker RE,Dosdall D (2009). Critical points and the upper limit of vulnerability for defibrillation. Cardiac Bioelectric Therapy: Mechanisms and Practical Implications, 165-187. (Read full article)
  6. Tabereaux PB,Dosdall DJ,Ideker R (2009). Mapping of Ventricular Tachycardia and Fibrillation: Role of the Purkinje System. Cardiac Mapping, Third Edition, 411-422. (Read full article)
  7. Dosdall DJ,Huang J,Ideker R (2009). Mechanisms of Defibrillation. Ventricular Arrhythmias and Sudden Cardiac Death, 277-288. (Read full article)

Conference Proceedings

  1. Angel N, Kholmovski EG, Ghafoori E, Dosdall DJ, MacLeod RS, Ranjan (2019). Regions of High Dominant Frequency in Chronic Atrial Fibrillation Anchored to Areas of Atrial Fibrosis. Computing in cardiology, 46, (Read full article)
  2. Hunt B,Kwan E,Dosdall D,MacLeod RS,Ranjan (2021). Siamese Neural Networks for Small Dataset Classification of Electrograms. Computing in cardiology, 2021-September, (Read full article)
  3. Hunt B,Kwan E,McMillan M,Dosdall D,MacLeod R,Ranjan (2020). Deep Learning Based Prediction of Atrial Fibrillation Disease Progression with Endocardial Electrograms in a Canine Model. Computing in cardiology, 2020-September, (Read full article)
  4. Dong H,Roussel T,Jackson D,Naber J,Koenig S,Keynton R,Dosdal D,Ideker (2010). Characterization of thin-film microelectrode array and signal conditioning microchip for high spatial resolution surface laplacian measurement. Proceedings of IEEE Sensors, 2464-2467. (Read full article)
  5. Dong H,Jackson D,Roussel T,Dosdall D,Ideker R,Naber J,Koenig S,Keynton (2010). Design and characterization of a signal conditioning microchip and Thin-film microelectrode array for high spatial resolution cardiac mapping. IFMBE proceedings, 31 IFMBE, 1417-1420. (Read full article)
  6. Dosdall DJ,Huang J,Ideker R (2009). Differential electrograms computed from unipolar endocardial recordings improve Purkinje activation identification. Computers in cardiology, 36, 225-228. (Read full article)
  7. Dosdall DJ,Sweeney JD,Brandon T (2003). Rapid Current Switching With An Endovascular Electrode Configuration Significantly Decreases Implantable Defibrillator Thresholds. Alliance for Engineering in Medicine and Biology. Proceedings of the Annual Conference, 1, 179-182. (Read full article)

Abstract

  1. Reighard J,Sweeney J,Dosdall D,Brandon (2000). Correlation of the defibrillation threshold and the upper limit of vulnerability for multipulse biphasic waveforms. Annals of biomedical engineering, 28(SUPPL. 1), (Read full article)