Dustin L. Williams

Dustin L. Williams, PhD

Languages spoken: English

Academic Information

Departments Primary - Orthopaedics , Adjunct - Pathology

Research Interests

  • Biofilms
  • Implant Infection
  • Antibiotic Development
  • Antibiofilm Strategies
  • Animal Modeling
  • Wound Research
  • Orthopaedics
  • Biomaterials
  • Heterotopic Ossification
  • Medical Device Development

Education History

Postdoctoral Fellowship University of Utah
 Postdoctoral Fellow
University of Utah
 PhD
Undergraduate Weber State University
 BS

Selected Publications

Journal Article

  1. Ong J, Godfrey R, Nazarian A, Tam J, Drake L, Isaacson B, Pasquina P, Williams D (2023). Antimicrobial blue light as a biofilm management therapy at the skin-implant interface in an ex vivo percutaneous osseointegrated implant model. J Orthop Res. (Read full article)
  2. Ong J, Godfrey R, Isaacson B, Pasquina P, Williams D (2022). Determining the Antibiofilm Efficacy of Oregano Gel in an Ex Vivo Model of Percutaneous Osseointegrated Implants. Microorganisms, 10(11). (Read full article)
  3. Hussan JR, Irwin SG, Mathews B, Swift S, Williams DL, Cornish J (2022). Optimal dose of lactoferrin reduces the resilience of in vitro Staphylococcus aureus colonies. PLoS One, 17(8), e0273088. (Read full article)
  4. Morco SR, Williams DL, Jensen BD, Bowden AE (2021). Structural biofilm resistance of carbon-infiltrated carbon nanotube coatings. J Orthop Res, 40(8), 1953-1960. (Read full article)
  5. Rawson KB, Neuberger T, Smith T, Reddy HRK, Haussener TJ, Sebahar PR, Looper RE, Isaacson BM, Shero J, Pasquina PF, Williams DL (2022). Antibiofilm potential of a negative pressure wound therapy foam loaded with a first-in-class tri-alkyl norspermidine-biaryl antibiotic. J Biomed Mater Res B Appl Biomater, 110(8), 1780-1788. (Read full article)
  6. DeKeyser GJ, Epperson R, Zhang C, Williams D, Olsen A, Haller JM (2022). Articular fragment restoration is critical to mitigate post-traumatic osteoarthritis in a porcine pilon fracture model. Osteoarthr Cartil Open, 4(2), 100266. (Read full article)
  7. Duffy HR, Godfrey RW, Williams DL, Ashton NN (2022). A Porcine Model for the Development and Testing of Preoperative Skin Preparations. Microorganisms, 10(5). (Read full article)
  8. Kay W, Hunt C, Nehring L, Barnum B, Ashton N, Williams D (2022). Biofilm Growth on Simulated Fracture Fixation Plates Using a Customized CDC Biofilm Reactor for a Sheep Model of Biofilm-Related Infection. Microorganisms, 10(4). (Read full article)
  9. Sadaphal B, Prasad B, Kay W, Nehring L, Nyugen T, Tepper J, Tanner M, Williams D, Ashton N, Greenberg D, Chopra R (2021). Feasibility of heating metal implants with alternating magnetic fields (AMF) in scaled up models. Int J Hyperthermia, 39(1), 81-96.
  10. Tashjian RZ, Kazmers NH, Epperson RT, Honeggar M, Ma Y, Chalmers PN, Williams DL, Jurynec MJ (2021). The effect of estrogen-like compound on rotator cuff tendon healing in a murine model. J Orthop Res, 39(12), 2711-2724. (Read full article)
  11. Epperson RT, Williams DL, Rogers B, Maxwell J, Stevens P (2021). Assessing the safety of an epiphyseal plate biopsy in a translational lamb model. J Orthop Res, 39(12), 2653-2662. (Read full article)
  12. Epperson RT, Isaacson BM, Rothberg DL, Olsen RE, Kawaguchi B, Maxwell JM, Dickerson M, Pasquina PF, Shero J, Williams DL (2021). Developing a combat-relevant translatable large animal model of heterotopic ossification. Bone Rep, 15, 101127. (Read full article)
  13. Stevens P, Epperson RT, Taylor NB, Dickerson M, Williams DL (2019). Assessing the effect of physeal biopsy on angular deformity in a rabbit model. J Pediatr Orthop B, 30(1), 93-100. (Read full article)
  14. Shaw JD, Brodke DS, Williams DL, Ashton NN (2020). Methylene Blue Is an Effective Disclosing Agent for Identifying Bacterial Biofilms on Orthopaedic Implants. J Bone Joint Surg Am, 102(20), 1784-1791. (Read full article)
  15. Miller M, Rogers JC, Badham MA, Cadenas L, Brightwell E, Adams J, Tyler C, Sebahar PR, Haussener TJ, Reddy HRK, Looper RE, Williams DL (2020). Examination of a first-in-class bis-dialkylnorspermidine-terphenyl antibiotic in topical formulation against mono and polymicrobial biofilms. PLoS One, 15(10), e0234832. (Read full article)
  16. Williams DL, Kawaguchi B, Taylor NB, Allyn G, Badham MA, Rogers JC, Peterson BR, Sebahar PR, Haussener TJ, Reddy HRK, Isaacson BM, Pasquina PF, Looper RE (2020). In vivo efficacy of a unique first-in-class antibiofilm antibiotic for biofilm-related wound infections caused by Acinetobacter baumannii. Biofilm, 2, 100032. (Read full article)
  17. Epperson RT, Barg A, Williams DL, Saltzman CL (2020). Histological Analysis of a Retrieved Porous Tantalum Total Ankle Replacement: A Case Report. JBJS Case Connect, 10(1), e0379. (Read full article)
  18. Williams DL, Lerdahl JM, Vinciguerra J, Bloebaum RD (2015). Does Vitamin E-blended UHMWPE Prevent Biofilm Formation? Clin Orthop Relat Res, 473(3), 928-935.
  19. Williams DL, Lerdahl JM, Haymond BS, Bloebaum RD (2014). In vitro efficacy of a novel active-release antimicrobial coating to eradicate biofilms of Pseudomonas aeruginosa. Antimicrob Agents Chemother, 58(4), 2400-2404.
  20. Sinclair KD, Pham TX, Williams DL, Farnsworth RW, Loc-Carrillo CM, Bloebaum RD (2013). Model development for determining the efficacy of a combination coating for the prevention of perioperative device related infections: a pilot study. J Biomed Mater Res B Appl Biomater, 101(7), 1143-53. (Read full article)
  21. Williams DL, Sinclair KD, Jeyapalina S, Bloebaum RD (2013). Characterization of a novel active release coating to prevent biofilm implant-related infections. J Biomed Mater Res B Appl Biomater, 101(6), 1078-89. (Read full article)

Review

  1. Ciarolla AA, Lapin N, Williams D, Chopra R, Greenberg DE (2022). Physical Approaches to Prevent and Treat Bacterial Biofilm. [Review]. Antibiotics (Basel), 12(1). (Read full article)
  2. Irwin S, Mackenzie BW, Matthews BG, Williams DL, Cornish J, Swift S (2021). Improve integration of in vitro biofilm body of knowledge to support clinical breakthroughs in surgical site infection. [Review]. J Am Acad Orthop Surg Glob Res Rev, 5(11), e20.00217. (Read full article)
  3. Busscher HJ, Woudstra W, van Kooten TG, Jutte P, Shi L, Liu J, Hinrichs WLJ, Frijlink HW, Shi R, Liu J, Parvizi J, Kates S, Rotello VM, Schaer TP, Williams D, Grainger DW, van der Mei HC (2019). Accepting higher morbidity in exchange for sacrificing fewer animals in studies developing novel infection-control strategies. [Review]. Biomaterials, 232, 119737. (Read full article)

Book

  1. Williams DL (2019). Targeting biofilms in translational research, device development, and industrial sectors. Cham: Springer International Publishing.

Book Chapter

  1. Williams DL, Bloebaum RD (2013). Biofilm-Related Periprosthetic Joint Infections. In Springer B, Parvizi J (Eds.), Periprosthetic Joint Infection of the Hip and Knee (pp. 85-96). Springer-Verlag, Berlin, Germany: Springer.

Patent

  1. Dustin Williams, Nicholas Ashton (2018). Therapeutic Delivery Device. U.S. Patent No. 16/047,917. Washington, D.C.:U.S. Patent and Trademark Office.
  2. Looper RE, Williams DL, Jeyapalina S, Haussener TJ, Sebahar PR, Reddy HRK (2018). Compositions and methods comprising a polyamine (International AU). U.S. Patent No. WO 2014/190096 A1. Washington, D.C.:U.S. Patent and Trademark Office.
  3. Looper RE, Williams DL, Jeyapalina S, Haussener TJ, Sebahar PR, Reddy HRK (2018). Compositions and methods comprising a polyamine (International CN). U.S. Patent No. ZL201480041542.1. Washington, D.C.:U.S. Patent and Trademark Office.
  4. Looper RE, Williams DL, Jeyapalina S, Haussener TJ, Sebahar PR, Reddy HRK (2017). Compositions comprising a biocidal polyamine. U.S. Patent No. 9,839,219 B2. Washington, D.C.:U.S. Patent and Trademark Office.
  5. Looper RE, Williams DL, Jeyapalina S, Haussener TJ, Sebahar PR, Reddy HRK (2017). Compositions and methods comprising a polyamine (International JP). U.S. Patent No. 6417404. Washington, D.C.:U.S. Patent and Trademark Office.
  6. Dustin Williams, Nicholas Ashton (2017). Therapeutic Delivery Device. U.S. Patent No. 62/537,596. Washington, D.C.:U.S. Patent and Trademark Office.
  7. Looper RE, Williams DL, Jeyapalina S, Haussener TJ, Sebahar PR, Reddy HRK (2016). Compositions and methods comprising a biocidal polyamine. U.S. Patent No. 9439433. Washington, D.C.:U.S. Patent and Trademark Office.
  8. Williams DL, Looper RE, Jeyapalina S, Haussener T, Sebahar PR, Reddy HK (2015). Methods of use comprising a biocidal polyamine. U.S. Patent No. 9,034,927. Washington, D.C.:U.S. Patent and Trademark Office.
  9. Looper RE, Williams DL, Jeyapalina S, Haussener T, Sebahar PR, Reddy HK (2015). Compositions comprising a biocidal polyamine. U.S. Patent No. US 14/076,143 B1. Washington, D.C.:U.S. Patent and Trademark Office.
  10. Looper RE, Williams DL, Jeyapalina S, Haussener TJ, Sebahar PR, Reddy HRK (2014). Compositions and methods comprising a polyamine and a silver substance. U.S. Patent No. WO 2014190097 A1. Washington, D.C.:U.S. Patent and Trademark Office.
  11. Williams DL, Savage PB, Bloebaum RD, Sinclair KD, Haymond BS (2013). Incorporation of Particulate Ceragenins in Polymers. U.S. Patent No. WO 2013/029055 A1. Washington, D.C.:U.S. Patent and Trademark Office.
  12. Williams DL, Savage PB, Bloebaum RD, Sinclair KD, Haymond BS (2013). Medical devices incorporating ceragenin-containing composites. U.S. Patent No. WO 2013/029059 A1. Washington, D.C.:U.S. Patent and Trademark Office.
  13. Paul B. Savage, Roy D. Bloebaum, Dustin L. Williams, Kristofer D. Sinclair, Bryan S. Haymond (2011). Incorporation of Particulate Ceragenins in Polymers.
  14. Dustin L. Williams, Paul B. Savage, Roy D. Bloebaum, Kristofer D. Sinclair, Bryan S. Haymond (2011). Medical Devices Incorporating Ceragenin-Containing Composites.
  15. Isaacson BM, Bloebaum RD, Williams DL (2010). Osseointegrated implant with electrical stimulation. U.S. Patent No. US 2010/0152864 A1. Washington, D.C.:U.S. Patent and Trademark Office.