Elena Y. Enioutina

Elena Y. Enioutina, MD, PhD

Languages spoken: English

Academic Information

Departments Primary - Pediatrics , Adjunct - Pathology

Divisions: Clinical Pharmacology

Research Interests

  • Immunopharmacology
  • Medicine, Herbal
  • Myeloid Derived Suppressor Cells (MDSCs)
  • Neonatal Infections/Sepsis
  • Pharmacology
  • Vaccination
  • Chlamydia Infections

Dr. Elena Yu Enioutina holds an M.D. degree in Pediatric Preventive Medicine and a Ph.D. in medicine with a specialization in pharmacology and toxicology. She has hands-on experience in immunopharmacology, pharmacology/toxicology, and animal modeling, as well as extensive academic research experience in immunology, vaccines, and immune senescence. Her long-standing interest in the prophylaxis of infectious diseases goes back to her medical school years. Immune senescence and modulation of immune responses in aged animals by cholesterol-lowering drugs was the topic of her Ph.D. work.


Her current research is mainly focused on phytodrugs dietary supplements: 1) their safety and efficacy, 2) potentiation of conventional drug toxicity by concomitant use with phytodrugs, 3) use of phytodrugs by special patient populations, and 4) use of phytodrugs as an alternative/complementary treatment to conventional antibiotics. She is a Principal Investigator in several clinical trials examining the pharmacokinetics and efficacy of herbal and other natural products. Additionally, Dr. Enioutina is interested in evaluating intravenous immunoglobulins' efficacy in pediatric patients with neurological disorders. She continues her work aimed at optimizing the treatment of neonatal sepsis.

Education History

Postdoctoral Fellowship University of Utah School of Medicine
 Postdoctoral Fellow
All Union Research Institute of Medicinal Plants (VILAR)
 PhD
Internship I.M. Sechenov First Moscow State Medical University
 Intern
I.M. Sechenov First Moscow Institute of Medicine
 MD
Undergraduate I.M. Sechenov First Moscow Institute of Medicine
 BA

Selected Publications

Journal Article

  1. Krepkova LV, Babenko AN, Lemyaseva SV, Saybel OL, Sherwin CM, Enioutina EY (2023). Modulation of Hepatic Functions by Chicory (Cichorium intybus L.) Extract: Preclinical Study in Rats. Pharmaceuticals (Basel), 16(10). (Read full article)
  2. Han X, Vollmer D, Enioutina EY (2023). Immunomodulatory Effects of Modified Bovine Colostrum, Whey, and Their Combination with Other Natural Products: Effects on Human Peripheral Blood Mononuclear Cells. Curr Ther Res Clin Exp, 99, 100720. (Read full article)
  3. Constance JE, McFarland MM, Casucci T, Deininger MW, Enioutina EY, Job K, Lemons RS, Lim CS, Ward RM, Yellepeddi V, Watt KM (2023). Mapping the Evidence for Opioid-Mediated Changes in Malignancy and Chemotherapeutic Efficacy: Protocol for a Scoping Review. JMIR Res Protoc, 12, e38167. (Read full article)
  4. Krepkova LV, Bortnikova VV, Babenko AN, Mizina PG, Mkhitarov VA, Job KM, Sherwin CM, Enioutina EY (2021). Effects of a new thyrotropic drug isolated from Potentilla alba on the male reproductive system of rats and offspring development. BMC Complement Med Ther, 21(1), 31. (Read full article)
  5. Enioutina EY, Job KM, Krepkova LV, Reed MD, Sherwin CM (2020). How can we improve the safe use of herbal medicine and other natural products? A clinical pharmacologist mission. Expert Rev Clin Pharmacol, 13(9), 935-944. (Read full article)
  6. Illamola SM, Amaeze OU, Krepkova LV, Birnbaum AK, Karanam A, Job KM, Bortnikova VV, Sherwin CMT, Enioutina EY (2020). Use of Herbal Medicine by Pregnant Women: What Physicians Need to Know. Front Pharmacol, 10(1483).
  7. Balch A, Wilkes J, Thorell E, Pavia A, Sherwin CMT, Enioutina EY (2019). Changing trends in IVIG use in pediatric patients: A retrospective review of practices in a network of major USA pediatric hospitals. Int Immunopharmacol, 76, 105868. (Read full article)
  8. Wagstaff JS, Durrant RJ, Newman MG, Eason R, Ward RM, Sherwin CMT, Enioutina EY (2019). Antibiotic treatment of suspected and confirmed neonatal sepsis within 28 days of birth: A retrospective analysis. Front Pharmacol, 10. (Read full article)
  9. Enioutina EY, Teng L, Fateeva TV, Brown JCS, Job KM, Bortnikova VV, Krepkova LV, Gubarev MI, Sherwin CMT (2017). Phytotherapy as an alternative to conventional antimicrobials: combating microbial resistance. Expert Rev Clin Pharmacol, 10(11), 1203-1214. (Read full article)
  10. Enioutina EY, Salis ER, Job KM, Gubarev MI, Krepkova LV, Sherwin CM (2017). Herbal Medicines: challenges in the modern world. Part 5. status and current directions of complementary and alternative herbal medicine worldwide. Expert Rev Clin Pharmacol, 10(3), 327-338. (Read full article)
  11. Yu T, Enioutina EY, Brunner HI, Vinks AA, Sherwin CM (2017). Clinical Pharmacokinetics and Pharmacodynamics of Biologic Therapeutics for Treatment of Systemic Lupus Erythematosus. Clin Pharmacokinet, 56(2), 107-125. (Read full article)
  12. Job KM, Kiang TK, Constance JE, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 4. Canada and United States. Expert Rev Clin Pharmacol, 9(12), 1597-1609. (Read full article)
  13. Teng L, Zu Q, Li G, Yu T, Job KM, Yang X, Di L, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 3. China and Japan. Expert Rev Clin Pharmacol, 9(9), 1225-33. (Read full article)
  14. Sammons HM, Gubarev MI, Krepkova LV, Bortnikova VV, Corrick F, Job KM, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 2. European Union and Russia. Expert Rev Clin Pharmacol, 9(8), 1117-27. (Read full article)
  15. Job KM, Olson J, Stockmann C, Constance JE, Enioutina EY, Rower JE, Linakis MW, Balch AH, Yu T, Liu X, Thorell EA, Sherwin CM (2016). Pharmacodynamic studies of voriconazole: informing the clinical management of invasive fungal infections. Expert Rev Anti Infect Ther, 14(8), 731-46. (Read full article)
  16. Barnes J, McLachlan AJ, Sherwin CM, Enioutina EY (2016). Herbal medicines: challenges in the modern world. Part 1. Australia and New Zealand. Expert Rev Clin Pharmacol, 9(7), 905-15. (Read full article)
  17. Enioutina EY, Bareyan D, Daynes RA (2011). A role for immature myeloid cells in immune senescence. J Immunol, 186(2), 697-707. (Read full article)
  18. Enioutina EY, Bareyan D, Daynes RA (2009). TLR-induced local metabolism of vitamin D3 plays an important role in the diversification of adaptive immune responses. J Immunol, 182(7), 4296-305. (Read full article)
  19. Enioutina EY, Visic D, Daynes RA (2000). The induction of systemic and mucosal immune responses to antigen-adjuvant compositions administered into the skin: alterations in the migratory properties of dendritic cells appears to be important for stimulating mucosal immunity. Vaccine, 18(24), 2753-67. (Read full article)
  20. Enioutina EY, Visic D, McGee ZA, Daynes RA (1999). The induction of systemic and mucosal immune responses following the subcutaneous immunization of mature adult mice: characterization of the antibodies in mucosal secretions of animals immunized with antigen formulations containing a vitamin D3 adjuvant. Vaccine, 17(23-24), 3050-64. (Read full article)
  21. Gubarev MIEnioutina EYTaylor JLVisic DMDaynes RA (1998). Plant-derived glycoalkaloids protect mice against lethal infection with Salmonella typhimurium. J Immunol, 12(2), 79-88. (Read full article)

Review

  1. Jain M, Stitt G, Son L, Enioutina EY (2023). Probiotics and Their Bioproducts: A Promising Approach for Targeting Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus. [Review]. Microorganisms, 11(10). (Read full article)
  2. Hudson RE, Metz TD, Ward RM, McKnite AM, Enioutina EY, Sherwin CM, Watt KM, Job KM (2023). Drug exposure during pregnancy: Current understanding and approaches to measure maternal-fetal drug exposure. [Review]. Front Pharmacol, 14, 1111601. (Read full article)
  3. Sayre CL, Yellepeddi VK, Job KM, Krepkova LV, Sherwin CMT, Enioutina EY (2023). Current use of complementary and conventional medicine for treatment of pediatric patients with gastrointestinal disorders. [Review]. Front Pharmacol, 14. (Read full article)
  4. Hudson RE, Job KM, Sayre CL, Krepkova LV, Sherwin CM, Enioutina EY (2022). Examination of Complementary Medicine for Treating Urinary Tract Infections Among Pregnant Women and Children. [Review]. Front Pharmacol, 13. (Read full article)
  5. Krepkova LV, Babenko AN, Saybel OL, Lupanova IA, Kuzina OS, Job KM, Sherwin CM, Enioutina EY (2021). Valuable Hepatoprotective Plants - How Can We Optimize Waste Free Uses of Such Highly Versatile Resources? [Review]. Front Pharmacol, 12, 738504. (Read full article)
  6. Job KM, Roberts JK, Enioutina EY, Illamola SM, Kumar SS, Rashid J, Ward RM, Fukuda T, Sherbotie J, Sherwin CM (2021). Treatment optimization of maintenance immunosuppressive agents in pediatric renal transplant recipients. [Review]. Expert Opin Drug Metab Toxicol, 17(7), 747-765. (Read full article)

Conference Proceedings

  1. Jonathan E Buckendorf, Elena Y Enioutina (2022). Virtual Laboratory Resources for Medical Microbiology Course. 9th Annual Education Symposium Proceedings – 2022, The Academy of Health Sciences Educators, University of Utah.

Editorial

  1. Enioutina EY, Job KM, Sherwin CMT (2020). Why we need to pay attention to toxicity associated with herbal medicines. 13(86(9)), 1793-1794.

Abstract

  1. JS Wagstaff, RM Eason, M Newman, CMT Sherwin, EY Enioutina (2018). Characterization and treatments of neonatal late-onset sepsis: a retrospective analysis of the University of Utah Hospital cases [Abstract]. ACCP 2018 meeting (September 2018).

Patent

  1. Michael I. Gubarev, Elena Y. Enioutina, Raymond A. Daynes (1997). Method to Enhance Innate Immunity Defense Mechanisms by Treatment with Plant-Derived Alkaloids.