Elizabeth Motunrayo Kolawole

Elizabeth Motunrayo Kolawole, PhD

Academic Information

Departments Primary - Pathology

Lab

My major interests lie in dissecting how TCR interacts with antigen as it occurs in 2D at the cell surface. As the cell membrane environment affects these protein interactions, my projects focus on the role that dietary fatty acids play in altering T cell affinity, force and cell flexibility for both infection and autoimmune disease.

Education History

Postdoctoral Training University of Utah School of Medicine
 Postdoctoral Researcher
Postdoctoral Training Emory University
 Postdoctoral Research Fellow
Doctoral Training Virginia Commonwealth University
 PhD
Undergraduate University of the West of England, Bristol
 BSc (Hons)

Selected Publications

Journal Article

  1. Nguyen NX, Richens AW, Sircy LM, Allard DE, Kolawole EM, Evavold BD, Bettini M, Hale JS (2022). Immunogen-Specific Strengths and Limitations of the Activation-Induced Marker Assay for Assessing Murine Antigen-Specific CD4+ T Cell Responses. J Immunol, 210(7), 916-925. (Read full article)
  2. Lo WL, Kuhlmann M, Rizzuto G, Ekiz HA, Kolawole EM, Revelo MP, Andargachew R, Li Z, Tsai YL, Marson A, Evavold BD, Zehn D, Weiss A (2023). A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function. Nat Immunol, 24(4), 676-689. (Read full article)
  3. Beskid NM, Kolawole EM, Coronel MM, Nguyen B, Evavold B, Garca AJ, Babensee JE (2022). IL-10-Functionalized Hydrogels Support Immunosuppressive Dendritic Cell Phenotype and Function. ACS Biomater Sci Eng, 8(10), 4341-4353. (Read full article)
  4. Zinzow-Kramer WM, Kolawole EM, Eggert J, Evavold BD, Scharer CD, Au-Yeung BB (2022). Strong Basal/Tonic TCR Signals Are Associated with Negative Regulation of Naive CD4(+) T Cells. Immunohorizons, 6(9), 671-683. (Read full article)
  5. Zhao X, Kolawole EM, Chan W, Feng Y, Yang X, Gee MH, Jude KM, Sibener LV, Fordyce PM, Germain RN, Evavold BD, Garcia KC (2022). Tuning T cell receptor sensitivity through catch bond engineering. Science, 376(6589), eabl5282. (Read full article)
  6. Taruselli MT, Kolawole EM, Qayum AA, Haque TT, Caslin HL, Abebayehu D, Kee SA, Dailey JM, Jackson KG, Burchett JR, Spence AJ, Pondicherry N, Barnstein BO, Gomez G, Straus DB, Ryan JJ (2021). Fluvastatin enhances IL-33-mediated mast cell IL-6 and TNF production. Cell Immunol, 371, 104457. (Read full article)
  7. Dileepan T, Malhotra D, Kotov DI, Kolawole EM, Krueger PD, Evavold BD, Jenkins MK (2021). MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells. Nat Biotechnol, 39(8), 943-948. (Read full article)
  8. Zareie P, Szeto C, Farenc C, Gunasinghe SD, Kolawole EM, Nguyen A, Blyth C, Sng XYX, Li J, Jones CM, Fulcher AJ, Jacobs JR, Wei Q, Wojciech L, Petersen J, Gascoigne NRJ, Evavold BD, Gaus K, Gras S, Rossjohn J, La Gruta NL (2020). Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling. Science, 372(6546). (Read full article)
  9. Kiwanuka KN, Motunrayo Kolawole E, Mcleod JJA, Baker B, Paez PA, Zellner MP, Haque TT, Paranjape A, Jackson K, Kee SA, Dailey J, Martin RK, Ryan JJ (2021). Stat5B is required for IgE-Mediated mast cell function in vitro and in vivo. . Cell Immunol.
  10. Singh NK, Alonso JA, Harris DT, Anderson SD, Ma J, Hellman LM, Rosenberg AM, Kolawole EM, Evavold BD, Kranz DM, Baker BM (2020).  An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes. . Biochemistry, 59(43), 4163-4175.
  11. Ren HM, Kolawole EM, Ren M, Jin G, Netherby-Winslow CS, Wade Q, Shwetank, Rahman ZSM, Evavold BD, Lukacher AE (2020). IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection. Sci Immunol, 5(51). (Read full article)
  12. Ren HM, Kolawole EM, Ren M, Jin G, Netherby-Winslow CS, Wade Q, Shwetank, Rahman ZSM, Evavold BD, Lukacher AE (2020). IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection. . Sci Immunol, 5(51), eabb5590..
  13. Paez PA, Kolawole M, Taruselli MT, Ajith S, Dailey JM, Kee SA, Haque TT, Barnstein BO, McLeod JJA, Caslin HL, Kiwanuka KN, Fukuoka Y, Le QT, Schwartz LB, Straus DB, Gewirtz DA, Martin RK, Ryan JJ (2020). Fluvastatin Induces Apoptosis in Primary and Transformed Mast Cells. . J Pharmacol Exp Ther, 374(1), 104-112.
  14. Liu B, Hood JD, Kolawole EM, Woodruff DM, Vignali DA, Bettini M, Evavold BD (2020).  A Hybrid Insulin Epitope Maintains High 2D Affinity for Diabetogenic T Cells in the Periphery. Diabetes, 69(3), 381-391.
  15. Bettini M, Scavuzzo MA, Liu B, Kolawole E, Guo L, Evavold BD, Borowiak M, Bettini ML (2020). A Critical Insulin TCR Contact Residue Selects High-Affinity and Pathogenic Insulin-Specific T Cells. . Diabetes, 69(3), 392-400.
  16. Chow IT, Gates TJ, Papadopoulos GK, Moustakas AK, Kolawole EM, Notturno RJ, McGinty JW, Torres-Chinn N, James EA, Greenbaum C, Nepom GT, Evavold BD, Kwok WW (2019). Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes. Sci Adv, 5(8), eaaw9336. (Read full article)
  17. Abebayehu D, Spence AJ, Caslin H, Taruselli M, Haque TT, Kiwanuka KN, Kolawole EM, Chumanevich AP, Sell SA, Oskeritzian CA, Ryan J, Kee SA (2019). Lactic acid suppresses IgE-mediated mast cell function in vitro and in vivo. Cell Immunol, 341, 103918. (Read full article)
  18. Kolawole EM, Andargachew R, Liu B, Jacobs JR, Evavold BD (2018). 2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes. Front Immunol, 9, 2348. (Read full article)
  19. Kolawole EM, Andargachew R, Liu B, Jacobs JR, Evavold BD (2018). 2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes. Front Immunol, 9, 2348. (Read full article)
  20. DiToro D, Winstead CJ, Pham D, Witte S, Andargachew R, Singer JR, Wilson CG, Zindl CL, Luther RJ, Silberger DJ, Weaver BT, Kolawole EM, Martinez RJ, Turner H, Hatton RD, Moon JJ, Way SS, Evavold BD, Weaver CT (2017). Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells. Science, 361(6407). (Read full article)
  21. Sibener LV, Fernandes RA, Kolawole EM, Carbone CB, Liu F, McAffee D, Birnbaum ME, Yang X, Su LF, Yu W, Dong S, Gee MH, Jude KM, Davis MM, Groves JT, Goddard WA 3rd, Heath JR, Evavold BD, Vale RD, Garcia KC (2017). Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding. Cell, 174(3), 672-687.e27. (Read full article)
  22. Andargachew R, Martinez RJ, Kolawole EM, Evavold BD (2018). CD4 T Cell Affinity Diversity Is Equally Maintained during Acute and Chronic Infection. J Immunol, 201(1), 19-30. (Read full article)
  23. Sanecka A, Yoshida N, Kolawole EM, Patel H, Evavold BD, Frickel EM (2018). T Cell Receptor-Major Histocompatibility Complex Interaction Strength Defines Trafficking and CD103+ Memory Status of CD8 T Cells in the Brain. Front Immunol, 9, 1290. (Read full article)
  24. Moore T, Wagner CR, Scurti GM, Hutchens KA, Godellas C, Clark AL, Kolawole EM, Hellman LM, Singh NK, Huyke FA, Wang SY, Calabrese KM, Embree HD, Orentas R, Shirai K, Dellacecca E, Garrett-Mayer E, Li M, Eby JM, Stiff PJ, Evavold BD, Baker BM, Le Poole IC, Dropulic B, Clark JI, Nishimura MI (2017). Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells. Cancer Immunol Immunother, 67(2), 311-325. (Read full article)
  25. McLeod JJA, Caslin HL, Spence AJ, Kolawole EM, Qayum AA, Paranjape A, Taruselli M, Haque TT, Kiwanuka KN, Elford HL, Ryan JJ (2017). Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription. Cell Immunol, 322, 41-48. (Read full article)
  26. Caslin HL, McLeod JJA, Spence AJ, Qayum AA, Kolawole EM, Taruselli MT, Paranjape A, Elford HL, Ryan JJ (2017). Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IL-33-induced cytokine production in primary mouse mast cells. Cell Immunol, 319, 10-16. (Read full article)
  27. Ndaw VS, Abebayehu D, Spence AJ, Paez PA, Kolawole EM, Taruselli MT, Caslin HL, Chumanevich AP, Paranjape A, Baker B, Barnstein BO, Haque TT, Kiwanuka KN, Oskeritzian CA, Ryan JJ (2017). TGF-β1 Suppresses IL-33-Induced Mast Cell Function. J Immunol, 199(3), 866-873. (Read full article)
  28. Abebayehu D, Spence AJ, Qayum AA, Taruselli MT, McLeod JJ, Caslin HL, Chumanevich AP, Kolawole EM, Paranjape A, Baker B, Ndaw VS, Barnstein BO, Oskeritzian CA, Sell SA, Ryan JJ (2016). Lactic Acid Suppresses IL-33-Mediated Mast Cell Inflammatory Responses via Hypoxia-Inducible Factor-1α-Dependent miR-155 Suppression. J Immunol, 197(7), 2909-17. (Read full article)
  29. Qayum AA, Paranjape A, Abebayehu D, Kolawole EM, Haque TT, McLeod JJ, Spence AJ, Caslin HL, Taruselli MT, Chumanevich AP, Baker B, Oskeritzian CA, Ryan JJ (2016). IL-10-Induced miR-155 Targets SOCS1 To Enhance IgE-Mediated Mast Cell Function. J Immunol, 196(11), 4457-67. (Read full article)
  30. Kolawole EM, McLeod JJ, Ndaw V, Abebayehu D, Barnstein BO, Faber T, Spence AJ, Taruselli M, Paranjape A, Haque TT, Qayum AA, Kazmi QA, Wijesinghe DS, Sturgill JL, Chalfant CE, Straus DB, Oskeritzian CA, Ryan JJ (2016). Fluvastatin Suppresses Mast Cell and Basophil IgE Responses: Genotype-Dependent Effects. J Immunol, 196(4), 1461-70. (Read full article)
  31. Oskeritzian CA, Hait NC, Wedman P, Chumanevich A, Kolawole EM, Price MM, Falanga YT, Harikumar KB, Ryan JJ, Milstien S, Sabbadini R, Spiegel S (2014). The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses. J Allergy Clin Immunol, 135(4), 1008-18.e1. (Read full article)
  32. Faber TW, Pullen NA, Fernando JF, Kolawole EM, McLeod JJ, Taruselli M, Williams KL, Rivera KO, Barnstein BO, Conrad DH, Ryan JJ (2014). ADAM10 is required for SCF-induced mast cell migration. Cell Immunol, 290(1), 80-8. (Read full article)
  33. Morales JK, Saleem SJ, Martin RK, Saunders BL, Barnstein BO, Faber TW, Pullen NA, Kolawole EM, Brooks KB, Norton SK, Sturgill J, Graham L, Bear HD, Urban JF Jr, Lantz CS, Conrad DH, Ryan JJ (2013). Myeloid-derived suppressor cells enhance IgE-mediated mast cell responses. J Leukoc Biol, 95(4), 643-50. (Read full article)
  34. Fernando J, Faber TW, Pullen NA, Falanga YT, Kolawole EM, Oskeritzian CA, Barnstein BO, Bandara G, Li G, Schwartz LB, Spiegel S, Straus DB, Conrad DH, Bunting KD, Ryan JJ (2013). Genotype-dependent effects of TGF-β1 on mast cell function: targeting the Stat5 pathway. J Immunol, 191(9), 4505-13. (Read full article)
  35. Falanga YT, Chaimowitz NS, Charles N, Finkelman FD, Pullen NA, Barbour S, Dholaria K, Faber T, Kolawole M, Huang B, Odom S, Rivera J, Carlyon J, Conrad DH, Spiegel S, Oskeritzian CA, Ryan JJ (2012). Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis. J Immunol, 188(9), 4360-8. (Read full article)
  36. Speiran K, Bailey DP, Fernando J, Macey M, Barnstein B, Kolawole M, Curley D, Watowich SS, Murray PJ, Oskeritzian C, Ryan JJ (2009). Endogenous suppression of mast cell development and survival by IL-4 and IL-10. J Leukoc Biol, 85(5), 826-36. (Read full article)
  37. Kozawa O, Suzuki A, Shinoda J, Oiso Y (1995). Genistein inhibits potentiation by wortmannin of protein kinase C-activated phospholipase D in osteoblast-like cells. Cell Signal, 7(3), 219-23. (Read full article)

Review

  1. Liu B, Kolawole EM, Evavold BD (2021). Mechanobiology of T Cell Activation: To Catch a Bond. [Review]. Annu Rev Cell Dev Biol, 37, 65-87. (Read full article)
  2. Kolawole EM, Lamb TJ, Evavold BD (2020). Relationship of 2D Affinity to T Cell Functional Outcomes. [Review]. Int J Mol Sci, 21(21). (Read full article)
  3. Kolawole EM, Lamb TJ, Evavold BD (2020).  Relationship of 2D Affinity to T Cell Functional Outcomes. . [Review]. Int J Mol Sci, 21(21).