Elliot H. Smith

Elliot H. Smith, PhD

Languages spoken: Indonesian, English, French

Academic Information

Departments Primary - Neurosurgery

Education History

Undergraduate University of Washington
 BS
Doctoral Training University of Utah
 PhD
Fellowship Columbia University
 Postdoctoral Training

Selected Publications

Journal Article

  1. James O'Sullivan, Jose Herrero, Elliot Smith, Catherine Schevon, Guy M McKhann, Sameer A Sheth, Ashesh D Mehta, Nima Mesgarani (2019). Hierarchical encoding of attended auditory objects in multi-talker speech perception. Neuron.
  2. Merricks EM, Smith EH, McKhann GM, Goodman RR, Bateman LM, Emerson RG, Schevon CA, Trevelyan AJ (2015). Single unit action potentials in humans and the effect of seizure activity. Brain, 138(Pt 10), 2891-906. (Read full article)
  3. Liou JY, Ma H, Wenzel M, Zhao M, Baird-Daniel E, Smith EH, Daniel A, Emerson R, Yuste R, Schwartz TH, Schevon CA (2018). Role of inhibitory control in modulating focal seizure spread. Brain, 141(7), 2083-2097. (Read full article)
  4. Smith EH, Banks GP, Mikell CB, Cash SS, Patel SR, Eskandar EN, Sheth SA (2015). Frequency-Dependent Representation of Reinforcement-Related Information in the Human Medial and Lateral Prefrontal Cortex. J Neurosci, 35(48), 15827-36. (Read full article)
  5. Edward M Merricks, Elliot H Smith, Ronald G Emerson, Lisa M Bateman, Guy M McKhann, Robert R Goodman, Sameer A Sheth, Bradley Greger, Paul A House, Andrew J Trevelyan, Catherine A Schevon (2021). Neuronal firing and waveform alterations through ictal recruitment in humans. J Neurosci.
  6. Melina Tsitsiklis, Jonathan Miller, Salman E Qasim, Cory S Inman, Robert E Gross, Jon T Willie, Elliot H Smith, Sameer A Sheth, Catherine A Schevon, Michael R Sperling, Ashwini Sharan, Joel M Stein, Joshua Jacobs (2020). Single-neuron representations of spatial targets in humans. Curr Biol.
  7. Elliot H Smith, Guillermo Horga, Mark J Yates, Charles B Mikell, Garrett P Banks, Yagna J Pathak, Catherine A Schevon, Guy M McKhann, Benjamin Y Hayden, Matthew M Botvinick, Sameer A Sheth (2019). Widespread temporal coding of cognitive control in the human prefrontal cortex. Nat Neurosci.
  8. Salman E Qasim, Jonathan Miller, Cory S Inman, Robert E Gross, Jon T Willie, Bradley Lega, Jui-Jui Lin, Ashwini Sharan, Chengyuan Wu, Michael R Sperling, Sameer A Sheth, Guy M McKhann, Elliot H Smith, Catherine Schevon, Joel M Stein, Joshua Jaco (2019). Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex. Nat Neurosci.
  9. Smith E, Kellis S, House P, Greger B (2013). Decoding stimulus identity from multi-unit activity and local field potentials along the ventral auditory stream in the awake primate: implications for cortical neural prostheses. J Neural Eng, 10(1), 016010. (Read full article)
  10. Liou JY, Smith EH, Bateman LM, McKhann GM, Goodman RR, Greger B, Davis TS, Kellis SS, House PA, Schevon CA (2017). Multivariate regression methods for estimating velocity of ictal discharges from human microelectrode recordings. J Neural Eng, 14(4), 044001. (Read full article)
  11. Hannah E Goldstein, Elliot H Smith, Robert E Gross, Barbara C Jobst, Bradley C Lega, Michael R Sperling, Gregory A Worrell, Kareem A Zaghloul, Paul A Wanda, Michael J Kahana, Daniel S Rizzuto, Catherine A Schevon, Guy M McKhann, Sameer A Sheth (2019). Risk of seizures induced by intracranial research stimulation: analysis of 770 stimulation sessions. J Neural Eng.
  12. Smith E, Duede S, Hanrahan S, Davis T, House P, Greger B (2013). Seeing is believing: neural representations of visual stimuli in human auditory cortex correlate with illusory auditory perceptions. PLoS One, 8(9), e73148. (Read full article)
  13. McGovern RA, Ratneswaren T, Smith EH, Russo JF, Jongeling AC, Bateman LM, Schevon CA, Feldstein NA, McKhann GM 2nd, Sheth S (2015). Investigating the function of deep cortical and subcortical structures using stereotactic electroencephalography: lessons from the anterior cingulate cortex.LID - 10.3791/52773 [doi]. J Vis Exp, (98). (Read full article)
  14. Bornali Kundu, Tyler S Davis, Brian Philip, Elliot H Smith, Amir Arain, Angela Peters, Blake Newman, Christopher R Butson, John D Rolston (2020). A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy. Brain Stimul.
  15. Smith EH, Liou JY, Davis TS, Merricks EM, Kellis SS, Weiss SA, Greger B, House PA, McKhann GM 2nd, Goodman RR, Emerson RG, Bateman LM, Trevelyan AJ, Schevon CA (2016). The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures. Nat Commun, 7, 11098. (Read full article)
  16. Miller J, Watrous AJ, Tsitsiklis M, Lee SA, Sheth SA, Schevon CA, Smith EH, Sperling MR, Sharan A, Asadi-Pooya AA, Worrell GA, Meisenhelter S, Inman CS, Davis KA, Lega B, Wanda PA, Das SR, Stein JM, Gorniak R, Jacobs J (2018). Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation. Nat Commun, 9(1), 2423. (Read full article)
  17. Abhinav Goyal, Jonathan Miller, Salman E Qasim, Andrew J Watrous, Honghui Zhang, Joel M Stein, Cory S Inman, Robert E Gross, Jon T Willie, Bradley Lega, Jui-Jui Lin, Ashwini Sharan, Chengyuan Wu, Michael R Sperling, Sameer A Sheth, Guy M McKhann, Elliot H Smith, Catherine Schevon, Joshua Jacobs (2020). Functionally distinct high and low theta oscillations in the human hippocampus. Nat Commun.
  18. Catherine A. Schevon Elliot H. Smith, Edward M. Merricks, Jyun-You Liou, Camilla Casadei, Lucia Melloni, Thomas Thesen, Daniel J. Friedman, Werner K. Doyle, Ronald G. Emerson, Robert R. Goodman, Guy M. McKhann II, Sameer A. Sheth, John D. Rolston (2020). Dual mechanisms of ictal high frequency oscillations in human rhythmic onset seizures. Sci Rep.
  19. Jyun-you Liou, Elliot H Smith, Lisa M Bateman, Samuel L Bruce, Guy M McKhann, Robert R Goodman, Ronald G Emerson, Catherine A Schevon, LF Abbott (2020). A model for focal seizure onset, propagation, evolution, and progression. Elife.
  20. Eissa TL, Tryba AK, Marcuccilli CJ, Ben-Mabrouk F, Smith EH, Lew SM, Goodman RR, McKhann GM Jr, Frim DM, Pesce LL, Kohrman MH, Emerson RG, Schevon CA, van Drongelen (2016). Multiscale Aspects of Generation of High-Gamma Activity during Seizures in Human Neocortex.LID - 10.1523/ENEURO.0141-15.2016 [doi]LID - ENEURO.0141-15.2016 [pii]. eNeuro, 3(2), (Read full article)
  21. Michael Wenzel, Shuting Han, Elliot Smith, Hoel Erik, Bradley Greger, Paul House, Rafael Yust (2019). Reduced repertoire of cortical microstates and neuronal ensembles in medically-induced loss of consciousness. Cell systems,
  22. Herman AB, Smith EH, Schevon CA, Yates MJ, McKhann GM, Botvinick M, Hayden BY, Sheth S (2023). Pretrial predictors of conflict response efficacy in the human prefrontal cortex. iScience, 26(11), 108047. (Read full article)
  23. Caston RM, Smith EH, Davis TS, Singh H, Rahimpour S, Rolston J (2023). Characterization of spatiotemporal dynamics of binary and graded tonic pain in humans using intracranial recordings. PloS one, 18(10), e0292808. (Read full article)
  24. Anderson DN, Charlebois CM, Smith EH, Davis TS, Peters AY, Newman BJ, Arain AM, Wilcox KS, Butson CR, Rolston J (2023). Closed-loop stimulation in periods with less epileptiform activity drives improved epilepsy outcomes. Brain, 147(2), 521-531. (Read full article)
  25. Caston RM, Davis TS, Smith EH, Rahimpour S, Rolston J (2023). A novel thermoelectric device integrated with a psychophysical paradigm to study pain processing in human subjects. Journal of neuroscience methods, 386, 109780. (Read full article)
  26. Myers JC, Smith EH, Leszczynski M, O'Sullivan J, Yates MJ, McKhann G, Mesgarani N, Schroeder C, Schevon C, Sheth S (2022). The Spatial Reach of Neuronal Coherence and Spike-Field Coupling across the Human Neocortex. The Journal of neuroscience, 42(32), 6285-6294. (Read full article)
  27. Haegens S, Pathak YJ, Smith EH, Mikell CB, Banks GP, Yates M, Bijanki KR, Schevon CA, McKhann GM, Schroeder CE, Sheth S (2022). Alpha and broadband high-frequency activity track task dynamics and predict performance in controlled decision-making. Psychophysiology, 59(5), e13901. (Read full article)
  28. Davis TS, Caston RM, Philip B, Charlebois CM, Anderson DN, Weaver KE, Smith EH, Rolston J (2022). Corrigendum: LeGUI: A Fast and Accurate Graphical User Interface for Automated Detection and Anatomical Localization of Intracranial Electrodes. Frontiers in neuroscience, 16, 858978. (Read full article)
  29. Smith EH, Liou JY, Merricks EM, Davis T, Thomson K, Greger B, House P, Emerson RG, Goodman R, McKhann GM, Sheth S, Schevon C, Rolston J (2022). Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges. eLife, 11, (Read full article)
  30. Anderson DN, Charlebois CM, Smith EH, Arain AM, Davis TS, Rolston J (2021). Probabilistic comparison of gray and white matter coverage between depth and surface intracranial electrodes in epilepsy. Scientific reports, 11(1), 24155. (Read full article)
  31. Davis TS, Caston RM, Philip B, Charlebois CM, Anderson DN, Weaver KE, Smith EH, Rolston J (2021). LeGUI: A Fast and Accurate Graphical User Interface for Automated Detection and Anatomical Localization of Intracranial Electrodes. Frontiers in neuroscience, 15, 769872. (Read full article)
  32. Merricks EM, Smith EH, Emerson RG, Bateman LM, McKhann GM, Goodman RR, Sheth SA, Greger B, House PA, Trevelyan AJ, Schevon C (2021). Neuronal Firing and Waveform Alterations through Ictal Recruitment in Humans. The Journal of neuroscience, 41(4), 766-779. (Read full article)
  33. Smith EH, Merricks EM, Liou JY, Casadei C, Melloni L, Thesen T, Friedman DJ, Doyle WK, Emerson RG, Goodman RR, McKhann GM 2nd, Sheth SA, Rolston JD, Schevon C (2020). Dual mechanisms of ictal high frequency oscillations in human rhythmic onset seizures. Scientific reports, 10(1), 19166. (Read full article)
  34. Kundu B, Davis TS, Philip B, Smith EH, Arain A, Peters A, Newman B, Butson CR, Rolston J (2020). A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy. Brain stimulation, 13(5), 1232-1244. (Read full article)
  35. Goyal A, Miller J, Qasim SE, Watrous AJ, Zhang H, Stein JM, Inman CS, Gross RE, Willie JT, Lega B, Lin JJ, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Jacobs (2020). Functionally distinct high and low theta oscillations in the human hippocampus. Nature communications, 11(1), 2469. (Read full article)
  36. Liou JY, Smith EH, Bateman LM, Bruce SL, McKhann GM, Goodman RR, Emerson RG, Schevon CA, Abbott L (2020). A model for focal seizure onset, propagation, evolution, and progression. eLife, 9, (Read full article)
  37. Tsitsiklis M, Miller J, Qasim SE, Inman CS, Gross RE, Willie JT, Smith EH, Sheth SA, Schevon CA, Sperling MR, Sharan A, Stein JM, Jacobs (2020). Single-Neuron Representations of Spatial Targets in Humans. Current biology, 30(2), 245-253.e4. (Read full article)
  38. Qasim SE, Miller J, Inman CS, Gross RE, Willie JT, Lega B, Lin JJ, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Stein JM, Jacobs (2019). Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex. Nature neuroscience, 22(12), 2078-2086. (Read full article)
  39. Goldstein HE, Smith EH, Gross RE, Jobst BC, Lega BC, Sperling MR, Worrell GA, Zaghloul KA, Wanda PA, Kahana MJ, Rizzuto DS, Schevon CA, McKhann GM, Sheth S (2019). Risk of seizures induced by intracranial research stimulation: analysis of 770 stimulation sessions. Journal of neural engineering, 16(6), 066039. (Read full article)
  40. Smith EH, Horga G, Yates MJ, Mikell CB, Banks GP, Pathak YJ, Schevon CA, McKhann GM 2nd, Hayden BY, Botvinick MM, Sheth S (2019). Widespread temporal coding of cognitive control in the human prefrontal cortex. Nature neuroscience, 22(11), 1883-1891. (Read full article)
  41. Wenzel M, Han S, Smith EH, Hoel E, Greger B, House PA, Yuste (2019). Reduced Repertoire of Cortical Microstates and Neuronal Ensembles in Medically Induced Loss of Consciousness. Cell systems, 8(5), 467-474.e4. (Read full article)
  42. Smith EH, Kellis SS, House PA, Greger (2012). Information transfer along the ventral auditory processing stream in the awake macaque. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2012, 5178-81. (Read full article)
  43. Smith EH, Rolston J (2018). Oscillations Travel Around the Human Brain. Neurosurgery, 83(5), E205-E206. (Read full article)
  44. Charlebois CM, Anderson DN, Smith EH, Davis TS, Newman BJ, Peters AY, Arain AM, Dorval AD, Rolston JD, Butson C (2024). Circadian changes in aperiodic activity are correlated with seizure reduction in patients with mesial temporal lobe epilepsy treated with responsive neurostimulation. Epilepsia, 65(5), 1360-1373. (Read full article)
  45. Yearley AG, Smith EH, Davis TS, Anderson D, Arain AM, Rolston J (2024). Interictal discharge traveling waves recorded from stereoelectroencephalography electrodes. Journal of neurosurgery, 141(4), 1115-1123. (Read full article)
  46. Trevelyan AJ, Marks VS, Graham RT, Denison T, Jackson A, Smith E (2025). On brain stimulation in epilepsy. Brain, 148(3), 746-752. (Read full article)
  47. Campbell JM, Cowan RL, Wahlstrom KL, Hollearn MK, Jensen D, Davis T, Rahimpour S, Shofty B, Arain A, Rolston JD, Hamann S, Wang S, Eisenman LN, Swift J, Xie T, Brunner P, Manns JR, Inman CS, Smith EH, Willie J (2024). Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala. bioRxiv, (Read full article)
  48. Campbell JM, Davis TS, Anderson DN, Arain A, Davis Z, Inman CS, Smith EH, Rolston J (2024). Macroscale traveling waves evoked by single-pulse stimulation of the human brain. bioRxiv, (Read full article)
  49. Cowan RL, Davis T, Kundu B, Rahimpour S, Rolston JD, Smith E (2024). More widespread and rigid neuronal representation of reward expectation underlies impulsive choices. bioRxiv, (Read full article)
  50. Caston RM, Smith EH, Davis TS, Singh H, Rahimpour S, Rolston J (2023). Characterization of spatiotemporal dynamics of binary and graded tonic pain in humans using intracranial recordings. bioRxiv, (Read full article)
  51. Zarr VM, Liou JY, Merricks EM, Davis TS, Thomson K, Greger B, House PA, Emerson RG, Goodman RR, McKhann GM 2nd, Sheth SA, Schevon CA, Rolston JD, Smith E (2025). Protocol for detecting and analyzing non-oscillatory traveling waves from high-spatiotemporal-resolution human electrophysiological recordings. STAR protocols, 6(1), 103659. (Read full article)
  52. Cao R, Brunner P, Chakravarthula PN, Wahlstrom KL, Inman C, Smith EH, Li X, Mamelak AN, Brandmeir NJ, Rutishauser U, Willie JT, Wang (2025). A neuronal code for object representation and memory in the human amygdala and hippocampus. Nature communications, 16(1), 1510. (Read full article)
  53. Norby JH, Hummel D, Ricks N, Rolston J, Rahimpour S, Cowan R, Voipio J, Trevelyan AJ, Smith EH, Parrish R (2025). Rodent and human seizures demonstrate a dynamic interplay with spreading depolarizations. Neurobiology of disease, 211, 106937. (Read full article)
  54. Campbell JM, Davis TS, Anderson DN, Arain A, Davis ZW, Inman CS, Smith EH, Rolston J (2025). Macroscale Traveling Waves Evoked by Single-Pulse Stimulation of the Human Brain. The Journal of neuroscience, 45(21), (Read full article)
  55. Cowan RL, Davis TS, Merricks EM, Kundu B, Shofty B, Rahimpour S, Schevon CA, Rolston JD, Smith E (2025). Cell-type-specific responses to single-pulse electrical stimulation of the human brain. Brain stimulation, 18(4), 1266-1278. (Read full article)
  56. Campbell JM, Cowan RL, Wahlstrom KL, Hollearn MK, Jensen D, Davis T, Rahimpour S, Shofty B, Arain A, Rolston JD, Hamann S, Wang S, Eisenman LN, Swift J, Xie T, Brunner P, Manns J, Inman C, Smith EH, Willie J (2025). Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala. eLife, 14, (Read full article)
  57. Omelyusik V, Davis TS, Nair SS, Noudoost B, Hackett PD, Smith EH, Rahimpour S, Rolston JD, Kundu (2025). Frontotemporal bursting supports human working memory. bioRxiv, (Read full article)
  58. Omelyusik V, Davis TS, Nair SS, Noudoost B, Hackett PD, Smith EH, Rahimpour S, Rolston JD, Kundu (2026). Frontotemporal bursting supports human working memory. NeuroImage, 327, 121718. (Read full article)

Review

  1. Smith EH (2011). Temporal processing in the auditory core: transformation or segregation? [Review]. J Neurophysiol, 106, (6), 2791-3. (Read full article)
  2. Smith EH, Schevon CA (2016). Toward a Mechanistic Understanding of Epileptic Networks. [Review]. Curr Neurol Neurosci Rep, 16, (11), 97. (Read full article)
  3. Caston RM, Smith EH, Davis TS, Rolston J (2020). The Cerebral Localization of Pain: Anatomical and Functional Considerations for Targeted Electrical Therapies. Journal of clinical medicine, 9(6), (Read full article)

Conference Proceedings

  1. Sklar S, Walmer M, Sacre P, Schevon CA, Srinivasan S, Banks GP, Yates MJ, McKhann GM, Sheth SA, Sarma SV, Smith EH (2017). Neuronal activity in human anterior cingulate cortex modulates with internal cognitive state during multi-source interference task. Conf Proc IEEE Eng Med Biol Soc, 2017, 962-65. (Read full article)
  2. Smith EH, Kellis SS, House PA, Greger (2012). Information transfer along the ventral auditory processing stream in the awake macaque. 5178-81.

Abstract

  1. Dyster TG, Pathak Y, Smith E, Sheth SA (2016). An easily implemented, open access, semi-automated pipeline for intracranial electrode localization [Abstract]. Neurosurgery, 63(CN_suppl_1), 156.
  2. Sheth S, Horga G, Yates M, Pathak Y, Schevon C, McKhann G, Smith E (2017). Neuronal mechanisms of cognitive control in human prefrontal cortex [Abstract]. Neurosurgery.
  3. Mikell C, Smith E, Brown L, McKhann G, Sheth S (2014). Spatial Conflict is Encoded in Human MT+ [Abstract]. Neurosurgery.