Hamid Ghandehari

Hamid Ghandehari, PhD

Languages spoken: English

Academic Information

Departments Primary - Molecular Pharmaceutics , Adjunct - Otolaryngology: Head & Neck Surgery

Research Interests

  • Nanomedicine
  • Nanotechnology
  • Drug Delivery Systems
  • Polymeric drug delivery systems
  • Targeted Drug Delivery Systems
  • Targeting mechanisms to enhance drug delivery and efficacy

Hamid Ghandehari is Professor and George S. and Dolores Doré Eccles Presidential Endowed Chair in the Department of Molecular Pharmaceutics, Professor of Biomedical Engineering, and Director of Utah Center for Nanomedicine at The University of Utah. His research focuses on the design of polymeric biomaterials for localized drug delivery and understanding the relationship between physicochemical properties of inorganic nanoparticles with their toxicity. He is author of over 230 peer reviewed manuscripts and book chapters, 500 abstracts and has given 265 invited talks. Dr. Ghandehari served as Executive Editor (2006-2011) and Editor in Chief (2012-2022) of Advanced Drug Delivery Reviews, the #1 cited journal in the pharmaceutical sciences category. He is Fellow of the American Institute for Medical and Biological Engineering, the American Association of Pharmaceutical Scientists, and Controlled Release Society. Dr. Ghandehari received his BS in Pharmacy (1989) and PhD in Pharmaceutics and Pharmaceutical Chemistry (1996) from the University of Utah.

Research Statement

The Ghandehari Lab focuses on new approaches for controlled drug delivery and better understanding of nanoparticle structural features that result in toxicity. Current projects in our lab include design of recombinant polymers for localized drug delivery and as liquid embolics, establishing a correlation between physicochemical properties of silica nanoparticles and their downstream immune adverse effects, development of lipid-based nanostructures for mRNA delivery, drug delivery approaches for more effective and less toxic treatment of chronic rhinosinusitis, drug modification strategies to reduce adsorption to extracorporeal membrane oxygenation systems, water-soluble polymer-collagen mimetic peptide conjugates for targeting tumor extracellular matrix, and imaging agent delivery for improving surgical outcomes in oropharyngeal squamous cell carcinoma.

Education History

Doctoral Training University of Utah
 PhD
Undergraduate University of Utah
 BS

Selected Publications

Journal Article

  1. Shipman PA, Yathavan B, Gill AS, Pollard CE, Yellepeddi V, Ghandehari H, Alt JA, Pulsipher A, Smith KA (2024). Quantification of Budesonide Retained in the Sinonasal Cavity After High-Volume Saline Irrigation in Post-Operative Chronic Rhinosinusitis. Am J Rhinol Allergy, 38(3), 169-177. (Read full article)
  2. Khurana N, Watkins K, Ghatak D, Staples J, Hubbard O, Yellepeddi V, Watt K, Ghandehari H (2024). Reducing hydrophobic drug adsorption in an in-vitro extracorporeal membrane oxygenation model. Eur J Pharm Biopharm, 198, 114261. (Read full article)
  3. Parrot M, Yathavan B, Averin O, Hoggard L, Rower JE, Voight M, Greene D, Tarrell A, Whelan A, Ghandehari H, Murphy N, Yellepeddi V (2024). Clinical pharmacokinetics of atropine oral gel formulation in healthy volunteers. Clin Transl Sci, 17(3), e13753. (Read full article)
  4. Khurana N, Snner T, Hubbard O, Imburgia CE, Yellepeddi V, Ghandehari H, Watt KM (2023). Direct and continuous dosing of propofol can saturate Ex vivo ECMO circuit to improve propofol recovery. J Extra Corpor Technol, 55(4), 194-196. (Read full article)
  5. Yathavan B, Chhibber T, Steinhauff D, Pulsipher A, Alt JA, Ghandehari H, Jafari P (2023). Matrix-Mediated Delivery of Silver Nanoparticles for Prevention of Staphylococcus aureus and Pseudomonas aeruginosa Biofilm Formation in Chronic Rhinosinusitis. Pharmaceutics, 15(10). (Read full article)
  6. Chen F, Sun J, Wang Y, Grunberger JW, Zheng Z, Khurana N, Xu X, Zhou X, Ghandehari H, Zhang J (2022). Silica nanoparticles induce ovarian granulosa cell apoptosis via activation of the PERK-ATF4-CHOP-ERO1α pathway-mediated IP3R1-dependent calcium mobilization. Cell Biol Toxicol, 39(4), 1715-1734. (Read full article)
  7. Yathavan B, Ellis A, Jedrzkiewicz J, Subrahmanyam N, Khurana N, Pulsipher A, Alt JA, Ghandehari H (2023). Systemic administration of budesonide in pegylated liposomes for improved efficacy in chronic rhinosinusitis. J Control Release, 360, 274-284. (Read full article)
  8. Khurana N, Babajanian E, McCrary H, Pulsipher A, Ghandehari H, Alt JA, Cannon RB (2023). Vascular permeability in HPV+ oropharyngeal cancers aids in fluorescent image-guided transoral robotic surgery using indocyanine green. Head Neck, 45(7), 1728-1740. (Read full article)
  9. Almomen A, Alsaleh NB, El-Toni AM, El-Mahrouky MA, Alhowyan AA, Alkholief M, Alshamsan A, Khurana N, Ghandehari H (2023). In Vitro Safety Assessment of In-House Synthesized Titanium Dioxide Nanoparticles: Impact of Washing and Temperature Conditions. Int J Mol Sci, 24(12). (Read full article)
  10. Khurana N, Snner T, Hubbard O, Imburgia C, Stoddard GJ, Yellepeddi V, Ghandehari H, Watt KM (2023). Micellar Encapsulation of Propofol Reduces its Adsorption on Extracorporeal Membrane Oxygenator (ECMO) Circuit. AAPS J, 25(4), 52. (Read full article)
  11. Zheng Z, Zuo W, Ye R, Grunberger JW, Khurana N, Xu X, Ghandehari H, Chen F (2023). Silica Nanoparticles Promote Apoptosis in Ovarian Granulosa Cells via Autophagy Dysfunction. Int J Mol Sci, 24(6). (Read full article)
  12. Subrahmanyam N, Yathavan B, Yu SM, Ghandehari H (2023). Targeting Intratibial Osteosarcoma Using Water-Soluble Copolymers Conjugated to Collagen Hybridizing Peptides. Mol Pharm, 20(3), 1670-1680. (Read full article)
  13. Grunberger JW, Ghandehari H (2023). Layer-by-Layer Hollow Mesoporous Silica Nanoparticles with Tunable Degradation Profile. Pharmaceutics, 15(3). (Read full article)
  14. Moghaddam SPH, Mohammadpour R, Ghandehari H (2023). Retraction notice to "In vitro and in vivo evaluation of degradation, toxicity, biodistribution, and clearance of silica nanoparticles as a function of size, porosity, density, and composition" [Journal of Controlled Release 311-312 (2019) Pages 1-15]. J Control Release, 355, 622-623. (Read full article)
  15. Subrahmanyam N, Yathavan B, Kessler J, Yu SM, Ghandehari H (2022). HPMA copolymer-collagen hybridizing peptide conjugates targeted to breast tumor extracellular matrix. J Control Release, 353, 278-288. (Read full article)
  16. Ashkarran AA, Gharibi H, Grunberger JW, Saei AA, Khurana N, Mohammadpour R, Ghandehari H, Mahmoudi M (2022). Sex-Specific Silica Nanoparticle Protein Corona Compositions Exposed to Male and Female BALB/c Mice Plasmas. ACS Bio Med Chem Au, 3(1), 62-73. (Read full article)
  17. Jensen MM, Hatlevik, Steinhauff DD, Griswold ED, Wei X, Isaacson KJ, Barber ZB, Huo E, Taussky P, Jedrzkiewicz J, Cappello J, Cheney D, Ghandehari H (2022). Protein-based polymer liquid embolics for cerebral aneurysms. Acta Biomater, 151, 174-182. (Read full article)
  18. Kaur K, Mohammadpour R, Ghandehari H, Reilly CA, Paine R 3rd, Kelly KE (2022). Effect of combustion particle morphology on biological responses in a Co-culture of human lung and macrophage cells. Atmos Environ (1994), 284. (Read full article)
  19. Steinhauff D, Armstrong B, Jensen MM, Ghandehari H (2022). Development of Thermoresponsive Protein Complexes for Targeting CD20 Receptors. Macromol Biosci, 22(7), e2200028. (Read full article)
  20. Zhang Q, Grunberger JW, Khurana N, Zhou X, Xu X, Ghandehari H, Chen F (2022). BECLIN-1-Mediated Autophagy Suppresses Silica Nanoparticle-Induced Testicular Toxicity via the Inhibition of Caspase 8-Mediated Cell Apoptosis in Leydig Cells. Cells, 11(12). (Read full article)
  21. Isaacson KJ, Van Devener BR, Steinhauff DB, Jensen MM, Cappello J, Ghandehari H (2022). Liquid-cell transmission electron microscopy for imaging of thermosensitive recombinant polymers. J Control Release, 344, 39-49. (Read full article)
  22. Zhang J, Ye R, Grunberger JW, Jin J, Zhang Q, Mohammadpour R, Khurana N, Xu X, Ghandehari H, Chen F (2022). Activation of Autophagy by Low-Dose Silica Nanoparticles Enhances Testosterone Secretion in Leydig Cells. Int J Mol Sci, 23(6). (Read full article)
  23. Hatlevik, Jensen M, Steinhauff D, Wei X, Huo E, Jedrzkiewicz J, Cappello J, Cheney D, Ghandehari H (2022). Translational Development of a Silk-Elastinlike Protein Polymer Embolic for Transcatheter Arterial Embolization. Macromol Biosci, 22(2), e2100401. (Read full article)
  24. Steinhauff D, Jensen MM, Griswold E, Jedrzkiewicz J, Cappello J, Oottamasathien S, Ghandehari H (2022). An Oligomeric Sulfated Hyaluronan and Silk-Elastinlike Polymer Combination Protects against Murine Radiation Induced Proctitis. Pharmaceutics, 14(1). (Read full article)
  25. Kaur K, Mohammadpour R, Sturrock A, Ghandehari H, Reilly C, Paine R 3rd, Kelly KE (2022). Comparison of biological responses between submerged, pseudo-air-liquid interface, and air-liquid interface exposure of A549 and differentiated THP-1 co-cultures to combustion-derived particles. J Environ Sci Health A Tox Hazard Subst Environ Eng, 57(7), 540-551. (Read full article)
  26. Khurana N, Yathavan B, Jedrzkiewicz J, Gill AS, Pulsipher A, Alt JA, Ghandehari H (2021). Vascular permeability in chronic rhinosinusitis enhances accumulation and retention of nanoscale pegylated liposomes. Nanomedicine, 38, 102453. (Read full article)
  27. Khurana N, Pulsipher A, Jedrzkiewicz J, Ashby S, Pollard CE, Ghandehari H, Alt JA (2020). Inflammation-driven vascular dysregulation in chronic rhinosinusitis. Int Forum Allergy Rhinol, 11(6), 976-983. (Read full article)
  28. Steinhauff D, Jensen M, Talbot M, Jia W, Isaacson K, Jedrzkiewicz J, Cappello J, Oottamasathien S, Ghandehari H (2021). Silk-elastinlike copolymers enhance bioaccumulation of semisynthetic glycosaminoglycan ethers for prevention of radiation induced proctitis. J Control Release, 332, 503-515. (Read full article)
  29. Khurana N, Pulsipher A, Ghandehari H, Alt JA (2020). Meta-analysis of global and high throughput public gene array data for robust vascular gene expression discovery in chronic rhinosinusitis: Implications in controlled release. J Control Release, 330, 878-888. (Read full article)
  30. Kaur K, Overacker D, Ghandehari H, Reilly C, Paine R 3rd, Kelly KE (2020). Determining real-time mass deposition with a quartz crystal microbalance in an electrostatic, parallel-flow, air-liquid interface exposure system. J Aerosol Sci, 151. (Read full article)
  31. Mohammadpour R, Cheney DL, Grunberger JW, Yazdimamaghani M, Jedrzkiewicz J, Isaacson KJ, Dobrovolskaia MA, Ghandehari H (2020). One-year chronic toxicity evaluation of single dose intravenously administered silica nanoparticles in mice and their Ex vivo human hemocompatibility. J Control Release, 324, 471-481. (Read full article)
  32. Isaacson KJ, Jensen MM, Steinhauff DB, Kirklow JE, Mohammadpour R, Grunberger JW, Cappello J, Ghandehari H (2020). Location of stimuli-responsive peptide sequences within silk-elastinlike protein-based polymers affects nanostructure assembly and drug-polymer interactions. J Drug Target, 28(7-8), 766-779. (Read full article)
  33. Jensen MM, Barber ZB, Khurana N, Isaacson KJ, Steinhauff D, Green B, Cappello J, Pulsipher A, Ghandehari H, Alt JA (2020). A dual-functional Embolization-Visualization System for Fluorescence image-guided Tumor Resection. Theranostics, 10(10), 4530-4543. (Read full article)
  34. Kaur K, Mohammadpour R, Jaramillo IC, Ghandehari H, Reilly C, Paine R, Kelly KE (2019). Application of a Quartz Crystal Microbalance to Measure the Mass Concentration of Combustion Particle Suspensions. J Aerosol Sci, 137. (Read full article)
  35. Yazdimamaghani M, Moos PJ, Ghandehari H (2019). Time- and dose-dependent gene expression analysis of macrophage response as a function of porosity of silica nanoparticles. Nanomedicine, 21, 102041. (Read full article)
  36. Jensen MM, Jia W, Schults AJ, Isaacson KJ, Steinhauff D, Green B, Zachary B, Cappello J, Ghandehari H, Oottamasathien S (2019). Temperature-responsive silk-elastinlike protein polymer enhancement of intravesical drug delivery of a therapeutic glycosaminoglycan for treatment of interstitial cystitis/painful bladder syndrome. Biomaterials, 217, 119293. (Read full article)
  37. Hadipour Moghaddam SP, Mohammadpour R, Ghandehari H (2019). RETRACTED: In vitro and in vivo evaluation of degradation, toxicity, biodistribution, and clearance of silica nanoparticles as a function of size, porosity, density, and composition. J Control Release, 311-312, 1-15. (Read full article)
  38. Mohammadpour R, Yazdimamaghani M, Reilly CA, Ghandehari H (2018). Transient Receptor Potential Ion Channel-Dependent Toxicity of Silica Nanoparticles and Poly(amido amine) Dendrimers. J Pharmacol Exp Ther, 370(3), 751-760. (Read full article)
  39. Mohammadpour R, Yazdimamaghani M, Cheney DL, Jedrzkiewicz J, Ghandehari H (2019). Subchronic toxicity of silica nanoparticles as a function of size and porosity. J Control Release, 304, 216-232. (Read full article)
  40. Kaur K, Jaramillo IC, Mohammadpour R, Sturrock A, Ghandehari H, Reilly C, Paine R 3rd, Kelly KE (2019). Effect of collection methods on combustion particle physicochemical properties and their biological response in a human macrophage-like cell line. J Environ Sci Health A Tox Hazard Subst Environ Eng, 54(12), 1170-1185. (Read full article)
  41. Saikia J, Mohammadpour R, Yazdimamaghani M, Northrup H, Hlady V, Ghandehari H (2018). Silica Nanoparticle-Endothelial Interaction: Uptake and Effect on Platelet Adhesion under Flow Conditions. ACS Appl Bio Mater, 1(5), 1620-1627. (Read full article)
  42. Liu GW, Prossnitz AN, Eng DG, Cheng Y, Subrahmanyam N, Pippin JW, Lamm RJ, Ngambenjawong C, Ghandehari H, Shankland SJ, Pun SH (2018). Glomerular disease augments kidney accumulation of synthetic anionic polymers. Biomaterials, 178, 317-325. (Read full article)
  43. Hadipour Moghaddam SP, Yazdimamaghani M, Ghandehari H (2018). Glutathione-sensitive hollow mesoporous silica nanoparticles for controlled drug delivery. J Control Release, 282, 62-75. (Read full article)
  44. Yellepeddi VK, Mohammadpour R, Kambhampati SP, Sayre C, Mishra MK, Kannan RM, Ghandehari H (2018). Pediatric oral formulation of dendrimer-N-acetyl-l-cysteine conjugates for the treatment of neuroinflammation. Int J Pharm, 545(1-2), 113-116. (Read full article)
  45. Kanamala M, Palmer BD, Ghandehari H, Wilson WR, Wu Z (2018). PEG-Benzaldehyde-Hydrazone-Lipid Based PEG-Sheddable pH-Sensitive Liposomes: Abilities for Endosomal Escape and Long Circulation. Pharm Res, 35(8), 154. (Read full article)
  46. Yazdimamaghani M, Moos PJ, Ghandehari H (2017). Global gene expression analysis of macrophage response induced by nonporous and porous silica nanoparticles. Nanomedicine, 14(2), 533-545. (Read full article)
  47. Isaacson KJ, Jensen MM, Watanabe AH, Green BE, Correa MA, Cappello J, Ghandehari H (2017). Self-Assembly of Thermoresponsive Recombinant Silk-Elastinlike Nanogels. Macromol Biosci, 18(1). (Read full article)
  48. Gao Z, Hadipour Moghaddam SP, Ghandehari H, Zharov I (2018). Synthesis of water-degradable silica nanoparticles from carbamate-containing bridged silsesquioxane precursor. RSC Adv, 8(9), 4914-4920. (Read full article)
  49. Jensen MM, Jia W, Isaacson KJ, Schults A, Cappello J, Prestwich GD, Oottamasathien S, Ghandehari H (2017). Silk-elastinlike protein polymers enhance the efficacy of a therapeutic glycosaminoglycan for prophylactic treatment of radiation-induced proctitis. J Control Release, 263, 46-56. (Read full article)
  50. Hadipour Moghaddam SP, Saikia J, Yazdimamaghani M, Ghandehari H (2017). Redox-Responsive Polysulfide-Based Biodegradable Organosilica Nanoparticles for Delivery of Bioactive Agents. ACS Appl Mater Interfaces, 9(25), 21133-21146. (Read full article)
  51. Mohammadpour R, Safarian S, Buckway B, Ghandehari H (2016). Comparative Endocytosis Mechanisms and Anticancer Effect of HPMA Copolymer- and PAMAM Dendrimer-MTCP Conjugates for Photodynamic Therapy. Macromol Biosci, 17(4). (Read full article)
  52. Frazier N, Payne A, Dillon C, Subrahmanyam N, Ghandehari H (2016). Enhanced efficacy of combination heat shock targeted polymer therapeutics with high intensity focused ultrasound. Nanomedicine, 13(3), 1235-1243. (Read full article)
  53. Zeller Meidell K, Robinson R, Vieira-de-Abreu A, Gormley AJ, Ghandehari H, W Grainger D, A Campbell R (2016). RGDfK-functionalized gold nanorods bind only to activated platelets. J Biomed Mater Res A, 105(1), 209-217. (Read full article)
  54. Saikia J, Yazdimamaghani M, Hadipour Moghaddam SP, Ghandehari H (2016). Differential Protein Adsorption and Cellular Uptake of Silica Nanoparticles Based on Size and Porosity. ACS Appl Mater Interfaces, 8(50), 34820-34832. (Read full article)
  55. Jung BK, Lee YK, Hong J, Ghandehari H, Yun CO (2016). Mild Hyperthermia Induced by Gold Nanorod-Mediated Plasmonic Photothermal Therapy Enhances Transduction and Replication of Oncolytic Adenoviral Gene Delivery. ACS Nano, 10(11), 10533-10543. (Read full article)
  56. Poursaid A, Jensen MM, Nourbakhsh I, Weisenberger M, Hellgeth JW, Sampath S, Cappello J, Ghandehari H (2016). Silk-Elastinlike Protein Polymer Liquid Chemoembolic for Localized Release of Doxorubicin and Sorafenib. Mol Pharm, 13(8), 2736-48. (Read full article)
  57. Mosallaei N, Mahmoudi A, Ghandehari H, Yellepeddi VK, Jaafari MR, Malaekeh-Nikouei B (2016). Solid lipid nanoparticles containing 7-ethyl-10-hydroxycamptothecin (SN38): Preparation, characterization, in vitro, and in vivo evaluations. Eur J Pharm Biopharm, 104, 42-50. (Read full article)
  58. Jeon HY, Jung SH, Jung YM, Kim YM, Ghandehari H, Ha KS (2016). Array-Based High-Throughput Analysis of Silk-Elastinlike Protein Polymer Degradation and C-Peptide Release by Proteases. Anal Chem, 88(10), 5398-405. (Read full article)
  59. Jones DE, Lund AM, Ghandehari H, Facelli JC (2016). Molecular dynamics simulations in drug delivery research: Calcium chelation of G3.5 PAMAM dendrimers. Cogent Chem, 2(1). (Read full article)
  60. Robinson R, Gerlach W, Ghandehari H (2015). Comparative effect of gold nanorods and nanocages for prostate tumor hyperthermia. J Control Release, 220(Pt A), 245-252. (Read full article)
  61. Hubbard D, Bond T, Ghandehari H (2015). Regional Morphology and Transport of PAMAM Dendrimers Across Isolated Rat Intestinal Tissue. Macromol Biosci, 15(12), 1735-43. (Read full article)
  62. Hubbard D, Enda M, Bond T, Moghaddam SP, Conarton J, Scaife C, Volckmann E, Ghandehari H (2015). Transepithelial Transport of PAMAM Dendrimers Across Isolated Human Intestinal Tissue. Mol Pharm, 12(11), 4099-107. (Read full article)
  63. Jones DE, Ghandehari H, Facelli JC (2015). Predicting cytotoxicity of PAMAM dendrimers using molecular descriptors. Beilstein J Nanotechnol, 6, 1886-96. (Read full article)
  64. Price R, Poursaid A, Cappello J, Ghandehari H (2015). In vivo evaluation of matrix metalloproteinase responsive silk-elastinlike protein polymers for cancer gene therapy. J Control Release, 213, 96-102. (Read full article)
  65. Gustafson HH, Holt-Casper D, Grainger DW, Ghandehari H (2015). Nanoparticle Uptake: The Phagocyte Problem. Nano Today, 10(4), 487-510. (Read full article)
  66. Poursaid A, Price R, Tiede A, Olson E, Huo E, McGill L, Ghandehari H, Cappello J (2015). In situ gelling silk-elastinlike protein polymer for transarterial chemoembolization. Biomaterials, 57, 142-52. (Read full article)
  67. Frazier N, Robinson R, Ray A, Ghandehari H (2015). Effects of heating temperature and duration by gold nanorod mediated plasmonic photothermal therapy on copolymer accumulation in tumor tissue. Mol Pharm, 12(5), 1605-14. (Read full article)
  68. Herd HL, Bartlett KT, Gustafson JA, McGill LD, Ghandehari H (2015). Macrophage silica nanoparticle response is phenotypically dependent. Biomaterials, 53, 574-82. (Read full article)
  69. Price R, Poursaid A, Cappello J, Ghandehari H (2014). Effect of shear on physicochemical properties of matrix metalloproteinase responsive silk-elastinlike hydrogels. J Control Release, 195, 92-8. (Read full article)
  70. Hubbard D, Ghandehari H, Brayden DJ (2014). Transepithelial transport of PAMAM dendrimers across isolated rat jejunal mucosae in ussing chambers. Biomacromolecules, 15(8), 2889-95. (Read full article)
  71. Astashkina AI, Jones CF, Thiagarajan G, Kurtzeborn K, Ghandehari H, Brooks BD, Grainger DW (2014). Nanoparticle toxicity assessment using an in vitro 3-D kidney organoid culture model. Biomaterials, 35(24), 6323-31. (Read full article)
  72. Buckway B, Frazier N, Gormley AJ, Ray A, Ghandehari H (2013). Gold nanorod-mediated hyperthermia enhances the efficacy of HPMA copolymer-90Y conjugates in treatment of prostate tumors. Nucl Med Biol, 41(3), 282-9. (Read full article)
  73. Buckway B, Wang Y, Ray A, Ghandehari H (2013). In vitro evaluation of HPMA-copolymers targeted to HER2 expressing pancreatic tumor cells for image guided drug delivery. Macromol Biosci, 14(1), 92-9. (Read full article)
  74. Sadekar S, Thiagarajan G, Bartlett K, Hubbard D, Ray A, McGill LD, Ghandehari H (2013). Poly(amido amine) dendrimers as absorption enhancers for oral delivery of camptothecin. Int J Pharm, 456(1), 175-85. (Read full article)
  75. Buckway B, Wang Y, Ray A, Ghandehari H (2013). Overcoming the stromal barrier for targeted delivery of HPMA copolymers to pancreatic tumors. Int J Pharm, 456(1), 202-11. (Read full article)
  76. Moos PJ, Honeggar M, Malugin A, Herd H, Thiagarajan G, Ghandehari H (2013). Transcriptional responses of human aortic endothelial cells to nanoconstructs used in biomedical applications. Mol Pharm, 10(8), 3242-52. (Read full article)
  77. Thiagarajan G, Greish K, Ghandehari H (2013). Charge affects the oral toxicity of poly(amidoamine) dendrimers. Eur J Pharm Biopharm, 84(2), 330-4. (Read full article)
  78. Sadekar S, Linares O, Noh G, Hubbard D, Ray A, Jant-Amsbury M, Peterson CM, Facelli J, Ghandehari H (2013). COMPARATIVE PHARMACOKINETICS OF PAMAM-OH DENDRIMERS AND HPMA COPOLYMERS IN OVARIAN-TUMOR-BEARING MICE. Drug Deliv Transl Res, 3(3), 260-271. (Read full article)
  79. Herd H, Daum N, Jones AT, Huwer H, Ghandehari H, Lehr CM (2013). Nanoparticle geometry and surface orientation influence mode of cellular uptake. ACS Nano, 7(3), 1961-73. (Read full article)
  80. Gustafson JA, Price RA, Frandsen J, Henak CR, Cappello J, Ghandehari H (2013). Synthesis and characterization of a matrix-metalloproteinase responsive silk-elastinlike protein polymer. Biomacromolecules, 14(3), 618-25. (Read full article)
  81. Gormley AJ, Larson N, Banisadr A, Robinson R, Frazier N, Ray A, Ghandehari H (2012). Plasmonic photothermal therapy increases the tumor mass penetration of HPMA copolymers. J Control Release, 166(2), 130-8. (Read full article)
  82. Thiagarajan G, Sadekar S, Greish K, Ray A, Ghandehari H (2013). Evidence of oral translocation of anionic G6.5 dendrimers in mice. Mol Pharm, 10(3), 988-98. (Read full article)
  83. Jones CF, Campbell RA, Brooks AE, Assemi S, Tadjiki S, Thiagarajan G, Mulcock C, Weyrich AS, Brooks BD, Ghandehari H, Grainger DW (2012). Cationic PAMAM dendrimers aggressively initiate blood clot formation. ACS Nano, 6(11), 9900-10. (Read full article)
  84. Yu T, Hubbard D, Ray A, Ghandehari H (2012). In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface characteristics. J Control Release, 163(1), 46-54. (Read full article)
  85. Jones CF, Campbell RA, Franks Z, Gibson CC, Thiagarajan G, Vieira-de-Abreu A, Sukavaneshvar S, Mohammad SF, Li DY, Ghandehari H, Weyrich AS, Brooks BD, Grainger DW (2012). Cationic PAMAM dendrimers disrupt key platelet functions. Mol Pharm, 9(6), 1599-611. (Read full article)
  86. Gormley AJ, Larson N, Sadekar S, Robinson R, Ray A, Ghandehari H (2012). Guided Delivery of Polymer Therapeutics Using Plasmonic Photothermal Therapy. Nano Today, 7(3), 158-167. (Read full article)
  87. Price R, Gustafson J, Greish K, Cappello J, McGill L, Ghandehari H (2011). Comparison of silk-elastinlike protein polymer hydrogel and poloxamer in matrix-mediated gene delivery. Int J Pharm, 427(1), 97-104. (Read full article)
  88. Larson N, Ghandehari H (2012). Polymeric conjugates for drug delivery. Chem Mater, 24(5), 840-853. (Read full article)
  89. Gormley AJ, Greish K, Ray A, Robinson R, Gustafson JA, Ghandehari H (2011). Gold nanorod mediated plasmonic photothermal therapy: a tool to enhance macromolecular delivery. Int J Pharm, 415(1-2), 315-8. (Read full article)
  90. Ray A, Larson N, Pike DB, Grner M, Naik S, Bauer H, Malugin A, Greish K, Ghandehari H (2011). Comparison of active and passive targeting of docetaxel for prostate cancer therapy by HPMA copolymer-RGDfK conjugates. Mol Pharm, 8(4), 1090-9. (Read full article)
  91. Yu T, Malugin A, Ghandehari H (2011). Impact of silica nanoparticle design on cellular toxicity and hemolytic activity. ACS Nano, 5(7), 5717-28. (Read full article)
  92. Anumolu R, Gustafson JA, Magda JJ, Cappello J, Ghandehari H, Pease LF 3rd (2011). Fabrication of highly uniform nanoparticles from recombinant silk-elastin-like protein polymers for therapeutic agent delivery. ACS Nano, 5(7), 5374-82. (Read full article)
  93. Herd HL, Malugin A, Ghandehari H (2011). Silica nanoconstruct cellular toleration threshold in vitro. J Control Release, 153(1), 40-8. (Read full article)
  94. Greish K, Ray A, Bauer H, Larson N, Malugin A, Pike D, Haider M, Ghandehari H (2011). Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release, 151(3), 263-70. (Read full article)
  95. Sadekar S, Ray A, Jant-Amsbury M, Peterson CM, Ghandehari H (2010). Comparative biodistribution of PAMAM dendrimers and HPMA copolymers in ovarian-tumor-bearing mice. Biomacromolecules, 12(1), 88-96. (Read full article)
  96. Larson N, Ray A, Malugin A, Pike DB, Ghandehari H (2010). HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res, 27(12), 2683-93. (Read full article)
  97. Vijayalakshmi N, Ray A, Malugin A, Ghandehari H (2010). Carboxyl-terminated PAMAM-SN38 conjugates: synthesis, characterization, and in vitro evaluation. Bioconjug Chem, 21(10), 1804-10. (Read full article)
  98. Gustafson JA, Price RA, Greish K, Cappello J, Ghandehari H (2010). Silk-elastin-like hydrogel improves the safety of adenovirus-mediated gene-directed enzyme-prodrug therapy. Mol Pharm, 7(4), 1050-6. (Read full article)
  99. Greish K, Frandsen J, Scharff S, Gustafson J, Cappello J, Li D, OMalley BW Jr, Ghandehari H (2010). Silk-elastinlike protein polymers improve the efficacy of adenovirus thymidine kinase enzyme prodrug therapy of head and neck tumors. J Gene Med, 12(7), 572-9. (Read full article)

Review

  1. Griswold E, Cappello J, Ghandehari H (2022). Silk-elastinlike protein-based hydrogels for drug delivery and embolization. [Review]. Adv Drug Deliv Rev, 191, 114579. (Read full article)
  2. Mohammapdour R, Ghandehari H (2021). Mechanisms of immune response to inorganic nanoparticles and their degradation products. [Review]. Adv Drug Deliv Rev, 180, 114022. (Read full article)
  3. Subrahmanyam N, Ghandehari H (2021). Harnessing Extracellular Matrix Biology for Tumor Drug Delivery. [Review]. J Pers Med, 11(2). (Read full article)
  4. Yellepeddi VK, Ghandehari H (2019). Pharmacokinetics of oral therapeutics delivered by dendrimer-based carriers. [Review]. Expert Opin Drug Deliv, 16(10), 1051-1061. (Read full article)
  5. Mohammadpour R, Dobrovolskaia MA, Cheney DL, Greish KF, Ghandehari H (2019). Subchronic and chronic toxicity evaluation of inorganic nanoparticles for delivery applications. [Review]. Adv Drug Deliv Rev, 144, 112-132. (Read full article)
  6. Yazdimamaghani M, Moos PJ, Dobrovolskaia MA, Ghandehari H (2018). Genotoxicity of amorphous silica nanoparticles: Status and prospects. [Review]. Nanomedicine, 16, 106-125. (Read full article)
  7. Isaacson KJ, Martin Jensen M, Subrahmanyam NB, Ghandehari H (2017). Matrix-metalloproteinases as targets for controlled delivery in cancer: An analysis of upregulation and expression. [Review]. J Control Release, 259, 62-75. (Read full article)
  8. Poursaid A, Jensen MM, Huo E, Ghandehari H (2016). Polymeric materials for embolic and chemoembolic applications. [Review]. J Control Release, 240, 414-433. (Read full article)
  9. Jones DE, Ghandehari H, Facelli JC (2016). A review of the applications of data mining and machine learning for the prediction of biomedical properties of nanoparticles. [Review]. Comput Methods Programs Biomed, 132, 93-103. (Read full article)
  10. Yellepeddi VK, Ghandehari H (2016). Poly(amido amine) dendrimers in oral delivery. [Review]. Tissue Barriers, 4(2), e1173773. (Read full article)
  11. Frazier N, Ghandehari H (2015). Hyperthermia approaches for enhanced delivery of nanomedicines to solid tumors. [Review]. Biotechnol Bioeng, 112(10), 1967-83. (Read full article)
  12. Price R, Poursaid A, Ghandehari H (2014). Controlled release from recombinant polymers. [Review]. J Control Release, 190, 304-13. (Read full article)
  13. Sadekar S, Ghandehari H (2011). Transepithelial transport and toxicity of PAMAM dendrimers: implications for oral drug delivery. [Review]. Adv Drug Deliv Rev, 64(6), 571-88. (Read full article)
  14. Frandsen JL, Ghandehari H (2012). Recombinant protein-based polymers for advanced drug delivery. [Review]. Chem Soc Rev, 41(7), 2696-706. (Read full article)

Editorial

  1. Ghandehari H (2019). ADDR Editor's Collection 2019. Adv Drug Deliv Rev, 151-152, 1. (Read full article)
  2. Ghandehari H (2018). ADDR Editor's Collection 2018. Adv Drug Deliv Rev, 136-137, 1. (Read full article)
  3. Ghandehari H (2017). ADDR Editor's Collection 2017. Adv Drug Deliv Rev, 122, 1. (Read full article)
  4. Ghandehari H (2017). Editorial: Editors' Collection 2016. Adv Drug Deliv Rev, 108, 1. (Read full article)
  5. Ghandehari H (2015). ADDR Editor's Collection 2015. Adv Drug Deliv Rev, 91, 1-2. (Read full article)

Patent

  1. Line B, Van Echo D, Kennedy A, Ghandehari H, Nan A (2005). Microparticles for Microarterial Imaging and Radiotherapy. U.S. Patent No. WO 2005/061009 A2. Washington, D.C.:U.S. Patent and Trademark Office.

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