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Hassan M. Yaish

Hassan M. Yaish, MD

Languages spoken: English, Arabic

Academic Information

Departments Emeritus - Pediatrics


Academic Office Information

Board Certification

  • American Board of Pediatrics (Pediatrics)
  • American Board of Pediatrics (Sub: Pediatric Hematology-Oncology)

Hassan M Yaish, MD.
Medical Director, Intermountain Hemophilia and Thrombosis Treatment Center.
Graduated from college of Medicine, University of Damascus in 1964
Internship in internal medicine and pediatrics at Augesta Victoria Hospital in Jerusalem and Damascus city Hospital in Damascus, Syria.
Residency in pediatrics at the Royal medical services at the base hospital in Amman, Jordan and William Beaumont Medical center in Royal Oak, Michigan
Hematology /Oncology fellowship at william Beaumont Medical center, Royal Oak , MI.
Clerkship at Fred Hutchinson cancer center, in Seattle, WA for bone marrow transplant in 1991.

Studies conducted during fellowship and early career in pediatric hematology were mostly on thrombocytopenia in children , neonatal hematology and bleeding disorders.
-Main interest therefore was in benign hematology such as: Anemia, Neutropenia and coagulation defects.
-Neonatal Hematological disorders , and hyperbilirubinemia.
-Bleeding disorders, inherited and acquired.
-Thrombosis and thrombophilia, diagnosis and management.

I gained some experience while working outside the united states in the diagnosis and manageconditions of conditions rarely seen in the USA.
- Red Blood Cell enzyme deficiency such as G6PD, clinical manifestations in various types and management.
-Hemoglobinopathy and Thalassemia.
- Lead poisoning .

Based on morphologic findings of blood smears in neonates and young infants, early diagnosis of red cell membrane defects , enzymopathies , and other hemolytic entities associated with hyperbilirubinemia can be identified in otherwise conditions which might have been labelled as "idiopathic"
-Hereditary Spherocytosis, Elliptocytosis, Pyropoikilocytosis.
-G6PD deficiency, Pyruvate kinase deficiency.
-Infantile pyknocytosis.
-Schistocytic hemolytic anemia.

Education History

Clerkship Fred Hutchinson Cancer Research Center
Clinical Clerkship
William Beaumont Hospital Medical Center
Residency William Beaumont Hospital Medical Center
Jordan Royal Medical Services
Internship Jordan Royal Medical Services
Damascus University
Undergraduate University of Damascus, College of Science

Selected Publications

Journal Article

  1. Yaish H, Matsushita T, Belhani M, Jimnez-Yuste V, Kavakli K, Korsholm L, Matytsina I, Philipp C, Reichwald K, Wu R (2019). Safety and efficacy of turoctocog alfa in the prevention and treatment of bleeds in previously untreated paediatric patients with severe haemophilia A: Results from the guardian 4 multinational clinical trial. Haemophilia.
  2. Grace RF, Rose C, Layton DM, Galactros F, Barcellini W, Morton DH, van Beers EJ, Yaish H, Ravindranath Y, Kuo KHM, Sheth S, Kwiatkowski JL, Barbier AJ, Bodie S, Silver B, Hua L, Kung C, Hawkins P, Jouvin MH, Bowden C, Glader B (2019). Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency. N Engl J Med, 381(10), 933-944.
  3. Bahr TM, Christensen RD, Ward DM, Meng F, Jackson LK, Doyle K, Christensen DR, Harvey AG, Yaish HM (2019). Ferritin in serum and urine: A pilot study. Blood Cells Mol Dis, 76, 59-62.
  4. Christensen RD, Agarwal AM, George TI, Bhutani VK, Yaish HM (2018). Acute neonatal bilirubin encephalopathy in the State of Utah 2009-2018. Blood Cells Mol Dis, 72, 10-13.
  5. Yaish HM, Christensen RD, Agarwal A (2013). A neonate with Coombs-negative hemolytic jaundice with spherocytes but normal erythrocyte indices: a rare case of autosomal-recessive hereditary spherocytosis due to alpha-spectrin deficiency. J Perinatol, 33(5), 404-6.
  6. Christensen RD, Yaish HM, Johnson CB, Bianchi P, Zanella A (2011). Six children with pyruvate kinase deficiency from one small town: molecular characterization of the PK-LR gene. J Pediatr, 159(4), 695-7.

Case Report

  1. Christensen RD, Yaish HM (2012). A neonate with the Pelger-Huet anomaly, cleft lip and palate, and agenesis of the corpus callosum, with a chromosomal microdeletion involving 1q41 to 1q42.12. J Perinatol, 32(3), 238-40.


  1. van Beers EJ, van Straaten S, Morton DH, Barcellini W, Eber SW, Glader B, Yaish HM, Chonat S, Kwiatkowski JL, Rothman JA, Sharma M, Neufeld EJ, Sheth S, Despotovic JM, Kollmar N, Pospilov D, Knoll CM, Kuo K, Pastore YD, Thompson AA, Newburger PE, Ravindranath Y, Wang WC, Wlodarski MW, Wang H, Holzhauer S, Breakey VR, Verhovsek M, Kunz J, McNaull MA, Rose MJ, Bradeen HA, Addonizio K, Li A, Al-Sayegh H, London WB, Grace RF (2018). Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study. [Letter to the editor]. Haematologica, 104(2), e51-e53.


  1. Yaish H, Rodgers G (2010). Alloantibodies in type 3 VWD: report of two cases and review of the literature [Abstract]. Haemophilia, 16(Suppl 4), 156.