Kubanek J., Brown J., Ye P., Butts Pauly K., Moore T., Newsome W. Transcranial ultrasound selectively biases decision-making in primates. BioRxiv 486134 (2019).
Kubanek J., Shukla P., Das A., Baccus S., Goodman M. Ultrasound elicits behavioral responses through mechanical effects on neurons and ion channels in a simple nervous system. The Journal of Neuroscience, 1458-17 (2018).
Kubanek J. Neuromodulation with transcranial focused ultrasound. Neurosurgical Focus44 (2018).
Kubanek J. Optimal decision-making and matching are tied through diminishing returns.PNAS, doi:10.1073/pnas.1703440114 (2017).
Kubanek J., Shi J., Marsh J., Chen D., Deng C., Cui J. Ultrasound modulates ion channel currents. Scientific Reports 6 (2016).
Kubanek J., Li J., Snyder L.H. Motor role of parietal cortex in a monkey model of hemi- spatial neglect. PNAS. 112, E2067-72 (2015).
Kubanek J., Snyder L.H. Reward-based Decision Signals in Parietal Cortex Are Partially Embodied. The Journal of Neuroscience, 35(12):4869–81 (2015).
Kubanek J., Snyder L.H. Reward size governs repeat-switch decisions and strongly mod- ulates the activity of neurons in parietal cortex. Cerebral Cortex (2015).
Kubanek J., Schalk G. NeuralAct: A tool to visualize electrocorticographic (ECoG) activity on a three-dimensional model of the cortex. Neuroinformatics, 13, 167-74 (2015).
Kubanek J., Snyder L.H, Abrams R.A. Rewards and punishments act as distinct factors in guiding behavior. Cognition, 139, 154–167 (2015).
Kubanek J., Snyder L.H. Matching Behavior as a Tradeoff Between Reward Maximization and Demands on Neural Computation. F1000Research (2015).
Kubanek J., Hill J., Snyder L.H, Schalk G. Cortical alpha activity reflects the degree of confidence in committing to an action. Frontiers in Neuroscience 9, 243 (2015).
Kubanek J., Snyder L.H., Brunton B.W., Brody C., Schalk G. A low frequency oscillatory neural signal in humans encodes a developing decision variable. NeuroImage, 83, 795808 (2013).
Kubanek J., Wang C., Snyder L.H. Neuronal responses to target onset in oculomotor and somatomotor parietal circuits differ markedly in a choice task. Journal of Neurophysiology110.10, 2247-2256 (2013).
Kubanek J., Brunner P., Gunduz A., Poeppel D., Schalk G. The Tracking of Speech Envelope in the Human Cortex. PLOS ONE 8, no. 1 (2013).
Kubanek J., Miller K.J., Ojemann J.G., Wolpaw J.R., Schalk G. Decoding flexion of indi- vidual fingers using electrocorticographic signals in humans. Journal of Neural Engineering, vol. 6 pp. 66001 (2009).
Schalk G., Kubanek J., Miller K.J., Anderson N., Leuthardt E.C., Ojemann J.G., Lim- brick D., Moran D., Gerhardt L.A., Wolpaw J.R. Decoding Two-Dimensional Movement Trajectories Using Electrocorticographic Signals in Humans. Journal of Neural Engineering, 4, 264-275 (2007).
Research Statement
Mental and neurological disorders are the world's leading cause of disability. Drug treatments have often been inadequate and have contributed to an alarming addiction situation. We need to be able to diagnose and treat the neural source of brain disorders. Toward that goal, our lab develops:
- Minimally invasive methods that enable to modulate individual neural circuits transiently and systematicall—one by one—until identifying the set that leads to a relief of a given sign or symptom.
- Methods for durable treatment of the involved circuit activity and connectivity.
This work will enable us to move beyond prescribing systemic drugs by addressing the source of a problem in each individual. At the basic science level, the ability to modulate (and in particular, suppress) neural circuits noninvasively and thereby systematically will lead to new, causal studies of how individual brain circuits are involved in specific behaviors in humans.
