Janet M. Shaw

Janet M. Shaw, PhD

Academic Information

Departments Primary - Biochemistry

Lab

Education History

Undergraduate University of California
 BA
Doctoral Training University of California
 PhD
Postdoctoral Fellowship University of California, Molecular Biology Institute
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Fukushima NH, Brisch E, Keegan BR, Bleazard W, Shaw J (2001). The GTPase effector domain sequence of the Dnm1p GTPase regulates self-assembly and controls a rate-limiting step in mitochondrial fission. Molecular biology of the cell, 12(9), 2756-66.
  2. Gorsich SW, Shaw J (2004). Importance of mitochondrial dynamics during meiosis and sporulation. Molecular biology of the cell, 15(10), 4369-81.
  3. Kondo-Okamoto N, Ohkuni K, Kitagawa K, McCaffery JM, Shaw JM, Okamoto (2006). The novel F-box protein Mfb1p regulates mitochondrial connectivity and exhibits asymmetric localization in yeast. Molecular biology of the cell, 17(9), 3756-67.
  4. Amiott EA, Cohen MM, Saint-Georges Y, Weissman AM, Shaw J (2009). A mutation associated with CMT2A neuropathy causes defects in Fzo1 GTP hydrolysis, ubiquitylation, and protein turnover. Molecular biology of the cell, 20(23), 5026-35.
  5. Lewandowska A, Macfarlane J, Shaw J (2013). Mitochondrial association, protein phosphorylation, and degradation regulate the availability of the active Rab GTPase Ypt11 for mitochondrial inheritance. Molecular biology of the cell, 24(8), 1185-95.
  6. Christensen CA, Gorsich SW, Brown RH, Jones LG, Brown J, Shaw JM, Drews G (2002). Mitochondrial GFA2 is required for synergid cell death in Arabidopsis. The Plant cell, 14(9), 2215-32.
  7. Amiott EA, Lott P, Soto J, Kang PB, McCaffery JM, DiMauro S, Abel ED, Flanigan KM, Lawson VH, Shaw J (2008). Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations. Experimental neurology, 211(1), 115-27.
  8. Singer JM, Hermann GJ, Shaw J (2000). Suppressors of mdm20 in yeast identify new alleles of ACT1 and TPM1 predicted to enhance actin-tropomyosin interactions. Genetics, 156(2), 523-34.
  9. Frederick RL, Okamoto K, Shaw J (2008). Multiple pathways influence mitochondrial inheritance in budding yeast. Genetics, 178(2), 825-37.
  10. Kondo-Okamoto N, Shaw JM, Okamoto (2003). Mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation. The Journal of biological chemistry, 278(49), 48997-9005.
  11. Bhar D, Karren MA, Babst M, Shaw J (2006). Dimeric Dnm1-G385D interacts with Mdv1 on mitochondria and can be stimulated to assemble into fission complexes containing Mdv1 and Fis1. The Journal of biological chemistry, 281(25), 17312-20.
  12. Koshiba T, Holman HA, Kubara K, Yasukawa K, Kawabata S, Okamoto K, MacFarlane J, Shaw J (2011). Structure-function analysis of the yeast mitochondrial Rho GTPase, Gem1p: implications for mitochondrial inheritance. The Journal of biological chemistry, 286(1), 354-62.
  13. Wong ED, Wagner JA, Gorsich SW, McCaffery JM, Shaw JM, Nunnari (2000). The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria. The Journal of cell biology, 151(2), 341-52.
  14. Mozdy AD, McCaffery JM, Shaw J (2000). Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. The Journal of cell biology, 151(2), 367-80.
  15. Frederick RL, McCaffery JM, Cunningham KW, Okamoto K, Shaw J (2004). Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. The Journal of cell biology, 167(1), 87-98.
  16. Karren MA, Coonrod EM, Anderson TK, Shaw J (2005). The role of Fis1p-Mdv1p interactions in mitochondrial fission complex assembly. The Journal of cell biology, 171(2), 291-301.
  17. Koirala S, Bui HT, Schubert HL, Eckert DM, Hill CP, Kay MS, Shaw J (2010). Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes. The Journal of cell biology, 191(6), 1127-39.
  18. Bui HT, Karren MA, Bhar D, Shaw J (2012). A novel motif in the yeast mitochondrial dynamin Dnm1 is essential for adaptor binding and membrane recruitment. The Journal of cell biology, 199(4), 613-22.
  19. Cohen MM, Amiott EA, Day AR, Leboucher GP, Pryce EN, Glickman MH, McCaffery JM, Shaw JM, Weissman A (2011). Sequential requirements for the GTPase domain of the mitofusin Fzo1 and the ubiquitin ligase SCFMdm30 in mitochondrial outer membrane fusion. Journal of cell science, 124(Pt 9), 1403-10.
  20. Voth WP, Richards JD, Shaw JM, Stillman D (2001). Yeast vectors for integration at the HO locus. Nucleic acids research, 29(12), E59-9.
  21. Singer JM, Shaw J (2003). Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Proceedings of the National Academy of Sciences of the United States of America, 100(13), 7644-9.
  22. Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw J (2013). Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proceedings of the National Academy of Sciences of the United States of America, 110(15), E1342-51.
  23. Nguyen TT, Oh SS, Weaver D, Lewandowska A, Maxfield D, Schuler MH, Smith NK, Macfarlane J, Saunders G, Palmer CA, Debattisti V, Koshiba T, Pulst S, Feldman EL, Hajnoczky G, Shaw J (2014). Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease. Proceedings of the National Academy of Sciences of the United States of America, 111(35), E3631-40.
  24. Coonrod EM, Karren MA, Shaw J (2007). Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion. Traffic (Copenhagen, Denmark), 8(5), 500-11.
  25. Nguyen TT, Lewandowska A, Choi JY, Markgraf DF, Junker M, Bilgin M, Ejsing CS, Voelker DR, Rapoport TA, Shaw J (2012). Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance. Traffic (Copenhagen, Denmark), 13(6), 880-90.
  26. Kondo-Okamoto N, Shaw JM, Okamoto (2008). Tetratricopeptide repeat proteins Tom70 and Tom71 mediate yeast mitochondrial morphogenesis. EMBO reports, 9(1), 63-9.
  27. Guo Q, Koirala S, Perkins EM, McCaffery JM, Shaw J (2012). The mitochondrial fission adaptors Caf4 and Mdv1 are not functionally equivalent. PloS one, 7(12), e53523.
  28. Schuler MH, Lewandowska A, Caprio GD, Skillern W, Upadhyayula S, Kirchhausen T, Shaw JM, Cunniff (2017). Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration. Molecular biology of the cell, 28(16), 2159-2169.

Review

  1. Okamoto K, Shaw JM (2005). Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. [Review]. Annu Rev Genet, 39, 503-36.
  2. Bui HT, Shaw J (2013). Dynamin assembly strategies and adaptor proteins in mitochondrial fission. Current biology, 23(19), R891-9.
  3. Shaw JM, Nunnari (2002). Mitochondrial dynamics and division in budding yeast. Trends in cell biology, 12(4), 178-84.
  4. Frederick RL, Shaw J (2007). Moving mitochondria: establishing distribution of an essential organelle. Traffic (Copenhagen, Denmark), 8(12), 1668-75.
  5. Mozdy AD, Shaw J (2003). A fuzzy mitochondrial fusion apparatus comes into focus. Nature reviews. Molecular cell biology, 4(6), 468-78.
  6. Shaw JM, Winge D (2009). Shaping the mitochondrion: mitochondrial biogenesis, dynamics and dysfunction. Conference on Mitochondrial Assembly and Dynamics in Health and Disease. EMBO reports, 10(12), 1301-5.