Jincheng Shen

Jincheng Shen, PhD, MS

Languages spoken: English

Academic Information

Departments Adjunct - Family & Preventive Medicine , Primary - Internal Medicine

Divisions: Public Health , Epidemiology

Jincheng Shen is an Assistant Professor in the Department of Population Health Sciences, and holds adjunct appointments with the Department of Internal Medicine and Department of Family & Preventive Medicine, at the University of Utah. He obtained his Ph.D. in Biostatistics from the University of Michigan, Ann Arbor. Prior to coming to Utah, he completed his postdoctoral training in the Department of Biostatistics at Harvard T.H. Chan School of Public Health. Jincheng joined the University of Utah in 2017.

Research Statement

Dr. Jincheng Shen is interested in statistical methodology development and its application for various health related questions, especially implementation of causal inference tools in cancer studies and statistical genetics and genomics research. His primary methodology research interests include: i) comparative effectiveness analysis in clinical trials and observational study with longitudinal data; ii) Heterogeneous treatment effect estimation and individual treatment rules identification in complex disease setting; iii) statistical analysis of high throughput genetics and epigenetics studies, including genome-wide association studies and mediation analysis. He is actively engaged in a wide spectrum of collaborations with clinicians, biologists and epidemiologists.

Education History

Undergraduate Tsinghua University
 BS
Graduate Training Tsinghua University
 MS
Doctoral Training University of Michigan
 PhD

Selected Publications

Journal Article

  1. Sideris K, Zhang M, Wohlfahrt P, Siu AF, Shen J, Carter S, Kyriakopoulos CP, Taleb I, Wever-Pinzon O, Shah K, Selzman CH, Rodriguez-Correa C, Kapelios C, Brinker L, Alharethi R, Hess R, Drakos SG, Steinberg BA, Fang JC, Kfoury AG, Melenovsky V, Greene T, Spertus JA, Stehlik (2024). Integration of Patient Reported Quality-of-life Data into Risk Assessment in Heart Failure. Journal of cardiac failure, 31(5), 761-770.
  2. Magel JS, Beneciuk JM, Siantz E, Fritz J, Garland EL, Hanley A, Shen J, Blosser P, Matev T, Gordon A (2024). PT-IN-MIND: study protocol for a multisite randomised feasibility trial investigating physical therapy with integrated mindfulness (PT-IN-MIND) for patients with chronic musculoskeletal pain and long-term opioid treatment who attend outpatient physical therapy. BMJ open, 14(7), e082611.
  3. Cooperman NA, Shen J, Gordon AJ, Garland E (2024). Commentary With Study Protocol: Implementation and Effectiveness of Mindfulness-Oriented Recovery Enhancement (MORE) as an Adjunct to Methadone Treatment for Opioid Use Disorder (IMPOWR-MORE). Substance use & addiction journal, 29767342241261890.
  4. Wang X, Lee H, Haaland B, Kerrigan K, Puri S, Akerley W, Shen (2024). A matching-based machine learning approach to estimating optimal dynamic treatment regimes with time-to-event outcomes. Statistical methods in medical research, 33(5), 794-806.
  5. Wu YP, Stump TK, Hay JL, Buller DB, Jensen JD, Grossman D, Shen J, Haaland BA, Jones J, Tercyak K (2024). Protocol for a cluster-randomized trial of a school-based skin cancer preventive intervention for adolescents. Contemporary clinical trials, 140, 107494.
  6. Bansal S, Boucher R, Shen J, Wei G, Chertow GM, Whelton PK, Cushman WC, Cheung AK, Beddhu S, , on behalf of SPRIN (2024). Role of Diuretics in Cardiovascular Events and Mortality in Systolic Blood Pressure Intervention Trial: A Post Hoc Analysis. Clinical journal of the American Society of Nephrology, 19(5), 620-627.
  7. Xu M, Feng R, Liu Z, Zhou X, Chen Y, Cao Y, Valeri L, Li Z, Liu Z, Cao SM, Liu Q, Xie SH, Chang ET, Jia WH, Shen J, Yao Y, Cai YL, Zheng Y, Zhang Z, Huang G, Ernberg I, Tang M, Ye W, Adami HO, Zeng YX, Lin (2024). Host genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation. Cell genomics, 4(2), 100474.
  8. Hashibe M, Wei M, Lee CJ, Tao R, Koric A, Wang J, Daud A, Tay D, Shen J, Lee YA, Chang C (2024). Incident Cardiovascular Disease Risk among Older Asian, Native Hawaiian and Pacific Islander Breast Cancer Survivors. Cancer epidemiology, biomarkers & prevention, 33(1), 126-135.
  9. Tjilos M, Drainoni ML, Burrowes SAB, Butler JM, Damschroder LJ, Bidwell Goetz M, Madaras-Kelly K, Reardon CM, Samore MH, Shen J, Stenehjem EA, Zhang Y, Barlam T (2023). A qualitative evaluation of frontline clinician perspectives toward antibiotic stewardship programs. Infection control and hospital epidemiology, 44(12), 1995-2001.
  10. Derington CG, Bress AP, Berchie RO, Herrick JS, Shen J, Ying J, Greene T, Tajeu GS, Sakhuja S, Ruiz-Negrón N, Zhang Y, Howard G, Levitan EB, Muntner P, Safford MM, Whelton PK, Weintraub WS, Moran AE, Bellows B (2023). Estimated Population Health Benefits of Intensive Systolic Blood Pressure Treatment Among SPRINT-Eligible US Adults. American journal of hypertension, 36(9), 498-508.
  11. Ghazi L, Shen J, Ying J, Derington CG, Cohen JB, Marcum ZA, Herrick JS, King JB, Cheung AK, Williamson JD, Pajewski NM, Bryan N, Supiano M, Sonnen J, Weintraub WS, Greene TH, Bress A (2023). Identifying Patients for Intensive Blood Pressure Treatment Based on Cognitive Benefit: A Secondary Analysis of the SPRINT Randomized Clinical Trial. JAMA network open, 6(5), e2314443.
  12. Nevala-Plagemann C, Sama S, Ying J, Shen J, Haaland B, Florou V, Garrido-Laguna (2023). A Real-World Comparison of Regorafenib and Trifluridine/Tipiracil in Refractory Metastatic Colorectal Cancer in the United States. Journal of the National Comprehensive Cancer Network, 21(3), 257-264.
  13. Sisco-Taylor BL, Magel JS, McFadden M, Greene T, Shen J, Fritz J (2022). Changes in Pain Catastrophizing and Fear-Avoidance Beliefs as Mediators of Early Physical Therapy on Disability and Pain in Acute Low-Back Pain: A Secondary Analysis of a Clinical Trial. Pain medicine (Malden, Mass.), 23(6), 1127-1137.
  14. Cochran G, Shen J, Cox N, Field C, Carlston K, Sengpraseut B, White A, Okifuji A, Jackman C, Haaland B, Ragsdale R, Gordon AJ, Tarter (2022). Addressing opioid medication misuse at point of service in community pharmacy: A study protocol for an interdisciplinary behavioral health trial. Contemporary clinical trials, 116, 106759.
  15. Xu Y, Greene TH, Bress AP, Sauer BC, Bellows BK, Zhang Y, Weintraub WS, Moran AE, Shen (2022). Estimating the optimal individualized treatment rule from a cost-effectiveness perspective. Biometrics, 78(1), 337-351.
  16. Wang X, Kerrigan K, Puri S, Shen J, Akerley W, Haaland (2022). Dynamic Prediction of Near-Term Overall Survival in Patients with Advanced NSCLC Based on Real-World Data. Cancers, 14(3),
  17. Liu Z, Shen J, Barfield R, Schwartz J, Baccarelli AA, Lin (2022). Large-Scale Hypothesis Testing for Causal Mediation Effects with Applications in Genome-wide Epigenetic Studies. Journal of the American Statistical Association, 117(537), 67-81.
  18. Burrowes SAB, Drainoni ML, Tjilos M, Butler JM, Damschroder LJ, Goetz MB, Madaras-Kelly K, Reardon CM, Samore MH, Shen J, Stenehjem E, Zhang Y, Barlam T (2021). Survey of physician and pharmacist steward perceptions of their antibiotic stewardship programs. Antimicrobial stewardship & healthcare epidemiology, 1(1), e48.
  19. Jones BE, Ying J, Nevers M, Alba PR, He T, Patterson OV, Jones MM, Stevens V, Shen J, Humpherys J, Peterson KS, Rutter ED, Gundlapalli AV, Weir CR, Dean NC, Fine MJ, Samore MC, Greene T (2021). Computerized Mortality Prediction for Community-acquired Pneumonia at 117 Veterans Affairs Medical Centers. Annals of the American Thoracic Society, 18(7), 1175-1184.
  20. Sauer BC, Chen W, Shen J, Accortt NA, Collier DH, Cannon G (2021). Potential for Major Therapeutic Changes to Produce Significant Clinical Response Across a Broad Range of Disease Activity: An Observational Study of US Veterans With Rheumatoid Arthritis. Arthritis care & research, 73(7), 964-974.
  21. Jhun MA, Mendelson M, Wilson R, Gondalia R, Joehanes R, Salfati E, Zhao X, Braun KVE, Do AN, Hedman ÅK, Zhang T, Carnero-Montoro E, Shen J, Bartz TM, Brody JA, Montasser ME, O'Connell JR, Yao C, Xia R, Boerwinkle E, Grove M, Guan W, Liliane P, Singmann P, Müller-Nurasyid M, Meitinger T, Gieger C, Peters A, Zhao W, Ware EB, Smith JA, Dhana K, van Meurs J, Uitterlinden A, Ikram MA, Ghanbari M, Zhi D, Gustafsson S, Lind L, Li S, Sun D, Spector TD, Chen YI, Damcott C, Shuldiner AR, Absher DM, Horvath S, Tsao PS, Kardia S, Psaty BM, Sotoodehnia N, Bell JT, Ingelsson E, Chen W, Dehghan A, Arnett DK, Waldenberger M, Hou L, Whitsel EA, Baccarelli A, Levy D, Fornage M, Irvin MR, Assimes T (2021). A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids. Nature communications, 12(1), 3987.
  22. Matías-García PR, Ward-Caviness CK, Raffield LM, Gao X, Zhang Y, Wilson R, Gào X, Nano J, Bostom A, Colicino E, Correa A, Coull B, Eaton C, Hou L, Just AC, Kunze S, Lange L, Lange E, Lin X, Liu S, Nwanaji-Enwerem JC, Reiner A, Shen J, Schöttker B, Vokonas P, Zheng Y, Young B, Schwartz J, Horvath S, Lu A, Whitsel EA, Koenig W, Adamski J, Winkelmann J, Brenner H, Baccarelli AA, Gieger C, Peters A, Franceschini N, Waldenberger (2021). DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function. Clinical epigenetics, 13(1), 121.
  23. Bress AP, Greene T, Derington CG, Shen J, Xu Y, Zhang Y, Ying J, Bellows BK, Cushman WC, Whelton PK, Pajewski NM, Reboussin D, Beddu S, Hess R, Herrick JS, Zhang Z, Kolm P, Yeh RW, Basu S, Weintraub WS, Moran AE, SPRINT Research Grou (2021). Patient Selection for Intensive Blood Pressure Management Based on Benefit and Adverse Events. Journal of the American College of Cardiology, 77(16), 1977-1990.
  24. Sauer BC, Chen W, Xu Y, Shen J, Accortt NA, Collier DH, Cannon G (2020). Empirical evidence of disease activity thresholds used to indicate need for major therapeutic change in US veterans with rheumatoid arthritis. Arthritis research & therapy, 22(1), 253.
  25. Breen M, Nwanaji-Enwerem JC, Karrasch S, Flexeder C, Schulz H, Waldenberger M, Kunze S, Ollert M, Weidinger S, Colicino E, Gao X, Wang C, Shen J, Just AC, Vokonas P, Sparrow D, Hou L, Schwartz JD, Baccarelli AA, Peters A, Ward-Caviness C (2020). Accelerated epigenetic aging as a risk factor for chronic obstructive pulmonary disease and decreased lung function in two prospective cohort studies. Aging, 12(16), 16539-16554.
  26. Barlam TF, Childs E, Zieminski SA, Meshesha TM, Jones KE, Butler JM, Damschroder LJ, Goetz MB, Madaras-Kelly K, Reardon CM, Samore MH, Shen J, Stenehjem E, Zhang Y, Drainoni M (2020). Perspectives of Physician and Pharmacist Stewards on Successful Antibiotic Stewardship Program Implementation: A Qualitative Study. Open forum infectious diseases, 7(7), ofaa229.
  27. Gao X, Colicino E, Shen J, Just AC, Nwanaji-Enwerem JC, Wang C, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli A (2019). Comparative validation of an epigenetic mortality risk score with three aging biomarkers for predicting mortality risks among older adult males. International journal of epidemiology, 48(6), 1958-1971.
  28. Beddhu S, Shen J, Cheung AK, Kimmel PL, Chertow GM, Wei G, Boucher RE, Chonchol M, Arman F, Campbell RC, Contreras G, Dwyer JP, Freedman BI, Ix JH, Kirchner K, Papademetriou V, Pisoni R, Rocco MV, Whelton PK, Greene (2019). Implications of Early Decline in eGFR due to Intensive BP Control for Cardiovascular Outcomes in SPRINT. Journal of the American Society of Nephrology, 30(8), 1523-1533.
  29. Gao X, Colicino E, Shen J, Just AC, Nwanaji-Enwerem JC, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli A (2019). Correction for: Accelerated DNA methylation age and the use of antihypertensive medication among older adults. Aging, 11(9), 2911.
  30. Li Z, Li X, Liu Y, Shen J, Chen H, Zhou H, Morrison AC, Boerwinkle E, Lin (2019). Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies. American journal of human genetics, 104(5), 802-814.
  31. Gao X, Colicino E, Shen J, Kioumourtzoglou MA, Just AC, Nwanaji-Enwerem JC, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli A (2019). Impacts of air pollution, temperature, and relative humidity on leukocyte distribution: An epigenetic perspective. Environment international, 126, 395-405.
  32. Gao X, Colicino E, Shen J, Just AC, Nwanaji-Enwerem JC, Wang C, Coull B, Lin X, Vokonas P, Zheng Y, Hou L, Schwartz J, Baccarelli A (2018). Accelerated DNA methylation age and the use of antihypertensive medication among older adults. Aging, 10(11), 3210-3228.
  33. Joyce BT, Zheng Y, Nannini D, Zhang Z, Liu L, Gao T, Kocherginsky M, Murphy R, Yang H, Achenbach CJ, Roberts LR, Hoxha M, Shen J, Vokonas P, Schwartz J, Baccarelli A, Hou (2018). DNA Methylation of Telomere-Related Genes and Cancer Risk. Cancer prevention research (Philadelphia, Pa.), 11(8), 511-522.
  34. Kresovich JK, Joyce BT, Gao T, Zheng Y, Zhang Z, Achenbach CJ, Murphy RL, Just AC, Shen J, Yang H, Vokonas P, Schwartz J, Baccarelli AA, Hou (2018). Promoter methylation of PGC1A and PGC1B predicts cancer incidence in a veteran cohort. Epigenomics, 10(6), 733-743.
  35. Joyce BT, Zheng Y, Zhang Z, Liu L, Kocherginsky M, Murphy R, Achenbach CJ, Musa J, Wehbe F, Just A, Shen J, Vokonas P, Schwartz J, Baccarelli AA, Hou (2018). miRNA-Processing Gene Methylation and Cancer Risk. Cancer epidemiology, biomarkers & prevention, 27(5), 550-557.
  36. Shen J, Wang L, Daignault S, Spratt DE, Morgan TM, Taylor JM (2018). Estimating the Optimal Personalized Treatment Strategy Based on Selected Variables to Prolong Survival via Random Survival Forest with Weighted Bootstrap. Journal of biopharmaceutical statistics, 28(2), 362-381.
  37. Richard MA, Huan T, Ligthart S, Gondalia R, Jhun MA, Brody JA, Irvin MR, Marioni R, Shen J, Tsai PC, Montasser ME, Jia Y, Syme C, Salfati EL, Boerwinkle E, Guan W, Mosley TH Jr, Bressler J, Morrison AC, Liu C, Mendelson MM, Uitterlinden AG, van Meurs JB, BIOS Consortium, Franco OH, Zhang G, Li Y, Stewart JD, Bis JC, Psaty BM, Chen YI, Kardia SLR, Zhao W, Turner ST, Absher D, Aslibekyan S, Starr JM, McRae AF, Hou L, Just AC, Schwartz JD, Vokonas PS, Menni C, Spector TD, Shuldiner A, Damcott CM, Rotter JI, Palmas W, Liu Y, Paus T, Horvath S, O'Connell JR, Guo X, Pausova Z, Assimes TL, Sotoodehnia N, Smith JA, Arnett DK, Deary IJ, Baccarelli AA, Bell JT, Whitsel E, Dehghan A, Levy D, Fornage (2017). DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation. American journal of human genetics, 101(6), 888-902.

Letter

  1. King JB, Sakhuja S, Derington CG, Kolm P, Herrick JS, Berchie RO, Shen J, Greene T, Tajeu GS, Howard G, Levitan EB, Muntner P, Safford MM, Ying J, Weintraub WS, Moran AE, Bress AP, Bellows B (2024). Annual Cost of Implementing Intensive Systolic Blood Pressure Goals in the United States. Journal of the American Heart Association, 13(18), e034515.

Other

  1. Jhun MA, Mendelson M, Wilson R, Gondalia R, Joehanes R, Salfati E, Zhao X, Braun KVE, Do AN, Hedman ÅK, Zhang T, Carnero-Montoro E, Shen J, Bartz TM, Brody JA, Montasser ME, O'Connell JR, Yao C, Xia R, Boerwinkle E, Grove M, Guan W, Liliane P, Singmann P, Müller-Nurasyid M, Meitinger T, Gieger C, Peters A, Zhao W, Ware EB, Smith JA, Dhana K, van Meurs J, Uitterlinden A, Ikram MA, Ghanbari M, Zhi D, Gustafsson S, Lind L, Li S, Sun D, Spector TD, Chen YI, Damcott C, Shuldiner AR, Absher DM, Horvath S, Tsao PS, Kardia S, Psaty BM, Sotoodehnia N, Bell JT, Ingelsson E, Chen W, Dehghan A, Arnett DK, Waldenberger M, Hou L, Whitsel EA, Baccarelli A, Levy D, Fornage M, Irvin MR, Assimes T (2021). Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids. Nature communications, 12(1), 4256.