John E. Greenlee

John E. Greenlee, MD

Languages spoken: English

Academic Information

Departments Emeritus - Neurology

Board Certification

  • American Board of Psychiatry & Neurology (Neurology)
  • National Board of Medical Examiners

Research Interests

  • Central Nervous System Infections
  • Leukoencephalopathy, Progressive Multifocal
  • Cerebrovascular Disorders
  • Remote effects of malignancy on the nervous system
  • Papovavirus Infections
  • Viral Oncogenesis

John E. Greenlee, MD, is professor of neurology and former interim department chair. His areas of specialty are central nervous system infections, autoimmune disorders of the central nervous system, and stroke. Dr. Greenlee was one of the first individuals to recognize the role of the immune response in causing central nervous system injury in patients with cancer.

Education History

Fellowship Johns Hopkins University
 Fellow
Chief Resident University of Virginia Hospitals
 Chief Resident
Residency University of Virginia Hospitals
 Assistant Resident
Residency University of Virginia Hospitals (Internal Medicine)
 Assistant Resident
Internship University of Virginia Hospitals
 Intern
Fellowship University of Rochester School of Medicine
 Student Fellow
Professional Medical University of Rochester
 MD
Undergraduate Columbia School of General Studies
Undergraduate Freie Universitat Berlin
Undergraduate Hamilton College
 BA

Selected Publications

Journal Article

  1. Galli JR, Austin SD, Greenlee JE, Clardy SL (2018). Stiff person syndrome with Anti-GAD65 antibodies within the national veterans affairs health administration. Muscle Nerve, 58(6), 801-804. (Read full article)
  2. Wilson MR, ODonovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, Shah MP, Richie MB, Gorman MP, Hajj-Ali RA, Calabrese LH, Zorn KC, Chow ED, Greenlee JE, Blum JH, Green G, Khan LM, Banerji D, Langelier C, Bryson-Cahn C, Harrington W, Lingappa JR, Shanbhag NM, Green AJ, Brew BJ, Soldatos A, Strnad L, Doernberg SB, Jay CA, Douglas V, Josephson SA, DeRisi JL (2018). Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing. JAMA Neurol, 75(8), 947-955. (Read full article)
  3. Williams JP, Carlson NG, Greenlee JE (2018). Antibodies in Autoimmune Human Neurological Disease: Pathogenesis and Immunopathology. Semin Neurol, 38(3), 267-277. (Read full article)
  4. Abenroth DC, Smith AG, Greenlee JE, Austin SD, Clardy SL (2017). Lambert-Eaton myasthenic syndrome: Epidemiology and therapeutic response in the national veterans affairs population. Muscle Nerve, 56(3), 421-426. (Read full article)
  5. McKasson M, Clardy SL, Clawson SA, Hill KE, Wood B, Carlson N, Bromberg M, Greenlee JE (2016). Voltage-gated calcium channel autoimmune cerebellar degeneration: Case and study of cytotoxicity. Neurol Neuroimmunol Neuroinflamm, 3(3), e222. (Read full article)
  6. Heiry M, Afra P, Matsuo F, Greenlee JE, Clardy SL (2015). Improvement of GAD65-associated autoimmune epilepsy with testosterone replacement therapy. Neurol Neuroimmunol Neuroinflamm, 2(5), e142. (Read full article)
  7. Greenlee JE, Clawson SA, Hill KE, Wood B, Clardy SL, Tsunoda I, Carlson NG (2015). Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. PLoS One, 10(4), e0123446. (Read full article)
  8. Greenlee JE, Clawson SA, Hill KE, Wood B, Tsunda I, Carlson NG (04/17/2015). Anti-Yo Antibody Interaction with its intracellular target antigen leads to targeted Purkinje Cell death rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. PLoS One, 10(4), e0123446.
  9. Greenlee JE (2014). The equine encephalitides. Handb Clin Neurol, 123, 417-32. (Read full article)
  10. Greenlee JE (2013). Treatment of paraneoplastic cerebellar degeneration. Curr Treat Options Neurol, 15(2), 185-200. (Read full article)
  11. Greenlee JE (2012). Encephalitis and postinfectious encephalitis. Continuum (Minneap Minn), 18(6 Infectious Disease), 1271-89. (Read full article)

Abstract

  1. Greenlee JE, Clawson, SA, Hill KE, Wood B, Liu SC, Clardy SL, Carlson NG (2018). Interaction of Normal and Antineuronal IgGs with Neurons in Rat Brain Slice Cultures: Comparison of IgG Uptake, Clearance, Intraneuronal Binding to Target Antigens, and Production of Neuronal Death. Neurology [Abstract]. 90(15 Supp P2), 403.
  2. Greenlee JE, Clawson SA, Hill KE, Wood B, Liu SC, Clardy, SL, Carlson, NG (2018). Interaction of Normal and Antineuronal IgGs with neurons in Rat Brain Slice Cultures: Comparison of IgG Uptake, Clearance, Intraneuronal Binding to Target Antigens, and Production of Neuronal  Death.   [Abstract]. 90 (15)(Suppl P. 2), 403.
  3. Liu S, Hill K, Wood B, Clawsom S, Clardy S, Carlson N, Greenlee J (2017). FcyRI (CD64) Receptors are Widely Expressed on CNS Neurons and are Required for Neuronal IgG Binding and Uptake:  Implications for Antibody-Mediated Neuronal Injury.  [Abstract].
  4. Greenlee J, Clawson S, Wood B, Hill K, Clardy C, Carlson N (2016). Neuronal Uptake of Paraneoplastic IgG Autoantibodies Reactive with Intracellular Antigens Requires the Fc Portion of the IgG Molecule and Can Be Blocked by Normal IgG. [Abstract].
  5. Liu SC, Hill KE, Clawson SA, Wood B, Clardy SL, Carlson NG, Greenlee JE (2016). FcyRI (DC64) Fc Receptors are Expressed on CNS Neurons:  A Potential Mechanism for Neuronal Immunoglobulin Uptake and Antibody-Mediated Neuronal Injury. [Abstract].
  6. Greenlee J, Clawson S, Wood, B, Hill K, Clardy S, Carlson N (2016). Neuronal Uptake of Paraneoplastic IgG Autoantibodies Reactive With Intracellular Antigens Requires the Fc Portion of the IgG Molecule and Can be Blocked by Normal IgG.  2016 Annual Meeting, American Academy of Neurology. [Abstract]. 86:16(Supp p. 5), 295.
  7. Liu, S, Hill KE, Clawson SA, Wood B, Clardy SL, Carlson NG, Greenlee JE (2016). FcyRI (CD64) Fc Receptors are Expressed on CNS Neurons:  A Potential Mechanism for Neuronal Immunoglobulin Uptake and Antibody-Mediated Neuronal Injury.  2016 Annual Meeting,  American Neurological Association. [Abstract]. 80(Suppl 20), M158.
  8. Clawson SA, Hill KE, Wood B, Clardy SL, Carlson NG, Greenlee JE (09/28/2015). Intracellular update of immunoglubulin G antibodies is common among CNS neurons and requires the Fc portion of the IgG molecule. Presented at the 140th Annual Meeting of the American Neurological Assocation [Abstract]. Ann Neurol, 78((Supplment 19)), S76.
  9. Greenlee JE, Clawson SA, Hill KA, Wood B, Clardy SL, Carlson NG (11/1/2014). Anti-Yo antibody, associated with paraneoplastic cerebellar degeneration, specifically produces Purkinje cell death by binding to the 62 kDa intracellular Yo antigen. Presented at Annual Meeting of the International Society for Neuroimmunology, Mainz, Germany [Abstract]. J Neuroimmunology, 275, 36-37.