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John E. Greenlee

John E. Greenlee, MD

Languages spoken: English

Academic Information

Departments Primary - Neurology

Board Certification

  • American Board of Psychiatry & Neurology (Neurology)
  • National Board of Medical Examiners

John E. Greenlee, MD, is professor of neurology and former interim department chair. His areas of specialty are central nervous system infections, autoimmune disorders of the central nervous system, and stroke. Dr. Greenlee was one of the first individuals to recognize the role of the immune response in causing central nervous system injury in patients with cancer.

Education History

Undergraduate Hamilton College
BA
Undergraduate Freie Universitat Berlin
Undergraduate Columbia School of General Studies
Professional Medical University of Rochester
MD
Fellowship University of Rochester School of Medicine
Student Fellow
Internship University of Virginia Hospitals
Intern
Residency University of Virginia Hospitals (Internal Medicine)
Assistant Resident
Residency University of Virginia Hospitals
Assistant Resident
Chief Resident University of Virginia Hospitals
Chief Resident
Fellowship Johns Hopkins University
Fellow

Selected Publications

Journal Article

  1. Galli JR, Austin SD, Greenlee JE, Clardy S (2018). Stiff person syndrome with Anti-GAD65 antibodies within the national veterans affairs health administration. Muscle & nerve, 58(6), 801-804. (Read full article)
  2. Abenroth DC, Smith AG, Greenlee JE, Austin SD, Clardy S (2017). Lambert-Eaton myasthenic syndrome: Epidemiology and therapeutic response in the national veterans affairs population. Muscle & nerve, 56(3), 421-426. (Read full article)
  3. Williams JP, Carlson NG, Greenlee J (2018). Antibodies in Autoimmune Human Neurological Disease: Pathogenesis and Immunopathology. Seminars in neurology, 38(3), 267-277. (Read full article)
  4. Greenlee J (2013). Treatment of paraneoplastic cerebellar degeneration. Current treatment options in neurology, 15(2), 185-200. (Read full article)
  5. Greenlee JE, Clawson SA, Hill KE, Wood B, Tsunda I, Carlson NG (2015). Anti-Yo Antibody Interaction with its intracellular target antigen leads to targeted Purkinje Cell death rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. PloS one, 10(4), e0123446.
  6. Greenlee JE, Clawson SA, Hill KE, Wood B, Clardy SL, Tsunoda I, Carlson N (2015). Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. PloS one, 10(4), e0123446. (Read full article)
  7. Greenlee J (2014). The equine encephalitides. Handbook of clinical neurology, 123, 417-32. (Read full article)
  8. Greenlee J (2012). Encephalitis and postinfectious encephalitis. Continuum (Minneapolis, Minn.), 18(6 Infectious Disease), 1271-89. (Read full article)
  9. Wilson MR, O'Donovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, Shah MP, Richie MB, Gorman MP, Hajj-Ali RA, Calabrese LH, Zorn KC, Chow ED, Greenlee JE, Blum JH, Green G, Khan LM, Banerji D, Langelier C, Bryson-Cahn C, Harrington W, Lingappa JR, Shanbhag NM, Green AJ, Brew BJ, Soldatos A, Strnad L, Doernberg SB, Jay CA, Douglas V, Josephson SA, DeRisi J (2018). Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing. JAMA neurology, 75(8), 947-955. (Read full article)
  10. McKasson M, Clardy SL, Clawson SA, Hill KE, Wood B, Carlson N, Bromberg M, Greenlee J (2016). Voltage-gated calcium channel autoimmune cerebellar degeneration: Case and study of cytotoxicity. Neurology(R) neuroimmunology & neuroinflammation, 3(3), e222. (Read full article)
  11. Heiry M, Afra P, Matsuo F, Greenlee JE, Clardy S (2015). Improvement of GAD65-associated autoimmune epilepsy with testosterone replacement therapy. Neurology(R) neuroimmunology & neuroinflammation, 2(5), e142. (Read full article)

Abstract

  1. Clawson SA, Hill KE, Wood B, Clardy SL, Carlson NG, Greenlee J (2015). Intracellular update of immunoglubulin G antibodies is common among CNS neurons and requires the Fc portion of the IgG molecule. Presented at the 140th Annual Meeting of the American Neurological Assocation. Annals of neurology, 78((Supplment 19)), S76.
  2. Greenlee JE, Clawson SA, Hill KA, Wood B, Clardy SL, Carlson N (2014). Anti-Yo antibody, associated with paraneoplastic cerebellar degeneration, specifically produces Purkinje cell death by binding to the 62 kDa intracellular Yo antigen. Presented at Annual Meeting of the International Society for Neuroimmunology, Mainz, Germany. 275, 36-37.
  3. Greenlee J, Clawson S, Wood B, Hill K, Clardy C, Carlson N (2016). Neuronal Uptake of Paraneoplastic IgG Autoantibodies Reactive with Intracellular Antigens Requires the Fc Portion of the IgG Molecule and Can Be Blocked by Normal IgG.
  4. Liu SC, Hill KE, Clawson SA, Wood B, Clardy SL, Carlson NG, Greenlee J (2016). FcyRI (DC64) Fc Receptors are Expressed on CNS Neurons: A Potential Mechanism for Neuronal Immunoglobulin Uptake and Antibody-Mediated Neuronal Injury.
  5. Liu S, Hill K, Wood B, Clawsom S, Clardy S, Carlson N, Greenlee J (2017). FcyRI (CD64) Receptors are Widely Expressed on CNS Neurons and are Required for Neuronal IgG Binding and Uptake: Implications for Antibody-Mediated Neuronal Injury. .
  6. Greenlee JE, Clawson, SA, Hill KE., Wood B, Liu SC, Clardy SL, Carlson NG (2018). Interaction of Normal and Antineuronal IgGs with Neurons in Rat Brain Slice Cultures: Comparison of IgG Uptake, Clearance, Intraneuronal Binding to Target Antigens, and Production of Neuronal Death. Neurology. 90(15 Supp P2), 403.
  7. Greenlee J, Clawson S, Wood, B, Hill K, Clardy S, Carlson N (2016). Neuronal Uptake of Paraneoplastic IgG Autoantibodies Reactive With Intracellular Antigens Requires the Fc Portion of the IgG Molecule and Can be Blocked by Normal IgG. 2016 Annual Meeting, American Academy of Neurology. 86:16(Supp p. 5), 295.
  8. Liu, S, Hill KE, Clawson SA, Wood B, Clardy SL, Carlson NG, Greenlee JE (2016). FcyRI (CD64) Fc Receptors are Expressed on CNS Neurons: A Potential Mechanism for Neuronal Immunoglobulin Uptake and Antibody-Mediated Neuronal Injury. 2016 Annual Meeting, American Neurological Association. 80(Suppl 20), M158.
  9. Greenlee JE, Clawson SA, Hill KE, Wood B, Liu SC, Clardy, SL, Carlson, N (2018). Interaction of Normal and Antineuronal IgGs with neurons in Rat Brain Slice Cultures: Comparison of IgG Uptake, Clearance, Intraneuronal Binding to Target Antigens, and Production of Neuronal Death. . 90 (15)(Suppl P. 2), 403.