John J. Ryan

John J. Ryan, MD, MB, BCh, BAO

Languages spoken: English

Academic Information

Departments Adjunct - Family & Preventive Medicine , Adjunct - Orthopaedics , Adjunct - Radiology & Imaging Sciences

Board Certification

  • American Board of Internal Medicine (Sub: Cardiovascular Disease)
  • American Board of Internal Medicine (Sub: Advanced Heart Failure & Transplant Cardiology)
  • Certification Board of Nuclear Cardiology
  • National Board of Physicians and Surgeons
  • Royal College of Physicians in Ireland
  • National Board of Echocardiography (Special Competence in Adult Echocardiography)

Dr. Ryan is Professor of Medicine in the Division of Cardiovascular Medicine at the University of Utah, with a focus on General Cardiology and Pulmonary Hypertension.

Research Statement

John J. Ryan MD, FACC, FAHA, is a cardiologist with extensive training and experience in research investigation and clinical patient care. He is an internationally renowned specialist in pulmonary hypertension and has an appointment in the Division of Cardiovascular Medicine at the University of Utah.

Dr. Ryan has won more than ten university awards in Ireland, Boston, Chicago and Utah. He received Ireland’s prestigious Ceannt Medal, for ranking first in Ireland’s National High School exit exam. He was also an acknowledged scholar at University College Cork and in 2004 received their Blayney Medal for graduating at the top of his class from the University College Cork, School of Medicine. He was also awarded the Stewart Medal from the National University of Ireland in 2004 for being among the highest-ranking medical graduates in Ireland.

After postgraduate training in Internal Medicine and General Surgery at Cork University Hospital in Cork, Ireland, he was moved to Boston University. Between 2005 and 2009 he trained in Boston in Internal Medicine, ultimately being selected as the Chief Resident for Boston University. In Boston, he received awards for humanism from Boston University and the Department of Medicine’s Faculty Teacher of the Year Award.

After Boston, Dr. Ryan moved to Chicago and completed a fellowship in Cardiovascular Medicine at the University of Chicago, where he served as Chief Cardiology Fellow. At the University of Chicago he was awarded Teaching Fellow of the Year from the Department of Medicine and was served on the Illinois-American College of Cardiology Board of Governors. After fellowship, he undertook advanced training in pulmonary hypertension. For his work in pulmonary hypertension he was awarded the Cournand and Comroe Young Investigator Award from the American Heart Association.

At the University of Utah, Dr. Ryan has continued to be involved in medical education, and has been awarded the Department of Family Medicine Outstanding Preceptor of the Year Award.

Dr. Ryan is on the editorial board of Circulation, Circulation: Cardiovascular Quality and Outcomes, Circulation: Heart Failure, The Canadian Journal of Cardiology, among others. Dr. Ryan’s research has been published in leading cardiovascular journals including Circulation, CHEST, The Journal of the American College of Cardiology, among others. Dr. Ryan is a writing member of the CHEST Pulmomary Arterial Hypertension guidelines.

Dr. Ryan is the director of the University of Utah Pulmonary Hypertension Center, which is the first accredited Pulmonary Hypertension Association Comprehensive Care Center in the Mountain West.

Dr Ryan is also Sports Cardiology Consultant for the United States Olympic Committee, the National Basketball Association, the Utah Jazz and the University of Utah Utes.

Dr. Ryan is board certified in Internal Medicine, Cardiovascular Medicine, Advanced Heart Failure and Transplant Cardiology, Echocardiography and Nuclear Cardiology.

Education History

Professional Medical University College Cork, Ireland
 MD
Internship Cork University Hospital
 Intern
Residency Boston Medical Center
 Resident
Chief Resident Boston Medical Center
 Chief Medical Resident
Fellowship University of Chicago Medical Center
 Fellow
Fellowship University of Chicago
 Chief Fellow
Research Fellow University of Chicago Medical Center
 Research Fellow

Selected Publications

Journal Article

  1. Ryan JJ, Rich JD, Thiruvoipati T, Swamy R, Kim GH, Rich S (2012). Current practice for determining pulmonary capillary wedge pressure predisposes to serious errors in the classification of patients with pulmonary hypertension. Am Heart J, 163(4), 589-94. (Read full article)
  2. Leary PJ, Jenny NS, Bluemke DA, Kawut SM, Kronmal RA, Lima JA, Maron BA, Ralph DD, Rayner SG, Ryan JJ, Steinberg ZL, Hinckley Stukovsky KD, Tedford R (2020). Endothelin-1, cardiac morphology, and heart failure: the MESA angiogenesis study. The Journal of heart and lung transplantation, 39(1), 45-52. (Read full article)
  3. Thenappan T, Ormiston ML, Ryan JJ, Archer S (2018). Pulmonary arterial hypertension: pathogenesis and clinical management. BMJ (Clinical research ed.), 360, j5492. (Read full article)
  4. Cirulis MM, Huston JH, Sardar P, Suksaranjit P, Wilson BD, Hatton ND, Liou TG, Ryan J (2018). Right-to-left ventricular end diastolic diameter ratio in severe sepsis and septic shock. Journal of critical care, 48, 307-310. (Read full article)
  5. Harrison A, Wilson BD, Ryan J (2014). Exploring the Role of Aldosterone in Right Ventricular Function. The Canadian journal of cardiology, 30(2), 155-158.
  6. Klinger JR, Elliott CG, Levine DJ, Bossone E, Duvall L, Fagan K, Frantsve-Hawley J, Kawut SM, Ryan JJ, Rosenzweig EB, Sederstrom N, Steen VD, Badesch D (2019). Therapy for Pulmonary Arterial Hypertension in Adults: Update of the CHEST Guideline and Expert Panel Report. Chest, 155(3), 565-586. (Read full article)
  7. Marsboom G, Toth PT, Ryan JJ, Hong Z, Wu X, Fang YH, Thenappan T, Piao L, Zhang HJ, Pogoriler J, Chen Y, Morrow E, Weir EK, Rehman J, Archer S (2012). Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Circulation research, 110(11), 1484-97. (Read full article)
  8. Ryan JJ, Archer S (2014). The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure. Circulation research, 115(1), 176-88. (Read full article)
  9. Hong Z, Kutty S, Toth PT, Marsboom G, Hammel JM, Chamberlain C, Ryan JJ, Zhang HJ, Sharp WW, Morrow E, Trivedi K, Weir EK, Archer S (2013). Role of dynamin-related protein 1 (drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus. Circulation research, 112(5), 802-15.
  10. Agarwal S, Spiekerkoetter E, Austin ED, de Jesus Perez V, Dezfulian C, Maron BA, Ryan JJ, Starks MA, Yu PB, Bonnet S, Perman S (2018). Career Development of Young Physician-Scientists in the Cardiovascular Sciences: Perspective and Advice From the Early Career Committee of the Cardiopulmonary, Critical Care, and Resuscitation Council of the American Heart Association. Circulation research, 122(10), 1330-1333. (Read full article)
  11. Ryan JJ, Suksaranjit P, Hatton N, Bull DA, Wilson B (2015). Eisenmenger syndrome with unrepaired patent ductus arteriosus. Circulation, 131(16), e409-11. (Read full article)
  12. Piao L, Fang YH, Parikh KS, Ryan JJ, D'Souza KM, Theccanat T, Toth PT, Pogoriler J, Paul J, Blaxall BC, Akhter SA, Archer S (2012). GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension. Circulation, 126(24), 2859-69.
  13. Maron BA, Ryan J (2019). A Concerning Trend for Patients With Pulmonary Hypertension in the Era of Evidence-Based Medicine. Circulation, 139(16), 1861-1864. (Read full article)
  14. Ryan JJ, Waxman A (2018). The Dyspnea Clinic. Circulation, 137(19), 1994-1996. (Read full article)
  15. Tong C, Ahmad T, Brittain EL, Bunch TJ, Damp JB, Dardas T, Hijar A, Hill JA, Hilliard AA, Houser SR, Jahangir E, Kates AM, Kim D, Lindman BR, Ryan JJ, Rzeszut AK, Sivaram CA, Valente AM, Freeman AM (2014). Challenges Facing Early Career Academic Cardiologists. Journal of the American College of Cardiology,
  16. Shah AM, Cikes M, Prasad N, Li G, Getchevski S, Claggett B, Rizkala A, Lukashevich I, O'Meara E, Ryan JJ, Shah SJ, Mullens W, Zile MR, Lam CSP, McMurray JJV, Solomon SD, PARAGON-HF Investigators (2019). Echocardiographic Features of Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction. Journal of the American College of Cardiology, 74(23), 2858-2873. (Read full article)
  17. Ratchford SM, Clifton HL, La Salle DT, Broxterman RM, Lee JF, Ryan JJ, Hopkins PN, Wright JB, Trinity JD, Richardson RS, Wray D (2020). Cardiovascular responses to rhythmic handgrip exercise in heart failure with preserved ejection fraction. Journal of applied physiology (Bethesda, Md., 129(6), 1267-1276. (Read full article)
  18. Marsboom G, Wietholt C, Haney CR, Toth PT, Ryan JJ, Morrow E, Thenappan T, Bache-Wiig P, Piao L, Paul J, Chen CT, Archer S (2012). Lung (1)(8)F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension. American journal of respiratory and critical care medicine, 185(6), 670-9. (Read full article)
  19. Ryan JJ, Marsboom G, Fang YH, Toth PT, Morrow E, Luo N, Piao L, Hong Z, Ericson K, Zhang HJ, Han M, Haney CR, Chen CT, Sharp WW, Archer S (2013). PGC1alpha-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension. American journal of respiratory and critical care medicine, 187(8), 865-78. (Read full article)
  20. Ryan JJ, Marsboom G, Fang YH, Toth PT, Morrow E, Luo N, Piao L, Hong Z, Zhang HJ, Haney C, Chen CT, Sharp W, Archer S (2013). Mitofusion-2 deficiency promotes smooth muscle cell proliferation and mitofusin-2 gene therapy regresses experimental pulmonary arterial hypertension in females. American journal of respiratory and critical care medicine,
  21. Piao L, Sidhu VK, Fang YH, Ryan JJ, Parikh KS, Hong Z, Toth PT, Morrow E, Kutty S, Lopaschuk GD, Archer S (2013). FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. Journal of molecular medicine (Berlin, Germany), 91(3), 333-46. (Read full article)
  22. Piao L, Fang YH, Parikh K, Ryan JJ, Toth PT, Archer S (2013). Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension. Journal of molecular medicine (Berlin, Germany), 91(10), 1185-97. (Read full article)
  23. Shin JH, Pokharna HK, Williams KA, Mehta R, Ward R (2009). SPECT myocardial perfusion imaging with prone-only acquisitions: correlation with coronary angiography. Journal of nuclear cardiology, 16(4), 590-6. (Read full article)
  24. Ryan JJ, Mehta R, Thiruvoipati T, Ward RP, Williams K (2012). Stress-only imaging in patients with prior SPECT MPI: a simulation study. Journal of nuclear cardiology, 19(2), 311-8. (Read full article)
  25. Ratchford SM, Clifton HL, Gifford JR, LaSalle DT, Thurston TS, Bunsawat K, Alpenglow JK, Richardson RS, Wright JB, Ryan JJ, Wray D (2019). Impact of acute antioxidant administration on inflammation and vascular function in heart failure with preserved ejection fraction. American journal of physiology. Regulatory, integrative and comparative physiology, 317(5), R607-R614. (Read full article)
  26. Vahdatpour CA, Ryan JJ, Zimmerman JM, MacCormick SJ, Palevsky HI, Alnuaimat H, Ataya (2021). Advanced airway management and respiratory care in decompensated pulmonary hypertension. Heart failure reviews, (Read full article)
  27. Kim GH, Ryan JJ, Archer S (2013). Epigenetics in Cardiovascular Medicine (ahead of print). Antioxidants & redox signaling,
  28. Maree AO, Vangjeli C, Jneid H, Ryan J, Cox D, Cannon CP, Shields DC, Fitzgerald D (2010). G-protein beta3 subunit polymorphism and bleeding in the orbofiban in patients with unstable coronary syndromes-thrombolysis in myocardial infarction 16 trial. Journal of thrombosis and haemostasis, 8(5), 934-41. (Read full article)
  29. Ryan JJ, Marsboom G, Archer S (2013). Rodent models of group 1 pulmonary hypertension. Handbook of experimental pharmacology, 218, 105-49. (Read full article)
  30. Keefe AC, Hymas JC, Emerson LL, Ryan J (2017). An atypical presentation of cardiac tamponade and periorbital swelling in a patient with eosinophilic granulomatosis with polyangiitis: a case report. Journal of medical case reports, 11(1), 271. (Read full article)
  31. Franco V, Ryan JJ, McLaughlin V (2019). Pulmonary Hypertension in Women. Heart failure clinics, 15(1), 137-145. (Read full article)
  32. Wohlfahrt P, Stehlik J, Pan IZ, Ryan J (2020). Empowering People Living with Heart Failure. Heart failure clinics, 16(4), 409-420. (Read full article)
  33. Zenger B, Swink JM, Turner JL, Bunch TJ, Ryan JJ, Shah RU, Turakhia MP, Piccini JP, Steinberg B (2020). Social Media Influence Does Not Reflect Scholarly or Clinical Activity in Real Life. Circulation. Arrhythmia and electrophysiology, 13(11), e008847. (Read full article)
  34. Ryan JJ, Musunuru K, Prakash S (2013). Top advances in functional genomics and translational biology for 2012. Circulation. Cardiovascular genetics, 6(1), 132-4. (Read full article)
  35. Ryan J (2013). Chloroquine in pulmonary arterial hypertension: a new role for an old drug?. Circulation. Cardiovascular genetics, 6(3), 310-1. (Read full article)
  36. Mayeux JD, Pan IZ, Dechand J, Jacobs JA, Jones TL, McKellar SH, Beck E, Hatton ND, Ryan J (2021). Management of Pulmonary Arterial Hypertension. Current cardiovascular risk reports, 15(1), 2. (Read full article)
  37. Ryan AM, Ryan J, Wan-Ahmed M, Hardiman O, Farrell MA, McNamara B, Sweeney B (2009). Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease.LID - 10.1136/bcr.08.2008.0650 [doi]LID - bcr08.2008.0650 [pii]. BMJ case reports, 2009, (Read full article)
  38. Kim GH, Ryan JJ, Marsboom G, Archer S (2011). Epigenetic mechanisms of pulmonary hypertension. Pulmonary circulation, 1(3), 347-56. (Read full article)
  39. Ryan JJ, Thenappan T, Luo N, Ha T, Patel AR, Rich S, Archer S (2012). The WHO classification of pulmonary hypertension: A case-based imaging compendium. Pulmonary circulation, 2(1), 107-21. (Read full article)
  40. Archer SL, Fang YH, Ryan JJ, Piao (2013). Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension. Pulmonary circulation, 3(1), 144-52. (Read full article)
  41. Harrison A, Hatton N, Ryan J (2015). The right ventricule under pressure: evaluating the adaptive and maladaptive changes in the right ventricle in pulmonary arterial hypertension using echocardiography. Pulmonary circulation, 5(1), 29-47.
  42. Ryan JJ, Butrous G, Maron BA (2014). The Heterogeneity of Clinical Practice Patterns among an International Cohort of Pulmonary Arterial Hypertension Experts. Pulmonary circulation,
  43. Cirulis MM, Ryan JJ, Archer S (2019). Pathophysiology, incidence, management, and consequences of cardiac arrhythmia in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Pulmonary circulation, 9(1), 2045894019834890. (Read full article)
  44. Ryan JJ, Melendres-Groves L, Zamanian RT, Oudiz RJ, Chakinala M, Rosenzweig EB, Gomberg-Maitland (2020). Care of patients with pulmonary arterial hypertension during the coronavirus (COVID-19) pandemic. Pulmonary circulation, 10(2), 2045894020920153. (Read full article)
  45. Fakhri S, Hannon K, Moulden K, Peterson R, Hountras P, Bull T, Maloney J, De Marco T, Ivy D, Thenappan T, Sager JS, Ryan JJ, Mazimba S, Hirsch R, Chakinala M, Shlobin O, Lammi M, Zwicke D, Robinson J, Benza RL, Klinger J, Grinnan D, Mathai S, Badesch (2020). Residence at moderately high altitude and its relationship with WHO Group 1 pulmonary arterial hypertension symptom severity and clinical characteristics: the Pulmonary Hypertension Association Registry. Pulmonary circulation, 10(4), 2045894020964342. (Read full article)
  46. DuBrock HM, Burger CD, Bartolome SD, Feldman JP, Ivy DD, Rosenzweig EB, Sager JS, Presberg KW, Mathai SC, Lammi MR, Klinger JR, Eggert M, De Marco T, Elwing JM, Badesch D, Bull TM, Cadaret LM, Ramani G, Thenappan T, Ford HJ, Al-Naamani N, Simon MA, Mazimba S, Runo JR, Chakinala M, Horn EM, Ryan JJ, Frantz RP, Krowka M (2021). Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: an analysis of the Pulmonary Hypertension Association Registry. Pulmonary circulation, 11(3), 20458940211020913. (Read full article)
  47. Lee JD, Burger CD, Delossantos GB, Grinnan D, Ralph DD, Rayner SG, Ryan JJ, Safdar Z, Ventetuolo CE, Zamanian RT, Leary P (2020). A Survey-based Estimate of COVID-19 Incidence and Outcomes among Patients with Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension and Impact on the Process of Care. Annals of the American Thoracic Society, 17(12), 1576-1582. (Read full article)
  48. Cruz L, Ryan J (2017). Nitric Oxide Signaling in Heart Failure With Preserved Ejection Fraction. JACC. Basic to translational science, 2(3), 341-343. (Read full article)
  49. Ryan J (2016). CD47-Blocking Antibodies and Atherosclerosis. JACC. Basic to translational science, 1(5), 413-415. (Read full article)
  50. Ryan J (2016). Tyrosine Kinase Inhibitors in Pulmonary Vascular Disease. JACC. Basic to translational science, 1(7), 684-686. (Read full article)
  51. Ryan JJ, Ryan A, McGrath (2004). Is Secondary Care Paediatrics Evidenced Based? An Evaluation in a County Hospital. 2/3, 3.
  52. Minhas J, Narasimmal SP, M Bull T, Marco T, McConnell JW, Lammi MR, Thenappan T, P Feldman J, S Sager J, B Badesch D, Ryan JJ, C Grinnan D, Zwicke D, M Horn E, Elwing JM, Moss JE, Eggert M, Shlobin OA, P Frantz R, D Bartolome S, Mathai SC, Mazimba S, C Pugliese S, Al-Naamani (2021). Health-related quality of life and hospitalizations in chronic thromboembolic pulmonary hypertension versus idiopathic pulmonary arterial hypertension: an analysis from the Pulmonary Hypertension Association Registry (PHAR). Pulmonary circulation, 11(4), 20458940211053196. (Read full article)
  53. Ratchford SM, Lee JF, Bunsawat K, Alpenglow JK, Zhao J, Ma CL, Ryan JJ, Khor LL, Wray D (2022). The Impact of Obesity on the Regulation of Muscle Blood Flow during Exercise in Patients with Heart Failure with a Preserved Ejection Fraction. Journal of applied physiology (Bethesda, Md., 132(5), 1240-1249. (Read full article)
  54. Chang KY, Duval S, Badesch DB, Bull TM, Chakinala MM, De Marco T, Frantz RP, Hemnes A, Mathai SC, Rosenzweig EB, Ryan JJ, Thenappan T, PHAR Investigators * (2022). Mortality in Pulmonary Arterial Hypertension in the Modern Era: Early Insights From the Pulmonary Hypertension Association Registry. Journal of the American Heart Association, 11, e024969. (Read full article)
  55. Alpenglow JK, Bunsawat K, Francisco MA, Craig JC, Iacovelli JJ, Ryan JJ, Wray D (2023). Evidence of impaired functional sympatholysis in patients with heart failure with preserved ejection fraction. American journal of physiology. Heart and circulatory physiology, 325(4), H806-H813. (Read full article)
  56. Alamri AK, Ma CL, Ryan J (2023). Novel Drugs for the Treatment of Pulmonary Arterial Hypertension: Where Are We Going?. Drugs, 83(7), 577-585. (Read full article)
  57. Ratchford SM, Bunsawat K, Alpenglow JK, Zhao J, Wright JB, Ryan JJ, Wray D (2023). Improved vascular function and functional capacity following l-citrulline administration in patients with heart failure with preserved ejection fraction: a single-arm, open-label, prospective pilot study. Journal of applied physiology (Bethesda, Md., 134(2), 328-338. (Read full article)
  58. Ingram D, Alamri AK, Penn BA, Mayeux JD, Ma CL, Clapham KR, Abraham AE, Klanderud D, Sadeh B, Beck EM, Hatton ND, Ryan J (2022). Characteristics of Patients With Pulmonary Arterial Hypertension in a Pulmonary Hypertension Association-Accredited Comprehensive Care Center: A Contrast in Features When Compared With US National Registry Data. Cureus, 14(11), e31764. (Read full article)
  59. Iacovelli JJ, Alpenglow JK, Ratchford SM, Craig JC, Simmons JM, Zhao J, Reese V, Bunsawat K, Ma CL, Ryan JJ, Wray D (2024). Statin therapy improves locomotor muscle microvascular reactivity in patients with heart failure with preserved ejection fraction. American journal of physiology. Heart and circulatory physiology, 327(4), H859-H865. (Read full article)
  60. Kogelschatz B, Penn BA, Leavitt AJ, Dranow E, Ma CL, Ryan J (2024). Efficacy of Activity Trackers in Patients With Heart Failure With Preserved Ejection Fraction. Cureus, 16(7), e65117. (Read full article)
  61. Alpenglow JK, Bunsawat K, Francisco MA, Broxterman RM, Craig JC, Iacovelli JJ, Weavil JC, Harrison JD, Morgan DE, Silverton NA, Reese VR, Ma CL, Ryan JJ, Wray D (2024). ¿-Adrenergic regulation of skeletal muscle blood flow during exercise in patients with heart failure with preserved ejection fraction. The Journal of physiology, 602(14), 3401-3422. (Read full article)

Review

  1. Ryan J, Bloch K, Archer S (2011). Rodent models of pulmonary hypertension: harmonisation with the world health organisation's categorisation of human PH. International journal of clinical practice. Supplement, (172), 15-34. (Read full article)
  2. Steiling K, Ryan J, Brody JS, Spira (2008). The field of tissue injury in the lung and airway. Cancer prevention research (Philadelphia, Pa.), 1(6), 396-403. (Read full article)
  3. Alamri AK, Ma CL, Ryan J (2022). Left Heart Disease-Related Pulmonary Hypertension. Cardiology clinics, 40(1), 69-76. (Read full article)
  4. Jacobs JA, Jahangir E, Ryan J (2022). Differentiating pulmonary hypertension associated with protein kinase inhibitors. Pulmonary circulation, 12(2), e12075. (Read full article)
  5. Tsarova K, Morgan AE, Melendres-Groves L, Ibrahim MM, Ma CL, Pan IZ, Hatton ND, Beck EM, Ferrel MN, Selzman CH, Ingram D, Alamri AK, Ratcliffe MB, Wilson BD, Ryan J (2022). Imaging in Pulmonary Vascular Disease-Understanding Right Ventricle-Pulmonary Artery Coupling. Comprehensive Physiology, 12(4), 3705-3730. (Read full article)

Book Chapter

  1. Ryan JJ, Marsboom G, Archer (2013). Pulmonary Hypertension: Animal Models. Chapter 5,
  2. Archer SL, Ryan JJ, Rich S, Nathan S, Tsai K, Patel AR, Fang Yh, Piao (2012). The Right Ventricle: Reemergence of the Forgotten Ventricle. CHAPTER 38,
  3. Archer SL, Ryan (2011). Mitochondrial ROS and Redox State in Pulmonary Vascular O2 sensing. CHAPTER 19,
  4. Gomberg-Maitland M, Thenappan T, Ryan J, Cipriani N, Hussain A, Fedson S, Archer S (2011). Cor Pulmonale. CHAPTER 97,

Case Report

  1. Ryan JJ, Swamy RS, Shah A (2011). Sudden cardiac death due to large coronary aneurysm successfully treated with a covered stent and ChromaFlo guidance. The Journal of invasive cardiology, 23(2), E22-5. (Read full article)
  2. Ryan AM, Ryan JJ, Wan-Ahmed M, Hardiman O, Farrell MA, McNamara B, Sweeney B (2007). Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease. Journal of neurology, neurosurgery, and psychiatry, 78(1), 98-9.
  3. Kundu A, Sardar P, Sen P, Chatterjee S, Huston J, Nairooz R, Ryan JJ, Aronow W (2015). Patient Taking A Novel Oral Anticoagulant Presents With Major GI Bleeding. Journal of atrial fibrillation, 8(3), 1218. (Read full article)
  4. Pan IZ, Carey JR, Jacobs JA, Dechand J, Sessions JJ, Sorensen T, Penn BA, Mayeux JD, Hatton ND, Ryan J (2020). Transitioning Between Prostanoid Therapies in Pulmonary Arterial Hypertension. Frontiers in medicine, 7, 81. (Read full article)
  5. Pugh A, Tonna JE, Youngquist S, Ryan JJ, Brant-Zawadzki (2020). Emergency department extracorporeal membrane oxygenation as a rescue therapy for ventricular tachycardia electrical storm: a case report. Journal of the American College of Emergency Physicians open, 1(4), 371-374. (Read full article)
  6. Ferrel MN, Iriana S, Raymond Thomason I, Ma CL, Tsarova K, Wilson BD, McKellar SH, Ryan J (2021). Constrictive pericarditis in the setting of repeated chest trauma in a mixed martial arts fighter. BMC cardiovascular disorders, 21(1), 561. (Read full article)
  7. Ferrel MN, Ryan JJ, Han F (2022). Acute myeloid leukemia causing acute thrombosis of the coronary arteries: a case report. Journal of medical case reports, 16(1), 149. (Read full article)

Editorial

  1. Ryan JJ, Rich S, Archer S (2011). Pulmonary endarterectomy surgery--a technically demanding cure for WHO Group IV Pulmonary Hypertension: requirements for centres of excellence and availability in Canada. The Canadian journal of cardiology, 27(6), 671-4. (Read full article)
  2. Luo N, Ryan J (2013). Transitioning between endothelin receptor blockers: monitoring to ensure a smooth transition. The Canadian journal of cardiology, 29(6), 659-61. (Read full article)
  3. Hatton N, Ryan J (2014). The complicated question of anticoagulation in pulmonary arterial hypertension: time to get some simple answers. The Canadian journal of cardiology, 30(8), 850-2. (Read full article)
  4. Hatton N, Ryan J (2014). Sex differences in response to pulmonary arterial hypertension therapy: is what's good for the goose, good for the gander?. Chest, 145(6), 1184-1186. (Read full article)
  5. Ryan JJ, Rehman J, Archer S (2011). Paracrine proliferative signaling by senescent cells in world health organization group 3 pulmonary hypertension: age corrupting youth?. Circulation research, 109(5), 476-9. (Read full article)
  6. Beck EM, Hatton ND, Ryan J (2019). Novel techniques for advancing our understanding of pulmonary arterial hypertension. The European respiratory journal, 53(5), (Read full article)
  7. Thenappan T, Ryan JJ, Archer S (2012). Evolving Epidemiology of Pulmonary Arterial Hypertension. American journal of respiratory and critical care medicine, 186, 707-709.
  8. Catino AB, Ryan J (2019). A Change in Focus. Circulation. Cardiovascular imaging, 12(5), e009186. (Read full article)
  9. Mathai SC, Ryan J (2018). The Growing Burden of Pulmonary Hypertension in the Modern Era: A Zebra No More?. Circulation. Cardiovascular quality and outcomes, 11(2), e004536. (Read full article)
  10. Gilbertson EA, Hatton ND, Ryan J (2020). Point of care ultrasound: the next evolution of medical education. Annals of translational medicine, 8(14), 846. (Read full article)
  11. Ferrel MN, Ryan J (2020). The Impact of COVID-19 on Medical Education. Cureus, 12(3), e7492. (Read full article)
  12. Cirulis MM, Ryan J (2018). Who's Who of Pulmonary Hypertension: Redefining Classification to Advance Precision Care. Circulation. Genomic and precision medicine, 11(4), e002116. (Read full article)

Letter

  1. Cirulis MM, Liou TG, Ryan J (2019). RV/LV ratio in severe sepsis and septic shock: Response to Letter to the Editor. Journal of critical care, 50, 311-312. (Read full article)
  2. Klinger JR, Elliott G, Levine DJ, Bossone E, Duvall L, Fagan K, Frantsve-Hawley J, Kawut SM, Ryan JJ, Rosenzweig EB, Sederstrom N, Steen VD, Badesch D (2019). Response. Chest, 156(1), 187-188. (Read full article)
  3. Ryan JJ, Kalscheur M, Dellefave L, McNally E, Archer S (2012). A KCNE1 missense variant (V47I) causing exercise-induced long QT syndrome (Romano Ward). International journal of cardiology, 156(2), e33-5. (Read full article)
  4. Ryan AM, Ryan J, Wan-Ahmed M, Hardiman O, Farrell MA, McNamara B, Sweeney B (2007). Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease. Journal of neurology, neurosurgery, and psychiatry, 78(1), 98-9. (Read full article)
  5. Ryan JJ, Maron B (2020). Vericiguat in Heart Failure with Reduced Ejection Fraction. The New England journal of medicine, 383(15), 1497. (Read full article)
  6. Leary PJ, Hess E, Barón AE, Branch KR, Choudhary G, Hough CL, Maron BA, Ralph DD, Ryan JJ, Tedford RJ, Weiss NS, Zamanian RT, Lahm (2018). H2 Receptor Antagonist Use and Mortality in Pulmonary Hypertension: Insight from the VA-CART Program. American journal of respiratory and critical care medicine, 197(12), 1638-1641. (Read full article)
  7. Bunsawat K, Ratchford SM, Alpenglow JK, Ryan JJ, Richardson RS, Wray D (2021). Direct Assessment of Muscle Sympathetic Nerve Activity During Exercise in Heart Failure With Preserved Ejection Fraction: A Case Report. Journal of cardiac failure, 27(1), 114-116. (Read full article)
  8. Jacobs JA, Ryan J (2021). Clinical uncertainty for the use of rivaroxaban in obesity. Journal of thrombosis and haemostasis, 19(3), 870-871. (Read full article)
  9. Lee JD, Burger CD, Rayner SG, Ryan JJ, Leary P (2021). Reply: COVID-19 Experience and Pulmonary Arterial Hypertension: Do Earlier Theses and New Data Still Match?. Annals of the American Thoracic Society, 18(6), 1081-1082. (Read full article)

Other

  1. Ryan J (2004). Author of several hundred columns for the 'weekly column' of Ireland's leading medical newspapers.
  2. Francisco MA, Lee JF, Barrett-O'Keefe Z, Groot HJ, Ratchford SM, Bunsawat K, Alpenglow JK, Ryan JJ, Nativi JN, Richardson RS, Wray D (2021). Locomotor Muscle Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction. Hypertension (Dallas, Tex., 78(6), 1750-1759. (Read full article)
  3. Nassif ME, Windsor SL, Borlaug BA, Kitzman DW, Shah SJ, Tang F, Khariton Y, Malik AO, Khumri T, Umpierrez G, Lamba S, Sharma K, Khan SS, Chandra L, Gordon RA, Ryan JJ, Chaudhry SP, Joseph SM, Chow CH, Kanwar MK, Pursley M, Siraj ES, Lewis GD, Clemson BS, Fong M, Kosiborod M (2021). The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial. Nature medicine, 27(11), 1954-1960. (Read full article)

Video/Film/CD/Web/Podcast

  1. Ryan J (2012). Digital Business Strategy.
  2. Ryan J (2012). Usability Project, Fellows-In-Training representative.