John R. Hoidal

John R. Hoidal, MD

Languages spoken: English

Academic Information

Departments Primary - Internal Medicine

Divisions: Public Health

Board Certification

  • American Board of Internal Medicine (Sub: Pulmonary Disease)
  • American Board of Internal Medicine (Internal Medicine)

John Hoidal, MD, is a professor and chair of the Department of Medicine at the University of Utah and an investigator of the Huntsman Cancer Institute. He holds the Clarence M. and Ruth N. Birrer Presidential Endowed Chair.

His research focuses on the genetic and molecular bases for nicotine addiction and the consequences of cigarette smoking. By gaining insights into biochemical pathways of addiction and ways to modify them, Hoidal hopes to find better ways to prevent and treat nicotine addiction and reduce the risk of smoking-related diseases such as lung cancer.

Hoidal received a bachelor's degree from Jamestown College, North Dakota, and a medical degree from the University of Minnesota.

Education History

Undergraduate Jamestown College
 BS
Professional Medical University of Minnesota
 MD
Internship University of Colorado at Denver and Health Sciences Center
 Intern
Residency University of Minnesota Hospitals
 Resident
Chief Resident University of Minnesota Hospitals
 Chief Resident
Fellowship University of Minnesota Hospitals
 Fellow

Selected Publications

Journal Article

  1. Reynolds PR, Kasteler SD, Schmitt RE, Hoidal J (2011). Receptor for advanced glycation end-products signals through Ras during tobacco smoke-induced pulmonary inflammation. American journal of respiratory cell and molecular biology, 45(2), 411-8. (Read full article)
  2. Jin H, Webb-Robertson BJ, Peterson ES, Tan R, Bigelow DJ, Scholand MB, Hoidal JR, Pounds JG, Zangar R (2011). Smoking, COPD, and 3-nitrotyrosine levels of plasma proteins. Environmental health perspectives, 119(9), 1314-20. (Read full article)
  3. Reynolds PR, Kasteler SD, Cosio MG, Sturrock A, Huecksteadt T, Hoidal J (2008). RAGE: developmental expression and positive feedback regulation by Egr-1 during cigarette smoke exposure in pulmonary epithelial cells. American journal of physiology. Lung cellular and molecular physiology, 294(6), L1094-101. (Read full article)
  4. Ismail S, Sturrock A, Wu P, Cahill B, Norman K, Huecksteadt T, Sanders K, Kennedy T, Hoidal (2009). NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-{beta}1 and insulin-like growth factor binding protein-3. American journal of physiology. Lung cellular and molecular physiology, 296(3), L489-99. (Read full article)
  5. Baker TB, Weiss RB, Bolt D, von Niederhausern A, Fiore MC, Dunn DM, Piper ME, Matsunami N, Smith SS, Coon H, McMahon WM, Scholand MB, Singh N, Hoidal JR, Kim SY, Leppert MF, Cannon D (2009). Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes. Nicotine & tobacco research, 11(7), 785-96. (Read full article)
  6. Liou TG, Adler FR, Argel N, Asfour F, Brown PS, Chatfield BA, Daines CL, Durham D, Francis JA, Glover B, Heynekamp T, Hoidal JR, Jensen JL, Keogh R, Kopecky CM, Lechtzin N, Li Y, Lysinger J, Molina O, Nakamura C, Packer KA, Poch KR, Quittner AL, Radford P, Redway AJ, Sagel SD, Sprandel S, Taylor-Cousar JL, Vroom JB, Yoshikawa R, Clancy JP, Elborn JS, Olivier KN, Cox D (2019). Prospective multicenter randomized patient recruitment and sample collection to enable future measurements of sputum biomarkers of inflammation in an observational study of cystic fibrosis. BMC medical research methodology, 19(1), 88. (Read full article)
  7. Mukherjee TK, Mukhopadhyay S, Hoidal J (2008). Implication of receptor for advanced glycation end product (RAGE) in pulmonary health and pathophysiology. Respiratory physiology & neurobiology, 162(3), 210-5. (Read full article)
  8. Chen Y, Hao H, He S, Cai L, Li Y, Hu S, Ye D, Hoidal J, Wu P, Chen (2010). Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of antiangiogenesis. Molecular cancer therapeutics, 9(8), 2164-74. (Read full article)
  9. Weiss RB, Baker TB, Cannon DS, von Niederhausern A, Dunn DM, Matsunami N, Singh NA, Baird L, Coon H, McMahon WM, Piper ME, Fiore MC, Scholand MB, Connett JE, Kanner RE, Gahring LC, Rogers SW, Hoidal JR, Leppert M (2008). A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS genetics, 4(7), e1000125. (Read full article)
  10. Liou TG, Adler FR, Keogh RH, Li Y, Jensen JL, Walsh W, Packer K, Clark T, Carveth H, Chen J, Rogers SL, Lane C, Moore J, Sturrock A, Paine R 3rd, Cox DR, Hoidal J (2012). Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis. PloS one, 7(8), e42748. (Read full article)
  11. Kwon OS, Decker ST, Zhao J, Hoidal JR, Heuckstadt T, Sanders KA, Richardson RS, Layec (2023). The receptor for advanced glycation end products (RAGE) is involved in mitochondrial function and cigarette smoke-induced oxidative stress. Free radical biology & medicine, 195, 261-269. (Read full article)
  12. Jessop F, Schwarz B, Scott D, Roberts LM, Bohrnsen E, Hoidal JR, Bosio C (2022). Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in mice. JCI insight, 7(2), (Read full article)
  13. Decker ST, Kwon OS, Zhao J, Hoidal JR, Heuckstadt T, Richardson RS, Sanders KA, Layec (2021). Skeletal muscle mitochondrial adaptations induced by long-term cigarette smoke exposure. American journal of physiology. Endocrinology and metabolism, 321(1), E80-E89. (Read full article)
  14. Quiles JM, Pepin ME, Sunny S, Shelar SB, Challa AK, Dalley B, Hoidal JR, Pogwizd SM, Wende AR, Rajasekaran N (2021). Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress. Scientific reports, 11(1), 11977. (Read full article)
  15. Malik P, Hoidal JR, Mukherjee T (2021). Recent Advances in Curcumin Treated Non-Small Cell Lung Cancers: An Impetus of Pleiotropic Traits and Nanocarrier Aided Delive ry. Current medicinal chemistry, 28(16), 3061-3106. (Read full article)
  16. Rajasekaran NS, Shelar SB, Jones DP, Hoidal J (2020). Reductive stress impairs myogenic differentiation. Redox biology, 34, 101492. (Read full article)
  17. Murphy PJ, Guo J, Jenkins TG, James ER, Hoidal JR, Huecksteadt T, Broberg DS, Hotaling JM, Alonso DF, Carrell DT, Cairns BR, Aston K (2020). NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure. PLoS genetics, 16(6), e1008756. (Read full article)
  18. Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal JR, Kensler TW, Dell'Italia L, Darley-Usmar V, Abel ED, Jones DP, Ping P, Rajasekaran N (2020). Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. Antioxidants & redox signaling, 32(18), 1293-1312. (Read full article)
  19. Wuren T, Huecksteadt T, Beck E, Warren K, Hoidal J, Ostrand-Rosenberg S, Sanders (2021). The receptor for advanced glycation endproducts (RAGE) decreases survival of tumor-bearing mice by enhancing the generation of lung metastasis-associated myeloid-derived suppressor cells. Cellular immunology, 365, 104379. (Read full article)
  20. Pratte KA, Curtis JL, Kechris K, Couper D, Cho MH, Silverman EK, DeMeo DL, Sciurba FC, Zhang Y, Ortega VE, O'Neal WK, Gillenwater LA, Lynch DA, Hoffman EA, Newell JD Jr, Comellas AP, Castaldi PJ, Miller BE, Pouwels SD, Hacken NHTT, Bischoff R, Klont F, Woodruff PG, Paine R, Barr RG, Hoidal J, Doerschuk CM, Charbonnier JP, Sung R, Locantore N, Yonchuk JG, Jacobson S, Tal-Singer R, Merrill D, Bowler R (2021). Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD. Respiratory research, 22(1), 127. (Read full article)

Review

  1. Malik P, Hoidal JR, Mukherjee T (2021). Implication of RAGE Polymorphic Variants in COPD Complication and Anti-COPD Therapeutic Potential of sRAGE. COPD, 18(6), 737-748. (Read full article)
  2. Mukherjee TK, Malik P, Hoidal J (2021). The emerging role of estrogen related receptor¿ in complications of non-small cell lung cancers. Oncology letters, 21(4), 258. (Read full article)
  3. Mukherjee TK, Malik P, Maitra R, Hoidal J (2021). Ravaging SARS-CoV-2: rudimentary diagnosis and puzzling immunological responses. Current medical research and opinion, 37(2), 207-217. (Read full article)
  4. Mukherjee TK, Malik P, Hoidal J (2021). Receptor for Advanced Glycation End Products (RAGE) and Its Polymorphic Variants as Predictive Diagnostic and Prognostic Markers of NSCLCs: a Perspective. Current oncology reports, 23(1), 12. (Read full article)