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John R. Hoidal

John R. Hoidal, MD

Languages spoken: English

Academic Information

Departments Emeritus - Internal Medicine

Divisions: Pulmonary

Academic Office Information

John Hoidal, MD, is a professor and chair of the Department of Medicine at the University of Utah and an investigator of the Huntsman Cancer Institute. He holds the Clarence M. and Ruth N. Birrer Presidential Endowed Chair.

His research focuses on the genetic and molecular bases for nicotine addiction and the consequences of cigarette smoking. By gaining insights into biochemical pathways of addiction and ways to modify them, Hoidal hopes to find better ways to prevent and treat nicotine addiction and reduce the risk of smoking-related diseases such as lung cancer.

Hoidal received a bachelor's degree from Jamestown College, North Dakota, and a medical degree from the University of Minnesota.

Education History

Fellowship University of Minnesota Hospitals
University of Minnesota Hospitals
Chief Resident
Residency University of Minnesota Hospitals
University of Colorado at Denver and Health Sciences Center
Professional Medical University of Minnesota
Jamestown College

Selected Publications

Journal Article

  1. Kwon OS, Decker ST, Zhao J, Hoidal JR, Heuckstadt T, Sanders KA, Richardson RS, Layec G (2022). The receptor for advanced glycation end products (RAGE) is involved in mitochondrial function and cigarette smoke-induced oxidative stress. Free Radic Biol Med, 195, 261-269.
  2. Jessop F, Schwarz B, Scott D, Roberts LM, Bohrnsen E, Hoidal JR, Bosio CM (2022). Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in mice. JCI Insight, 7(2).
  3. Wuren T, Huecksteadt T, Beck E, Warren K, Hoidal J, Ostrand-Rosenberg S, Sanders K (2021). The receptor for advanced glycation endproducts (RAGE) decreases survival of tumor-bearing mice by enhancing the generation of lung metastasis-associated myeloid-derived suppressor cells. Cell Immunol, 365, 104379.
  4. Decker ST, Kwon OS, Zhao J, Hoidal JR, Heuckstadt T, Richardson RS, Sanders KA, Layec G (2021). Skeletal muscle mitochondrial adaptations induced by long-term cigarette smoke exposure. Am J Physiol Endocrinol Metab, 321(1), E80-E89.
  5. Quiles JM, Pepin ME, Sunny S, Shelar SB, Challa AK, Dalley B, Hoidal JR, Pogwizd SM, Wende AR, Rajasekaran NS (2021). Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress. Sci Rep, 11(1), 11977.
  6. Pratte KA, Curtis JL, Kechris K, Couper D, Cho MH, Silverman EK, DeMeo DL, Sciurba FC, Zhang Y, Ortega VE, ONeal WK, Gillenwater LA, Lynch DA, Hoffman EA, Newell JD Jr, Comellas AP, Castaldi PJ, Miller BE, Pouwels SD, Hacken NHTT, Bischoff R, Klont F, Woodruff PG, Paine R, Barr RG, Hoidal J, Doerschuk CM, Charbonnier JP, Sung R, Locantore N, Yonchuk JG, Jacobson S, Tal-Singer R, Merrill D, Bowler RP (2021). Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD. Respir Res, 22(1), 127.
  7. Malik P, Hoidal JR, Mukherjee TK (2020). Recent Advances in Curcumin Treated Non-Small Cell Lung Cancers: An Impetus of Pleiotropic Traits and Nanocarrier Aided Delive ry. Curr Med Chem, 28(16), 3061-3106.
  8. Rajasekaran NS, Shelar SB, Jones DP, Hoidal JR (2020). Reductive stress impairs myogenic differentiation. Redox Biol, 34, 101492.
  9. Murphy PJ, Guo J, Jenkins TG, James ER, Hoidal JR, Huecksteadt T, Broberg DS, Hotaling JM, Alonso DF, Carrell DT, Cairns BR, Aston KI (2020). NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure. PLoS Genet, 16(6), e1008756.
  10. Shanmugam G, Wang D, Gounder SS, Fernandes J, Litovsky SH, Whitehead K, Radhakrishnan RK, Franklin S, Hoidal JR, Kensler TW, DellItalia L, Darley-Usmar V, Abel ED, Jones DP, Ping P, Rajasekaran NS (2020). Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction. Antioxid Redox Signal, 32(18), 1293-1312.
  11. Liou TG, Adler FR, Argel N, Asfour F, Brown PS, Chatfield BA, Daines CL, Durham D, Francis JA, Glover B, Heynekamp T, Hoidal JR, Jensen JL, Keogh R, Kopecky CM, Lechtzin N, Li Y, Lysinger J, Molina O, Nakamura C, Packer KA, Poch KR, Quittner AL, Radford P, Redway AJ, Sagel SD, Sprandel S, Taylor-Cousar JL, Vroom JB, Yoshikawa R, Clancy JP, Elborn JS, Olivier KN, Cox DR (2019). Prospective multicenter randomized patient recruitment and sample collection to enable future measurements of sputum biomarkers of inflammation in an observational study of cystic fibrosis. BMC Med Res Methodol, 19(1), 88.
  12. Liou TG, Adler FR, Keogh RH, Li Y, Jensen JL, Walsh W, Packer K, Clark T, Carveth H, Chen J, Rogers SL, Lane C, Moore J, Sturrock A, Paine R 3rd, Cox DR, Hoidal JR (2012). Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis. PLoS One, 7(8), e42748.
  13. Jin H, Webb-Robertson BJ, Peterson ES, Tan R, Bigelow DJ, Scholand MB, Hoidal JR, Pounds JG, Zangar RC (2011). Smoking, COPD, and 3-nitrotyrosine levels of plasma proteins. Environ Health Perspect, 119(9), 1314-20.
  14. Reynolds PR, Kasteler SD, Schmitt RE, Hoidal JR (2011). Receptor for advanced glycation end-products signals through Ras during tobacco smoke-induced pulmonary inflammation. Am J Respir Cell Mol Biol, 45(2), 411-8.
  15. Chen Y, Hao H, He S, Cai L, Li Y, Hu S, Ye D, Hoidal J, Wu P, Chen X (2010). Lipoxin A4 and its analogue suppress the tumor growth of transplanted H22 in mice: the role of antiangiogenesis. Mol Cancer Ther, 9(8), 2164-74.
  16. Baker TB, Weiss RB, Bolt D, von Niederhausern A, Fiore MC, Dunn DM, Piper ME, Matsunami N, Smith SS, Coon H, McMahon WM, Scholand MB, Singh N, Hoidal JR, Kim SY, Leppert MF, Cannon DS (2009). Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes. Nicotine Tob Res, 11(7), 785-96.
  17. Ismail S, Sturrock A, Wu P, Cahill B, Norman K, Huecksteadt T, Sanders K, Kennedy T, Hoidal J (2009). NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-{beta}1 and insulin-like growth factor binding protein-3. Am J Physiol Lung Cell Mol Physiol, 296(3), L489-99.
  18. Mukherjee TK, Mukhopadhyay S, Hoidal JR (2008). Implication of receptor for advanced glycation end product (RAGE) in pulmonary health and pathophysiology. Respir Physiol Neurobiol, 162(3), 210-5.
  19. Weiss RB, Baker TB, Cannon DS, von Niederhausern A, Dunn DM, Matsunami N, Singh NA, Baird L, Coon H, McMahon WM, Piper ME, Fiore MC, Scholand MB, Connett JE, Kanner RE, Gahring LC, Rogers SW, Hoidal JR, Leppert MF (2008). A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. PLoS Genet, 4(7), e1000125.
  20. Reynolds PR, Kasteler SD, Cosio MG, Sturrock A, Huecksteadt T, Hoidal JR (2008). RAGE: developmental expression and positive feedback regulation by Egr-1 during cigarette smoke exposure in pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol, 294(6), L1094-101.


  1. Malik P, Hoidal JR, Mukherjee TK (2021). Implication of RAGE Polymorphic Variants in COPD Complication and Anti-COPD Therapeutic Potential of sRAGE. [Review]. COPD, 18(6), 737-748.
  2. Mukherjee TK, Malik P, Hoidal JR (2021). The emerging role of estrogen related receptorα in complications of non-small cell lung cancers. [Review]. Oncol Lett, 21(4), 258.
  3. Mukherjee TK, Malik P, Maitra R, Hoidal JR (2020). Ravaging SARS-CoV-2: rudimentary diagnosis and puzzling immunological responses. [Review]. Curr Med Res Opin, 37(2), 207-217.
  4. Mukherjee TK, Malik P, Hoidal JR (2021). Receptor for Advanced Glycation End Products (RAGE) and Its Polymorphic Variants as Predictive Diagnostic and Prognostic Markers of NSCLCs: a Perspective. [Review]. Curr Oncol Rep, 23(1), 12.