June Round

June Round, PhD

Languages spoken: English

Academic Information

Departments Primary - Pathology

Lab

Research Statement

The microbiota is now appreciated to have clear and important effects on mammalian health. However, this community is complex including bacterial, fungal and viral members. Moreover, most research in this area is correlative and lacks clear mechanistic studies. My research program is designed to extend beyond the correlative studies and draw causal associations between gut microbes and health. I have designed this program to analyze a diverse array of microbes including bacteriophages (viral), fungi and bacteria and to uncover the mechanistic underpinnings of how these organisms influence disease. Our work extends into many areas of health including gastro-intestinal diseases such as IBD and colorectal cancer, neurological disorders and metabolism. Given this breadth, my research program integrates a wealth of collaborators to ensure well-rounded expertise in all areas. This has allowed us to move into new areas and forge an inter-disciplinary training program for students and post-doctoral fellows that train in my laboratory. My end goal is to exploit interactions with commensal microbes and the host immune system to harness microbial products for therapies.

Education History

Undergraduate California Lutheran University
 BS
Graduate Training University of the Pacific
 MS
Doctoral Training University of California at Los Angeles
 DPhil
Postdoctoral Fellowship California Institute of Technology
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Hill JH, Round J (2021). SnapShot: Microbiota effects on host physiology. Cell, 184(10), 2796-2796.e1.
  2. Klag KA, Round J (2021). Microbiota-Immune Interactions Regulate Metabolic Disease. Journal of immunology (Baltimore, Md., 207(7), 1719-1724.
  3. Mazmanian SK, Round JL, Kasper D (2008). A microbial symbiosis factor prevents intestinal inflammatory disease. Nature, 453(7195), 620-5.
  4. Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round J (2021). Adaptive immunity induces mutualism between commensal eukaryotes. Nature, 596(7870), 114-118.
  5. Zegarra-Ruiz DF, Kim DV, Norwood K, Kim M, Wu WH, Saldana-Morales FB, Hill AA, Majumdar S, Orozco S, Bell R, Round JL, Longman RS, Egawa T, Bettini ML, Diehl G (2021). Thymic development of gut-microbiota-specific T cells. Nature, 594(7863), 413-417.
  6. Round JL, Mazmanian S (2010). Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proceedings of the National Academy of Sciences of the United States of America, 107(27), 12204-9.
  7. Soto R, Petersen C, Novis CL, Kubinak JL, Bell R, Stephens WZ, Lane TE, Fujinami RS, Bosque A, O'Connell RM, Round J (2017). Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor. Proceedings of the National Academy of Sciences of the United States of America, 114(21), 5497-5502.
  8. Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian S (2011). The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science (New York, N.Y.), 332(6032), 974-7.
  9. Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O'Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round J (2019). T cell-mediated regulation of the microbiota protects against obesity. Science (New York, N.Y.), 365(6451),
  10. Chiaro T, Round J (2021). Fungi prevent intestinal healing. Science (New York, N.Y.), 371(6534), 1102-1103.
  11. Klag K, Round J (2020). Immunology: How the Microbiota Digests Bile to Protect against Viral Infection. Current biology, 30(20), R1271-R1272.
  12. Eisele Y, Mallea PM, Gigic B, Stephens WZ, Warby CA, Buhrke K, Lin T, Boehm J, Schrotz-King P, Hardikar S, Huang LC, Pickron TB, Scaife CL, Viskochil R, Koelsch T, Peoples AR, Pletneva MA, Bronner M, Schneider M, Ulrich AB, Swanson EA, Toriola AT, Shibata D, Li CI, Siegel EM, Figueiredo J, Janssen KP, Hauner H, Round J, Ulrich CM, Holowatyj AN, Ose (2021). Fusobacterium nucleatum and Clinicopathologic Features of Colorectal Cancer: Results From the ColoCare Study. Clinical colorectal cancer, 20(3), e165-e172.
  13. Sanchez JMS, Doty DJ, DePaula-Silva AB, Brown DG, Bell R, Klag KA, Truong A, Libbey JE, Round JL, Fujinami R (2020). Molecular patterns from a human gut-derived Lactobacillus strain suppress pathogenic infiltration of leukocytes into the central nervous system. Journal of neuroinflammation, 17(1), 291.
  14. Bauer KM, Round JL, O'Connell R (2021). No small matter: emerging roles for exosomal miRNAs in the immune system. The FEBS journal, 289(14), 4021-4037.
  15. Kubinak JL, Petersen C, Stephens WZ, Soto R, Bake E, O'Connell RM, Round J (2015). MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health. Cell host & microbe, 17(2), 153-63.
  16. Gogokhia L, Buhrke K, Bell R, Hoffman B, Brown DG, Hanke-Gogokhia C, Ajami NJ, Wong MC, Ghazaryan A, Valentine JF, Porter N, Martens E, O'Connell R, Jacob V, Scherl E, Crawford C, Stephens WZ, Casjens SR, Longman RS, Round J (2019). Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis. Cell host & microbe, 25(2), 285-299.e8.
  17. Yeung F, Chen YH, Lin JD, Leung JM, McCauley C, Devlin JC, Hansen C, Cronkite A, Stephens Z, Drake-Dunn C, Fulmer Y, Shopsin B, Ruggles KV, Round JL, Loke P, Graham AL, Cadwell (2020). Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization. Cell host & microbe, 27(5), 809-822.e6.
  18. Weis AM, Round J (2021). Microbiota-antibody interactions that regulate gut homeostasis. Cell host & microbe, 29(3), 334-346.
  19. Chiaro TR, Soto R, Zac Stephens W, Kubinak JL, Petersen C, Gogokhia L, Bell R, Delgado JC, Cox J, Voth W, Brown J, Stillman DJ, O'Connell RM, Tebo AE, Round J (2017). A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice. Science translational medicine, 9(380),
  20. Kubinak JL, Stephens WZ, Soto R, Petersen C, Chiaro T, Gogokhia L, Bell R, Ajami NJ, Petrosino JF, Morrison L, Potts WK, Jensen PE, O'Connell RM, Round J (2015). MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection. Nature communications, 6, 8642.
  21. Huffaker TB, Ekiz HA, Barba C, Lee SH, Runtsch MC, Nelson MC, Bauer KM, Tang WW, Mosbruger TL, Cox JE, Round JL, Voth WP, O'Connell R (2021). A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages. Nature communications, 12(1), 2620.
  22. Gogokhia L, Round J (2021). Immune-bacteriophage interactions in inflammatory bowel diseases. Current opinion in virology, 49, 30-35.
  23. Stephens WZ, Kubinak JL, Ghazaryan A, Bauer KM, Bell R, Buhrke K, Chiaro TR, Weis AM, Tang WW, Monts JK, Soto R, Ekiz HA, O'Connell RM, Round J (2021). Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition. Cell reports, 37(5), 109916.
  24. Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, Round J (2019). The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling. eLife, 8,
  25. Kirsch JM, Brzozowski RS, Faith D, Round JL, Secor PR, Duerkop B (2021). Bacteriophage-Bacteria Interactions in the Gut: From Invertebrates to Mammals. Annual review of virology, 8(1), 95-113.

Review

  1. Ost, K. and June L. Round (2018). Communication between the microbiota and mammalian immunity. [Review]. Annu Rev Microbiol, 72, 399-422.
  2. Kubinak, J., and June L. Roun (2016). Do antibodies select a healthy microbiota?. Nature reviews. Immunology, 16, 767-774.

Editorial

  1. Ost, K. and June L. Roun (2017). A Few Good Commensals: Gut microbes use IFN-? to Fight Salmonella. 46(6), 977-979.
  2. Brown, D.G., and June L. Roun (2017). Friends in low places: Intestinal commensals limit colitis through molecular mimcry. 171(3), 503-505.
  3. Round, J.L. and Noah Pal (2018). Casual effects of the microbiota on immune-mediated disease. 9(3), 20.