Justin A. Bosch

Justin A. Bosch, PhD

Academic Information

Departments Primary - Human Genetics

Academic Office Information

jabosch@genetics.utah.edu

Education History

Postdoctoral Fellowship Harvard Medical School
 Postdoctoral Fellow
University of California, Berkeley
 PhD
Undergraduate University of Wisconsin–Madison
 BS

Selected Publications

Journal Article

  1. Bosch JA, Keith N, Escobedo F, Fisher WW, LaGraff JT, Rabasco J, Wan KH, Weiszmann R, Hu Y, Kondo S, Brown JB, Perrimon N, Celniker SE (2023). Molecular and functional characterization of the Drosophila melanogaster conserved smORFome. Cell Rep, 42(11), 113311. (Read full article)
  2. Zirin J, Jusiak B, Lopes R, Ewen-Campen B, Bosch J, Risbeck A, Forman C, Villalta C, Hu Y, Perrimon N (2023). Expanding the Drosophila toolkit for dual control of gene expression. bioRxiv. (Read full article)
  3. McGee AV, Liu YV, Griffith AL, Szegletes ZM, Wen B, Kraus C, Miller NW, Steger RJ, Velasco BE, Bosch JA, Zirin JD, Viswanatha R, Sontheimer EJ, Goodale A, Greene MA, Green TM, Doench JG (2023). Modular vector assembly enables rapid assessment of emerging CRISPR technologies. bioRxiv. (Read full article)
  4. Bosch JA, Ugur B, Pichardo-Casas I, Rabasco J, Escobedo F, Zuo Z, Brown B, Celniker S, Sinclair DA, Bellen HJ, Perrimon N (2022). Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila. Elife, 11. (Read full article)
  5. Bosch JA, Perrimon N (2022). Prime Editing for Precise Genome Engineering in Drosophila. Methods Mol Biol, 2540, 113-134. (Read full article)
  6. Droujinine IA, Meyer AS, Wang D, Udeshi ND, Hu Y, Rocco D, McMahon JA, Yang R, Guo J, Mu L, Carey DK, Svinkina T, Zeng R, Branon T, Tabatabai A, Bosch JA, Asara JM, Ting AY, Carr SA, McMahon AP, Perrimon N (2021). Proteomics of protein trafficking by in vivo tissue-specific labeling. Nat Commun, 12(1), 2382. (Read full article)
  7. Bosch JA, Birchak G, Perrimon N (2021). Precise genome engineering in Drosophila using prime editing. Proc Natl Acad Sci U S A, 118(1). (Read full article)
  8. Bosch JA, Knight S, Kanca O, Zirin J, Yang-Zhou D, Hu Y, Rodiger J, Amador G, Bellen HJ, Perrimon N, Mohr SE (2019). Use of the CRISPR-Cas9 System in Drosophila Cultured Cells to Introduce Fluorescent Tags into Endogenous Genes. Curr Protoc Mol Biol, 130(1), e112. (Read full article)
  9. Xu C, Franklin B, Tang HW, Regimbald-Dumas Y, Hu Y, Ramos J, Bosch JA, Villalta C, He X, Perrimon N (2019). An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity. Proc Natl Acad Sci U S A, 117(1), 464-471. (Read full article)
  10. Bosch JA, Colbeth R, Zirin J, Perrimon N (2019). Gene Knock-Ins in Drosophila Using Homology-Independent Insertion of Universal Donor Plasmids. Genetics, 214(1), 75-89. (Read full article)
  11. Branon TC, Bosch JA, Sanchez AD, Udeshi ND, Svinkina T, Carr SA, Feldman JL, Perrimon N, Ting AY (2018). Efficient proximity labeling in living cells and organisms with TurboID. Nat Biotechnol, 36(9), 880-887. (Read full article)
  12. Bosch JA, Sumabat TM, Hariharan IK (2016). Persistence of RNAi-Mediated Knockdown in Drosophila Complicates Mosaic Analysis Yet Enables Highly Sensitive Lineage Tracing. Genetics, 203(1), 109-18. (Read full article)
  13. Bosch JA, Tran NH, Hariharan IK (2015). CoinFLP: a system for efficient mosaic screening and for visualizing clonal boundaries in Drosophila. Development, 142(3), 597-606. (Read full article)
  14. Bosch JA, Sumabat TM, Hafezi Y, Pellock BJ, Gandhi KD, Hariharan IK (2014). The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling. Elife, 3, e03383. (Read full article)
  15. Anderson RM, Delous M, Bosch JA, Ye L, Robertson MA, Hesselson D, Stainier DY (2013). Hepatocyte growth factor signaling in intrapancreatic ductal cells drives pancreatic morphogenesis. PLoS Genet, 9(7), e1003650. (Read full article)
  16. Hafezi Y, Bosch JA, Hariharan IK (2012). Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries. Dev Biol, 368(2), 358-69. (Read full article)
  17. Tittle RK, Sze R, Ng A, Nuckels RJ, Swartz ME, Anderson RM, Bosch J, Stainier DY, Eberhart JK, Gross JM (2010). Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens. Dev Biol, 350(1), 50-63. (Read full article)
  18. Anderson RM, Bosch JA, Goll MG, Hesselson D, Dong PD, Shin D, Chi NC, Shin CH, Schlegel A, Halpern M, Stainier DY (2009). Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Dev Biol, 334(1), 213-23. (Read full article)
  19. Bosch JA, Heo K, Sliwinski MK, Baum DA (2011). An exploration of LEAFY expression in independent evolutionary origins of rosette flowering in Brassicaceae. Am J Bot, 95(3), 286-93. (Read full article)
  20. Sliwinski MK, Bosch JA, Yoon HS, Balthazar Mv, Baum DA (2007). The role of two LEAFY paralogs from Idahoa scapigera (Brassicaceae) in the evolution of a derived plant architecture. Plant J, 51(2), 211-9. (Read full article)

Review

  1. Zirin J, Bosch J, Viswanatha R, Mohr SE, Perrimon N (2021). State-of-the-art CRISPR for in vivo and cell-based studies in Drosophila. [Review]. Trends Genet, 38(5), 437-453. (Read full article)
  2. Bosch JA, Chen CL, Perrimon N (2020). Proximity-dependent labeling methods for proteomic profiling in living cells: An update. [Review]. Wiley Interdiscip Rev Dev Biol, 10(1), e392. (Read full article)