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Justin G. English

Justin G. English, PhD

Academic Information

Departments Primary - Biochemistry

Academic Office Information

My laboratory focuses on understanding how cells interpret and respond to information in their environment in human health and disease. We focus primarily on the pharmacology of G-protein coupled receptors, the main targets of the majority of approved drugs, and the design of tools to measure and understand how these proteins communicate with the cell.

Education History

Graduate Training University of North Carolina School of Medicine
Cornell University

Selected Publications

Journal Article

  1. Zahm AM, Owens WS, Himes SR, Rondem KE, Fallon BS, Gormick AN, Bloom JS, Kosuri S, Chan H, English JG (2023). Discovery and Validation of Context-Dependent Synthetic Mammalian Promoters.
  2. Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL (2021). Structure, function and pharmacology of human itch GPCRs. Nature, 600(7887), 170-175.
  3. Nagai Y, Miyakawa N, Takuwa H, Hori Y, Oyama K, Ji B, Takahashi M, Huang XP, Slocum ST, DiBerto JF, Xiong Y, Urushihata T, Hirabayashi T, Fujimoto A, Mimura K, English JG, Liu J, Inoue KI, Kumata K, Seki C, Ono M, Shimojo M, Zhang MR, Tomita Y, Nakahara J, Suhara T, Takada M, Higuchi M, Jin J, Roth BL, Minamimoto T (2020). Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. Nat Neurosci, 23(9), 1157-1167.
  4. Olsen RHJ, DiBerto JF, English JG, Glaudin AM, Krumm BE, Slocum ST, Che T, Gavin AC, McCorvy JD, Roth BL, Strachan RT (2020). TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome. Nat Chem Biol, 16(8), 841-849.
  5. Che T, English J, Krumm BE, Kim K, Pardon E, Olsen RHJ, Wang S, Zhang S, Diberto JF, Sciaky N, Carroll FI, Steyaert J, Wacker D, Roth BL (2020). Nanobody-enabled monitoring of kappa opioid receptor states. Nat Commun, 11(1), 1145.
  6. English JG, Olsen RHJ, Lansu K, Patel M, White K, Cockrell AS, Singh D, Strachan RT, Wacker D, Roth BL (2019). VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells. Cell, 178(4), 1030.
  7. English JG, Roth BL (2015). Chemogenetics-A Transformational and Translational Platform. JAMA Neurol, 72(11), 1361-6.
  8. English JG, Shellhammer JP, Malahe M, McCarter PC, Elston TC, Dohlman HG (2015). MAPK feedback encodes a switch and timer for tunable stress adaptation in yeast. Sci Signal, 8(359), ra5.


  1. Olsen RHJ, English JG (2022). Advancements in G protein-coupled receptor biosensors to study GPCR-G protein coupling. [Review]. Br J Pharmacol, 180(11), 1433-1443.


  1. Fallon BS, English JG (2022). Ion-ing out the genetic variants of Kir2.1. Elife, 11.