Karim Khader

Karim Khader, PhD, MStat, MS

Languages spoken: English

Academic Information

Departments Adjunct - Population Health Sciences , Primary - Internal Medicine

Divisions: Epidemiology

Karim Khader's research areas of interest are the advancing of statistical methodology and the use of mathematical models and computer simulations to understand the behavior of complex systems. These two general interests are complementary to one another; mathematical modeling and computer simulation represent a data-generating process which can be analyzed through the use of various statistical methodologies, while advances in statistical methodologies are needed to inform and parameterize computer simulations as the data-generating processes become increasingly complex. He has pursued these interests across multiple domains of study with a particular focus on transmission and infection due to antimicrobial resistant organisms in healthcare facilities, particularly with respect to understanding how to improve patient outcomes by reducing rates of healthcare-associated infections and gaining deeper insights into the key factors that result in infection.

Education History

Undergraduate University of Utah
 BS
Graduate Training University of Rhode Island
 MS
Graduate Training University of Utah
 MStat
Doctoral Training University of Utah
 PhD
Postdoctoral Fellowship Division of Epidemiology, University of Utah
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Nelson R, Deka R, Khader K, Stevens V, Schweizer M, Rubin (2017). Dynamic transmission models for economic analysis applied to healthcare associated infections: A review of the literature. American journal of infection control,
  2. Jones M, Nielson C, Gupta K, Khader K, Evans (2014). Collateral benefit of screening patients for methicillin-resistant Staphylococcus aureus at hospital admission: Isolation of patients with multidrug-resistant gram-negative bacteria. American journal of infection control,
  3. Toth DJA, Khader K, Slayton RB, Kallen AJ, Gundlapalli AV, O'Hagan JJ, Fiore AE, Rubin MA, Jernigan JA, Samore M (2017). The potential for interventions in a long-term acute care hospital to reduce transmission of carbapenem-resistant enterobacteriaceae in affiliated healthcare facilities. Clinical infectious diseases,
  4. Nelson RE, Samore MH, Khader K, Jones M, Stevens V, Evans ME, Schweizer ML, Perencevich EL, Rubin M (2016). Economic analysis of Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections. American journal of preventive medicine,
  5. Chiang HY, Perencevich EN, Nair R, Nelson RE, Samore M, Khdaer K, Chorazy ML, Herwaldt LA, Blevins A, Ward MA, Schweizer M (2017). Incidence and outcomes associated with infections caused by vancomycin-resistant enterococci in the united states: systematic literature review and meta-analysis. Infection control and hospital epidemiology,
  6. Nelson R, Schweizer M, Perencevich E, Nelson S, Khader K, Chiang H, Chorazy M, Blevins A, Ward M, Samore (2016). Costs and mortality associated with healthcare-associated multi-drug resistant Acinetobacter infections. Infection control and hospital epidemiology,
  7. Stevens V, Khader K, Nelson R, Jones M, Rubin M, Brown K, Evans M, Greene T, Slade E, Samore (2015). Excess length of stay attributable to clostridium difficile infection (CDI) in the acute care setting: A multistate model. Infection control and hospital epidemiology,
  8. Nelson R, Nelson S, Khader K, Perencevich E, Schweizer M, Rubin M, Graves N, Harbarth S, Stevens V, Samore (2015). The magnitude of time-dependent bias in the estimation of excess length of stay attributable to healthcare-associated infections. Infection control and hospital epidemiology,
  9. Perencevich EN, Harris AD, Pfeiffer CD, Rubin MA, Hill JN, Baracco GJ, Evans ME, Klutts JS, Streit JA, Nelson RE, Khader K, Reisinger H (2018). Establishing a Research Agenda for Preventing Transmission of Multidrug-Resistant Organisms in Acute-Care Settings in the Veterans Health Administration. Infection control and hospital epidemiology, 39(2), 189-195.
  10. McDanel J, Schweizer M, Crabb V, Nelson R, Samore M, Khader K, Blevins AE, Diekema D, Chiang HY, Nair R, Perencevich (2017). Incidence of Extended-Spectrum ß-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Infections in the United States: A Systematic Literature Review. Infection control and hospital epidemiology, 38(10), 1209-1215.
  11. Nelson RE, Slayton RB, Stevens V, Jones M, Khader K, Rubin MA, Jernigan JA, Samore (2017). Attributable Mortality of Healthcare-Associated Infections Due to Multidrug-Resistant Gram-Negative Bacteria and Methicillin-Resistant Staphylococcus Aureus. Infection control and hospital epidemiology, 38(07), 1-9.
  12. Slayton R,Toth D, Lee B, Tanner W, Bartsch S, Khader K, Wong K, Brown K, McKinnell J, Ray W, Miller L, Rubin M, Kim D, Adler F, Cao C, Avery L, Stone N, Kallen A, Samore M, Huang S, Fridkin S, Jernigan (2015). Vital Signs: Estimated effects of a coordinated approach for action to reduce antibiotic-resistant infections in health care facilities ¿ United States. MMWR. Morbidity and mortality weekly report,
  13. Fridkin S, Baggs J, Fagan R, Magill S, Pollack L, Malpiedi P, Slayton R, Khader K, Rubin M, Jones M, Samore M, Dumyati G, Dodds-Ashley E, Meek J, Yousey-Hindes K, Jernigan J, Shehab N, Herrera R, McDonald C, Schneider A, Srinivasan (2014). Vital Signs: Improving antibiotic use among hospitalized patients. MMWR. Morbidity and mortality weekly report,
  14. Toth D, Gudlapalli A, Khader K, Pettey W, Rubin M, Adler F, Samore (2015). Estimates of outbreak risk from new introductions of Ebola with immediate and delayed transmission control. Emerging infectious diseases,
  15. Khader K, Leecaster M, Greene T, Samore M, Thomas (2014). Improved hidden Markov model for nosocomial infections. Mathematical medicine and biology, 31(4), 338-52. (Read full article)
  16. Thomas A, Redd A, Khader K, Leecaster M, Greene T, Samore (2015). Efficient parameter estimation for models of healthcare-associated pathogen transmission in discrete and continuous time. Mathematical medicine and biology, 32(1), 79-98. (Read full article)
  17. Thomas A, Khader K, Redd A, Leecaster M, Zhang Y, Jones M, Greene T, Samore (2018). Extended models for nosocomial infection: parameter estimation and model selection. Mathematical medicine and biology, 35(suppl_1), 29-49. (Read full article)
  18. Rubin MA, Jones M, Leecaster M, Khader K, Ray W, Huttner A, Huttner B, Toth D, Sablay T, Borotkanics RJ, Gerding DN, Samore M (2013). A simulation-based assessment of strategies to control Clostridium difficile transmission and infection. PloS one, 8(11), e80671. (Read full article)
  19. Nelson RE, Jones M, Leecaster M, Samore MH, Ray W, Huttner A, Huttner B, Khader K, Stevens VW, Gerding D, Schweizer ML, Rubin M (2016). An Economic Analysis of Strategies to Control Clostridium Difficile Transmission and Infection Using an Agent-Based Simulation Model. PloS one,
  20. Toth D, Tanner W, Khader K, Gundlapalli (2016). Estimates of the risk of a large or long-lasting outbreak of Middle East respiratory syndrome (MERS) after an importation outside the Arabian Peninsula. Epidemics,
  21. Livorsi DJ, Chorazy ML, Schweizer ML, Balkenende EC, Blevins A, Nair R, Samore M, Nelson RE, Khader K, Perencevich E (2018). A systematic review of the epidemiology of carbapenem-resistant Enterobacteriaceae in the United States. Antimicrobial resistance and infection control, 7(1),
  22. Stevens VW, Nelson RE, Schwab-Daugherty EM, Khader K, Jones MM, Brown KA, Greene T, Croft LD, Neuhauser M, Glassman P, Goetz MB, Samore MH, Rubin M (2017). Comparative effectiveness of vancomycin and metronidazole for the prevention of recurrence and death in patients with clostridium difficile infection. JAMA internal medicine,
  23. Khader K, Thomas A, Huskins WC, Leecaster M, Zhang Y, Greene T, Redd A, Samore M (2017). A dynamic transmission model to evaluate the effectiveness of infection control strategies. Open forum infectious diseases,
  24. Nelson Chang NC, Leecaster M, Fridkin S, Dube W, Katz M, Polgreen P, Roghmann MC, Khader K, Li L, Dumyati G, Tsay R, Lynfield R, Mahoehney JP, Nadle J, Hutson J, Pierce R, Zhang A, Wilson C, Haroldsen C, Mulvey D, Reddy SC, Stone ND, Slayton RB, Thompson ND, Stratford K, Samore M, Visnovsky L (2023). Assessing Pathogen Transmission Opportunities: Variation in Nursing Home Staff-Resident Interactions. Journal of the American Medical Directors Association, 24(5), 735.e1-735.e9. (Read full article)
  25. Britt NS, Khader K, He T, Willson TM, Effiong A, Timbrook TT, Potter EM, Lodise T (2023). Examining the clinical impact of rapid multiplex polymerase chain reaction-based diagnostic testing for bloodstream infections in a national cohort of the Veterans Health Administration. Pharmacotherapy, 43(1), 24-34. (Read full article)
  26. Jones M, Khader K, Branch-Elliman (2022). Estimated Impact of the US COVID-19 Vaccination Campaign-Getting to 94% of Deaths Prevented. JAMA network open, 5(7), e2220391. (Read full article)
  27. Keegan LT, Tanner W, Orleans B, Slayton RB, Jernigan JA, McDonald LC, Noble-Wang J, Leecaster M, Haroldsen C, Khader K, Toth DJA, O'Sullivan T, Samore MH, Brazelton W, Rubin (2025). Environmental and Health Care Personnel Sampling and Unobserved Clostridium difficile Transmission in ICU. JAMA network open, 8(4), e252787. (Read full article)
  28. Pham TM, Zhang Y, Nevers M, Li H, Khader K, Grad YH, Lipsitch M, Samore (2024). Trends in infection incidence and antimicrobial resistance in the US Veterans Affairs Healthcare System: a nationwide retrospective cohort study (2007-22). The Lancet. Infectious diseases, 24(12), 1333-1346. (Read full article)
  29. Hutcherson C, Luke B, Khader K, Dhaher Y (2024). Unraveling the complex interplay of sex, endocrinology, and inflammation in post-Injury articular cartilage breakdown through in silico modeling. Scientific reports, 14(1), 28654. (Read full article)
  30. Mitchell C, Keegan LT, Le TTT, Khader K, Beams A, Samore MH, Toth DJ (2024). Importance of underlying mechanisms for interpreting relative risk of Clostridioides difficile infection among antibiotic-exposed patients in healthcare facilities. PloS one, 19(8), e0306622. (Read full article)
  31. Duong KNC, Nguyen DT, Kategeaw W, Liang X, Khaing W, Visnovsky LD, Veettil SK, McFarland MM, Nelson RE, Jones BE, Pavia AT, Coates E, Khader K, Love J, Vega Yon GG, Zhang Y, Willson T, Dorsan E, Toth DJA, Jones MM, Samore MH, Chaiyakunapruk (2024). Incorporating social determinants of health into transmission modeling of COVID-19 vaccine in the US: a scoping review. Lancet regional health. Americas, 35, 100806. (Read full article)
  32. Smith M, Crnich C, Donskey C, Evans CT, Evans M, Goto M, Guerrero B, Gupta K, Harris A, Hicks N, Khader K, Kralovic S, McKinley L, Rubin M, Safdar N, Schweizer ML, Tovar S, Wilson G, Zabarsky T, Perencevich E (2024). Research agenda for transmission prevention within the Veterans Health Administration, 2024-2028. Infection control and hospital epidemiology, 45(8), 1-10. (Read full article)