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Karin Chen, MD

Languages spoken: English, Mandarin Chinese

Academic Information

Departments Adjunct - Pediatrics

Divisions: Allergy / Immunology

Board Certification

  • American Board of Pediatrics (Pediatrics)

Dr. Karin Chen received her medical degree from the University of California, Irvine School of Medicine. She then completed her residency in Pediatrics and a clinical fellowship in Allergy & Immunology at UCLA. She is an Assistant Professor in the Division of Allergy and Immunology, Department of Pediatrics. Dr. Chen’s research involves the investigation of primary immunodeficiency diseases, with an emphasis in genetics and disease pathogenesis. She has been involved in the gene discovery of NFKB2 as a cause of an inherited primary immunodeficiency disease syndrome.Dr. Karin Chen received her medical degree from the University of California, Irvine School of Medicine. She then completed her residency in Pediatrics and a clinical fellowship in Allergy & Immunology at UCLA. She is an Assistant Professor in the Division of Allergy and Immunology, Department of Pediatrics. Dr. Chen’s research involves the investigation of primary immunodeficiency diseases, with an emphasis in genetics and disease pathogenesis. She has been involved in the gene discovery of NFKB2 as a cause of an inherited primary immunodeficiency disease syndrome.

Education History

Undergraduate University of California, Davis, Division of Biological Sciences
 BS
Professional Medical University of California, Irvine School of Medicine
 MD
Residency David Geffen School of Medicine, UCLA
 Resident
Fellowship David Geffen School of Medicine at UCLA
 Fellow

Selected Publications

Journal Article

  1. Chen K, Coonrod EM, Kumanovics A, Franks ZF, Durtschi JD, Margraf RL, Wu W, Heikal NM, Augustine NH, Ridge PG, Hill HR, Jorde LB, Weyrich AS, Zimmerman GA, Gundlapalli AV, Bohnsack JF, Voelkerding KV (2013). Germline mutations in NFKB2 implicate the noncanonical NF-kappaB pathway in the pathogenesis of common variable immunodeficiency. Am J Hum Genet, 93(5), 812-24. (Read full article)
  2. Singleton MV, Guthery SL, Voelkerding KV, Chen K, Kennedy B, Margraf RL, Durtschi J, Eilbeck K, Reese MG, Jorde LB, Huff CD, Yandell M (2014). Phevor combines multiple biomedical ontologies for accurate identification of disease-causing alleles in single individuals and small nuclear families. Am J Hum Genet, 94(4), 599-610. (Read full article)
  3. Bosticardo M, Yamazaki Y, Cowan J, Giardino G, Corsino C, Scalia G, Prencipe R, Ruffner M, Hill DA, Sakovich I, Yemialyanava I, Tam JS, Padem N, Elder ME, Sleasman JW, Perez E, Niebur H, Seroogy CM, Sharapova S, Gebbia J, Kleiner GI, Peake J, Abbott JK, Gelfand EW, Crestani E, Biggs C, Butte MJ, Hartog N, Hayward A, Chen K, Heimall J, Seeborg F, Bartnikas LM, Cooper MA, Pignata C, Bhandoola A, Notarangelo LD (2019). Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis. Am J Hum Genet, 105(3), 549-561. (Read full article)
  4. Verma A, Chen K, Bender C, Gorney N, Leonard W, Barnette P (2019). PEGylated E. coli asparaginase desensitization: an effective and feasible option for pediatric patients with acute lymphoblastic leukemia who have developed hypersensitivity to pegaspargase in the absence of asparaginase Erwinia chrysanthemi availability. Pediatr Hematol Oncol, 36(5), 277-286. (Read full article)
  5. Land MH, Garcia-Lloret MI, Borzy MS, Rao PN, Aziz N, McGhee SA, Chen K, Gorski J, Stiehm E (2007). Long-term results of bone marrow transplantation in complete DiGeorge syndrome. The Journal of allergy and clinical immunology, 120(4), 908-15. (Read full article)
  6. Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Pai SY, Ballard B, Bauer SC, Bleesing JJ, Boyle M, Brower A, Buckley RH, van der Burg M, Burroughs LM, Candotti F, Cant AJ, Chatila T, Cunningham-Rundles C, Dinauer MC, Dvorak CC, Filipovich AH, Fleisher TA, Bobby Gaspar H, Gungor T, Haddad E, Hovermale E, Huang F, Hurley A, Hurley M, Iyengar S, Kang EM, Logan BR, Long-Boyle JR, Malech HL, McGhee SA, Modell F, Modell V, Ochs HD, O'Reilly RJ, Parkman R, Rawlings DJ, Routes JM, Shearer WT, Small TN, Smith H, Sullivan KE, Szabolcs P, Thrasher A, Torgerson TR, Veys P, Weinberg K, Zuniga-Pflucker J (2014). Primary Immune Deficiency Treatment Consortium (PIDTC) report. The Journal of allergy and clinical immunology, 133(2), 335-47. (Read full article)
  7. Lee YN, Frugoni F, Dobbs K, Walter JE, Giliani S, Gennery AR, Al-Herz W, Haddad E, LeDeist F, Bleesing JH, Henderson LA, Pai SY, Nelson RP, El-Ghoneimy DH, El-Feky RA, Reda SM, Hossny E, Soler-Palacin P, Fuleihan RL, Patel NC, Massaad MJ, Geha RS, Puck JM, Palma P, Cancrini C, Chen K, Vihinen M, Alt FW, Notarangelo L (2014). A systematic analysis of recombination activity and genotype-phenotype correlation in human recombination-activating gene 1 deficiency. The Journal of allergy and clinical immunology, 133(4), 1099-108. (Read full article)
  8. Walter JE, Lo MS, Kis-Toth K, Tirosh I, Frugoni F, Lee YN, Csomos K, Chen K, Pillai S, Dunham J, Tsokos GC, Luning Prak ET, Notarangelo L (2015). Impaired receptor editing and heterozygous RAG2 mutation in a patient with systemic lupus erythematosus and erosive arthritis. The Journal of allergy and clinical immunology, 135(1), 272-3. (Read full article)
  9. Kumanovics A, Lee YN, Close DW, Coonrod EM, Ujhazi B, Chen K, MacArthur DG, Krivan G, Notarangelo LD, Walter J (2017). Estimated disease incidence of RAG1/2 mutations: A case report and querying the Exome Aggregation Consortium. The Journal of allergy and clinical immunology, 139(2), 690-692.e3. (Read full article)
  10. de la Morena MT, Leonard D, Torgerson TR, Cabral-Marques O, Slatter M, Aghamohammadi A, Chandra S, Murguia-Favela L, Bonilla FA, Kanariou M, Damrongwatanasuk R, Kuo CY, Dvorak CC, Meyts I, Chen K, Kobrynski L, Kapoor N, Richter D, DiGiovanni D, Dhalla F, Farmaki E, Speckmann C, Espanol T, Shcherbina A, Hanson IC, Litzman J, Routes JM, Wong M, Fuleihan R, Seneviratne SL, Small TN, Janda A, Bezrodnik L, Seger R, Raccio AG, Edgar JD, Chou J, Abbott JK, van Montfrans J, Gonzalez-Granado LI, Bunin N, Kutukculer N, Gray P, Seminario G, Pasic S, Aquino V, Wysocki C, Abolhassani H, Dorsey M, Cunningham-Rundles C, Knutsen AP, Sleasman J, Costa Carvalho BT, Condino-Neto A, Grunebaum E, Chapel H, Ochs HD, Filipovich A, Cowan M, Gennery A, Cant A, Notarangelo LD, Roifman C (2017). Long-term outcomes of 176 patients with X-linked hyper-IgM syndrome treated with or without hematopoietic cell transplantation. The Journal of allergy and clinical immunology, 139(4), 1282-1292. (Read full article)
  11. Chinn IK, Chan AY, Chen K, Chou J, Dorsey MJ, Hajjar J, Jongco AM 3rd, Keller MD, Kobrynski LJ, Kumanovics A, Lawrence MG, Leiding JW, Lugar PL, Orange JS, Patel K, Platt CD, Puck JM, Raje N, Romberg N, Slack MA, Sullivan KE, Tarrant TK, Torgerson TR, Walter J (2020). Diagnostic interpretation of genetic studies in patients with primary immunodeficiency diseases: A working group report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma & Immunology. The Journal of allergy and clinical immunology, 145(1), 46-69. (Read full article)
  12. Marsh RA, Leiding JW, Logan BR, Griffith LM, Arnold DE, Haddad E, Falcone EL, Yin Z, Patel K, Arbuckle E, Bleesing JJ, Sullivan KE, Heimall J, Burroughs LM, Skoda-Smith S, Chandrakasan S, Yu LC, Oshrine BR, Cuvelier GDE, Thakar MS, Chen K, Teira P, Shenoy S, Phelan R, Forbes LR, Chellapandian D, Dávila Saldaña BJ, Shah AJ, Weinacht KG, Joshi A, Boulad F, Quigg TC, Dvorak CC, Grossman D, Torgerson T, Graham P, Prasad V, Knutsen A, Chong H, Miller H, de la Morena MT, DeSantes K, Cowan MJ, Notarangelo LD, Kohn DB, Stenger E, Pai SY, Routes JM, Puck JM, Kapoor N, Pulsipher MA, Malech HL, Parikh S, Kang EM, submitted on behalf of the Primary Immune Deficiency Treatment Consortium (2019). Chronic Granulomatous Disease-Associated IBD Resolves and Does Not Adversely Impact Survival Following Allogeneic HCT. Journal of clinical immunology, 39(7), 653-667. (Read full article)
  13. Walter JE, Rosen LB, Csomos K, Rosenberg JM, Mathew D, Keszei M, Ujhazi B, Chen K, Lee YN, Tirosh I, Dobbs K, Al-Herz W, Cowan MJ, Puck J, Bleesing JJ, Grimley MS, Malech H, De Ravin SS, Gennery AR, Abraham RS, Joshi AY, Boyce TG, Butte MJ, Nadeau KC, Balboni I, Sullivan KE, Akhter J, Adeli M, El-Feky RA, El-Ghoneimy DH, Dbaibo G, Wakim R, Azzari C, Palma P, Cancrini C, Capuder K, Condino-Neto A, Costa-Carvalho BT, Oliveira JB, Roifman C, Buchbinder D, Kumanovics A, Franco JL, Niehues T, Schuetz C, Kuijpers T, Yee C, Chou J, Masaad MJ, Geha R, Uzel G, Gelman R, Holland SM, Recher M, Utz PJ, Browne SK, Notarangelo L (2016). Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. The Journal of clinical investigation, 126(11), 4389. (Read full article)
  14. Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, Garcia-Lloret MI, Chen K, Ozen A, Carmeliet P, Li MO, Pellegrini M, Chatila T (2019). Functional reprogramming of regulatory T cells in the absence of Foxp3. Nature immunology, 20(9), 1208-1219. (Read full article)
  15. Viera L, Chen K, Nel A, Lloret M (2009). The impact of air pollutants as an adjuvant for allergic sensitization and asthma. Current allergy and asthma reports, 9(4), 327-33. (Read full article)
  16. Kuo CY, Garcia-Lloret MI, Slev P, Bohnsack JF, Chen (2017). Profound T-cell lymphopenia associated with prenatal exposure to purine antagonists detected by TREC newborn screening. The journal of allergy and clinical immunology. In practice, 5(1), 198-200. (Read full article)
  17. Gernez Y, Freeman AF, Holland SM, Garabedian E, Patel NC, Puck JM, Sullivan KE, Akhter J, Secord E, Chen K, Buckley R, Haddad E, Ochs HD, Fuleihan R, Routes J, Muskat M, Lugar P, Mancini J, Cunningham-Rundles (2018). Autosomal Dominant Hyper-IgE Syndrome in the USIDNET Registry. The journal of allergy and clinical immunology. In practice, 6(3), 996-1001. (Read full article)
  18. Farmer JR, Foldvari Z, Ujhazi B, De Ravin SS, Chen K, Bleesing JJH, Schuetz C, Al-Herz W, Abraham RS, Joshi AY, Costa-Carvalho BT, Buchbinder D, Booth C, Reiff A, Ferguson PJ, Aghamohammadi A, Abolhassani H, Puck JM, Adeli M, Cancrini C, Palma P, Bertaina A, Locatelli F, Di Matteo G, Geha RS, Kanariou MG, Lycopoulou L, Tzanoudaki M, Sleasman JW, Parikh S, Pinero G, Fischer BM, Dbaibo G, Unal E, Patiroglu T, Karakukcu M, Al-Saad KK, Dilley MA, Pai SY, Dutmer CM, Gelfand EW, Geier CB, Eibl MM, Wolf HM, Henderson LA, Hazen MM, Bonfim C, Wolska-Ku'nierz B, Butte MJ, Hernandez JD, Nicholas SK, Stepensky P, Chandrakasan S, Miano M, Westermann-Clark E, Goda V, Kriván G, Holland SM, Fadugba O, Henrickson SE, Ozen A, Karakoc-Aydiner E, Baris S, Kiykim A, Bredius R, Hoeger B, Boztug K, Pashchenko O, Neven B, Moshous D, Villartay JP, Bousfiha AA, Hill HR, Notarangelo LD, Walter J (2019). Outcomes and Treatment Strategies for Autoimmunity and Hyperinflammation in Patients with RAG Deficiency. The journal of allergy and clinical immunology. In practice, 7(6), 1970-1985.e4. (Read full article)
  19. Lee YN, Frugoni F, Dobbs K, Tirosh I, Du L, Ververs FA, Ru H, Ott de Bruin L, Adeli M, Bleesing JH, Buchbinder D, Butte MJ, Cancrini C, Chen K, Choo S, Elfeky RA, Finocchi A, Fuleihan RL, Gennery AR, El-Ghoneimy DH, Henderson LA, Al-Herz W, Hossny E, Nelson RP, Pai SY, Patel NC, Reda SM, Soler-Palacin P, Somech R, Palma P, Wu H, Giliani S, Walter JE, Notarangelo L (2016). Characterization of T and B cell repertoire diversity in patients with RAG deficiency. Science immunology, 1(6), (Read full article)

Case Report

  1. Parsons K, Cipriano SD, Rosen LB, Browne SK, Walter JE, Stone BL, Keeshin S, Chen (2019). Severe Facial Herpes Vegetans and Viremia in NFKB2-Deficient Common Variable Immunodeficiency. Frontiers in pediatrics, 7, 61. (Read full article)
  2. Simpson AM, Chen K, Bohnsack JF, Lamont MN, Siddiqi FA, Gociman (2018). Pyoderma Gangrenosum-like Wounds in Leukocyte Adhesion Deficiency: Case Report and Review of Literature. Plastic and reconstructive surgery. Global open, 6(8), e1886. (Read full article)

Editorial

  1. Chen K, Rondina MT, Weyrich AS (2013). A sticky story for signal transducer and activator of transcription 3 in platelets. Circulation, 127(4), 421-3. (Read full article)

Letter

  1. Chen K, Wu W, Mathew D, Zhang Y, Browne SK, Rosen LB, McManus MP, Pulsipher MA, Yandell M, Bohnsack JF, Jorde LB, Notarangelo LD, Walter J (2014). Autoimmunity due to RAG deficiency and estimated disease incidence in RAG1/2 mutations. The Journal of allergy and clinical immunology, 133(3), 880-2.e10. (Read full article)
  2. Goda V, Malik A, Kalmar T, Maroti Z, Patel B, Ujhazi B, Csomos K, Hale JE, Chen K, Bleesing J, Palma P, Cancrini C, Comeau AM, Krivan G, Walter J (2018). Partial RAG deficiency in a patient with varicella infection, autoimmune cytopenia, and anticytokine antibodies. The journal of allergy and clinical immunology. In practice, 6(5), 1769-1771.e2. (Read full article)