Katharine Diehl

Katharine Diehl, PhD

Academic Information

Departments Primary - Medicinal Chemistry

Academic Office Information

k.diehl@utah.edu

Education History

University of North Carolina at Chapel Hill
 BS

Selected Publications

Journal Article

  1. Diehl KL, Muir TW (2020). Chromatin as a key consumer in the metabolite economy. Nat Chem Biol, 16(6), 620-629.
  2. Diehl KL, Ge EJ, Weinberg DN, Jani KS, Allis CD, Muir TW (2019). PRC2 engages a bivalent H3K27M-H3K27me3 dinucleosome inhibitor. Proc Natl Acad Sci U S A, 116(44), 22152-22157.
  3. Ge EJ, Jani KS, Diehl KL, Mller MM, Muir TW (2019). Nucleation and Propagation of Heterochromatin by the Histone Methyltransferase PRC2: Geometric Constraints and Impact of the Regulatory Subunit JARID2. J Am Chem Soc, 141(38), 15029-15039.
  4. Jain SU, Do TJ, Lund PJ, Rashoff AQ, Diehl KL, Cieslik M, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir TW, Garcia BA, Jabado N, Lewis PW (2019). PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nat Commun, 10(1), 2146.
  5. Jani KS, Jain SU, Ge EJ, Diehl KL, Lundgren SM, Mller MM, Lewis PW, Muir TW (2019). Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. Proc Natl Acad Sci U S A, 116(17), 8295-8300.
  6. Dann GP, Liszczak GP, Bagert JD, Mller MM, Nguyen UTT, Wojcik F, Brown ZZ, Bos J, Panchenko T, Pihl R, Pollock SB, Diehl KL, Allis CD, Muir TW (2017). ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference. Nature, 548(7669), 607-611.
  7. Diehl KL, Ivy MA, Rabidoux S, Petry SM, Mller G, Anslyn EV (2015). Differential sensing for the regio- and stereoselective identification and quantitation of glycerides. Proc Natl Acad Sci U S A, 112(30), E3977-86.
  8. Diehl KL, Anslyn EV (2013). Array sensing using optical methods for detection of chemical and biological hazards. Chem Soc Rev, 42(22), 8596-611.